Article
Cell & Tissue Engineering
Wei-Cheng Tseng, Pei-Ying Lee, Ming-Tsun Tsai, Fu-Pang Chang, Nien-Jung Chen, Chiang-Ting Chien, Shih-Chieh Hung, Der-Cherng Tarng
Summary: This study demonstrates that the enhancing effect of MSCs, especially HMSCs, on tissue autophagy can be applied to suppress renal tubular apoptosis and attenuate renal impairment during renal I/R injury in rats. These findings provide further mechanistic support for HMSC therapy and its investigation in clinical trials of ischemic AKI.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Pharmacology & Pharmacy
Marcella Liciani Franco, Stephany Beyerstedt, erika Bevilaqua Rangel
Summary: Chronic kidney disease (CKD) and acute kidney injury (AKI) are public health problems associated with comorbidities such as diabetes mellitus and hypertension. Klotho has shown promising potential as a therapeutic approach for these kidney conditions. It exerts renoprotective effects by reducing inflammation, oxidative stress, and fibrosis. Mesenchymal stem cells (MSCs) are an important strategy for delivering Klotho.
Review
Immunology
Qiuxia Han, Xiaochen Wang, Xiaonan Ding, Jun He, Guangyan Cai, Hanyu Zhu
Summary: Drug-induced nephrotoxicity is a significant cause of acute kidney injury, and recent studies suggest that mesenchymal stem cells may have therapeutic potential in treating this condition. The source of MSCs can impact their immunomodulatory abilities and should be considered in treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pei-Wen Lee, Bo-Sheng Wu, Chih-Yu Yang, Oscar Kuang-Sheng Lee
Summary: Mesenchymal stem cells (MSCs) and MSC-derived EVs are considered promising cellular therapies for treating AKI, as they benefit kidney regeneration by releasing paracrine factors and extracellular vesicles. Research aims to deepen the understanding of molecular signaling and cellular communication between donor MSCs and recipient kidney cells, in order to develop more effective therapies for AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Pingping Wanyan, Xin Wang, Nenglian Li, Yong Huang, Yali She, Li Zhang
Summary: This study aimed to evaluate the efficacy of mesenchymal stem cells (MSCs) for acute kidney injury (AKI) in preclinical studies and explore the optimal transplantation strategy of MSCs. The results showed that MSCs could significantly improve renal function and injured renal tissue in AKI rats. However, there are limitations in the current preclinical studies and more high-quality research is needed to confirm the best transplantation strategy of MSCs in AKI.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cell Biology
Lingfei Zhao, Chenxia Hu, Fei Han, Dajin Chen, Yanhong Ma, Junni Wang, Jianghua Chen
Summary: Cellular senescence is a widespread cellular programme characterized by permanent cell cycle arrest and a changed secretory phenotype. While it has been thought to be a protective factor against cancer, it also has a dual effect on individuals. Activation of cellular senescence can provide advantages in certain processes, but aberrant generation of senescent cells can lead to age-related conditions and tissue deterioration.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Urology & Nephrology
Hye-Jeong Park, Min Jung Kong, Hyo-Ju Jang, Jeong-In Cho, Eui-Jung Park, In-Kyu Lee, Jorgen Frokiaer, Rikke Norregaard, Kwon Moo Park, Tae-Hwan Kwon
Summary: Cell therapy using genome-engineered stem cells for kidney diseases involves generating hUC-MSCs that secrete specific factors through gene integration. The research shows that genome editing does not affect the differentiation potential of these stem cells. Therapeutic effects were achieved in a mouse model of acute kidney injury using scaffold-free cell sheets of genome-edited mesenchymal stem cells.
KIDNEY INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Jing-Yuan Cao, Bin Wang, Tao-Tao Tang, Yi Wen, Zuo-Lin Li, Song-Tao Feng, Min Wu, Dan Liu, Di Yin, Kun-Ling Ma, Ri-Ning Tang, Qiu-Li Wu, Hui-Yao Lan, Lin-Li Lv, Bi-Cheng Liu
Summary: In this study, MSC-exos were found to preferentially target injured kidneys and localize to proximal tubules in ischemic AKI. The researchers demonstrated that MSC-exos ameliorated ischemic AKI and promoted tubular repair by targeting the cell cycle arrest and apoptosis of TECs through the miR-125b-5p/p53 pathway. This study provides new insights into the role of MSC-exos in renal tubule repair and highlights their potential as a promising therapeutic strategy for AKI.
