Article
Cardiac & Cardiovascular Systems
Bradley S. Lander, Yanling Zhao, Kohei Hasegawa, Mathew S. Maurer, Albree Tower-Rader, Michael A. Fifer, Muredach P. Reilly, Yuichi J. Shimada
Summary: This multicenter case-control study demonstrates that plasma proteomics profiling can effectively distinguish patients with and without late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM). By identifying patients with a high pre-test probability of having LGE, this study lays the groundwork for establishing a panel of circulating protein biomarkers to improve clinical decision-making and utilization of cardiac magnetic resonance imaging (CMR).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sebastian Weingaertner, Oemer B. Demirel, Francisco Gama, Iain Pierce, Thomas A. Treibel, Jeanette Schulz-Menger, Mehmet Akcakaya
Summary: This study proposes a method to obtain phase-resolved late gadolinium enhancement (LGE) images using cardiac magnetic resonance imaging. The method involves three steps and has been evaluated in phantom imaging, healthy subjects, and patients. The results demonstrate reliable imaging in the phantom and healthy subjects, while the imaging resolution and noise resilience in patients are lower compared to the reference technique. The proposed technique shows potential in integrating the advantages of phase-resolved cardiac magnetic resonance with LGE imaging, but further improvements are needed for clinical use.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Karolina Melinyte-Ankudavice, Paulius Bucius, Vaida Mizariene, Tomas Lapinskas, Gintare Sakalyte, Jurgita Plisiene, Renaldas Jurkevicius
Summary: In patients with non-ischemic dilated cardiomyopathy (NIDCM), the presence of myocardial fibrosis (MF) is correlated with reduced mechanical parameters in both ventricles and atria. Left ventricle global longitudinal strain (GLS), left atrial strain during the reservoir phase (LASr), and left ventricle global circumferential strain (GCS) are the most accurate 2D echocardiography predictive factors for the presence of MF.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Chen Zhang, Hongbo Zhang, Lei Zhao, Zhipeng Wei, Yongqiang Lai, Xiaohai Ma
Summary: This study found differential expression of miRNAs in myocardial tissues of patients with hypertrophic cardiomyopathy (HCM). Some miRNAs were found to be correlated with left ventricular mass index and late gadolinium enhancement quantification. These myocardial miRNA levels could be potential biomarkers for LV hypertrophy, fibrosis, and remodeling.
Article
Radiology, Nuclear Medicine & Medical Imaging
Cailing Pu, Xi Hu, Sangying Lv, Yan Wu, Feidan Yu, Wenchao Zhu, Lingjie Zhang, Jingle Fei, Chengbin He, Xiaoli Ling, Fuyan Wang, Hongjie Hu
Summary: The developed predictive model is able to identify patients with high risk of fibrosis in hypertrophic cardiomyopathy (HCM) through fusion of image and radiomic features, and screen out patients without fibrosis, avoiding unnecessary injection of contrast.
EUROPEAN RADIOLOGY
(2023)
Article
Biophysics
Imran Rashid, Sadeer Al-Kindi, Varun Rajagopalan, Jonathan Walker, Sanjay Rajagopalan, Nicole Seiberlich, Jesse I. Hamilton
Summary: The feasibility of generating multi-contrast synthetic LGE images from post-contrast T1 and T2 maps acquired using magnetic resonance fingerprinting (MRF) was assessed in this study. The synthetic images showed comparable scar detection rates to conventional LGE images. The study suggests that synthetic multi-contrast LGE images can be generated without additional scan time and may have potential clinical applications.
NMR IN BIOMEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zi-Yi Gu, Yu-Fan Qian, Bing-Hua Chen, Chong-Wen Wu, Lei Zhao, Song Xue, Lei Zhao, Lian-Ming Wu, Yong-Yi Wang
Summary: This study investigated the prognostic value of left ventricular (LV) entropy in patients with hypertrophic cardiomyopathy (HCM). The results showed that increased LV entropy was associated with a higher risk of adverse events such as heart failure and cardiac death in HCM patients.
