Article
Engineering, Environmental
Ping Wu, Peixin Cui, Huan Du, Marcelo Eduardo Alves, Dongmei Zhou, Yujun Wang
Summary: This study investigated the dissolution and transformation of ZnO nanoparticles in different soils and found that they rapidly dissolved in both acidic and near-neutral soils, transforming into stable forms. The results provide a better understanding of the fate of ZnO in soils and its potential for remediating ZnO-polluted soils.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Energy & Fuels
Yue Zhao, Zhaoyi Dai, Chong Dai, Samridhdi Paudyal, Xin Wang, Saebom Ko, Amy T. Kan, Mason Tomson
Summary: The study investigates the formation and inhibition of celestite scale, develops a semiempirical model based on experimental and literature data, and predicts the minimum inhibitor concentration required for celestite scale control.
Article
Engineering, Environmental
Alireza Namayandeh, Olaf J. Borkiewicz, Nefeli M. Bompoti, Maria Chrysochoou, F. Marc Michel
Summary: The transformation rate and pathway of ferrihydrite under oxic conditions are influenced by temperature, pH, and the presence of other ions such as nitrate, sulfate, and arsenate. The effects of surface complex type and strength on the transformation process have been partially understood. A kinetic model has been developed to describe the impact of surface complex type and strength on the transformation of ferrihydrite to goethite and hematite. The results show that the rate of transformation decreases significantly for oxyanion surface complexes dominated by strong inner-sphere bonding. The type of surface complex also affects the transformation pathway, with a smaller fraction of goethite forming compared to hematite as the strength of bonding increases.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Banghao Du, Weiwei Yu, Lun Yang, Gongduan Fan, Shuo Yang, Hui Jiang, Shenglan Bi, Cheng Yu
Summary: The study revealed that E1-3S has a higher migration capacity and leaching mobility in soil compared to E1, and undergoes hydrolysis and abiotic transformation in sterilized soil. Additionally, potential transformation products of E1 and E1-3S were identified in soil after column transport experiments.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2022)
Article
Pharmacology & Pharmacy
Snezana Radivojev, Gerfried Luschin-Ebengreuth, Joana T. Pinto, Peter Laggner, Alessandro Cavecchi, Nicola Cesari, Massimo Cella, Fabrizio Melli, Amrit Paudel, Eleonore Froehlich
Summary: Orally inhaled products are receiving increasing attention for the treatment of various diseases via pulmonary delivery. This study used an in vitro-in silico approach to investigate the biopharmaceutics behavior of inhaled Salbutamol Sulphate and Budesonide. The results showed that media containing lipids and albumin had the most significant impact on Budesonide solubility, while no notable impact was seen for Salbutamol Sulphate. The use of simple media like phosphate buffer saline may be sufficient for soluble and permeable drugs, but may be limited for poorly soluble drugs due to potential interactions in vivo.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Jibriil P. Ibrahim, Shadabul Haque, Robert J. Bischof, Andrew K. Whittaker, Michael R. Whittaker, Lisa M. Kaminskas
Summary: Enhancing the delivery of therapeutic agents to the lung lymph can significantly improve the treatment and prevention of lung-related illnesses. However, the access of liposomes, a commonly used carrier, to the lung lymphatics after inhalation is limited. Alternative approaches need to be identified to maximize the delivery of drugs to the lung lymph.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Mojtaba Falahati, Anwarul Hasan, Hojjat Alizadeh Zeinabad, Vahid Serpooshan, J. H. von der Thusen, Timo L. M. ten Hagen
Summary: This review explores the interaction between inhaled nanoparticles (NPs) and pulmonary surfactant (PSf), and discusses the engineering of PSf in the lung environment. It provides valuable insights into the role of biofluids in the cellular uptake of NPs and their nanotoxic effects.
