Article
Oncology
Yoshihisa Numata, Tetsuya Abe, Eiji Higaki, Takahiro Hosoi, Hironori Fujieda, Takuya Nagao, Nobuhiro Hanai, Hidenori Suzuki, Daisuke Nishikawa, Keitaro Matsuo, Tsutomu Fujii, Yasuhiro Shimizu
Summary: Metastases to supraclavicular lymph nodes have a significant impact on the prognosis of patients with cervical esophageal cancer. These lymph nodes may be considered extra-regional in this patient population.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Markus H. Lerchbaumer, Katharina Margherita Wakonig, Philipp Arens, Steffen Dommerich, Thomas Fischer
Summary: Persisting cervical lymphadenopathy requires further evaluation to distinguish between benign infectious enlargement and malignant diseases. Ultrasound examination is the preferred imaging method, and our study suggests that adding multiparametric applications such as tissue stiffness and micro-vascularization can improve the accuracy of ultrasound diagnosis.
Article
Clinical Neurology
Adam Al-Diwani, Jakob Theorell, Valentina Damato, Joshua Bull, Nicholas McGlashan, Edward Green, Anne-Kathrin Kienzler, Ruby Harrison, Tasneem Hassanali, Leticia Campo, Molly Browne, Alistair Easton, Hooman Soleymani Majd, Keiko Tenaka, Raffaele Iorio, Russell C. Dale, Paul Harrison, John Geddes, Digby Quested, David Sharp, Soon-Tae Lee, David W. Nauen, Mateusz Makuch, Belinda Lennox, Darren Fowler, Fintan Sheerin, Patrick Waters, M. Isabel Leite, Adam E. Handel, Sarosh R. Irani
Summary: This study provides evidence that NR1-autoantibody production originates from active germinal centres in ovarian teratomas and cervical lymph nodes. These findings suggest the importance of studying immune activity in these anatomical locations.
Article
Multidisciplinary Sciences
Mehmet Sait Albayram, Garrett Smith, Fatih Tufan, Ibrahim Sacit Tuna, Mehmet Bostanciklioglu, Michael Zile, Onder Albayram
Summary: This study non-invasively visualizes lymphatic structures in the human brain, showing evidence of lymphatic flow from cranial nerves to cervical lymph nodes, as well as differences by age and sex.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Chunbo Li, Keqin Hua
Summary: This study used single-cell RNA sequencing to describe the composition and functional status of immune cells and mesenchymal cells during cervical cancer progression. The results showed distinct cell subpopulations at different stages of cervical cancer, with high-grade intraepithelial neoplasia exhibiting a low, recently activated tumor microenvironment, tumor tissue displaying an immunosuppressive state, and metastatic lymph node showing an early activated phase of immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Bei Wei, Jincao Yao, Chanjuan Peng, Shanshan Zhao, Hui Wang, Liping Wang, Xi Zhu, Yuting Kong, Liyu Chen, Dong Xu
Summary: The purpose of this study was to investigate the relationship between clinical characteristics and cervical lymph node metastasis in patients with thyroid carcinoma. The study found that male gender, younger age, larger tumor size, bilateral lesions, and extrathyroidal extension were risk factors for cervical lymph node metastasis. Ultrasound and contrast enhanced computed tomography had a higher sensitivity in detecting lateral lymph node metastasis compared to central lymph node metastasis. The study concluded that preoperative clinical characteristics and imaging examinations are crucial in evaluating cervical lymph nodes and guiding surgical treatments.
Article
Oncology
Wentao Zhang, Jian Peng, Shan Zhao, Wenli Wu, Junjun Yang, Junyong Ye, Shengsheng Xu
Summary: This study investigated the application of deep learning combined with traditional radiomics methods in classifying enlarged cervical lymph nodes. The results showed that the discrimination model constructed using radiomics features achieved high accuracy, specificity, and sensitivity in diagnosing different types of lymphadenopathy. The diagnostic performance of the model was significantly different from that of radiologists.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Tomoyuki Furubayashi, Daisuke Inoue, Shunsuke Kimura, Akiko Tanaka, Toshiyasu Sakane
Summary: The study demonstrated that direct nasal-CLN pathway contributed more to the transport of methotrexate to the CLNs than the direct blood-CLN pathway.
Article
Radiology, Nuclear Medicine & Medical Imaging
O. Meadows, J. Sarkodieh
Summary: In the absence of other concerning signs or symptoms, ultrasound evaluation of persistent lymph nodes in young patients showed mostly normal or reactive nodes, indicating that persistence of non-enlarged lymph nodes is not a predictor for malignancy. Clear guidelines should be used to promote optimal use of imaging techniques.
