Article
Multidisciplinary Sciences
Woon Yong Kwon, Gil Joon Suh, Yoon Sun Jung, Seung Min Park, Subi Oh, Sung Hee Kim, A. Rum Lee, Jeong Yeon Kim, Hayoung Kim, Kyung Ah Kim, Young Kim, Byoung Choul Kim, Taegyun Kim, Kyung Su Kim, Kiyoshi Itagaki, Carl J. Hauser
Summary: The study revealed a strong association between circulating ND6 levels in patients with septic shock and the development of secondary infection, as well as increased mortality rates. Suppression of PMN chemotaxis may play a key role in the increased susceptibility to secondary infection in these patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Geng Chen, Xiankun Wang, Qiwen Liao, Yunjun Ge, Haizhan Jiao, Qiang Chen, Yezhou Liu, Wenping Lyu, Lizhe Zhu, Gydo C. P. van Zundert, Michael J. Robertson, Georgios Skiniotis, Yang Du, Hongli Hu, Richard D. Ye
Summary: The formyl peptide receptor 1 (FPR1) plays a critical role in detecting short peptides characteristic of protein synthesis in bacteria and mitochondria, and is important in phagocyte migration and activation during bacterial infection, tissue injury and inflammation. This study reveals the structural basis of FPR1 recognition of bacteria-derived chemotactic peptides, providing insights for developing FPR1-targeting agents.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Runa Kuley, Ryan D. Stultz, Bhargavi Duvvuri, Ting Wang, Marvin J. Fritzler, Roger Hesselstrand, J. Lee Nelson, Christian Lood
Summary: This study reveals for the first time the important role of mitochondrial component fMet in neutrophil-mediated inflammation in SSc.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shun-Chin Yang, Yi-Hsuan Wang, Chiu-Ming Ho, Yung-Fong Tsai, Ping-Jyun Sung, Tony Eight Lin, Tsong-Long Hwang
Summary: In this study, it was found that the cyclic lipopeptide IA-1 from marine Bacillus amyloliquefaciens can inhibit the inflammatory response of neutrophils and mitigate inflammatory damage in ARDS. IA-1 acts as a competitive antagonist for the damage-sensing receptor FPR1, reducing downstream signaling pathways and inflammatory injuries. This suggests that IA-1 could be a therapeutic option for ARDS.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Paola Cuomo, Chiara Medaglia, Ivana Allocca, Angela Michela Immacolata Montone, Fabrizia Guerra, Serena Cabaro, Ernesto Mollo, Daniela Eletto, Marina Papaianni, Rosanna Capparelli
Summary: The study demonstrates that Caulerpin, a bis-indole alkaloid isolated from algae, can serve as a molecular antagonist of FPRs, reducing immune response against Hp culture filtrate by reverting FPR2-related signaling cascade and counteracting inflammatory reactions triggered by Hp peptide Hp(2-20). The findings suggest Caulerpin as a promising therapeutic or adjuvant agent for attenuating inflammation caused by Hp infection and its adverse clinical outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Runa Kuley, Bhargavi Duvvuri, Jeffrey J. Wallin, Nam Bui, Mary Vic Adona, Nicholas G. O'Connor, Sharon K. Sahi, Ian B. Stanaway, Mark M. Wurfel, Eric D. Morrell, W. Conrad Liles, Pavan K. Bhatraju, Christian Lood
Summary: Neutrophil dysregulation is a recognized feature of COVID-19, but the factors contributing to neutrophil activation in this disease are not well understood. This study found elevated levels of calprotectin, neutrophil extracellular traps (NETs), and N-formyl methionine (fMet) in COVID-19 patients, particularly in critically ill patients. The levels of NETs were higher in ICU patients with COVID-19 compared to ICU patients without COVID-19, suggesting a significant contribution of NETs in COVID-19. In vitro experiments showed that plasma from COVID-19 patients induced neutrophil activation through fMet/FPR1-dependent mechanisms. The study concludes that fMet is an important factor contributing to neutrophil activation in COVID-19 and may be a potential target for therapeutic intervention.
Review
Biochemistry & Molecular Biology
Paola Cuomo, Marina Papaianni, Rosanna Capparelli, Chiara Medaglia
Summary: Formyl peptide receptors (FPRs) are cell surface receptors that play a key role in regulating inflammatory responses, with FPRL1 being the most versatile receptor recognizing various ligands and participating in Helicobacter pylori-induced gastric inflammation. Investigating the role of FPRs in H. pylori-associated chronic inflammation suggests them as potential targets for mitigating microbial and sterile inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Stefano Bagatella, Neda Haghayegh Jahromi, Camille Monney, Margherita Polidori, Flavio Max Gall, Emma Marchionatti, Fabienne Serra, Rainer Riedl, Britta Engelhardt, Anna Oevermann
Summary: This study investigates the chemotaxis of bovine polymorphonuclear neutrophils (PMN) towards Listeria monocytogenes (Lm) and infected brain cell populations. The results show that microglia have a primary role in initiating PMN chemotaxis towards Lm in the brain during neurolisteriosis, and blockade of the factors involved in this process could be a potential therapeutic target.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Veterinary Sciences
Harpreet Dhingra, Kamaljit Kaur, Baljit Singh
Summary: AMPs have been shown to be effective against M. haemolytica while minimizing the risk of drug residues. HBD3, 28AA, and 20AA analogues exhibited intermediate bactericidal activity against M. haemolytica, with the 10AA analogue showing higher activity likely due to lower final inoculum size. Neutrophils showed chemotaxis towards HBD3 and 20AA peptides in vitro.
