Review
Immunology
Qiuxia Han, Xiaochen Wang, Xiaonan Ding, Jun He, Guangyan Cai, Hanyu Zhu
Summary: Drug-induced nephrotoxicity is a significant cause of acute kidney injury, and recent studies suggest that mesenchymal stem cells may have therapeutic potential in treating this condition. The source of MSCs can impact their immunomodulatory abilities and should be considered in treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Heng-Chih Pan, Yau-Hung Chen, Wei-Ching Fang, Vin-Cent Wu, Chiao-Yin Sun
Summary: KDM4C plays a critical role in kidney development and acute kidney injury (AKI). Knockdown of KDM4C leads to impaired kidney development and decreased cell survival in zebrafish and mouse models. Furthermore, KDM4C may exert a protective effect on cell survival in AKI by regulating mitochondrial dynamics and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Jennifer S. Y. Li, Harry Robertson, Katie Trinh, Arti M. Raghubar, Quan Nguyen, Nicholas Matigian, Ellis Patrick, Angus W. Thomson, Andrew J. Mallett, Natasha M. Rogers
Summary: Ischemia reperfusion injury is a common cause of acute kidney injury. Adoptively transferred tolerogenic dendritic cells can successfully limit kidney injury and provide protection against ischemia reperfusion injury.
KIDNEY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Yumi Yamada, Ayumu Nakashima, Shigehiro Doi, Naoki Ishiuchi, Ryo Kanai, Kisho Miyasako, Takao Masaki
Summary: Renal artery injection of MSCs is more effective than intravenous injection at reducing IRI-induced renal fibrosis and leads to longer retention of MSCs in the injured kidneys. MSCs injected through the renal artery primarily localize in the glomeruli initially, but then shift to tubular walls and interstitium, potentially due to areas of damage caused by IRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Behnaz Mokhtari, Reza Badalzadeh, Nahid Aboutaleb
Summary: This study demonstrated that hAM-MSCs-CM has cardioprotective effects against MI/R injury by modulating autophagy through the mTOR/ULK1 pathway, improving cardiac function and reducing fibrosis. These findings suggest that hAM-MSCs-CM may be a promising candidate for attenuating MI/R injury in the future, although further investigations are needed.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Cell Biology
Jianni Huang, Hao Cao, Binbin Cui, Xiaoyan Ma, Ling Gao, Chao Yu, Fengchen Shen, Xinyu Yang, Na Liu, Andong Qiu, Guangyan Cai, Shougang Zhuang
Summary: This study investigated the therapeutic effects and mechanisms of exosomes in a miniature pig model of I/R-AKI. The findings showed that infusion of hUC-MSC exosomes improved renal function, reduced cell apoptosis and necroptosis, suppressed inflammation, and promoted renal tubular cell repair and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Lang Shi, Zhixia Song, Chenglong Li, Fangjing Deng, Yao Xia, Jing Huang, Xiongfei Wu, Jiefu Zhu
Summary: HDAC6 plays an important role in ischemic and nephrotoxic acute kidney injury (AKI) by inhibiting autophagy and the acetylation of alpha-tubulin. Inhibition of HDAC6 protects tubular cells from AKI-induced damage.
Article
Cell & Tissue Engineering
Pengyu Zhou, Hao Liu, Ximao Liu, Xiao Ling, Zezhou Xiao, Peng Zhu, Yufeng Zhu, Jun Lu, Shaoyi Zheng
Summary: Preservation of donor hearts with hypoxic CdM derived from BMSCs can improve post-transplant graft function by reducing apoptosis and inflammation. The cardioprotective effects were demonstrated by shorter time to spontaneous contraction, better left ventricular function, lower histopathological scores, higher ejection fraction, and fractional shortening.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Jinwei Gao, Zheng Wang, Zhangzhang Ye
Summary: This study examined the effectiveness of madder as a medicine to treat ischemia-reperfusion injury. The results showed that madder treatment can effectively reduce the area of myocardial infarction, restore arterial blood flow velocity and myocardial contractility, and inhibit the expression of inflammatory factors, autophagy factors, and apoptosis factors in mice. Madder treatment can also alleviate myocardial ischemia-reperfusion injury in mice and inhibit the occurrence of inflammatory response by inhibiting the activity of the NF-kappa B pathway.
MEDIATORS OF INFLAMMATION
(2023)
Article
Immunology
Stine Lohmann, Marco Eijken, Ulla Moldrup, Bjarne K. Moller, James Hunter, Cyril Moers, Henri Leuvenink, Rutger J. Ploeg, Marian C. Clahsen-van Groningen, Martin Hoogduijn, Carla C. Baan, Anna Krarup Keller, Bente Jespersen
Summary: The study demonstrated that intraarterial MSC infusion to transplant kidneys is a safe and effective method to deliver MSCs to the graft, but no positive effects of this cell treatment were detected within the 14-day observation period.
