Article
Agriculture, Dairy & Animal Science
Aridany Suarez-Trujillo, Nguyen Hoang, Leela Robinson, Conor J. McCabe, Dawn Conklin, Radiah C. Minor, Jonathan Townsend, Karen Plaut, Uduak Z. George, Jacquelyn Boerman, Theresa M. Casey
Summary: The metabolic, circadian, sleep, and reproductive systems are interconnected and regulated, but the understanding of their mechanism is limited. This study disrupted the circadian timing system in pregnant nonlactating cows and found that body temperature and hormone concentrations were affected, especially in relation to gestation.
JOURNAL OF DAIRY SCIENCE
(2022)
Review
Biology
Zachary A. Grieb, Joseph S. Lonstein
Summary: The interaction between oxytocin and central dopamine and serotonin systems is crucial for behavioral adaptations during the postpartum period. Oxytocin-dopamine interaction regulates maternal motivation and active caregiving behaviors, while oxytocin-serotonin interaction influences other aspects such as nursing, aggression, anxiety-like behavior, and stress coping strategy.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Gyanendra Kumar, Kirti R. Saad, Bijesh Puthusseri, Monisha Arya, Nandini P. Shetty, Parvatam Giridhar
Summary: The study observed an increase in isoflavone content in soybean culture under treatment with serotonin and melatonin. Additionally, there may be a correlation between ethylene biosynthesis and isoflavone biosynthesis under these treatments.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Jinxing Li, Yuxin Liu, Lei Yuan, Baibing Zhang, Estelle Spear Bishop, Kecheng Wang, Jing Tang, Yu-Qing Zheng, Wenhui Xu, Simiao Niu, Levent Beker, Thomas L. Li, Gan Chen, Modupeola Diyaolu, Anne-Laure Thomas, Vittorio Mottini, Jeffrey B. -H. Tok, James C. Y. Dunn, Bianxiao Cui, Sergiu P. Pasca, Yi Cui, Aida Habtezion, Xiaoke Chen, Zhenan Bao
Summary: Neurotransmitters play crucial roles in regulating neural circuit dynamics in the central and peripheral nervous systems, including the gastrointestinal tract. However, there is a lack of bioelectronic tools for real-time monitoring of neurotransmitter dynamics in vivo, especially in the enteric nervous system. In this study, the researchers developed a tissue-mimicking, stretchable neurochemical biological interface called NeuroString, which allows chronic in vivo real-time monitoring of monoamine levels in the brain and serotonin dynamics in the gut. This interface has the potential for studying the impact of neurotransmitters on gut microbes and brain-gut communication.
Article
Biotechnology & Applied Microbiology
Yingying Yu, Guojing Li, Xiaoying He, Yu Lin, Zheng Chen, Xianhua Lin, Hong Xu
Summary: This study demonstrated that miR-21 and TLR8 were significantly upregulated in PCOS granulosa cells, leading to increased inflammatory response. These findings provide important insights into the pathogenesis of PCOS.
Article
Psychiatry
Gal Levin, Tsachi Ein-Dor
Summary: Peripartum depression (PPD) is a common and debilitating disorder that affects the development of mothers and infants. There is currently no accurate screening tool for PPD and some women are resistant to current treatments. A unified understanding of the biological basis of PPD, specifically focusing on the kynurenine pathway and the KP-serotonin ratio, has the potential to guide future research and identify novel treatments.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Reproductive Biology
M. Chiara Perego, Nicholas Bellitto, Excel Rio S. Maylem, Francesca Caloni, Leon J. Spicer
Summary: This study established a hormone responsive granulosa cell culture system for measuring steroidogenic and cell proliferation responses in feline ovaries. It was found that IGF1 alone and combined with FSH stimulated cell proliferation and estradiol production, while EGF inhibited estradiol production induced by FSH and IGF1.
