Article
Chemistry, Medicinal
Chia-Wen Liu, Chu-Yi Hsieh, Jyh-Yih Chen
Summary: This study demonstrates that synthetic peptides derived from tilapia piscidin (TP)2, TP2-5 and TP2-6 have multifaceted effects in skin wound healing, including enhancing cell proliferation and migration, upregulating key factors expression, promoting angiogenesis, and accelerating wound healing.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Polymer Science
Fabrizio Fiorentini, Giulia Suarato, Pietro Grisoli, Arkadiusz Zych, Rosalia Bertorelli, Athanassia Athanassiou
Summary: Natural polymeric films combining zein and pectin were prepared and showed accelerated degradation in water due to the ability of pectin to be released from the protein matrix. The developed biocomposite patches exhibited effective inhibition of pathogen growth and good biocompatibility in vitro experiments.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Engineering, Biomedical
Rajib Dey, Riya Mukherjee, Jayanta Haldar
Summary: This report introduces an intrinsically antimicrobial hydrogel (HyDex) that exhibits broad-spectrum antimicrobial activity, hemostatic ability, and rapid wound closure efficacy. The hydrogel demonstrates effective antibacterial and antifungal effects, rapid blood clotting, and reduction in inflammatory responses in various models, showing great potential in addressing resistant bacteria, fungal infections, bleeding, and inflammation.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Applied
Xavier Alvarez, Andreia Alves, Maximiano P. Ribeiro, Massimo Lazzari, Paula Coutinho, Ana Otero
Summary: Exopolysaccharides (EPS) produced by cyanobacteria have potential biomedical applications, such as new wound dressings. Addition of acetate ions to the culture medium can stimulate EPS production, leading to gel formation and promotion of fibroblast migration and proliferation. These Nostoc EPS hydrogels show promising properties for skin injury treatment.
CARBOHYDRATE POLYMERS
(2021)
Review
Infectious Diseases
Ali Pormohammad, Nadia K. Monych, Sougata Ghosh, Diana L. Turner, Raymond J. Turner
Summary: Wounds continue to be a serious medical concern, with infectious microbes in biofilm form delaying the healing process. Developing novel wound dressing drug formulations and materials with combined antibacterial, antibiofilm, and wound healing properties are necessary. Nanomaterials show promising applicability for various wound types with their unique properties.
Article
Chemistry, Inorganic & Nuclear
Lingmin Meng, Shanyou Li, Changxu Wanyan
Summary: This study successfully prepared a novel chitosan-based metal nanocomposite, which showed promising antimicrobial activity and promoted wound healing.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Hafiza Mahreen Mehwish, Ge Liu, Muhammad Shahid Riaz Rajoka, Huiming Cai, Jianfeng Zhong, Xun Song, Lixin Xia, Mingzhong Wang, Rana Muhammad Aadil, Muhammad Inam-Ur-Raheem, Yongai Xiong, Haiqiang Wu, Muhammad Imran Amirzada, Qinchang Zhu, Zhendan He
Summary: This study investigated the potential of polysaccharide isolated from Moringa oleifera seed and its nanocomposite with silver as alternative wound dressing materials. The synthesized MOS-PS-AgNPs showed no cytotoxicity towards mouse fibroblast cells, promoted in-vitro migration, and exhibited strong antimicrobial activity against wound infectious pathogenic bacteria. Overall, the results indicated that MOS-PS-AgNPs might be an excellent candidate for optimal wound dressing materials.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Plant Sciences
Mehmet Evren Okur, Ayse Esra Karadag, Yagmur Ozhan, Hande Sipahi, Sule Ayla, Benay Daylan, Suekran Kultur, Betuel Demirci, Fatih Demirci
Summary: The study demonstrates the antioxidant and anti-inflammatory properties of Phlomis rigida, as well as its positive effects on wound healing through both in vitro and in vivo experiments.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Bahare Salehi, Celia F. Rodrigues, Gregorio Peron, Stefano Dall'Acqua, Javad Sharifi-Rad, Lubna Azmi, Ila Shukla, Uttam Singh Baghel, Abhay Prakash Mishra, Ahmed M. Elissawy, Abdel Nasser Singab, Raffaele Pezzani, Marco Redaelli, Jayanta Kumar Patra, Chidambaram Kulandaisamy Venil, Gitishree Das, Deeksha Singh, Priyanka Kriplani, Alessandro Venditti, Patrick Valere Tsouh Fokou, Marcello Iriti, Ryszard Amarowicz, Miquel Martorell, Natalia Cruz-Martins
Summary: Curcumin, the active ingredient of turmeric, has a long history of medicinal value. Despite its strong antimicrobial potential, issues such as low aqueous solubility and rapid metabolism need to be addressed for better therapeutic efficacy, which can be improved with nanoformulations.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Applied
Yongsheng Ma, Shuyi Xu, Pengpeng Yue, Hankun Cao, Yongkang Zou, Lizhe Wang, Haitao Long, Shuangquan Wu, Qifa Ye
Summary: There is an urgent need to design broad-spectrum antibacterial materials with good biocompatibility to treat bacterial infections. In this study, a polysaccharide-based material called imidazolium salt chitin (IMSC) was synthesized by grafting imidazole onto chitin. IMSC exhibited good water solubility, broad-spectrum antimicrobial activity, hemocompatibility, and biocompatibility. Moreover, IMSC showed great potential in treating infected wounds by reducing inflammation and promoting wound healing.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Maria Onaira Goncalves Ferreira, Alessandra Braga Ribeiro, Marcia S. Rizzo, Antonia Carla de Jesus Oliveira, Josy Anteveli Osajima, Leticia M. Estevinho, Edson C. Silva-Filho
Summary: In this study, a gel based on chicha gum, chitosan, and Mauritia flexuosa oil (CGCHO) was developed for wound treatment. The gel exhibited good antimicrobial activity against Gram-positive bacteria and promoted cell growth and tissue healing through thermal stability and roughness.