VETERINARY RESEARCH
(2021)
Review
Biology
Edward S. Wickstead, Egle Solito, Simon McArthur
Summary: This review describes the similarities and differences between the two principal pro-inflammatory and anti-inflammatory FPR receptors, FPR1 and FPR2, and discusses their importance in the development of neuroinflammatory diseases and their potential as therapeutic targets.
Article
Biochemistry & Molecular Biology
Germana Lentini, Giuseppe Valerio De Gaetano, Agata Fama, Roberta Galbo, Francesco Coppolino, Giuseppe Mancuso, Giuseppe Teti, Concetta Beninati
Summary: The mechanisms of neutrophil response to live and dead organisms are unknown. It has been discovered that neutrophils produce significantly higher levels of the Cxcl2 chemokine in response to live bacteria compared to killed bacteria or isolated bacterial components. This response requires three signals, with two of them being provided by signal peptides released by live bacteria.
Article
Cell Biology
Simon Lind, Claes Dahlgren, Rikard Holmdahl, Peter Olofsson, Huamei Forsman
Summary: The study reveals that RE-04-001 specifically targets and activates FPR1 at very low concentrations, leading to biased signaling towards the PLC-PIP2-Ca(2+) pathway and ERK1/2 activation while avoiding beta-arrestin recruitment. Compared to the peptide agonist fMLF, RE-04-001 displays a more resistant response and a functional selective effect on human neutrophils, making it a potential tool for further studies and drug development targeting FPR1.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Immunology
Bhargavi Duvvuri, Al Anoud Baddour, Kevin D. Deane, Marie L. Feser, J. Lee Nelson, M. Kristen Demoruelle, Christian Lood
Summary: Elevated levels of total fMet in the circulation of RA patients are associated with disease activity, joint involvement, and the development of rheumatoid nodules. Total fMet levels can predict erosive disease and improve the prognostic ability of ACPA, suggesting a potential role as novel biomarkers for disease monitoring and prognosis in RA. Additionally, circulating mtNFPs induce neutrophil activation through FPR1-dependent mechanisms, indicating FPR1 as a potential therapeutic target for RA.
JOURNAL OF AUTOIMMUNITY
(2021)
Review
Cell Biology
Qiwen Liao, Richard D. Ye
Summary: G protein-coupled chemoattractant receptors, such as FPR2, play a crucial role in leukocyte chemotaxis and have diverse cellular functions in response to various agonists. Recent studies have provided insights into the structural and conformational aspects of FPR2, revealing its ability to bind different ligands in different poses.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Neurosciences
Jiahui Zhu, Lingfei Li, Jiao Ding, Jinyu Huang, Anwen Shao, Bo Tang
Summary: Formyl peptide receptors (FPRs) are important biomarkers for neurological diseases as they regulate inflammatory responses and affect neurological disease progression. FPRs have dual inflammatory functional properties in the central nervous system, with FPR2 mediating the active resolution of inflammation and FPR1 being related to angiogenesis, cell proliferation, and neurogenesis. Treatment with FPRs-modulation may be effective for neurological diseases.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Sung Kyun Lee, Geon Ho Bae, Ye Seon Kim, Hyung Sik Kim, Mingyu Lee, Jaewang Ghim, Brian A. Zabel, Sung Ho Ryu, Yoe-Sik Bae
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Sung Kyun Lee, Ye Seon Kim, Geon Ho Bae, Ha Young Lee, Yoe-Sik Bae
SCIENTIFIC REPORTS
(2019)
Article
Hematology
Geon Ho Bae, Ye Seon Kim, Ji Ye Park, Mingyu Lee, Sung Kyun Lee, Ji Cheol Kim, Jang Gyu Kim, Ye Ji Shin, Ho Lee, Soo-Youl Kim, Yong-Soo Bae, Brian A. Zabel, Hong Sook Kim, Yoe-Sik Bae
Summary: Lung-resident neutrophils (LNs) play essential roles in protecting the lungs against damage and inflammation, and they show distinct characteristics compared to bone marrow and blood neutrophils.
Article
Biochemistry & Molecular Biology
Geon Ho Bae, Sung Kyun Lee, Hyung Sik Kim, Mingyu Lee, Ha Young Lee, Yoe-Sik Bae
EXPERIMENTAL AND MOLECULAR MEDICINE
(2017)