Review
Pharmacology & Pharmacy
Zhizhong Shang, Yanbiao Jiang, Xin Guan, Anan Wang, Bin Ma
Summary: The study evaluated the effects of different stem cells on renal function in animals with ischemia-reperfusion injury. Stem cells from diverse sources showed improvement in renal function, with ADMSCs and MDMSCs possibly having the highest therapeutic potential. However, the overall quality of evidence is low and further clinical studies are needed to determine the exact efficacy of stem cell therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Gecai Chen, Meixiang Wang, Zhongbao Ruan, Li Zhu, Chengchun Tang
Summary: The study demonstrated that MSCs-derived exosomes have a protective role in myocardial I/R injury by regulating autophagy. miR-143-3p was found to be involved in H/R-induced myocardial autophagy through the CHK2-Beclin2 pathway, reducing cell apoptosis. These findings suggest that exosomal miR-143-3p may serve as a promising therapeutic option for I/R injury.
Article
Cell & Tissue Engineering
Yen-Ta Chen, Fei-Chi Chuang, Chih-Chao Yang, John Y. Chiang, Pei-Hsun Sung, Yi-Ching Chu, Chi-Ruei Huang, Kuan-Hui Huang, Hon-Kan Yip
Summary: The combined use of melatonin and adipose-derived mesenchymal stem cells effectively protects the testis against acute testicular torsion-induced ischemia-reperfusion injury.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Man J. Livingston, Shaoqun Shu, Ying Fan, Ze Li, Qiong Jiao, Xiao-Ming Yin, Manjeri A. Venkatachalam, Zheng Dong
Summary: Following acute kidney injury, autophagy in renal tubular cells leads to the production of FGF2, which acts as a paracrine factor to activate fibroblasts and promote renal fibrosis. This process has been confirmed in renal biopsies from post-AKI patients.
Review
Immunology
Jiale Li, Qinbao Peng, Ronghua Yang, Kunsheng Li, Peng Zhu, Yufeng Zhu, Pengyu Zhou, Gabor Szabo, Shaoyi Zheng
Summary: This review discusses the use of machine perfusion and mesenchymal stem cells to improve the quality and outcomes of marginal organs in transplantation. By continuously perfusing the organs to mimic physiological conditions, evaluating pre-transplant organ function, and treating the organs with pharmacological, gene, and stem cell therapy, the quality and adaptability of the organs can be enhanced. Promising preclinical results indicate the potential clinical translation of this innovative strategy to improve the quality of marginal grafts.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Chih-Yu Yang, Jia-Sin Liu, Wei-Cheng Tseng, Ming-Tsun Tsai, Ming-Huang Lin, Zih-Kai Kao, Yao-Ping Lin, Chih-Cheng Hsu, Der-Cherng Tarng
CRITICAL CARE MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Chou-Pin Kuo, Ming-Tsun Tsai, Kuo-Hua Lee, Yao-Ping Lin, Shao-Sung Huang, Chin-Chou Huang, Wei-Cheng Tseng, Der-Cherng Tarng
Summary: This study investigated the dose-response effects of physical activity on mortality and major cardiorenal events in chronic kidney disease patients. The results showed that physical activity of 7.5 to <15 MET-h/week was associated with lower risks of adverse cardiorenal outcomes.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Nutrition & Dietetics
Ming-Tsun Tsai, Shuo-Ming Ou, Huan-Yuan Chen, Wei-Cheng Tseng, Kuo-Hua Lee, Chih-Yu Yang, Ruey-Bing Yang, Der-Cherng Tarng
Summary: Plasma galectin-3 levels are associated with protein-energy wasting in patients undergoing maintenance hemodialysis, but galectin-3 is not superior in predicting PEW compared to other nutritional indicators. Novel biomarkers are needed to detect patients at risk for malnutrition and implement appropriate interventions.
Article
Nutrition & Dietetics
Ming-Tsun Tsai, Wei-Cheng Tseng, Shuo-Ming Ou, Kuo-Hua Lee, Chih-Yu Yang, Der-Cherng Tarng
Summary: The study compared the simplified creatinine index (SCI) and circulating inflammatory markers as nutritional screening tools in hemodialysis patients, finding that SCI performed better in assessing nutritional status. Risk factors for low fat-free mass index (FFMI) included older age, female gender, lower body mass index, SCI, and GNRI scores. While a positive association between systemic inflammation markers and low FFMI was observed, this association disappeared in multivariate analysis.
Article
Medicine, General & Internal
Shuo-Ming Ou, Ming-Tsun Tsai, Huan-Yuan Chen, Fu-An Li, Wei-Cheng Tseng, Kuo-Hua Lee, Fu-Pang Chang, Yao-Ping Lin, Ruey-Bing Yang, Der-Cherng Tarng
Summary: The study revealed that plasma Gal-3 levels are inversely correlated with eGFR but positively correlated with renal fibrosis, potentially involving immune response and associated pathways, supporting the role of Gal-3 as a predictive marker of renal fibrosis.