Article
Pharmacology & Pharmacy
Alaa S. Tulbah
Summary: This study successfully developed inhaled nanotechnology for lung cancer treatment and demonstrated the feasibility of atorvastatin micellar nanoparticles in drug therapy through in vitro experiments. The results showed that these nanoparticles can be delivered to the tumor site via inhalation and are non-toxic to the cell model.
CURRENT DRUG DELIVERY
(2022)
Review
Chemistry, Multidisciplinary
Jianfeng Ran, Xuxu Wang, Yuanhong Liu, Shaohua Yin, Shiwei Li, Libo Zhang
Summary: This review focuses on the recent progress in microreactor synthesis of micro/nanomaterials. The fabrication and design principles of existing microreactors are summarized and classified. Typical examples of micro/nanomaterials fabrication, including metal nanoparticles, inorganic nonmetallic nanoparticles, organic nanoparticles, Janus particles, and MOFs, are shown. The future research prospects and key issues of microreactor-based micro/nanomaterials are also discussed.
MATERIALS HORIZONS
(2023)
Article
Multidisciplinary Sciences
Mobeen Murtaza, Mohammed Yousef Rasm, Sulaiman A. Alarifi, Muhammad Shahzad Kamal, Mohamed Mahmoud, Mohammed Al-Ajmi
Summary: A new formulation for removing barite scale, consisting of a small volume of chelating agent and a converting agent, was proposed. Experimental results showed that a 15 wt% concentration of potassium base EDTA with 10 wt% K2CO3 as a converting agent at high pH was highly effective in dissolving up to 100% of 3 wt% BaSO4 in less than 6 h at temperatures of 200°F and 300°F.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2023)
Article
Soil Science
Angelika Kolbl, Klaus Kaiser, Aaron Thompson, Luke Mosley, Rob Fitzpatrick, Petra Marschner, Leopold Sauheitl, Robert Mikutta
Summary: This study tested the potential of wheat straw-derived dissolved organic carbon (DOC) for remediation of sandy sulfuric soil. The results showed that addition of wheat straw-derived DOC can induce reduction reactions and rapidly increase soil pH under submerged conditions. This method has the potential for rapid and sustainable remediation of sandy sulfuric subsoils.
Article
Environmental Sciences
Ling Tong, Peng Duan, Xiang Tian, Jiaolong Huang, Jun Ji, Zhaojin Chen, Jianwei Yang, Haiying Yu, Weicheng Zhang
Summary: This study found that polystyrene microplastics can induce the oxidative dissolution, transformation, and toxicity enhancement of silver nanoparticles under simulated sunlight irradiation. Similar processes also occurred in realistic water. This has important implications for the coexistence of polystyrene microplastics and silver nanoparticles in freshwater environments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Muhammad Umair, Sehrish Huma Zafar, Mumtaz Cheema, Rashid Minhas, Abdul Manan Saeed, Muhammad Saqib, Muhammad Aslam
Summary: This study investigated the interactive effects of zinc sulfate nanoparticles (ZnSO4 NPs) and potassium fertilizers (SOP and MOP) on the growth and quality of maize under different moisture regimes in cadmium contaminated soils. The results showed that the combination of ZnSO4 NPs and potassium fertilizers significantly improved the growth and composition of maize, reduced Cd bioavailability in soil, and decreased Cd concentration in plants. This strategy can help reduce Cd exposure through food consumption and ensure food safety.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Materials Science, Multidisciplinary
Jiajun Xi, Guangxiong Ji, Yalong Liao, Qingfeng Liu, Yue Wu
Summary: Due to the complexity and scarcity of copper resources, a large amount of refractory polymetallic complex chalcopyrite is produced. This study proposes the technology of hydrothermal leaching under oxygen pressure without acid to efficiently and selectively extract copper and simultaneously precipitate iron by hematite process, solving the problems of producing dangerous solid wastes like lead jarosite and high iron content in leaching solution. The experimental results show that the copper leaching rate can reach 99.86% under specific conditions, while the iron content in the leaching solution is only 4.3 g/L. Chalcopyrite, porphyrite, pyrite, galena, and other mineral phases can completely react to form corresponding metal sulfate, inhibiting the formation of dangerous solid waste such as lead jarosite.
METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCESS METALLURGY AND MATERIALS PROCESSING SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Qian Zhang, Minying Wu, Yuanyuan Fang, Chao Deng, Hsin-Hui Shen, Yi Tang, Yajun Wang
Summary: Mesoporous silica materials with large dendritic mesopores have been successfully prepared by using barium sulfate nanoparticles and in situ-formed 3-aminophenol/formaldehyde resin. The resulting hollow mesoporous silica nanoparticles show high enzyme loading capacity and efficient catalytic activity in the degradation reaction of H2O2.
Article
Public, Environmental & Occupational Health
Silke Gabbert, Miriam Mathea, Susanne N. Kolle, Robert Landsiedel
Summary: This article explores and compares different approaches to quantify the Borderline Range (BR) of experimental results, which represent ranges where the study result is ambiguous. The precision of the testing methods determines the size of their BRs, and consensus on a BR is needed to account for the limited precision of testing methods.
Review
Chemistry, Multidisciplinary
Wendel Wohlleben, Annette Mehling, Robert Landsiedel
Summary: Chemicals can be assessed for hazard in groups based on their similar structures and toxicological properties, similar to how elements are grouped in the periodic system. Strategies for chemical grouping have been used to support the evaluation of human health hazards, exposures, and risks, as shown in case studies. Structural similarity is commonly used as the basis for grouping, but it may not always be sufficient. Ten principles for grouping have been derived, including transparency, adequacy of methods, and consideration of toxicological properties, which can facilitate effective risk management.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Medicine, Legal
Susanne N. Kolle, Melanie Flach, Marcus Kleber, David A. Basketter, Britta Wareing, Annette Mehling, Lars Hareng, Nico Watzek, Steffen Bade, Dorothee Funk-Weyer, Robert Landsiedel
Summary: In the past decade, several non-animal methods have been adopted as OECD test guidelines to identify skin sensitization hazards. However, the predictive accuracy of these methods for substances beyond the chemical domains of individual validation studies remains largely untested. This study compares the skin sensitization test results from in vitro and in chemico methods to available in vivo data for plant extracts and polymeric materials.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Biographical-Item
Toxicology
Jan G. Hengstler, Hermann Bolt, Uwe Heinrich, Andrea Hartwig, Robert Landsiedel
ARCHIVES OF TOXICOLOGY
(2023)
Correction
Toxicology
Jan G. Hengstler, Hermann Bolt, Uwe Heinrich, Andrea Hartwig, Robert Landsiedel
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dunja Dimitrijevic, Eric Fabian, Dorothee Funk-Weyer, Robert Landsiedel
Summary: In pharmacokinetics, plasma protein binding (PPB) is an important parameter affecting drug metabolism. The unbound fraction (fu) is considered the effective concentration at the target site. In vitro models, such as physiologically based toxicokinetic models (PBTK), are increasingly used in pharmacology and toxicology. This study compared three methods (rapid equilibrium dialysis, ultrafiltration, and ultracentrifugation) to quantify fu and found that the selection of the separation method should be based on the properties of the test substance. Rapid equilibrium dialysis was suitable for a broader range of substances, while ultrafiltration and ultracentrifugation were suitable for polar substances.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Sabina Ramirez-Hincapie, Barbara Birk, Philipp Ternes, Varun Giri, Volker Haake, Michael Herold, Franziska Maria Zickgraf, Andreas Verlohner, Hans-Albrecht Huener, Hennicke Kamp, Peter Driemert, Robert Landsiedel, Elke Richling, Dorothee Funk-Weyer, Bennard van Ravenzwaay