Article
Psychiatry
Jesper Vestlund, Qian Zhang, Olesya T. Shevchouk, Daniel Hovey, Lundstrom Sebastian, Lars Westberg, Elisabet Jerlhag
Summary: Aggression is a complex social behavior that is regulated by the gut-brain hormone GLP-1. Preclinical and human genetic association studies have shown that GLP-1 can suppress aggressive behaviors through central neurotransmission.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Uliana Semaniuk, Olha Strilbytska, Karina Malinovska, Kenneth B. Storey, Alexander Vaiserman, Volodymyr Lushchak, Oleh Lushchak
Summary: This study focuses on the expression profiles of DILP2, DILP3, and DILP5 produced by insulin-producing cells in the brain of Drosophila. The data suggest that the transcript levels of DILPs are influenced by various conditions such as nutrition, environment, and gene manipulation.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Developmental Biology
Excel R. S. Maylem, Leon J. Spicer
Summary: This study identified TGFB1 as a major regulator of feline ovarian function, in addition to EGF, IGF1, melatonin, LH and FSH. These studies provide important information for future development of fertility control in feline species.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2022)
Article
Endocrinology & Metabolism
Daniela avila-Gonzalez, Italo Romero-Morales, Lizette Caro, Alejandro Martinez-Juarez, Larry J. Young, Francisco Camacho-Barrios, Omar Martinez-Alarcon, Analia E. Castro, Raul G. Paredes, Nestor F. Diaz, Wendy Portillo
Summary: This study examines the effects of social interactions and copulation on the proliferation and differentiation of neural progenitor cells (NPCs) in adult voles. The researchers found that social exposure and social cohabitation with mating induce changes in the properties of NPCs and lead to increased proliferation and biased differentiation potential in both male and female voles. The results suggest that neurogenesis in the subventricular zone (SVZ) may play a crucial role in pair bond formation, and the response to hormonal and growth factors treatments varies depending on the sociosexual context or sex.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Neurosciences
Courtney E. King, William C. Griffin, Marcelo F. Lopez, Howard C. Becker
Summary: Both preclinical and clinical evidence suggest that exogenous administration of oxytocin may be a promising therapeutic strategy for reducing heavy alcohol drinking. This study demonstrates that targeted activation of hypothalamic oxytocin neurons can reduce alcohol consumption, indicating a role for oxytocin in the regulation of alcohol self-administration behavior. Furthermore, the ability of oxytocin to reduce alcohol drinking is mediated by signaling at oxytocin receptors in the brain.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Zhaohuan Huang, Ling Liu, Jian Zhang, Kristie Conde, Jay Phansalkar, Zhongzhong Li, Lei Yao, Zihui Xu, Wei Wang, Jiangning Zhou, Guoqiang Bi, Feng Wu, Randy J. Seeley, Michael M. Scott, Cheng Zhan, Zhiping P. Pang, Ji Liu
Summary: This study identified a population of glucose-sensing GLP-1 receptor neurons in the dorsomedial hypothalamic nucleus, which can decrease blood glucose levels through communication with the pancreas. The mechanism by which this central GLP-1 signal controls glucose levels was also elucidated.
Article
Endocrinology & Metabolism
Katarina Mis, Ana-Marija Lulic, Tomaz Mars, Sergej Pirkmajer, Maja Katalinic
Summary: The first aim of this study was to determine if PNPLA7 is functionally expressed in human skeletal muscle cells, and the second aim was to investigate the regulation of PNPLA7 by insulin, glucocorticoids, cAMP/protein kinase A pathway, and glucose. The results show that PNPLA7 is expressed in human muscle cells and is regulated by metabolic signals.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Joshua P. Torres, Zhenjian Lin, Maren Watkins, Paula Florez Salcedo, Robert P. Baskin, Shireen Elhabian, Helena Safavi-Hemami, Dylan Taylor, Jortan Tun, Gisela P. Concepcion, Noel Saguil, Angel A. Yanagihara, Yixin Fang, Jeffrey R. McArthur, Han-Shen Tae, Rocio K. Finol-Urdaneta, B. Duygu Ozpolat, Baldomero M. Olivera, Eric W. Schmidt
Summary: Venomous cone snails use small molecules in their venom to mimic natural mating pheromones of their prey polychaete worms, evoking mating behavior. These specialized metabolites are species-specific and structurally diverse, indicating that cone snails may adopt various prey-hunting strategies facilitated by small molecules. In the phenomenon of aggressive mimicry, C. imperialis uses metabolically stable mimics of prey pheromones, highlighting a unique aspect of biological mimicry in chemical ecology.
