Article
Obstetrics & Gynecology
Alexandra Dietz de Loos, Martin Hund, Katharina Buck, Cindy Meun, Johanna Sillman, Joop S. E. Laven
Summary: The study aimed to determine a cutoff for the Elecsys AMH Plus immunoassay to aid in PCOM diagnosis. The results showed that a cutoff of 3.2 ng/mL (23 pmol/L) demonstrated high sensitivity and specificity for PCOM diagnosis, with consistent performance across different ages and PCOS phenotypes.
FERTILITY AND STERILITY
(2021)
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Christos Damaskos, Nikolaos Garmpis, Kleio Vrettou, Anna Garmpi, Efstathios A. Antoniou, Athanasios Chionis, Konstantinos Nikolettos, Konstantinos Kontzoglou, Dimitrios Dimitroulis
Summary: Polycystic ovary syndrome (PCOS) is strongly associated with ovarian torsion, which is a significant risk in patients with enlarged ovaries. The most common symptom is acute lower abdominal pain, and diagnosis usually involves ultrasound and CT or MRI scans. Emergency laparoscopy with ovarian or adnexal detorsion is the standard treatment, while ovariopexy or ovariectomy/adnexectomy may be considered for recurrent torsions.
Review
Endocrinology & Metabolism
Huize Chen, Chujun Deng, Zeyu Meng, Shengxi Meng
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease characterized by menstrual disorders, infertility, and obesity, often accompanied by insulin resistance and metabolic disorders. Traditional Chinese medicine (TCM) has significant advantages in treating PCOS and can effectively reduce insulin levels, regulate lipid metabolism, and improve ovulation and pregnancy rates. This article reviews the efficacy and safety of Chinese herbs and other TCM treatments (such as acupuncture) for PCOS and its complications, as well as their impact on cellular endocrine and mechanisms, providing new clinical ideas for PCOS treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Leticia Morales-Ledesma, Angelica Trujillo Hernandez, Maria Isabel Ramirez, Gabriela Rosas, Rosa Linares
Summary: In both cyclic animals and EV-PCOS models, blocking VIP receptors reveals differential effects on ovarian function, with changes in steroidogenesis and ovarian catecholamine levels. The binding of VIP to its receptors regulates the responses of steroid hormones and catecholamines in the ovaries, highlighting the importance of VIP signaling in the pathophysiology of PCOS.
Review
Endocrinology & Metabolism
Basak Ozgen Saydam, Bulent Okan Yildiz
Summary: PCOS is associated with structural and functional abnormalities in the central nervous system, leading to nonhomeostatic eating, diminished appetitive responses, cognitive dysfunction, and mood disorders in patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Obstetrics & Gynecology
Fisun Vural, Birol Vural, Eyupcan Kardas, Ayse Deniz Erturk Coskun, Irem Yildirim
Summary: This study investigated the utilization of Anti-Mullerian hormone (AMH) alone or replacing polycystic ovarian morphology (PCOM) in the PCOS diagnostic criteria. The results showed that AMH can be used with high diagnostic accuracy instead of PCOM in Rotterdam criteria, especially for phenotype A and D.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Ponsiglione, Arnaldo Stanzione, Gaia Spadarella, Agah Baran, Luca Alessandro Cappellini, Kevin Groot Lipman, Peter Van Ooijen, Renato Cuocolo
Summary: The overall methodological rigor of radiomics studies in the ovarian field is not ideal, with a lack of prospective design and formal validation of results. This limits the reproducibility of results and potential translation to clinical setting.
