Article
Neurosciences
Anna E. Bruus, Gunhild Waldemar, Asmus Vogel
Summary: Autobiographical memory may be impaired in the early stages of Alzheimer's disease, even when standardized tests show no decline, suggesting that subjective cognitive decline may be an indicator of early AD-related memory deficits.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Daniele Altomare, Sara Stampacchia, Federica Ribaldi, Szymon Tomczyk, Claire Chevalier, Geraldine Poulain, Saina Asadi, Bianca Bancila, Moira Marizzoni, Marta Martins, Aurelien Lathuiliere, Max Scheffler, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Ilse Kern, Miguel Frias, Valentina Garibotto, Giovanni B. Frisoni
Summary: This study aimed to confirm the correlations between plasma and traditional Alzheimer's disease (AD) biomarkers, assess the diagnostic accuracy of plasma biomarkers compared to traditional biomarkers, and estimate the potential savings in traditional exams by using plasma biomarkers. The results showed significant correlations between plasma biomarkers and traditional biomarkers, and high accuracy in discriminating biomarker status. The implementation of plasma biomarkers could save a significant proportion of expensive traditional exams, making the diagnostic workup more cost-effective and improving patient care.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Lourdes Alvarez-Sanchez, Carmen Pena-Bautista, Laura Ferre-Gonzalez, Laura Cubas, Angel Balaguer, Bonaventura Casanova-Estruch, Miguel Baquero, Consuelo Chafer-Pericas
Summary: This study aims to evaluate the use of several plasma biomarkers to develop an early and specific screening method for Alzheimer's disease (AD). The results show that plasma p-Tau181 and GFAP levels are higher in AD dementia patients and have significant correlations with clinical AD characteristics. Plasma NfL levels are higher in frontotemporal dementia (FTD) patients but not significantly correlated with AD. The developed partial least squares (PLS) diagnosis model shows good accuracy in distinguishing AD patients from subjective cognitive impairment (SCI) patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Pengxu Wei
Summary: Alzheimer's pathology can be assessed using A beta and tau biomarkers. The preclinical period of the disease is long-lasting. While effective therapies for blocking the disease's pathological processes are lacking, developed countries have seen a decrease in the incidence and prevalence of dementia. Education, cognitive training, physical exercise, and a healthy lifestyle can protect cognitive function and promote healthy aging. Detection and intervention in the transitional cognitive decline stage may be more effective compared to the mild cognitive impairment (MCI) stage. New tools are needed for rapid screening of cognitive function.
Article
Neurosciences
Herrer Abdulrahman, Edo Richard, Willem A. van Gool, Eric P. Moll van Charante, Jan Willem van Dalen
Summary: Sex differences do not significantly modify the predictive value of SMC and IADL-I for the risk of dementia and mortality, but the competing risk of death for these factors differs considerably between men and women.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Tian-Shin Yeh, Changzheng Yuan, Alberto Ascherio, Bernard A. Rosner, Walter C. Willett, Deborah Blacker
Summary: The study found that higher intake of dietary flavonoids was associated with a lower risk of subjective cognitive decline (SCD), especially for flavones, flavanones, and anthocyanins. This suggests that consuming foods rich in flavonoids, such as strawberries, oranges, and citrus juices, may help maintain cognitive function in US men and women.
Article
Clinical Neurology
Tian-Shin Yeh, Changzheng Yuan, Alberto Ascherio, Bernard A. Rosner, Walter C. Willett, Deborah Blacker
Summary: Higher intake of dietary flavonoids, especially flavonols, flavanones, and anthocyanins, was associated with lower odds of subjective cognitive decline (SCD). Foods rich in flavonoids, such as strawberries, oranges, grapefruits, and apples, were significantly associated with reduced risk of SCD. These findings suggest a potential benefit of consuming flavonoid-rich foods for maintaining cognitive function.
