Article
Nutrition & Dietetics
Maha N. Abu Hajleh, Khaled M. Khleifat, Moath Alqaraleh, Esra'a Al-Hraishat, Muhamad O. Al-limoun, Haitham Qaralleh, Emad A. S. Al-Dujaili
Summary: The aqueous extract of Ephedra foeminea shows promising antidiabetic properties in streptozotocin-induced diabetic rats, with significant improvements in blood glucose levels, lipid profile, and liver and kidney functions. The extract also exhibits antioxidant activity and may have potential medicinal benefits.
Article
Horticulture
Maria Dinu, Rodica Soare, Cristina Babeanu, Mihai Botu
Summary: This study evaluated the production elements, bioactive compound content, and antioxidant activity of different types of garlic. The results showed that Rocambole garlic had higher levels of vitamin C and flavonoids, while chives had higher levels of phenolic compounds. The content of bioactive compounds was higher in younger organs. Among Rocambole garlic, cloves had the highest vitamin C content. The bioactive profile of garlic depends on the age of the morphological organ and decreases with maturity.
Article
Biochemistry & Molecular Biology
Amir Taldaev, Anastasiya D. Savina, Vera V. Olicheva, Sergey V. Ivanov, Roman P. Terekhov, Igor R. Ilyasov, Anastasiya K. Zhevlakova, Irina A. Selivanova
Summary: Oxidative stress is a key factor in the development of diabetes and its complications. In this study, the protective properties of taxifolin spheroidal form (TS) were examined in a rat model of diabetes. Treatment with TS for 4 weeks resulted in a significant decrease in fasting blood glucose levels and feed intake in diabetic rats. TS also showed a protective effect on the pancreas and liver against the cytotoxic action of streptozotocin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Roxana Perez-Villavicencio, Javier Flores-Estrada, Martha Franco, Bruno Escalante, Oscar Perez-Mendez, Adriana Mercado, Rocio Bautista-Perez
Summary: This study investigated the effect of empagliflozin on sphingomyelin and its metabolites in diabetic and hypertensive rats. The results showed that empagliflozin decreased hyperglycemia in diabetic rats and reduced the levels of sphingomyelin and related substances. It also regulated the activity of certain enzymes. In hypertensive rats, empagliflozin mainly decreased the levels of sphingomyelin in the catabolic pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dina Mostafa Mohammed, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Mohamed El-Sherbiny, Wael A. Mahdi, Sultan Alshehri, Hasnaa A. Ebrahim, Amr Farouk
Summary: This study aims to examine the potential impact of key flavors and their nanocapsules on health and diseases, such as type 2 diabetes mellitus. The results showed that these flavors and nanocapsules have a potential anti-hyperglycemic effect and improved the rat health without any health drawbacks.
Article
Biochemistry & Molecular Biology
Miguel Lopez-Moreno, Estefania Jimenez-Moreno, Antonio Marquez Gallego, Gema Vera Pasamontes, Jose Antonio Uranga Ocio, Marta Garces-Rimon, Marta Miguel-Castro
Summary: In recent years, quinoa has been proposed as an emerging crop for functional food production. Quinoa hydrolysates obtained from the crop have shown in vitro biological activity. This study aimed to evaluate the beneficial effects of red quinoa hydrolysate on oxidative stress and cardiovascular health in an in vivo experimental model of hypertension. The results revealed that oral administration of red quinoa hydrolysate significantly reduced blood pressure and exhibited antioxidant effects, thereby ameliorating hypertension and its associated complications.
Article
Biochemistry & Molecular Biology
Tiago Morais, Sofia S. Pereira, Sara Andrade, Diogo Neves, Marta Guimaraes, Mario Nora, Marcos C. Carreira, Felipe F. Casanueva, Mariana P. Monteiro
Summary: GLP-1 plays a crucial role in regulating energy balance through the gut/brain axis. Truncal vagotomy in rats resulted in lower food intake, body weight, adipose tissue, and an altered response to GLP-1. These findings indicate that the vagus nerve is involved in whole-body energy homeostasis and mediates the anorectic effects of GLP-1.