EUROPEAN RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Qingjie Peng, Xiaojiang Chen, Xiaoxia Liang, Jiahui Ouyang, Qiangqiang Wang, Shuai Ren, Haibo Xie, Chunhong Wang, Yaqun Sun, Xin Wu, Hetao Liu, Changchun Hei, Miao Sun, Qing Chang, Xinrui Liu, Guangyong Li, Rui He
Summary: The study investigated the effect of metformin on PCOS using a PCOS mouse model and explored the mechanism of metformin in regulating PCOS mice through the ferroptosis pathway. The results showed that metformin not only improved body weight and metabolic disorders but also improved ovarian dysfunction in PCOS mice.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Zhongkun Bao, Qing Zhang, Manman Pan, Xi Xi, Yuanlin Wang, Fangfang Zhang, Fangfang Wang, Yu Zou, Fan Qu
Summary: There is a different pattern of brain metrics in PCOS offspring in utero, including changes in brain structure size and ADC values.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Endocrinology & Metabolism
Marlene Hager, Didier Dewailly, Rodrig Marculescu, Stefan Ghobrial, John Preston Parry, Johannes Ott
Summary: In a retrospective cohort study, it was found that women with stress-induced functional hypothalamic amenorrhea (FHA) have a higher prevalence of polycystic ovarian morphology (PCOM) compared to women with exercise-induced FHA. The stress group also exhibited higher levels of prolactin and a trend towards higher levels of dehydroepiandrosterone-sulphate (DHEAS). This suggests that the well-known stress sensitivity in women with polycystic ovary syndrome (PCOS) may explain their propensity to develop FHA and the high prevalence of PCOM in FHA women.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Amir Pejman Hashemi Taheri, Behnaz Moradi, Amir Reza Radmard, Milad Sanginabadi, Mostafa Qorbani, Mohammad Reza Mohajeri-Tehrani, Nooshin Shirzad, Saeed Hosseini, Azita Hekmatdoost, Sedigheh Asadi, Majid Samadi, Asieh Mansour
Summary: Intake of resveratrol has been associated with improved ovarian morphology, as evidenced by a significantly higher rate of improvement in ovarian morphology and a more dominant follicle in women with polycystic ovary syndrome (PCOS). However, other factors like follicle count per ovary, stromal area, ovarian echogenicity, and distribution of follicles were not significantly altered.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Medicine, Research & Experimental
Manuel R. Garcia-Saenz, Miry Lobaton-Ginsberg, Claudia Ramirez-Renteria, Nitzia Lopez-Juarez, Renata Saucedo, Jorge Valencia-Ortega, Aldo Ferreira-Hermosillo
Summary: This study evaluated the clinical and biochemical characteristics of patients with type 1 diabetes (T1D) with and without polycystic ovarian syndrome (PCOS). The results showed a prevalence of 39% for PCOS in T1D patients, and significant differences were found between patients with and without PCOS in terms of insulin usage, glucose levels, ovarian volume, and Ferriman-Gallwey scores. Additionally, PCOS women had a higher incidence of insulin resistance and metabolic syndrome.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Zhifeng Zhou, Xiaoqiao Chen, Zhibin Zeng, Fangjing Zhang, Jing Yan, Gangqiang Hou
Summary: The study aimed to evaluate the specific imaging features of ovarian sclerosing stromal tumor (SST), improve its accuracy and specificity in imaging diagnosis, and prevent overestimation of malignancy. Analysis of MRI and CT images of 14 cases confirmed as ovarian SST showed that MRI with lake-island signs on T2WI and MRI/CT dynamic enhancement could potentially play a critical role in facilitating appropriate preoperative diagnosis.
