Elucidating the role of hypoxia-inducible factor in rheumatoid arthritis

HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review

(2021) Kiichi Hirota   Biomedicines

Angiogenesis as a potential treatment strategy for rheumatoid arthritis

(2021) Yan Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activation of GPR43 suppresses TNF-α-induced inflammatory response in human fibroblast-like synoviocytes

(2020) Chi Zhang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Neutralization of Bombina variegata peptide 8 suppresses retinal neovascularization in two different murine models: The oxygen-induced retinopathy model and the rhodopsin promoter/VEGF transgenic mouse model

(2020) Yiyun Yao et al.   EXPERIMENTAL EYE RESEARCH

A long hypoxia-inducible factor 3 isoform 2 is a transcription activator that regulates erythropoietin

(2019) Jussi-Pekka Tolonen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ubiquitin, SUMO, and NEDD8: Key Targets of Bacterial Pathogens

(2018) David Ribet et al.   TRENDS IN CELL BIOLOGY

Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin

(2018) James A Smythies et al.   EMBO REPORTS

A compendium of proteins that interact with HIF-1α

(2017) Gregg L. Semenza   EXPERIMENTAL CELL RESEARCH

Dysregulated bioenergetics: a key regulator of joint inflammation

(2016) M Biniecka et al.   ANNALS OF THE RHEUMATIC DISEASES

Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015)

(2016) Hyun Seung Ban et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Insights into the therapeutic potential of hypoxia-inducible factor-1α small interfering RNA in malignant melanoma delivered via folate-decorated cationic liposomes

(2016) Xingwang Zhang et al.   International Journal of Nanomedicine

Studies on novel HIF activators, A-503451s

(2016) Hideki Kobayashi et al.   JOURNAL OF ANTIBIOTICS

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

(2016) Caroline Wigerup et al.   PHARMACOLOGY & THERAPEUTICS

Differential sub-nuclear distribution of hypoxia-inducible factors (HIF)-1 and -2 alpha impacts on their stability and mobility

(2016) S. E. Taylor et al.   Open Biology

DUBs, New Members in the Hypoxia Signaling clUb

(2016) Amelie S. Schober et al.   Frontiers in Oncology

Hypoxia-inducible factors in T lymphocyte differentiation and function. A Review in the Theme: Cellular Responses to Hypoxia

(2015) Jin-Hui Tao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The pathogenic role of angiogenesis in rheumatoid arthritis

(2015) Hatem A. Elshabrawy et al.   ANGIOGENESIS

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

NF-κB and HIF crosstalk in immune responses

(2015) Laura D'Ignazio et al.   FEBS Journal

SDF-1 signaling: a promising target in rheumatic diseases

(2014) Amanda Villalvilla et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Hypoxia-inducible factors in regulation of immune responses in tumour microenvironment

(2014) Vinit Kumar et al.   IMMUNOLOGY

The potential role of angiogenic factors in rheumatoid arthritis

(2014) Gholamreza Azizi et al.   International Journal of Rheumatic Diseases

Tight Control of Hypoxia-inducible Factor-α Transient Dynamics Is Essential for Cell Survival in Hypoxia

(2014) James Bagnall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mimicking Hypoxia to Treat Anemia: HIF-Stabilizer BAY 85-3934 (Molidustat) Stimulates Erythropoietin Production without Hypertensive Effects

(2014) Ingo Flamme et al.   PLoS One

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

IL-29 enhances Toll-like receptor-mediated IL-6 and IL-8 production by the synovial fibroblasts from rheumatoid arthritis patients

(2013) Lingxiao Xu et al.   ARTHRITIS RESEARCH & THERAPY

Notch-1 mediates hypoxia-induced angiogenesis in rheumatoid arthritis

(2012) Wei Gao et al.   ARTHRITIS AND RHEUMATISM

The updated biology of hypoxia-inducible factor

(2012) Samantha N Greer et al.   EMBO JOURNAL

Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors

(2012) Yan Xia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

(2011) Minna Heikkilä et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Bortezomib represses HIF-1α protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells

(2011) Christina D. Befani et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis

(2011) F. G. Goh et al.   RHEUMATOLOGY

Expression and regulation of HIF-1alpha in macrophages under inflammatory conditions; significant reduction of VEGF by CaMKII inhibitor

(2010) Johanna Westra et al.   BMC MUSCULOSKELETAL DISORDERS

Roles of hypoxia-inducible factor-1α (HIF-1α) versus HIF-2α in the survival of hepatocellular tumor spheroids

(2010) Heidi Menrad et al.   HEPATOLOGY

Hypoxia-inducible factor (HIF)-3α is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2

(2010) Annika Pasanen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia-inducible transcription factor 1α/vascular endothelial growth factor-mediated pathway in immunodeficient mice

(2009) Manuel J. del Rey et al.   ARTHRITIS AND RHEUMATISM

Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis

(2009) Mohammed A Akhavani et al.   ARTHRITIS RESEARCH & THERAPY

Hypoxic synovial environment and expression of macrophage inflammatory protein 3γ/CCL20 in juvenile idiopathic arthritis

(2008) Maria Carla Bosco et al.   ARTHRITIS AND RHEUMATISM

Nonviral Nanoscale-Based Delivery of Antisense Oligonucleotides Targeted to Hypoxia-Inducible Factor 1  Enhances the Efficacy of Chemotherapy in Drug-Resistant Tumor

(2008) Y. Wang et al.   CLINICAL CANCER RESEARCH

Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1 

(2008) M. Y. Koh et al.   MOLECULAR CANCER THERAPEUTICS

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

IL-33 exacerbates antigen-induced arthritis by activating mast cells

(2008) D. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of hypoxia-inducible factor-1  in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes

(2008) J. K. Ahn et al.   RHEUMATOLOGY