Review
Neurosciences
Lulu Liu, Adam Bulley, Muireann Irish
Summary: This article delves into the capacity of subjective time perception in humans, and the potential disruptions in time perception and mental time travel that may occur in dementia syndromes, highlighting the significant consequences for independent functioning in everyday life. The neurocognitive mechanisms underlying changes in time perception and mental time travel across different dementia disorders are explored, along with the functional implications of altered subjective timing on prospective memory and intertemporal decision-making. The review sheds light on the transdiagnostic implications of subjective timing disturbances in dementia, emphasizing the high variability in performance across clinical syndromes and functional domains.
Review
Neurosciences
Laura Glass Umfleet, Robert M. Bilder, David W. Loring, April Thames, Benjamin M. Hampstead, Russell M. Bauer, Daniel L. Drane, Lucia Cavanagh
Summary: Cognitive screening instruments (CSI) have limited effectiveness for detecting dementia in older adults living in the community. This article proposes a framework for transitioning from traditional CSI to advanced dementia screening methods that incorporate psychometrics, neuroscience, and technology. A psychometrically advanced, automated selective assessment model utilizing item response theory is suggested for an assessment revolution. The article also discusses the modernization of CSIs, diversity and inclusion issues, challenges in differentiating normal from pathological aging, and ethical considerations.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Psychology, Clinical
Kerryn E. Pike, Marina G. Cavuoto, Lily Li, Bradley J. Wright, Glynda J. Kinsella
Summary: Subjective Cognitive Decline (SCD) is associated with an increased risk of developing dementia and mild cognitive impairment (MCI). Factors such as worry in the SCD definition, younger age, and recruitment source impact the risk of developing MCI, while they have little influence on the risk of developing dementia. Further research is needed to identify effective interventions for risk reduction and cognitive management in individuals with SCD.
NEUROPSYCHOLOGY REVIEW
(2022)
Article
Psychology, Multidisciplinary
Xianghe Zhu, Martina Luchetti, Damaris Aschwanden, Amanda A. A. Sesker, Yannick Stephan, Angelina R. R. Sutin, Antonio Terracciano
Summary: This study examined the associations between subjective well-being and risk of all-cause dementia, Alzheimer's disease, and vascular dementia. The results showed that general happiness, health and family satisfaction, and satisfaction breadth were associated with lower risk of all-cause dementia. Health satisfaction and the breadth of satisfaction were also associated with lower risk of Alzheimer's disease and vascular dementia.
JOURNAL OF HAPPINESS STUDIES
(2023)
Article
Neurosciences
Ximena Oyarzun-Gonzalez, Erin L. Abner, Pablo Toro, Catterina Ferreccio
Summary: Background: Subjective memory complaints (SMC) are commonly studied in older adults and have been identified as potentially prodromal to dementia and Alzheimer's disease. We aimed to estimate the prevalence of SMC and investigate factors associated with it among Maule Cohort (MAUCO) participants. Methods: Cross-sectional analysis was performed using MAUCO baseline data (N = 6,687). Multinomial logistic regression models evaluated risk factors for SMC within age and global cognitive status groups. Results: The overall prevalence of SMC was 16.4%, with higher rates among older participants (17.6%) compared to younger participants (15.9%). Female sex, comorbidities, and poor self-reported health status were associated with higher odds of SMC. Conclusion: The prevalence of SMC in MAUCO participants was 16%. The risk factors for SMC varied depending on age and global cognitive status. Future research should consider sex-specific assessments, evaluate the influence of self-reported health status on SMC reporting, and examine the impact of the SARS-CoV-2 pandemic on SMC reporting.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Salvatore Mazzeo, Assunta Ingannato, Giulia Giacomucci, Alberto Manganelli, Valentina Moschini, Juri Balestrini, Arianna Cavaliere, Carmen Morinelli, Giulia Galdo, Filippo Emiliani, Diletta Piazzesi, Chiara Crucitti, Daniele Frigerio, Cristina Polito, Valentina Berti, Silvia Bagnoli, Sonia Padiglioni, Sandro Sorbi, Benedetta Nacmias, Valentina Bessi
Summary: Plasma neurofilament light chain (NfL) can accurately predict Alzheimer's disease and the progression of cognitive decline, serving as an important non-invasive tool for early diagnosis.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Quynh T. Vo, Benjamin Koethe, Sarah Holmes, Linda Simoni-Wastila, Becky A. Briesacher
Summary: This study compared long-term outcomes among newly admitted skilled nursing facility patients with delirium, incident ADRD, and both conditions. The results showed that delirium increased the risk of death and transfer to long-term care in the first 100 days after admission, regardless of incident ADRD diagnosis. Patients with delirium and/or ADRD were also less likely to be discharged home.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Shirlene Vianna Moreira, Francis Ricardo dos Reis Justi, Carlos Falcao de Azevedo Gomes, Marcos Moreira
Summary: This study suggests that a music therapy intervention can be promising for improving episodic memory in older adults, especially those with dementia.