Article
Integrative & Complementary Medicine
Dan Li, Peng Bai, Jin-yang Wu, Min Xie, Rui-zhen Zhao, Zhong-peng Wang, Xiao-han Qi
Summary: Acupuncture and metformin can improve ovary morphology and function in DHEA-induced PCOS model rats, reducing weight gain, FSH, LH, and T levels while increasing E-2 and P levels significantly. IL-6 and visfatin levels were also decreased in both treatment groups.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Article
Endocrinology & Metabolism
Lim Leek Mei, Muhammad Azrai Abu, Kah Teik Chew, Aniza Ismail, Ani Amelia Zainuddin, Abdul Ghani Nur Azurah
Summary: The Polycystic Ovary Syndrome Questionnaire is a reliable tool for measuring health-related quality of life. The Malay version of this questionnaire has been developed and found to be valid for assessing the impact of polycystic ovary syndrome on Malaysian women's health.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ines Barroso, Mark I. McCarthy
Article
Public, Environmental & Occupational Health
Christel M. Middeldorp, Anubha Mahajan, Momoko Horikoshi, Neil R. Robertson, Robin N. Beaumont, Jonathan P. Bradfield, Mariona Bustamante, Diana L. Cousminer, Felix R. Day, N. Maneka De Silva, Monica Guxens, Dennis O. Mook-Kanamori, Beate St Pourcain, Nicole M. Warrington, Linda S. Adair, Emma Ahlqvist, Tarunveer S. Ahluwalia, Peter Almgren, Wei Ang, Mustafa Atalay, Juha Auvinen, Meike Bartels, Jacques S. Beckmann, Jose Ramon Bilbao, Tom Bond, Judith B. Borja, Alana Cavadino, Pimphen Charoen, Zhanghua Chen, Lachlan Coin, Cyrus Cooper, John A. Curtin, Adnan Custovic, Shikta Das, Gareth E. Davies, George V. Dedoussis, Liesbeth Duijts, Peter R. Eastwood, Anders U. Eliasen, Paul Elliott, Johan G. Eriksson, Xavier Estivill, Joao Fadista, Iryna O. Fedko, Timothy M. Frayling, Romy Gaillard, W. James Gauderman, Frank Geller, Frank Gilliland, Vincente Gilsanz, Raquel Granell, Niels Grarup, Leif Groop, Dexter Hadley, Hakon Hakonarson, Torben Hansen, Catharina A. Hartman, Andrew T. Hattersley, M. Geoffrey Hayes, Johannes Hebebrand, Joachim Heinrich, Oyvind Helgeland, Anjali K. Henders, John Henderson, Tine B. Henriksen, Joel N. Hirschhorn, Marie-France Hivert, Berthold Hocher, John W. Holloway, Patrick Holt, Jouke-Jan Hottenga, Elina Hypponen, Carmen Iniguez, Stefan Johansson, Astanand Jugessur, Mika Kahonen, Heidi J. Kalkwarf, Jaakko Kaprio, Ville Karhunen, John P. Kemp, Marjan Kerkhof, Gerard H. Koppelman, Antje Korner, Sailesh Kotecha, Eskil Kreiner-Moller, Benard Kulohoma, Ashish Kumar, Zoltan Kutalik, Jari Lahti, Joan M. Lappe, Henrik Larsson, Terho Lehtimaki, Alexandra M. Lewin, Jin Li, Paul Lichtenstein, Cecilia M. Lindgren, Virpi Lindi, Allan Linneberg, Xueping Liu, Jun Liu, William L. Lowe, Sebastian Lundstrom, Leo-Pekka Lyytikainen, Ronald C. W. Ma, Aurelien Mace, Reedik Magi, Per Magnus, Abdullah A. Mamun, Minna Mannikko, Nicholas G. Martin, Hamdi Mbarek, Nina S. McCarthy, Sarah E. Medland, Mads Melbye, Erik Melen, Karen L. Mohlke, Claire Monnereau, Camilla S. Morgen, Andrew P. Morris, Jeffrey C. Murray, Ronny Myhre, Jackob M. Najman, Michel G. Nivard, Ellen A. Nohr, Ilja M. Nolte, Ioanna Ntalla, Paul O'Reilly, Sharon E. Oberfield, Emily Oken, Albertine J. Oldehinkel, Katja Pahkala, Teemu Palviainen, Kalliope Panoutsopoulou, Oluf Pedersen, Craig E. Pennell, Goran Pershagen, Niina