FRONTIERS IN MEDICINE
(2021)
Article
Health Care Sciences & Services
Shuo-Ming Ou, Kuo-Hua Lee, Ming-Tsun Tsai, Wei-Cheng Tseng, Yuan-Chia Chu, Der-Cherng Tarng
Summary: Sepsis survivors have a higher risk of long-term complications, including acute kidney injury. This study utilized an artificial intelligence-based machine learning approach to predict the risk of rehospitalization with acute kidney injury in sepsis survivors. The LGBM model exhibited the best performance in predicting this risk.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Kuo-Hua Lee, Shuo-Ming Ou, Ming-Tsun Tsai, Wei-Cheng Tseng, Chih-Yu Yang, Yao-Ping Lin, Der-Cherng Tarng
Summary: This study explored the impact of AN69 membranes in CVVH on patients with severe sepsis and found that for patients with SOFA scores ≥15, the 90-day survival rate was higher in the high UFR group. High UFR settings in CVVH may reduce mortality risk in high-risk patients with sepsis-induced MODS.
Article
Medicine, General & Internal
Shuo-Ming Ou, Kuo-Hua Lee, Ming-Tsun Tsai, Wei-Cheng Tseng, Yuan-Chia Chu, Der-Cherng Tarng
Summary: The study revealed that patients with chronic kidney disease discharged from hospitalization for sepsis are at higher risks of subsequent renal adverse events compared to non-sepsis group.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Kuo-Hua Lee, Yuan-Chia Chu, Ming-Tsun Tsai, Wei-Cheng Tseng, Yao-Ping Lin, Shuo-Ming Ou, Der-Cherng Tarng
Summary: This study used machine learning to predict the risk of end-stage renal disease (ESRD) in sepsis survivors. The researchers found that estimated glomerular filtration rates, hemoglobin, and proteinuria were important predictors of ESRD development.
Article
Biochemistry & Molecular Biology
Shuo-Ming Ou, Ming-Tsun Tsai, Huan-Yuan Chen, Fu-An Li, Kuo-Hua Lee, Wei-Cheng Tseng, Fu-Pang Chang, Yao-Ping Lin, Ruey-Bing Yang, Der-Cherng Tarng
Summary: Plasma galectin-3 is associated with organ fibrosis, and this study explored the potential of urinary galectin-3 as a biomarker for kidney disease progression. Patients with higher urinary galectin-3 levels had lower eGFRs and higher proteinuria levels. Higher levels of urinary galectin-3 were also associated with more severe renal fibrosis. The study suggests that urinary galectin-3 levels may be useful for identifying patients at high risk of kidney disease progression and renal fibrosis.
Article
Cardiac & Cardiovascular Systems
Shuo-Ming Ou, Chieh-Ju Chao, Ming-Tsun Tsai, Kuo-Hua Lee, Wei-Cheng Tseng, Pin-Jie Bin, Yao-Ping Lin, Chien-Yi Hsu, Der-Cherng Tarng
Summary: Heart failure is prevalent in patients with chronic kidney disease (CKD), and its impact on renal function and long-term outcomes in different subtypes of heart failure remains uncertain. This study found that heart failure is associated with worse clinical outcomes, and patients with HFrEF have the highest risk.
Article
Mathematical & Computational Biology
Shuo-Ming Ou, Ming-Tsun Tsai, Kuo-Hua Lee, Wei-Cheng Tseng, Chih-Yu Yang, Tz-Heng Chen, Pin-Jie Bin, Tzeng-Ji Chen, Yao-Ping Lin, Wayne Huey-Herng Sheu, Yuan-Chia Chu, Der-Cherng Tarng
Summary: This study aimed to develop predictive models for the risk of developing ESRD in newly diagnosed T2DM patients using machine learning. XGBoost was found to be the best model with high discriminative ability. These models can be used as risk assessment tools for clinical decision-making and early intervention strategies.
Article
Medical Laboratory Technology
Ming-Tsun Tsai, Ruey-Bing Yang, Shuo-Ming Ou, Wei-Cheng Tseng, Kuo-Hua Lee, Chih-Yu Yang, Fu -Pang Chang, Der-Cherng Tarng
Summary: Plasma galectin-9 levels are associated with varying stages of chronic kidney disease (CKD), and high levels are correlated with older age, decreased renal function, increased proteinuria, and greater interstitial fibrosis. In renal tissue, galectin-9 expression is positively correlated with plasma galectin-9 levels and is mainly expressed in macrophages.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Wei-Cheng Tseng, Jin-Siang Lin, Yao-Min Feng, Min Sun
Summary: This study introduces a hierarchical model combining primitive policies to efficiently generate complex behaviors in new tasks and improve the diversity and utilization rate of primitives through the design of regularization terms. Experimental results demonstrate the superior performance of this method in tasks with continuous action space and its broader transferring range.
THIRTY-FIFTH AAAI CONFERENCE ON ARTIFICIAL INTELLIGENCE, THIRTY-THIRD CONFERENCE ON INNOVATIVE APPLICATIONS OF ARTIFICIAL INTELLIGENCE AND THE ELEVENTH SYMPOSIUM ON EDUCATIONAL ADVANCES IN ARTIFICIAL INTELLIGENCE
(2021)