Article
Biochemistry & Molecular Biology
Chih-Hsin Wang, Juin-Hong Cherng, Chuan-Chieh Liu, Tong-Jing Fang, Zhi-Jie Hong, Shu-Jen Chang, Gang-Yi Fan, Sheng-Der Hsu
Summary: Chitosan dressing demonstrated excellent antimicrobial and procoagulant properties, accelerating wound healing by protecting against microbial infection and promoting the growth of beneficial microbiota. The dressing exhibited good biocompatibility and outstanding blood absorption ability, inhibiting bacterial growth up to 8 days post-surgery. These findings suggest that chitosan dressing provides a suitable environment for beneficial microbiota and is effective in promoting wound repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Zejun Xu, Guiting Liu, Li Zheng, Jun Wu
Summary: A hydrogel with enhanced antimicrobial and antioxidant properties (CMGFC) was developed to accelerate diabetic wound healing. The CMGFC hydrogel showed high antibacterial efficiency and strong ROS scavenging ability, protecting cells from oxidative stress. In vivo results demonstrated reduced inflammatory responses, enhanced angiogenesis, and improved wound healing with the CMGFC hydrogel.
Review
Pharmacology & Pharmacy
Paolo Pino, Francesca Bosco, Chiara Mollea, Barbara Onida
Summary: Chronic wounds are a global health concern, with increasing incidence due to age and age-related comorbidities. Antimicrobial bionanocomposites, such as nano-ZnO-BNC, offer promising solutions for wound healing with their antimicrobial properties. However, standardized testing procedures and a comprehensive understanding of their antimicrobial mechanism are still lacking.
Article
Public, Environmental & Occupational Health
Hayford Odoi, Vivian Etsiapa Boamah, Yaw Duah Boakye, Christian Agyare
Summary: This study in the Ashanti region of Ghana investigated the prevalence of multidrug-resistant P. aeruginosa in hospitals, poultry farms, and environmental samples. Results revealed a high prevalence of resistance genes and efflux capacity in the multidrug-resistant strains. Regular surveillance of antibiotic-resistant bacteria is recommended to inform antibiotic therapy selection in clinical and veterinary practice in Ghana.
JOURNAL OF ENVIRONMENTAL AND PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Akosua Dufie Ankomah, Yaw Duah Boakye, Theresa Appiah Agana, Francis Adu, Christian Agyare
Summary: Cnestis ferruginea shows antimicrobial activity and can enhance bacteria susceptibility to antibiotics while reducing biofilm formation.
Article
Public, Environmental & Occupational Health
Hayford Odoi, Vivian Etsiapa Boamah, Yaw Duah Boakye, Cornelius Cecil Dodoo, Christian Agyare
Summary: This study characterized Pseudomonas aeruginosa isolates from various environments and patients in Ghana. The isolates were found to be susceptible to ceftazidime and piperacillin, while resistant to gentamycin and ciprofloxacin. Multiple drug resistant isolates carried various plasmids, and several clones with resistance to all tested antipseudomonal agents were identified.
ENVIRONMENTAL HEALTH INSIGHTS
(2022)
Article
Immunology
Yaw Duah Boakye, Newman Osafo, James Oppong-Kyekyeku, Wonder Kofi Mensah Abotsi, Eric Boakye-Gyasi, Elke Heiss, Christian Agyare
Summary: Xylopic acid (XA), a kaurene diterpene found in African plants, has been shown to possess acute and chronic anti-inflammatory activities. This study investigates the potential molecular target(s) of XA, revealing an inhibitory effect on NF-kappa B activity and an increased activity of Nrf2, accompanied by changes in the expression of related proteins.
INFLAMMOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Akosua Dufie Ankomah, Yaw Duah Boakye, Theresah Appiah Agana, Vivian Etsiapa Boamah, Paul Poku Sampene Ossei, Francis Adu, Christian Agyare
Summary: This study investigated the dermal toxicity and wound healing potential of Cnestis ferruginea. The results showed that treatment with C. ferruginea significantly reduced wound size and promoted wound healing without causing skin toxicity.
ADVANCES IN PHARMACOLOGICAL AND PHARMACEUTICAL SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Dominic Nkwantabisa Kuma, Alex Boye, Godwin Kwakye-Nuako, Yaw Duah Boakye, Justice Kwaku Addo, Ernest Amponsah Asiamah, Eugene Agyei Aboagye, Orleans Martey, Mainprice Akuoko Essuman, Victor Yao Atsu Barku
Summary: This study confirms the wound healing and antimicrobial effects of Parkia clappertoniana fruit husk extract (PCFHE) in rats with excisional wounds, validating its traditional use. The presence of quercetin and catechin in PCFHE contributes to its reported pharmacological properties.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Ahmed Wahab Obeng, Yaw Duah Boakye, Theresa Appiah Agana, Vivian Etsiapa Boamah, James Oppong-Kyekyeku, Abena Amponsaa Brobbey, Francis Adu, Stephen Yao Gbedema, Christian Agyare
Summary: The study found that Carica papaya and Ceiba pentandra have antitrypanosomal and anthelminthic activities. The extracts from these plants showed moderate to strong activity against Trypanosoma brucei brucei and Pheretima posthuma worms in vitro. However, the extracts also exhibited potential toxic effects. Preliminary phytochemical analysis identified compounds with antitrypanosomal and anthelminthic properties in the plants.
JOURNAL OF CHEMISTRY
(2022)
Article
Biology
Francis Kwaku Dzideh Amankwah, Stephen Yao Gbedema, Yaw Duah Boakye, Marcel Tunkumgmen Bayor, Vivian Etsiapah Boamah
Summary: Microorganisms were isolated from different environments in Ghana and 10 of them exhibited antimicrobial activity. One Pseudomonas aeruginosa isolate (DO5) showed the highest activity and had broad-spectrum antimicrobial effects. The metabolites of DO5 have the potential to be developed into potent antibiotics for infection treatment.
Review
Integrative & Complementary Medicine
Jonathan Jato, Emmanuel Orman, Yaw Duah Boakye, Emelia Oppong Bekoe, Samuel Oppong Bekoe, Samuel Asare-Nkansah, Verena Spiegler, Andreas Hensel, Eva Liebau, Christian Agyare
Summary: Soil-transmitted helminthiasis is a sanitary problem in Africa, causing economic burden and poor animal health. Medicinal plants in Africa have shown potential as anthelmintic agents. This review examines studies conducted on African medicinal plants in the past two decades and highlights their significant anthelmintic potential.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Adwoa Frema Amanfo, Samuel Kyei, Yaw Duah Boakye, Clement Osei Akoto, Justice Kwaku Addo, Kofi Oduro Yeboah, Newman Osafo
Summary: This study investigates the potential of the aqueous extract of Aspilia africana flowers (AAE) as an anticataract remedy. The results demonstrate that AAE can delay the progression of diabetic and senile cataracts, and preserve lens transparency and function.
ADVANCES IN PHARMACOLOGICAL AND PHARMACEUTICAL SCIENCES
(2023)
Article
Biology
Adwoa Frema Amanfo, Samuel Kyei, Yaw Duah Boakye, Clement Osei Akoto, Justice Kwaku Addo, Kofi Oduro Yeboah, Newman Osafo
Summary: This study investigated the potential of the aqueous stem bark extract of Alstonia boonei as an anticataract remedy. The extract showed promise in delaying the progression of cataracts in rat models. The findings suggest that Alstonia boonei could be used as a herbal treatment for cataracts.
Article
Parasitology
Bright Osei-Mensah, Yaw Duah Boakye, William Kofi Anyan, Theresa Appiah Agana, Eugene Agyei Aboagye, Ivy Bentil, Elvis Suatey Lomotey, Francis Adu, Christian Agyare
Summary: By assessing the cercaricidal activity of four local plants in Ghana, including Ocimum viride leaves, Momordica charantia leaves, Spathodea campanulata stem bark, and Newbouldia laevis stem bark, against Schistosoma mansoni cercariae, this study revealed their potential in curbing schistosomiasis.
JOURNAL OF PARASITOLOGY RESEARCH
(2023)