Pitkanen, Robert Plomin, Christine Power, Rashmi B. Prasad, Inga Prokopenko, Lea Pulkkinen, Katri Raikkonen, Olli T. Raitakari, Rebecca M. Reynolds, Rebecca C. Richmond, Fernando Rivadeneira, Alina Rodriguez, Richard J. Rose, Rany Salem, Loreto Santa-Marina, Seang-Mei Saw, Theresia M. Schnurr, James G. Scott, Saskia Selzam, John A. Shepherd, Angela Simpson, Line Skotte, Patrick M. A. Sleiman, Harold Snieder, Thorkild I. A. Sorensen, Marie Standl, Eric A. P. Steegers, David P. Strachan, Leon Straker, Timo Strandberg, Michelle Taylor, Yik-Ying Teo, Elisabeth Thiering, Maties Torrent, Jessica Tyrrell, Andre G. Uitterlinden, Toos van Beijsterveldt, Peter J. van der Most, Cornelia M. van Duijn, Jorma Viikari, Natalia Vilor-Tejedor, Suzanne Vogelezang, Judith M. Vonk, Tanja G. M. Vrijkotte, Eero Vuoksimaa, Carol A. Wang, William J. Watkins, H-Erich Wichmann, Gonneke Willemsen, Gail M. Williams, James F. Wilson, Naomi R. Wray, Shujing Xu, Cheng-Jian Xu, Hanieh Yaghootkar, Lu Yi, Mohammad Hadi Zafarmand, Eleftheria Zeggini, Babette S. Zemel, Anke Hinney, Timo A. Lakka, Andrew J. O. Whitehouse, Jordi Sunyer, Elisabeth E. Widen, Bjarke Feenstra, Sylvain Sebert, Bo Jacobsson, Pal R. Njolstad, Camilla Stoltenberg, George Davey Smith, Debbie A. Lawlor, Lavinia Paternoster, Nicholas J. Timpson, Ken K. Ong, Hans Bisgaard, Klaus Bonnelykke, Vincent W. V. Jaddoe, Henning Tiemeier, Marjo-Riitta Jarvelin, David M. Evans, John R. B. Perry, Struan F. A. Grant, Dorret I. Boomsma, Rachel M. Freathy, Mark I. McCarthy, Janine F. Felix
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2019)
Article
Genetics & Heredity
Anne E. Justice, Tugce Karaderi, Heather M. Highland, Kristin L. Young, Mariaelisa Graff, Yingchang Lu, Valerie Turcot, Paul L. Auer, Rebecca S. Fine, Xiuqing Guo, Claudia Schurmann, Adelheid Lempradl, Eirini Marouli, Anubha Mahajan, Thomas W. Winkler, Adam E. Locke, Carolina Medina-Gomez, Tonu Esko, Sailaja Vedantam, Ayush Giri, Ken Sin Lo, Tamuno Alfred, Poorva Mudgal, Maggie C. Y. Ng, Nancy L. Heard-Costa, Mary F. Feitosa, Alisa K. Manning, Sara M. Willems, Suthesh Sivapalaratnam, Goncalo Abecasis, Dewan S. Alam, Matthew Allison, Philippe Amouyel, Zorayr Arzumanyanm, Beverley Balkau, Lisa Bastarache, Sven Bergmann, Lawrence F. Bielak, Matthias Blueher, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Carsten A. Boeger, Jette Bork-Jensen, Erwin P. Bottinger, Donald W. Bowden, Ivan Brandslund, Linda Broer, Amber A. Burt, Adam S. Butterworth, Markj Caulfield, Giancarlo Cesana, John C. Chambers, Daniel Chasman, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audreyy Chu, Francis S. Collins, James P. Cook, Amanda J. Cox, David S. Crosslin, John Danesh, Paul I. W. de Bakker, Simon de Denus, Renee de Mutsert, George Dedoussis, Ellen W. Demerath, Joe G. Dennis, Josh C. Denny, Emanuele Di Angelantonio, Marcus Doerr, Fotios Drenos, Marie-Pierre Dube, Alison M. Dunning, Douglas F. Easton, Paul Elliott, Evangelos Evangelou, Aliki-Eleni Farmaki, Shuang Feng, Ele Ferrannini, Jean Ferrieres, Jose C. Florez, Myriam Fornage, Caroline S. Fox, Paul W. Franks, Nele Friedrich, Wei Gan, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Giorgia Girotto, Mathias Gorski, Harald Grallert, Niels Grarup, Megan L. Groves, Stefan Gustafsson, Jeff Haessler, Torben Hansen, Andrew T. Hattersley, Caroline