INSIGHTS INTO IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Sruti Rao, Stephanie Y. Tseng, Amol Pednekar, Saira Siddiqui, Murat Kocaoglu, Munes Fares, Sean M. Lang, Shelby Kutty, Adam B. Christopher, Laura J. Olivieri, Michael D. Taylor, Tarek Alsaied
Summary: Parametric mapping is a pixel-wise mapping of magnetic relaxation parameters, which allows for quantification of myocardial tissue-specific magnetic relaxation. It has expanded the diagnostic potential of cardiac magnetic resonance and is important for the diagnosis of nonfocal diseases, longitudinal disease monitoring, and risk stratification.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nikki van der Velde, H. Carlijne Hassing, Brendan J. Bakker, Piotr A. Wielopolski, R. Marc Lebel, Martin A. Janich, Isabella Kardys, Ricardo P. J. Budde, Alexander Hirsch
Summary: The study showed that a DL-based reconstruction algorithm can significantly improve LGE image quality, but its impact on scar quantification varies depending on the quantification technique used. The FWHM method, which is independent of NR levels, is preferred for scar quantification.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Qiang Zhang, Matthew K. Burrage, Elena Lukaschuk, Mayooran Shanmuganathan, Iulia A. Popescu, Chrysovalantou Nikolaidou, Rebecca Mills, Konrad Werys, Evan Hann, Ahmet Barutcu, Suleyman D. Polat, Michael Salerno, Michael Jerosch-Herold, Raymond Y. Kwong, Hugh C. Watkins, Christopher M. Kramer, Stefan Neubauer, Vanessa M. Ferreira, Stefan K. Piechnik
Summary: The study introduced a new CMR technology called VNE that can achieve LGE-like imaging without the need for contrast agent. VNE demonstrated high agreement with LGE in lesion distribution and quantification, while also providing significantly better image quality.
Review
Radiology, Nuclear Medicine & Medical Imaging
Jason Craft, Yulee Li, Salman Bhatti, Jie Jane Cao
Summary: Left atrial late gadolinium enhancement imaging is a powerful tool in predicting cardiovascular events, with standardized protocols outlining key components such as localization and post-processing techniques. With sufficient experience and optimized protocols, this imaging technique serves as a valuable addition to cardiac magnetic resonance imaging.
Article
Cardiac & Cardiovascular Systems
Xiaoying Zhao, Fuwei Jin, Jin Wang, Xinxiang Zhao, Lujing Wang, Hua Wei
Summary: This study aimed to investigate the use of entropy generated from LGE cardiac magnetic resonance for risk stratification in hypertrophic cardiomyopathy (HCM) and its correlation with LGE mass%. The results showed that patients in the high-risk group had higher LGE entropy and LGE mass% compared to the low-risk group, and endpoint events were associated with higher LGE entropy and LGE mass%. LGE entropy is a reliable, usable, and repeatable metric for risk classification in HCM and is an independent prognostic indicator of endpoint events.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Bjorn Stroier Larsen, Litten Bertelsen, Hanne Christensen, Rakin Hadad, Mark Aplin, Nis Host, Louisa Marguerite Christensen, Inger Havsteen, Eva Prescott, Helena Dominguez, Gorm Boje Jensen, Niels Vejlstrup, Ahmad Sajadieh
Summary: This study aims to evaluate the extent of left atrial fibrosis in stroke patients without atrial fibrillation and controls without cardiovascular disease. Cardiac magnetic resonance was used to detect late gadolinium enhancement as a proxy for left atrial fibrosis. The results showed that stroke patients had a higher extent of left atrial fibrosis compared to controls.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Kalpit Modi, Stephanie Joppa, Ko-Hsuan Amy Chen, Pal Satyajit Singh Athwal, Osama Okasha, Pratik S. Velangi, Matthew Hooks, Prabhjot S. Nijjar, Anne H. Blaes, Chetan Shenoy
Summary: The study investigated the prevalence of LGE in cancer patients with cardiomyopathy related to anthracyclines and/or trastuzumab, and found that LGE was present in only a minority with no unique profile, and there were alternative explanations for almost all cases. Interestingly, LGE was also present in cancer patients who did not receive anthracyclines and/or trastuzumab treatment.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Medicine, General & Internal
Anna Nogue Infante, Christopher Chieh Yang Koo, Alfred Yip, Ying Ha Lim, Wee Tiong Yeo, Swee Tian Quek, Toon Wei Lim, Swee Chong Seow, Ping Chai, Ching Ching Ong, Lynette Teo, Devinder Singh, Pipin Kojodjojo
Summary: The study found that the presence of late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) imaging independently predicted adverse clinical events in Asian patients with dilated cardiomyopathy (DCM). This suggests that routine use of CMR imaging to characterize myocardial substrate is recommended for enhanced risk stratification and should strongly influence clinical management.
