Article
Biochemistry & Molecular Biology
Gul Merve Yalcin-Ulker, Murat Gunbatan, Gonca Duygu, Merva Soluk-Tekkesin, Ceyda Ozcakir-Tomruk
Summary: This study examines the preventive effect of deferoxamine (DFO) on medication-related osteonecrosis of the jaw (MRONJ). Female Sprague Dawley rats were treated with zoledronic acid (ZA) to create an osteonecrosis model, and DFO was applied locally to prevent MRONJ. The results showed no significant difference in new bone formation between the treatment groups, although HIF-1 alpha levels were higher in the DFO-treated group. Further large-scale studies are needed to understand the preventive effects of DFO on MRONJ.
Article
Pharmacology & Pharmacy
Chunxia Chen, Shihai Yan, Zhirong Geng, Zhilin Wang
Summary: The HIF-1 alpha PHD inhibitor IOX2 improves the proliferation and migration of BMSCs by upregulating intracellular Ca2+ and decreasing ROS, thus promoting fracture healing.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Rong Du, Junjun Zhao, Yang Wen, Yaqin Zhu, Long Jiang
Summary: The promotion of DPC migration by DFO was partially reversed by inhibiting the HIF-1α gene, indicating the crucial role of HIF-1α in regulating DPC migration in response to DFO.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Review
Ophthalmology
Angela H. Kim, Masha Kolesnikova, Wei Kiong Ngo, Stephen H. Tsang
Summary: Hypoxia-inducible factor (HIF) is crucial in cellular adaptation to varying oxygen levels. HIF-1 alpha plays diverse roles in cellular repair, survival, and energy metabolism, and its dysregulation is associated with cancer. HIF-1 alpha modulation is being explored as a therapy for degenerative diseases and overactive cell proliferation, but its potential toxicities must be evaluated. Several HIF-1 alpha inhibitors and activators are being studied for their application in retinal disorders like macular degeneration and retinopathy.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Immunology
Essa M. Sabi, Anuja Singh, Ziyad M. Althafar, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al-Harrasi, Hosam M. Alqahtani, Simona Bungau
Summary: Rheumatoid arthritis is a chronic disease that affects millions of people worldwide and is closely associated with factors such as hypoxia and angiogenesis. This review will examine how hypoxia activates molecular pathways and how other pathways involving inflammatory signals develop and sustain synovitis in rheumatoid arthritis.
INFLAMMOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Bing Xu, Zeyu Luo, Duan Wang, Zeyu Huang, Zongke Zhou, Haoyang Wang
Summary: In this study, a nanocellulose-collagen-nano hydroxyapatite organic-inorganic hybrid aerogel loaded with stromal cell derived factor-1 and sclerostin monoclonal antibody was synthesized and investigated for its ability to repair steroid-induced osteonecrosis. The scaffold demonstrated good elastic modulus, appropriate pore structure, and sustained release of the loaded substances. In vitro and in vivo studies showed promising osteogenesis and tissue repair results.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Zirong Pan, Guodong Ma, Linglei Kong, Guanhua Du
Summary: Stroke is an acute cerebrovascular disease caused by sudden rupture or blockage of blood vessels in the brain, and HIF-1 plays an important role in regulating various pathways in the pathological process. The roles of HIF-1 in stroke are controversial, involving factors such as ischemic time and degree, and its regulatory mechanisms include inflammation, autophagy, oxidative stress, and apoptosis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cell & Tissue Engineering
Yanlin Zhu, Bei Chang, Yuxuan Pang, Huimin Wang, Yanmin Zhou
Summary: Deferoxamine (DFO) is an FDA-approved iron chelator that can upregulate hypoxia-inducible factor-1 alpha (HIF-1 alpha), leading to accelerated vascularization. It has multiple functions such as stem cell regulation, immunoregulation, provascularization, and pro-osteogenesis. DFO can also bind excess iron ions in chronic inflammation wounds and serve as an antioxidant. These characteristics make DFO a potent modulator in tissue engineering for enhancing tissue integration and wound healing.
TISSUE ENGINEERING PART B-REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Kai-Hua Chang, Pouria Shoureshi, Frank Lay, Raul Sebastian, Zahra Alikhassy Habibabady, Louis J. Born, Guy P. Marti, Stephen J. Meltzer, John M. Abraham, John W. Harmon
Summary: The study demonstrated that utilizing DNA plasmid delivery for HIF-1α gene increased mRNA levels in tissue, reducing necrotic area in surgical flaps and promoting angiogenesis. This offers a potential therapeutic strategy for enhancing the viability of surgical pedicle flaps through ischemic preconditioning with HIF-1α DNA plasmid.
Article
Dermatology
F. Toberer, H. A. Haenssle, M. Heinzel-Gutenbrunner, A. Enk, W. Hartschuh, P. Helmbold, H. Kutzner
Summary: The study highlights the crucial role of HIF-1α in MCC pathogenesis and suggests significant metabolic differences between McPyV(+) and McPyV(-) tumors.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Medicine, Research & Experimental
Min Kyung Park, Jun Ji, Keeok Haam, Tae-Hee Han, Seona Lim, Mi-Jung Kang, Soon Sung Lim, Hyun Seung Ban
Summary: Licochalcone A, a component of Glycyrrhiza uralensis, demonstrates potential as a therapeutic agent in hypoxic cancer cells by inhibiting HIF-1 alpha accumulation and mitochondrial respiration, leading to increased oxygen content and suppression of cancer cell viability.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Neurosciences
Hongxiu Chen, Di Ma, Feixue Yue, Yajie Qi, Manman Dou, Liuping Cui, Yingqi Xing
Summary: Studies have shown that HIF-1 is involved in the pathogenesis of various CNS-related disorders and may serve as a potential therapeutic target.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Ophthalmology
Flavia Plastino, Alvaro Santana-Garrido, Noemi Anna Pesce, Monica Aronsson, Emma Lardner, Alfonso Mate, Anders Kvanta, Carmen Maria Vazquez, Helder Andre
Summary: Our study demonstrates that Echinomycin can inhibit HIF-mediated angiogenesis in vitro and reduce vascular lesions in a mouse model of CNV, suggesting potential implications for the treatment of neovascular age-related macular degeneration in patients.
EXPERIMENTAL EYE RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Baoqi Yu, Xia Wang, Yanting Song, Guomin Xie, Shiyu Jiao, Li Shi, Xuejie Cao, Xinyao Han, Aijuan Qu
Summary: Cardiovascular diseases are the leading cause of death worldwide, and hypoxia-inducible factors (HIFs) play an important role in their pathogenesis. Recent studies have revealed the role of cell-specific HIFs in various cardiovascular diseases, but the potential clinical application of HIF inhibitors in the treatment of cardiovascular diseases is not well understood.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cell Biology
Hyun-Ju An, Kyung Rae Ko, Minjung Baek, Yoonhui Jeong, Hyeon Hae Lee, Hyungkyung Kim, Do Kyung Kim, So-Young Lee, Soonchul Lee
Summary: The study aimed to investigate the therapeutic effects of combinatorial therapy using adipose tissue-derived pericytes and NELL-1 on osteonecrosis. The results showed synergistic effects on pro-angiogenic and osteogenic efficacy, with maximum bone formation observed in the mouse model for osteonecrosis. This combination therapy may have potential as a novel treatment for osteonecrosis.