Hayward, Iris M. Heid, Oddgeir L. Holmen, G. Kees Hovingh, Joanna M. M. Howson, Yao Hu, Yi-Jen Hung, Kristian Hveem, M. Arfan Ikram, Erik Ingelsson, Anne U. Jackson, Gail P. Jarvik, Yucheng Jia, Torben Jorgensen, Pekka Jousilahti, Johanne M. Justesen, Bratati Kahali, Maria Karaleftheri, Sharon L. R. Kardia, Fredrik Karpe, Frank Kee, Hidetoshi Kitajima, Pirjo Komulainen, Jaspal S. Kooner, Peter Kovacs, Bernhard K. Kraemer, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo A. Lakka, David Lamparter, Leslie A. La Nge, Claudia Langenberg, Eric B. Larson, Nanette R. Lee, Wen-Jane Lee, Terho Lehtimaeki, Cora E. Lewis, Huaixing Li, Jin Li, RuifangLi-Gao, Li-An Lin, Xu Lin, Lars Lind, Jaana Lindstroem, Allan Linneberg, Ching-Ti Liu, Dajiang J. Liu, Jian'an Luan, Leo-Pekka Lyytikainen, Stuart MacGregor, Reedik Magi, Satu Mannisto, Gaelle Marenne, Jonathan Marten, Nicholas G. D. Mascal, Mark McCarthy, Karina Meidtner, Evelin Mihailov, Leena Moilanen, Marie Moitry, Dennis O. Mook-Kanamori, Anna Morgan, Andrew P. Morris, Martina Mueller-Nurasyid, Patricia B. Munroe, Narisu Narisu, Christopher P. Nelson, Matt Neville, Ioanna Ntalla, Katharine R. Owen, Oluf Pedersen, Gina M. Peloso, Craig E. Pennell, Markus Perola, A. James, John R. B. Perry, Tune H. Pers, Ailith Ewing, Ozren Polasek, Asif Rasheed, Chelsea K. Raulerson, Rainer Rauramaa, Dermot F. Reilly, Alex P. Reiner, Paul M. Ridker, Manuel A. Rivas, Neil R. Robertson, Antonietta Robino, Igor Rudan, Katherine S. Ruth, Danish Saleheen, Veikko Salomaa, Nilesh J. Samani, Pamela J. Schreiner, Matthias B. Schulze, Robert A. Scott, Marcelo Segura-Lepe, Xueling Sim, Andrew J. Slater, Kerrin S. Small, Blair H. Smith, Jennifer A. Smith, Lorraine Southam, Timothy D. Spector, Elizabeth K. Speliotes, Kari Stefansson, Valgerdur Steinthorsdottir, Kathleen E. Stirrups, Konstantin Strauch, Heather M. Stringham, Michael Stumvoll, Liang Sun, Praveen Surendran, Karin M. A. Swart, Jean-Claude Tardif, Kent D. Taylor, Alexander Teumer, Deborah J. Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Betina H. Thuesen, Anke Toenjes, Mina Torres, Emmanouil Tsafantakis, Jaakko Tuomilehto, Andre G. Uitterlinden, Matti Uusitupa, Cornelia M. van Duijn, Mauno Vanhala, Rohit Varma, Sita H. Vermeulen, Henrik Vestergaard, Veronique Vitart, Thomas F. Vogt, Dragana Vuckovic, Lynne E. Wagenknecht, Mark Walker, Lars Wallentin, Feijie Wang, Carol A. Wang, Shuai Wang, N. Icholas J. Wareham, Helen R. Warren, Dawn M. Waterworth, Jennifer Wessel, Harvey D. White, Cristen J. Willer, James G. Wilson, Andrew R. Wood, Ying Wu, Hanieh Yaghootkar, Jie Yao, Laura M. Verges-Armstrong, Robin Young, Eleftheria Zeggini, Xiaowei Zhan, Weihua Zhang, Jing Hua Zhao, Wei Zhao, He Zheng, Wei Zhou, M. Carola Zillikens, Fernando Rivadeneira, Ingrid B. Borecki, J. Andrew Pospisilik, Panos Deloukas, Timothy M. Frayling, Guillaume Lettre, Karen L. Mohlke, Jerome Rotter, Zoltan Kutalik, Joel N. Hirschhorn, L. Adrienne Cupples, Ruth J. F. Loos, Kari E. North, Cecilia M. Lindgren, Jeffrey R. O'Connell, Olli T. Raitakari, John Danesh, Praveen Surendran, Robin Young, Ching-Ti Liu, Ingrid B. Borecki, L. Adrienne Cupples, Kari E. North, Eric Boerwinkle, Myriam Fornage, James G. Wilson, Leslie A. Lange, M. Arfan Ikram, Andr G. Uitterlinden, Anne E. Justice, Heather M. Highland, Kristin L. Young, Mariaelisa