CLINICAL RADIOLOGY
(2021)
Article
Immunology
Aline M. Thomas, Ethan Yang, Matthew D. Smith, Chengyan Chu, Peter A. Calabresi, Kristine Glunde, Peter C. M. van Zijl, Jeff W. M. Bulte
Summary: The study explores the utility of CEST MRI in monitoring disease activity in MS, showing that CEST signals correspond temporally with disease activity and correlate with cellular and metabolic composition of lymph nodes during the active stage of experimental autoimmune encephalomyelitis (EAE). Correlations were also found between CEST MRI biomarkers, immune activation, and LN metabolite levels.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Health Care Sciences & Services
Hiromu Nakamura, Tetsuya Ogawa, Shunpei Yamanaka, Daisuke Inukai, Takashi Maruo, Taishi Takahara, Akira Satou, Toyonori Tsuzuki, Susumu Suzuki, Ryuzo Ueda, Yasushi Fujimoto
Summary: Neck dissection is a commonly used procedure for treating cervical lymph node metastasis in head and neck cancer patients. However, with the emergence of immunotherapy, the removal of lymph nodes with immune function needs to be reconsidered. A study on HPV16-positive head and neck squamous cell carcinoma patients found that preserving non-metastatic lymph nodes is important for their immune function during neck dissection and when administering immunotherapy. Head and neck surgical oncologists should consider the role of immunotherapy and neck dissection in the treatment of head and neck cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Mei Ji, Yuan Liu, Yan Hu, Jing Sun, Haiyan Zhu
Summary: The purpose of this study was to compare patterns of recurrence in 2009 FIGO Stage IB-IIA cervical cancer patients with cN0 and cN1. The results showed that tumor recurrence and death were significantly less common in cN0 patients than cN1 patients, and the time to recurrence and death was significantly longer in cN0 patients.
Article
Oncology
Ester Paulien Olthof, Hans Wenzel, Jacobus van der Velden, Anje M. Spijkerboer, Ruud Bekkers, Jogchum J. Beltman, Hans W. Nijman, Brigitte Slangen, Ramon Smolders, Nienke van Trommel, Petra L. M. Zusterzeel, Ronald Zweemer, Lukas J. A. Stalpers, Maaike van der Aa, Constantijne Mom
Summary: This study found no survival benefit from either nodal boosting or debulking strategy in patients with suspicious bulky nodes. Nodal boosting might, however, be associated with less toxicity.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Oncology
Katharina Margherita Wakonig, Steffen Dommerich, Thomas Fischer, Philipp Arens, Bernd Hamm, Heidi Olze, Markus Herbert Lerchbaumer
Summary: The qualitative assessment of multiparametric ultrasound (mpUS) can improve diagnostic performance in distinguishing between benign and malignant cervical lymph nodes (CLNs). Shear wave elastography (SWE) and contrast-enhanced ultrasound (CEUS) show the highest overall diagnostic performance, while CEUS exhibits the best diagnostic performance among all investigated ultrasound techniques. These findings suggest that mpUS can aid in the decision-making process for enlarged CLNs.