SINGAPORE MEDICAL JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Pascal de Grootea, Marie Delobellea, Eleonore Hebbara, Thomas Merciera, Marie Fertina, Celine Goeminnec, Anju Duva Pentiaha, Andre Vincentellid, Christophe Bautersa, Nicolas Lamblina
Summary: This study aimed to identify the best hemodynamic parameters for risk stratification in patients with advanced systolic heart failure. The analysis revealed that baseline right atrial pressure and pulmonary vascular resistance, as well as mean pulmonary arterial pressure after an inotropic challenge, were independent predictors of major cardiac events in these patients.
ARCHIVES OF CARDIOVASCULAR DISEASES
(2022)
Editorial Material
Pediatrics
Antoine Martenot, Imad Labbassi, Amelie Delfils-Stern, Philippe Deruelle, Pierre Kuhn
Article
Cardiac & Cardiovascular Systems
Marilyne Jarjour, Jacinthe Leclerc, Nadia Bouabdallaoui, Charaf Ahnadi, Denis Brouillette, Simon de Denus, Annik Fortier, Patrick Garceau, Genevieve Giraldeau, Serge Lepage, Mark Liszkowski, Eileen O'Meara, Marie -Claude Parent, Normand Racine, Maxime Tremblay-Gravel, Michel White, Jean-Lucien Rouleau, Anique Ducharme
Summary: This study evaluated the association between adherence to guidelines and outcomes in patients with heart failure. The results showed that patients intolerant or contraindicated to treatment had the worst prognosis, while those undertreated and in-titration were at intermediate risk. Therefore, up-titration of therapy should be attempted whenever possible, considering patients' limitations, to potentially improve outcomes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lauren Basmadjian, Nadia Bouabdallaoui, Francois Simard, Eileen O'Meara, Anique Ducharme, Jean-Lucien Rouleau, Normand Racine, Michel White, Martin G. Sirois, Anita Asgar, Reda Ibrahim, Jean-Francois Dorval, Raoul Bonan, Raymond Cartier, Jessica Forcillo, Ismail El-Hamamsy, Christine Henri
Summary: Elevated GDF-15 levels are associated with impaired cardiac function, decreased functional capacity, and LV dysfunction in patients with aortic stenosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Josep Iglesies-Grau, Valerie Dionne, Louis Bherer, Nadia Bouabdallaoui, Lise Aubut, Florent Besnier, Johanne Bertholet, Annie Berthiaume, Marc Bisaillon, Mathieu Gayda, Christine Gagnon, Nacima Hamrioui, Elise Latour, Philippe L. L'Allier, Morissette C. Marie-Helene, Anil Nigam, Veronique Pelletier, Genevieve Tessier, Martin Juneau
Summary: This study presents a retrospective analysis of a 12-month, single-center, structured multidomain lifestyle intervention clinic for individuals with prediabetes and type 2 diabetes. The results show that a multidomain, expert-guided lifestyle intervention significantly improves metabolic profiles, with reductions in weight and A1C levels, and a substantial proportion of individuals achieving remission criteria.
CANADIAN JOURNAL OF DIABETES
(2023)
Article
Cardiac & Cardiovascular Systems
Jean-Claude Tardif, Jean Rouleau, Glenn M. Chertow, Ayman Al-Shurbaji, Vera Lisovskaja, Stephanie Gustavson, Yanli Zhao, Nadia Bouabdallaoui, Akshay S. Desai, Alexander Chernyavskiy, Maria Evsina, Bela Merkely, John J. V. McMurray, Marc A. Pfeffer
Summary: The PRIORITIZE-HF study, which aimed to evaluate the benefits and risks of using SZC to intensify RAAS inhibitor therapy in patients with heart failure and reduced ejection fraction (HFrEF), was prematurely terminated due to challenges related to the COVID-19 pandemic. The study did not demonstrate a statistically significant increase in the intensity of RAAS inhibitor therapies with SZC compared to placebo.