Graff, Megan L. Grove, Nancy L. Heard-Costa, M. Carola Zillikens, John Danesh, Praveen Surendran, Robin Young, James P. Cook, Helen R. Warren, Hanieh Yaghootkar, Nicholas G. D. Masca, Evelin Mihailov, Jonathan Marten, Kathleen E. Stirrups, Matt Neville, Neil R. Robertson, Weihua Zhang, Evangelos Evangelou, Christopher P. Nelson, Jianan Luan, Robert A. Scott, Aliki-Eleni Farmaki, Ozren Polasek, Igor Rudan, Paul W. Franks, Timothy D. Spector, Nicholas J. Wareham, Tnu Esko, Erik Ingelsson, Paul Iw De Bakker, John C. Chambers, Jaspal S. Kooner, Fredrik Karpe, Jaakko Tuomilehto, Andrew P. Morris, Kristian Hveem, Cristen J. Willer, Veikko Salomaa, Mark McCarthy, Paul Elliott, Eleftheria Zeggini, Caroline Hayward, Mark J. Caulfield, Anubha Mahajan, Andrew P. Morris, Nilesh J. Samani, Cecilia M. Lindgren, Patricia B. Munroe, Cristen J. Willer, Alisa K. Manning, Xueling Sim, Adam E. Locke, Anne U. Jackson, Heather M. Stringham, Michael Boehnke, Jaakko Tuomilehto, Francis S. Collins, Karen L. Mohlke, Goncalo Abecasis, Martina Mller-Nurasyid, Manuel A. Rivas, Anubha Mahajan, Kerrin S. Small, Cecilia M. Lindgren, Neil R. Robertson, Andrew P. Morris, Andrew T. Hattersley, Timothy D. Spector, Timothy M. Frayling, Mark McCarthy, Sara M. Willems, Alisa K. Manning, Timothy M. Frayling, Jose C. Florez, John C. Chambers, Jaspal S. Kooner, Weihua Zhang, Mark McCarthy, Cecilia M. Lindgren, Anubha Mahajan, Andrew P. Morris, Manuel A. Rivas, Sara M. Willems, Markku Laakso, Michael Boehnke, Xueling Sim, Adam E. Locke, Goncalo Abecasis, James G. Wilson, Heather M. Highland, Donald W. Bowden, Eleftheria Zeggini, Michael Boehnke, Jose C. Florez, Mark McCarthy
Article
Genetics & Heredity
Serena Sanna, Natalie R. van Zuydam, Anubha Mahajan, Alexander Kurilshikov, Arnau Vich Vila, Urmo Vosa, Zlatan Mujagic, Ad A. M. Masclee, Daisy M. A. E. Jonkers, Marge Oosting, Leo A. B. Joosten, Mihai G. Netea, Lude Franke, Alexandra Zhernakova, Jingyuan Fu, Cisca Wijmenga, Mark McCarthy
Review
Radiology, Nuclear Medicine & Medical Imaging
Daniel Jarrett, Eleanor Stride, Katherine Vallis, Mark J. Gooding
BRITISH JOURNAL OF RADIOLOGY
(2019)
Article
Oncology
Lisanne V. van Dijk, Lisa Van den Bosch, Paul Aljabar, Devis Peressutti, Stefan Both, Roel. J. H. M. Steenbakkers, Johannes A. Langendijk, Mark J. Gooding, Charlotte L. Brouwer
RADIOTHERAPY AND ONCOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jinzhong Yang, Harini Veeraraghavan, Wouter van Elmpt, Andre Dekker, Mark Gooding, Greg Sharp
Article
Radiology, Nuclear Medicine & Medical Imaging
Xikai Tang, Esmaeel Jafargholi Rangraz, Walter Coudyzer, Jeroen Bertels, David Robben, Georg Schramm, Wies Deckers, Geert Maleux, Kristof Baete, Chris Verslype, Mark J. Gooding, Christophe M. Deroose, Johan Nuyts
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)
Review
Engineering, Biomedical
Michael J. Trimpl, Sergey Primakov, Philippe Lambin, Eleanor P. J. Stride, Katherine A. Vallis, Mark J. Gooding
Summary: Semi-automatic and fully automatic contouring tools have emerged as alternatives to manual segmentation, reducing time and improving quality. However, reviewed by clinicians, the resulting contours may not be suitable for clinical practice. This review presents alternative methods along the spectrum of user interactivity and data availability, addressing the challenge of determining optimal user interaction. While deep learning is widely used for fully automatic tools, interactive methods are just beginning to be transformed by it.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Engineering, Biomedical