Summary: Cell-based metabolomics provides multiparametric readouts for decision making in compound development. A LC-MS/MS-based metabolomics platform was developed for liver toxicity classification in HepG2 cells. The platform showed dose response and differentiation between liver toxicity modes of action, and identified specific metabolite patterns for each mode of action. This method offers a mechanistic-based, cost-effective screening for compound development pipelines.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Toxicology
Sabina Ramirez-Hincapie, Barbara Birk, Philipp Ternes, Varun Giri, Franziska Maria Zickgraf, Volker Haake, Michael Herold, Hennicke Kamp, Peter Driemert, Robert Landsiedel, Elke Richling, Dorothee Funk-Weyer, Bennard van Ravenzwaay
Summary: This study applied a high-throughput LC-MS/MS-based broad targeted metabolomics system to investigate the metabolic dynamics of nitrofurantoin over time and concentration and derived a mechanistic-anchored approach for point of departure (PoD) derivation. The results showed clear time and concentration effects on the metabolome of HepG2 cells. This approach allows for the derivation of PoD that can be mechanistically anchored to established key events and contribute to the development of new adverse outcome pathways.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pia Wilhelmi, Varun Giri, Franziska Maria Zickgraf, Volker Haake, Stefan Henkes, Peter Driemert, Paul Michaelis, Wibke Busch, Stefan Scholz, Burkhard Flick, Marta Barenys, Barbara Birk, Hennicke Kamp, Robert Landsiedel, Dorothee Funk-Weyer
Summary: Through LC-MS/MS and GC-MS metabolomics, this study investigated the changes in endogenous metabolites in zebrafish embryos as indicators of developmental toxicity pathways. The results showed that exposure to the compound PTU led to morphological alterations and significant metabolic changes, which could be linked to the inhibition of thyroid peroxidase and potential neurodevelopmental impairments. This study demonstrated that metabolite changes in zebrafish embryos provide mechanistic information associated with the mode of action of PTU.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Medicine, Legal
Jens C. Otte, Heli Miriam Hollnagel, Christiane Nagel, Renata Friederike Gerhardt, Wendel Wohlleben, Nathalie Vallotton, Diederik Schowanek, Gordon Sanders, Joe M. Frasca, Tushar Mahale, Mark Pemberton, Bjoern Hidding, Robert Landsiedel
Summary: This study proposes a three-tiered regulatory approach for assessing polymers, which includes grouping the polymers based on their chemistry, physico-chemical properties, and hazard similarity. By reducing animal testing and providing sufficient data, this approach aims to achieve an adequate level of protection.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Toxicology
Franziska M. Zickgraf, Aishwarya Murali, Robert Landsiedel
Summary: This article summarizes studies on the effects of engineered nanomaterials (ENM) on the gut microbiome, showing that ENM can affect the microbiome in various ways, although few studies demonstrate a link to adverse effects on the host. Based on these findings, future studies can assess the hazards and risks of ENM through changes in the microbiome.
CURRENT OPINION IN TOXICOLOGY
(2023)
Correction
Environmental Sciences
Johannes G. Keller, Michael Persson, Philipp Mueller, Lan Ma-Hock, Kai Werle, Josje Arts, Robert Landsiedel, Wendel Wohlleben
Meeting Abstract
Environmental Sciences
Naveed Honarvar, Astrid Zander, Eva Dony, Miyuki Shigano, Brandy Williamson Riffle, Markus Frericks, Tobias Seiser, Dorothee Funk-Weyer, Robert Landsiedel
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2022)
Meeting Abstract
Environmental Sciences
Naveed Honarvar, Alina Goepfert, Claudia Ruelker, Michael Eichenlaub, Bogdan Tokovenko, Gomez Caroline, Dorothee Funk-Weyer, Robert Landsiedel
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2022)
Article
Biochemistry & Molecular Biology
Annette Mehling, Susanne N. Kolle, Britta Wareing, Robert Landsiedel
Summary: Significant progress has been made in the past two decades in developing alternative methods to animal testing for regulatory and safety testing. In 2021, a breakthrough in regulatory testing was achieved with the acceptance of non-animal test methods for skin sensitization as OECD guideline 497. This achievement required the hard work and perseverance of many individuals.