Article
Neurosciences
Jauhtai Cheng, J. Kaci Fairchild, M. Windy McNerney, Art Noda, J. Wesson Ashford, Trisha Suppes, Steven Z. Chao, Joy Taylor, Allyson C. Rosen, Timothy C. Durazzo, Laura C. Lazzeroni, Jerome Yesavage
Summary: This study aimed to investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on cognitive function in Veterans with multiple medical comorbidities. The results showed that rTMS improved auditory-verbal memory but may have a negative impact on semantic verbal fluency. These findings need to be confirmed by larger-scale studies.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biology
I. Richter, B. R. Roberts, S. F. Sailley, E. Sullivan, V. V. Cheung, J. Eales, M. Fortnam, J. B. Jontila, C. Maharja, T. Ha. Nguyen, S. Pahl, R. A. Praptiwi, J. Sugardjito, J. D. C. Sumeldan, W. M. Syazwan, A. Y. Then, M. C. Austen
Summary: This article discusses the integration of data from different disciplines in order to improve resource management and communication strategies. The authors propose a standardized methodology to connect and explore various types of data, and demonstrate its application using examples from natural and social sciences.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Elizabeth B. Campbell, Mia Delgadillo, Laura C. Lazzeroni, Peter N. Louras, Jonathan Myers, Jerome Yesavage, J. Kaci Fairchild
Summary: This study examines the impact of combined exercise and cognitive training (CT) on cognition for older adults with mild cognitive impairment (MCI). The results suggest that both aquatic- and land-based exercise with CT interventions can significantly improve learning and memory outcomes for MCI patients, but improvement in executive functioning, processing speed, language, and visuospatial abilities is limited to water-based and CT treatment groups. The differences in linear growth patterns between groups were not significant.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Madeline D. W. Noland, Emily W. Paolillo, Art Noda, Laura C. Lazzeroni, Jon-Erik C. Holty, Ware G. Kuschner, Jerome Yesavage, Lisa M. Kinoshita
Summary: This study aimed to examine the independent and interactive effects of PTSD and OSA on cognitive functioning in older adult veterans. The results showed that PTSD significantly predicted poorer attention and processing speed, while increased OSA severity predicted poorer learning and memory. This suggests that older adults with these comorbid conditions may experience a wider array of cognitive difficulties.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Noah S. Philip, Dhakshin Ramanathan, Bruno Gamboa, McKenna C. Brennan, Frank Andrew Kozel, Laura Lazzeroni, Michelle R. Madore
Summary: Mild traumatic brain injury (mTBI) is common in veterans with major depressive disorder (MDD) and posttraumatic stress disorder (PTSD), but its impact on therapeutic transcranial magnetic stimulation (TMS) outcomes is not well understood. This study found that the presence of mTBI did not significantly affect TMS outcomes in veterans with MDD and PTSD, supporting the safety and effectiveness of TMS in this population.