Article
Plant Sciences
Carla Georgia Rodrigues Guimaraes Souto, Bethania Rosa Lorencone, Aline Aparecida Macedo Marques, Rhanany Alan Calloi Palozi, Paulo Vitor Moreira Romao, Lucas Pires Guarnier, Cleide Adriane Signor Tirloni, Ariany Carvalho dos Santos, Roosevelt Isaias Carvalho Souza, Priscila Megda Joao Job Zago, Francislaine Aparecida dos Reis Livero, Emerson Luiz Botelho Lourenco, Denise Brentan Silva, Arquimedes Gasparotto Junior
Summary: The ethanolic extract of Talinum paniculatum showed significant cardiorenal protective effects in rats, normalizing electrocardiographic and hemodynamic alterations, and preventing ventricle remodeling. These effects were associated with serum antioxidant activity and angiotensin-converting enzyme (ACE) inhibition, indicating potential benefits for hypertensive patients with doxorubicin-induced cardiotoxicity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Desiyani Saryono, Atikah Sarmoko, Desiyani Nani, Atikah Proverawati, Agis Taufik
Summary: This study found that brewed black solo garlic (BSG) has a positive effect on liver and kidney function in STZ-induced white rats, suggesting its safety for use.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Dina Mostafa Mohammed, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Mohamed El-Sherbiny, Wael A. Mahdi, Sultan Alshehri, Hasnaa A. Ebrahim, Amr Farouk
Summary: This study aims to examine the potential impact of key flavors and their nanocapsules on health and diseases, such as type 2 diabetes mellitus (T2DM). The findings suggest that these flavors and nanocapsules may have a beneficial effect on T2DM without any health drawbacks.
Article
Multidisciplinary Sciences
Lucia Sandra Perez-Borroto, Maria Carla Guzzo, Gisella Posada, Andrea Natalia Pena Malavera, Atilio Pedro Castagnaro, Justo Lorenzo Gonzalez-Olmedo, Yamilet Coll-Garcia, Esteban Mariano Pardo
Summary: The BR functional analogue DI-31 has been found to improve soybean tolerance to drought by enhancing growth, photosynthesis, water relations, antioxidant metabolism, nodulation, and nitrogen homeostasis. Additionally, regular foliar applications of DI-31 can increase the absolute yield and reduce drought-induced yield losses in commercial cultivars. These findings demonstrate the practical value of DI-31 as an environmentally friendly alternative for managing soybean resilience under drought conditions.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Physical
Zejun Xu, Guiting Liu, Li Zheng, Jun Wu
Summary: A hydrogel with enhanced antimicrobial and antioxidant properties (CMGFC) was developed to accelerate diabetic wound healing. The CMGFC hydrogel showed high antibacterial efficiency and strong ROS scavenging ability, protecting cells from oxidative stress. In vivo results demonstrated reduced inflammatory responses, enhanced angiogenesis, and improved wound healing with the CMGFC hydrogel.
Article
Biochemistry & Molecular Biology
Marisa Lopez, Laura Quintero-Macias, Miguel Huerta, Alejandrina Rodriguez-Hernandez, Valery Melnikov, Yolitzy Cardenas, Jaime Alberto Bricio-Barrios, Enrique Sanchez-Pastor, Armando Gamboa-Dominguez, Caridad Leal, Xochitl Trujillo, Monica Rios-Silva
Summary: This study investigated the effects of chronic capsaicin administration on hepcidin expression, kidney iron deposits, and urinary biomarkers in a male rat model with both iron overload and diabetes mellitus. The results showed that capsaicin reduced renal iron depositions and increased levels of circulating hepcidin in the animal model.
Article
Reproductive Biology
Jiamei Liu, Ting Yao, Xiuxiu Weng, Rongyu Yao, Wanhong Li, Lixia Xie, Xiangpeng Yue, Fadi Li
Summary: The study aimed to investigate the differences in anti-oxidative activity in the epididymis between high and low fertility levels of Hu sheep. The results showed that the high fertility group had higher antioxidative indices and lower levels of oxidative damage compared to the low fertility group, indicating a stronger antioxidative activity in the epididymis of high-fertility sheep.
Article
Plant Sciences
Manas Jyoti Das, Dipanjan Banerjee, Amartya Banerjee, Sangita Muchahary, Archana Sinha, Debananda Gogoi, Pronobesh Chattopadhyay, Suman Dasgupta, Sankar Chandra Deka
Summary: Lagenaria siceraria (Molina) Standl. Juice has demonstrated promising anti-inflammatory properties as well as the capacity to inhibit the digestion enzymes glucosidase and amylase, opening new avenues for further research into its antidiabetic potential.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)