Review
Medicine, General & Internal
Kenji Tsuji, Hiroyuki Nakanoh, Kazuhiko Fukushima, Shinji Kitamura, Jun Wada
Summary: Acute kidney injury (AKI) is a serious clinical syndrome characterized by a decrease in urine output and kidney function, leading to electrolyte and acid-base imbalances. Early diagnosis and treatment are crucial, and miRNAs have shown potential as biomarkers and therapeutic targets for AKI.
Article
Engineering, Environmental
Qiuxia Han, Sifan Ai, Quan Hong, Chuyue Zhang, Yanqi Song, Xiaochen Wang, Xu Wang, Shaoyuan Cui, Zongjin Li, Hanyu Zhu, Zhimou Yang, Xiangmei Chen, Guangyan Cai
Summary: A novel Biotin-(D)FYIGSRGD hydrogel was developed by conjugating YIGSR and RGD peptides, which prolonged the survival of MSCs and enhanced their anti-apoptotic and anti-inflammatory effects on kidney injury.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Sekyung Oh, Sang-Ho Kwon
Summary: This article discusses the challenges of diagnosing acute kidney injury (AKI) and the discovery and application of EVs as biomarkers, as well as the importance of EVs for treating AKI. Future research will focus on addressing the shortcomings of current EV-based AKI diagnosis and therapeutic applications, with the aim of bringing more innovation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Anatomy & Morphology
Rui-ning Liang, De-qi Yan, Xing-ping Zhang, Xu Chen, Wen-hui Zhang, Hong -lin Jia
Summary: The objective of this experiment was to demonstrate the therapeutic effects of kidney-derived mesenchymal stem cells (MSCs) on cisplatin-induced kidney injury and renal cell apoptosis through the paracrine pathway. MSCs were isolated from the kidneys of young rats and characterized using molecular and immunofluorescence techniques. The self-renewal ability of kidney mesenchymal stem cells (KMSCs) was observed, and KMSCs at logarithmic growth stage were transplanted into rats via the tail vein. The results showed that KMSCs homed to the kidney tissues, reduced inflammation, and improved renal function. Pathological damage and apoptosis in rat kidneys induced by cisplatin were alleviated by KMSCs. The expression of pro-apoptotic and anti-apoptotic proteins in kidney tissues was also modulated by KMSCs. In conclusion, KMSCs have therapeutic effects against cisplatin-induced kidney injury in rats.
Article
Endocrinology & Metabolism
Jun Guo, Rong Wang, Donghai Liu
Summary: The study showed that BMSCs could alleviate sepsis-induced acute kidney injury by inhibiting inflammation, promoting mitophagy, and upregulating SIRT1/Parkin. These findings provide evidence for the role of BMSCs in treating SI-AKI.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Si-Yang Wang, Yue Xu, Quan Hong, Xiang-Mei Chen, Guang-Yan Cai
Summary: This study demonstrated that aged mice are more susceptible to AKI injury and identified an important role for the upregulation of the senescence-associated DNA damage/p53 pathway in this susceptibility. MSC treatment can reduce the degree of DNA damage and apoptosis. Furthermore, downregulation of let-7b-5p may lead to increased renal AKI susceptibility, and the presence of let-7b-5p in MSC-derived Exos can alleviate tubular epithelial cell apoptosis by inhibiting p53.