Letter
Psychiatry
Yash B. Joshi, Juan L. Molina, David L. Braff, Michael F. Green, Ruben C. Gur, Raquel E. Gur, Keith H. Nuechterlein, William S. Stone, Tiffany A. Greenwood, Laura C. Lazzeroni, Allen D. Radant, Jeremy M. Silverman, Joyce Sprock, Catherine A. Sugar, Debby W. Tsuang, Ming T. Tsuang, Bruce I. Turetsky, Neal R. Swerdlow, Gregory A. Light
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Daniela Zanetti, Laurel Stell, Stefan Gustafsson, Fahim Abbasi, Philip S. Tsao, Joshua W. Knowles, Bjorn Zethelius, Johan Arnlov, Beverley Balkau, Mark Walker, Laura C. Lazzeroni, Lars Lind, John R. Petrie, Themistocles L. Assimes
Summary: High-throughput plasma proteomic profiling can identify protein signatures that correlate with the M value, a measure of whole-body insulin sensitivity. These signatures can improve the estimation of insulin sensitivity and potentially identify individuals at risk of insulin resistance-related adverse health consequences.
Article
Environmental Studies
Daniela Anghileri, Matt Kandel, Melanie C. Austen, Vikki V. Cheung, Helen Coskeran, Adam J. M. Devenish, Patrick S. M. Dunlop, Mawuli Dzodzomenyo, Hong C. Goh, Sithembile Mwamakamba, Vanessa Ross, John Spafford, Precious Yeki, Genevieve Agaba
Summary: This paper aims to investigate the impact of COVID-19 on international development projects, with a focus on the relationship between research institutions in the global north and south. Through reflection and a survey, the paper offers recommendations on devolving project management, allocating dedicated resources, adopting hybrid and agile approaches, and improving funder-implementer collaboration to enhance project resilience and equity in north-south partnerships.
Meeting Abstract
Clinical Neurology
Allison Morehouse, Kathleen O'Hora, Beatriz Hernandez, Laura Lazzeroni, Jamie Zeitzer, Leah Friedman, Donn Posner, Clete Kushida, Jerome Yesavage, Andrea Goldstein-Piekarski
Article
Psychology, Clinical
Brian A. Maruyama, Valerie Z. Alipio Jocson, Julie Gretler, Kelly Doudell, Laura C. Lazzeroni, Beatriz Hernandez, Art Noda, Jerome A. Yesavage, Lisa M. Kinoshita
Summary: This study assessed the predictive diagnostic utility of the Benton VFDT in older Veterans and found that higher VFDT scores were associated with lower odds of cognitive/functional impairment. The VFDT may enhance the confidence of dementia diagnosis in older adult Veterans.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2023)
Meeting Abstract
Clinical Neurology
Adam Krause, Maryam Ahmadi, Kathleen O'Hora, Beatriz Hernandez, Laura Lazzeroni, Jamie Zeitzer, Leah Friedman, Donn Posner, Clete Kushida, Jerome Yesavage, Jared Saletin, Andrea Goldstein-Piekarski
Meeting Abstract
Clinical Neurology
Mateo Lopez, Adam Krause, Kathleen O'Hora, Beatriz Hernandez, Laura Lazzeroni, Jamie Zeitzer, Leah Friedman, Donn Posner, Clete Kushida, Jerome Yesavage, Andrea Goldstein-Piekarski
Meeting Abstract
Clinical Neurology
Allison Morehouse, Kathleen O'Hora, Beatriz Hernandez, Laura Lazzeroni, Jamie Zeitzer, Leah Friedman, Donn Posner, Clete Kushida, Jerome Yesavage, Andrea Goldstein-Piekarski
Meeting Abstract
Neurosciences
Adam Krause, Maryam Ahmadi, Kathleen O'Hora, Beatriz Hernandez, Laura Lazzeroni, Jamie Zeitzer, Leah Friedman, Donn Posner, Clete Kushida, Jerome Yesavage, Jared Saletin, Andrea Goldstein-Piekarski
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Maryam Ahmadi, Adam J. Krause, Kathleen O'Hora, Beatriz Hernandez, Laura Lazzeroni, Jamie Zeitzer, Leah Friedman, Donn Posner, Clete Kushida, Jerome A. Yesavage, Jared Saletin, Andrea Goldstein-Piekarski
BIOLOGICAL PSYCHIATRY
(2022)