Michael Claessens, Verdi Vanreusel, Geert De Kerf, Isabelle Mollaert, Fredrik Lofman, Mark J. Gooding, Charlotte Brouwer, Piet Dirix, Dirk Verellen
Summary: This article introduces an automated quality assurance framework to detect inaccurate auto-segmentations. By using quantitative comparison metrics as input features for a machine learning classification model, the output quality of the primary model can be predicted.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Oncology
Yasmin McQuinlan, Charlotte L. Brouwer, Zhixiong Lin, Yong Gan, Jin Sung Kim, Wouter van Elmpt, Mark J. Gooding
Summary: This study investigates the impact of geographic population on the performance of an autocontouring system. The results show that while there are some differences in organ volume and quantitative similarity, observer perception bias has a greater impact on clinical acceptability.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Djamal Boukerroui, Eliana Vasquez Osorio, Ellen Brunenberg, Mark J. Gooding
Summary: A recent survey of contour similarity measures (CSMs) calculation tools revealed a high level of variability in reported values. This variability in output measurements hinders meaningful comparison between studies. The aim of this study was to create a dataset with analytically calculated gold standard values in order to promote standardization and ensure accuracy of CSM implementations. This dataset, generated in the DICOM format, along with the software used for its creation, is publicly available to encourage robust testing of CSM implementations for accuracy and to improve consistency between different implementations.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2023)
Article
Oncology
Mark J. Gooding, Djamal Boukerroui, Eliana Vasquez Osorio, Rene Monshouwer, Ellen Brunenberg
Summary: This study aimed to assess the variation in output when applying different implementations of quantitative measures in radiation oncology. The survey results showed significant differences in the reported results between institutions due to variations in definitions and implementations of contouring measures. Therefore, caution must be taken when comparing quantitative results from different studies, and validation of such tools is necessary before their use.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2022)
Article
Oncology
Femke Vaassen, Djamal Boukerroui, Padraig Looney, Richard Canters, Karolien Verhoeven, Stephanie Peeters, Indra Lubken, Jolein Mannens, Mark J. Gooding, Wouter van Elmpt
Summary: This study evaluated user-adjustments after deep-learning contouring in radiotherapy for organs-at-risk (OARs) in the thorax region. The results showed that manual adjustments were still needed for most organs, and subsampling reduced the amount of adjustments on interpolated slices.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2022)
Article
Oncology
Femke Vaassen, Colien Hazelaar, Ana Vaniqui, Mark Gooding, Brent van der Heyden, Richard Canters, Wouter van Elmpt
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2020)