Article
Geriatrics & Gerontology
Emma Gabrielle Dupuy, Florent Besnier, Christine Gagnon, Juliana Breton, Thomas Vincent, Catherine-Alexandra Gregoire, Catia Lecchino, Marie Payer, Beatrice Berube, Miloudza Olmand, Marianne Levesque, Nadia Bouabdallaoui, Josep Iglesies-Grau, Martin Juneau, Paolo Vitali, Mathieu Gayda, Anil Nigam, Louis Bherer
Summary: This study explores the interaction between cardiorespiratory fitness and age in moderating the relationship between cognition and mobility. The results suggest that lower levels of physical fitness significantly impact mobility in older adults, but to a greater extent in younger older adults.
INNOVATION IN AGING
(2023)
Letter
Obstetrics & Gynecology
Philippe Deruelle, Audrey Tranchant
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
C. Milot, A. Koch, G. Averous, S. Mayeur, P. Deruelle
Summary: This study aims to explore whether the occurrence and type of placental lesions vary according to the time of onset of COVID-19 in pregnant women. The results showed that the COVID-19 group had a higher rate of vascular complications, fetal and maternal vascular malperfusion, and signs of inflammation compared to the control group. Moreover, the occurrence of chronic villitis differed between the COVID-19 group that delivered within 14 days after infection and the group that delivered more than 14 days after infection.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Christophe Guignabert, Laurent Savale, Athenais Boucly, Raphael Thuillet, Ly Tu, Mina Ottaviani, Christopher J. Rhodes, Pascal De Groote, Gregoire Prevot, Emmanuel Bergot, Arnaud Bourdin, Luke S. Howard, Elie Fadel, Antoine Beurnier, Anne Roche, Mitja Jevnikar, Xavier Jais, David Montani, Martin R. Wilkins, Olivier Sitbon, Marc Humbert
Summary: Activin A and FSTL3 serum levels are associated with transplant-free survival in PAH. They can serve as prognostic biomarkers for PAH, and their diagnostic values have been confirmed in an independent validation cohort. The activin signaling system in PAH involves phosphorylated Smad2/3 nuclear accumulation and differential immunoreactivities of various proteins in vascular endothelial and smooth muscle layers.
Meeting Abstract
Cardiac & Cardiovascular Systems
Cristina T. Pop, Julie Hussin, Christine Des Rosiers, Nadia Bouabdallaoui
JOURNAL OF CARDIAC FAILURE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Myriam Bellemare, Liane Bourcier, Maxime Tremblay-Gravel, Henri Christine, Michel White, Nadia Bouabdallaoui
JOURNAL OF CARDIAC FAILURE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Myriam Bellemare, Christine Henri, Maxime Tremblay-Gravel, Michel White, Nadia Bouabdallaoui
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Geriatrics & Gerontology
Christine Gagnon, Miloudza Olmand, Emma Gabrielle Dupuy, Florent Besnier, Thomas Vincent, Catherine-Alexandra Gregoire, Marianne Levesque, Marie Payer, Beatrice Berube, Juliana Breton, Catia Lecchino, Nadia Bouabdallaoui, Josep Iglesies-Grau, Mathieu Gayda, Paolo Vitali, Anil Nigam, Martin Juneau, Carol Hudon, Louis Bherer
Summary: This study aimed to develop French-Quebec normative data for videoconference-administered MoCA, taking sociodemographic characteristics into consideration. The obtained normative data will enable clinicians to continue conducting remote assessments during the pandemic and perform cognitive assessments for patients in remote areas.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Psychology, Clinical
Christine Gagnon, Kathia Saillant, Miloudza Olmand, Mathieu Gayda, Anil Nigam, Nadia Bouabdallaoui, Jean-Lucien Rouleau, Laurence Desjardins-Crepeau, Louis Bherer
Summary: This study compared the performances of patients with different cardiovascular diseases on the Montreal Cognitive Assessment (MoCA) and its subscores, finding differences in specific subscores between patients with different cardiovascular diseases.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2022)