Article
Engineering, Biomedical
Hitesh Tekchandani, Shrish Verma, Narendra D. Londhe, Rajiv Ratan Jain, Avani Tiwari
Summary: The study proposed a deep learning-based CADx system for the detection and diagnosis of cervical lymph nodes in head and neck cancer. Results showed that the system achieved high sensitivity and accuracy in both CLNs detection and diagnosis.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Article
Genetics & Heredity
Eugenia Cordelli, Jana Keller, Patrizia Eleuteri, Paola Villani, Lan Ma-Hock, Markus Schulz, Robert Landsiedel, Francesca Pacchierotti
Review
Toxicology
Amy J. Clippinger, David Allen, Holger Behrsing, Kelly A. BeruBe, Michael B. Bolger, Warren Casey, Michael DeLorme, Marianna Gaca, Sean C. Gehen, Kyle Glover, Patrick Hayden, Paul Hinderliter, Jon A. Hotchkiss, Anita Iskandar, Brian Keyser, Karsta Luettich, Lan Ma-Hock, Anna G. Maione, Patrudu Makena, Jodie Melbourne, Lawrence Milchak, Sheung P. Ng, Alicia Paini, Kathryn Page, Grace Patlewicz, Pilar Prieto, Hans Raabe, Emily N. Reinke, Clive Roper, Jane Rose, Monita Sharma, Wayne Spoo, Peter S. Thorne, Daniel M. Wilson, Annie M. Jarabek
TOXICOLOGY IN VITRO
(2018)
Article
Chemistry, Multidisciplinary
Martin Wiemann, Ursula G. Sauer, Antje Vennemann, Sandra Baecker, Johannes-Georg Keller, Lan Ma-Hock, Wendel Wohlleben, Robert Landsiedel
Letter
Food Science & Technology
C. Frieke Kuper, Maarten C. Bosland
FOOD AND CHEMICAL TOXICOLOGY
(2019)
Article
Multidisciplinary Sciences
Ramon M. Molina, Nagarjun V. Konduru, Priscila M. Queiroz, Benjamin Figueroa, Dan Fu, Lan Ma-Hock, Sibylle Groeters, Dirk Schaudien, Joseph D. Brain
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Johannes G. Keller, Uschi M. Graham, Johanna Koltermann-Juelly, Robert Gelein, Lan Ma-Hock, Robert Landsiedel, Martin Wiemann, Guenter Oberdoerster, Alison Elder, Wendel Wohlleben
SCIENTIFIC REPORTS
(2020)
Article
Nanoscience & Nanotechnology
Jutta Tentschert, Peter Laux, Harald Jungnickel, Josephine Brunner, Irina Estrela-Lopis, Carolin Merker, Jan Meijer, Heinrich Ernst, Lan Ma-Hock, Jana Keller, Robert Landsiedel, Andreas Luch
Article
Pathology
Johanna Koltermann-Juelly, Lan Ma-Hock, Sibylle Groeters, Robert Landsiedel
TOXICOLOGIC PATHOLOGY
(2020)
Letter
Nanoscience & Nanotechnology
Jutta Tentschert, Peter Laux, Harald Jungnickel, Josephine Brunner, Irina Estrela-Lopis, Carolin Merker, Jan Meijer, Heinrich Ernst, Lan Ma-Hock, Jana Keller, Robert Landsiedel, Andreas Luch
Review
Biochemistry & Molecular Biology
C. Frieke Kuper, Raymond H. H. Pieters, Jolanda H. M. van Bilsen
Summary: This article discusses the important role of the serosal immune system in the thoracic and peritoneal cavities, as well as the effects of nanomaterials on this system. ILCs are crucial in the first defense against pathogenic viruses and bacteria, and exposure to NMs may reduce resistance to pathogens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Lan Ma-Hock, Ursula G. Sauer, Emmanuel Ruggiero, Johannes-Georg Keller, Wendel Wohlleben, Robert Landsiedel
Summary: When studying the effects of nanomaterials, it is important to consider the differences between in vitro and in vivo models. The use of IVIVE procedures can help reduce exposure differences and improve research outcomes.
Correction
Multidisciplinary Sciences
Johannes G. Keller, Uschi M. Graham, Johanna Koltermann-Jully, Robert Gelein, Lan Ma-Hock, Robert Landsiedel, Martin Wiemann, Gunter Oberdorster, Alison Elder, Wendel Wohlleben
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Legal
Heidi Stratmann, Wendel Wohlleben, Martin Wiemann, Antje Vennemann, Nicole End, Ulrich Veith, Lan Ma-Hock, Robert Landsiedel
Summary: A non-animal testing battery was presented to identify poorly soluble, low toxicity substances based on solubility, surface reactivity, and effects on alveolar macrophages in vitro. The results showed that this battery could effectively classify pigments into different categories, reducing the need for animal testing and guiding product development towards safer applications.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Pathology
Tracey L. Papenfuss, Lauren Himmel, C. Frieke Kuper, Sunish Mohanan, Johannes Harleman, Susan A. Elmore
Summary: The evaluation of changes in the immune system is important for determining the effectiveness and potential adverse effects of new products. Toxicologic pathologists play critical roles in identifying immune system changes and assessing immunosafety. The recent growth in immunomodulatory therapies presents challenges in evaluating the clinical relevance and potential adversity of immune system changes.
TOXICOLOGIC PATHOLOGY
(2023)
Article
Toxicology
Susan Dekkers, Lan Ma-Hock, Iseult Lynch, Mike Russ, Mark R. Miller, Roel P. F. Schins, Jana Keller, Isabella Romer, Karin Kuettler, Volker Strauss, Wim H. De Jong, Robert Landsiedel, Flemming R. Cassee
INHALATION TOXICOLOGY
(2018)