CELL AND TISSUE RESEARCH
(2022)
Article
Cell Biology
Jianni Huang, Hao Cao, Binbin Cui, Xiaoyan Ma, Ling Gao, Chao Yu, Fengchen Shen, Xinyu Yang, Na Liu, Andong Qiu, Guangyan Cai, Shougang Zhuang
Summary: This study investigated the therapeutic effects and mechanisms of exosomes in a miniature pig model of I/R-AKI. The findings showed that infusion of hUC-MSC exosomes improved renal function, reduced cell apoptosis and necroptosis, suppressed inflammation, and promoted renal tubular cell repair and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pathology
Shabirul Haque, Xiqian Lan, Hongxiu Wen, Rivka Lederman, Amrita Chawla, Mohamed Attia, Ramchandra P. Bongu, Mohammad Husain, Joanna Mikulak, Moin A. Saleem, Waldemar Popik, Ashwani Malhotra, Praveen N. Chander, Pravin C. Singhal
AMERICAN JOURNAL OF PATHOLOGY
(2016)
Article
Cell Biology
Qian Yang, Yiqiong Ma, Yipeng Liu, Wei Liang, Xinghua Chen, Zhilong Ren, Huiming Wang, Pravin C. Singhal, Guohua Ding
MOLECULAR BIOLOGY OF THE CELL
(2016)
Article
Virology
Joanna Mikulak, Ferdinando Oriolo, Federica Portale, Paolo Tentorio, Xiqian Lan, Moin A. Saleem, Karl Skorecki, Pravin C. Singhal, Domenico Mavilio
Article
Pathology
Nirupama Chandel, Kamesh Ayasolla, Hongxiu Wen, Xiqian Lan, Shabirul Haque, Moin A. Saleem, Ashwani Malhotra, Pravin C. Singhal
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2017)
Article
Oncology
Xiqian Lan, Hongxiu Wen, Kang Cheng, Andrei Plagov, Seyedeh Shadafarin Marashi Shoshtari, Ashwani Malhotra, Pravin C. Singhal
EXPERIMENTAL CELL RESEARCH
(2017)
Meeting Abstract
Gastroenterology & Hepatology
Andrew Nickerson, Trey Rottgen, Emily Minor, Shabina Rehman, Geoffrey I. Sandle, Vazhaikkurichi M. Rajendran
Article
Biochemistry & Molecular Biology
Xiqian Lan, Hongxiu Wen, Rukhsana Aslam, Seyedeh Shadafarin Marashi Shoshtari, Abheepsa Mishra, Vinod Kumar, Haichao Wang, Guisheng Wu, Huairong Luo, Ashwani Malhotra, Pravin C. Singhal
BIOSCIENCE REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Hongxiu Wen, Vinod Kumar, Xiqian Lan, Seyedeh Shadafarin Marashi Shoshtari, Judith M. Eng, Xiaogang Zhou, Fang Wang, Haichao Wang, Karl Skorecki, Guolan Xing, Guisheng Wu, Huairong Luo, Ashwani Malhotra, Pravin C. Singhal
BIOSCIENCE REPORTS
(2018)
Article
Pathology
Vinod Kumar, Himanshu Vashistha, Xiqian Lan, Nirupama Chandel, Kamesh Ayasolla, Seyedeh Shadafarin Marashi Shoshtari, Rukhsana Aslam, Nitpriya Paliwal, Frank Abbruscato, Joanna Mikulak, Waldemar Popik, Mohamed G. Atta, Praveen N. Chander, Ashwani Malhotra, Catherine Meyer-Schwesinger, Karl Skorecki, Pravin C. Singhal
AMERICAN JOURNAL OF PATHOLOGY
(2018)
Article
Pediatrics
Tariq M. Wani, Mohammed Hakim, Archana Ramesh, Shabina Rehman, Yasser Majid, Rebecca Miller, Dmitry Tumin, Joseph D. Tobias
PEDIATRIC SURGERY INTERNATIONAL
(2018)
Article
Gastroenterology & Hepatology
Shabina Rehman, Karthikeyan Narayanan, Andrew J. Nickerson, Steven D. Coon, Kazi Mirajul Hoque, Geoffrey Sandle, Vazhaikkurichi M. Rajendran
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Joyita Bharati, Praveen N. N. Chander, Pravin C. C. Singhal
Summary: Glomerular parietal epithelial cells (PECs) play crucial roles in both repair and pathogenesis of kidney diseases. Recent studies have shown that microRNA-193a (miR193a) is involved in the modulation of PEC behavior and its role in diseases such as focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CrescGN), where PECs exhibit abnormal proliferation. Inhibition of miR193a reduces crescent lesions in a mouse model of CrescGN, while its induction leads to dedifferentiation of podocytes in a mouse model of primary FSGS.
Meeting Abstract
Biochemistry & Molecular Biology
Shabina Rehman, Jamil Talukder
Meeting Abstract
Biochemistry & Molecular Biology
Shabina Rehman, Alok C. Bharti, Bhudev C. Das, Jamil Talukder
Article
Biochemistry & Molecular Biology
Shabirul Haque, Gauri Patil, Abheepsa Mishra, Xiqian Lan, Waldemar Popik, Ashwani Malhotra, Karl Skorecki, Pravin C. Singhal
BIOSCIENCE REPORTS
(2017)