Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Franziska Pankratz, Aziza Maksudova, Roman Goesele, Lena Meier, Kora Proelss, Katia Marenne, Ann-Kathrin Thut, Gerhard Sengle, Annkatrin Correns, Jeanina Begelspacher, Deniz Alkis, Patrick M. Siegel, Christian Smolka, Sebastian Grundmann, Martin Moser, Qian Zhou, Jennifer S. Esser
Summary: This study aims to investigate the role of BMP endothelial cell precursor-derived regulator (BMPER) in neointima formation. The expression of BMPER increased after vessel injury, but decreased in the tunica media. Silencing of BMPER enhanced the proliferation and migration capacity of vSMCs, while recombinant BMPER protein had the opposite effect. Mechanistically, BMPER modulated IGF signaling through binding to IGFBP4. Additionally, perivascular application of recombinant BMPER protein prevented neointima formation in mice after carotid ligation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Bo Chen, Huimin Xu, Yayu Guo, Paul Grunhofer, Lukas Schreiber, Jinxing Lin, Ruili Li
Summary: The study comprehensively analyzed the cambium in Populus tomentosa, including morphological observations, transcriptome profiles, DNA methylome, and miRNA analysis. It was found that the active cambial zone displayed increased cell layers, and differentially expressed genes associated with vascular development were mainly involved in plant hormone signal transduction, cell division and expansion, and cell wall biosynthesis.
HORTICULTURE RESEARCH
(2021)
Review
Immunology
Mireia Medrano-Bosch, Blanca Simon-Codina, Wladimiro Jimenez, Elazer R. Edelman, Pedro Melgar-Lesmes
Summary: Monocytes are circulating leukocytes that interact with endothelial cells to regulate inflammation, angiogenesis, and tissue remodeling under physiological and pathophysiological conditions. They transdifferentiate into macrophages and release various substances that induce vascular and tissue remodeling or propagate inflammatory responses. The interactions between infiltrating monocytes and endothelial cells contribute to pathophysiological conditions such as cardiovascular and chronic liver diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Jenniffer Linares, Juan A. Marin-Jimenez, Jordi Badia-Ramentol, Alexandre Calon
Summary: Multiple lines of evidence suggest that cancer development and malignant progression are influenced not only by cancer cell-autonomous processes but also by interactions with the tumor microenvironment, particularly through cancer-associated fibroblasts (CAFs) that regulate key mechanisms during metastasis and treatment response. Recent advances in CAFs biology highlight the potential of CAFs-secreted factors as druggable targets and biomarkers for cancer diagnosis and prognosis, paving the way for further research and clinical applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yusuke Adachi, Kazutaka Ueda, Seitaro Nomura, Kaoru Ito, Manami Katoh, Mikako Katagiri, Shintaro Yamada, Masaki Hashimoto, Bowen Zhai, Genri Numata, Akira Otani, Munetoshi Hinata, Yuta Hiraike, Hironori Waki, Norifumi Takeda, Hiroyuki Morita, Tetsuo Ushiku, Toshimasa Yamauchi, Eiki Takimoto, Issei Komuro
Summary: Inflammation plays a key role in atherosclerosis development. Perivascular adipose tissue (PVAT) undergoes beiging in response to vascular injury, which regulates inflammation and vascular remodeling. Beige adipocytes in PVAT secrete Nrg4, which promotes alternative activation of macrophages and reduces vascular inflammation. The beiging of PVAT is observed in patients with acute aortic dissection.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Roberta Giordo, Zena Wehbe, Panagiotis Paliogiannis, Ali H. Eid, Arduino A. Mangoni, Gianfranco Pintus
Summary: Tumor growth and progression are dependent on adequate blood supply. Tumor cells drive the formation of new blood vessels through the release of pro-angiogenic molecules. The processes involved in tumor angiogenesis are similar to normal vascular development, but with less control mechanisms. Targeting tumor blood vessels has been a focus of research, and nanomedicine offers advantages in specific drug delivery. This review comprehensively assesses key modulators of tumor vascular biology, promising nano-strategies, and future directions.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marta T. Gomes, Yang Bai, Simone R. Potje, Lu Zhang, Angelia D. Lockett, Roberto F. Machado
Summary: This review discusses the role of bioenergetic and inflammatory impairments in the development of pulmonary arterial hypertension (PAH).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
France Dierick, Julien Solinc, Juliette Bignard, Florent Soubrier, Sophie Nadaud
Summary: This review summarizes the importance of cellular processes and dysfunction in the development of pulmonary arterial hypertension, as well as the roles of circulating and resident vascular cells in pulmonary vascular remodeling.
Article
Oncology
Jianfeng Peng, Xiaoyan Yin, Wenhua Yun, Xiangjiao Meng, Zhaoqin Huang
Summary: The benefits of immunotherapy have been proven in many cancers, however, a significant number of patients do not respond well to this treatment. The tumor physical microenvironment (TpME) has been found to affect tumor growth, metastasis, and treatment. The unique physical hallmarks of the tumor microenvironment (TME) contribute to tumor progression and immunotherapy resistance. Radiotherapy, a traditional treatment, can remodel the TME and improve the response rate of immune checkpoint inhibitors (ICIs) to some extent.
Article
Medicine, Research & Experimental
Yuyi Wang, Ombretta Salvucci, Hidetaka Ohnuki, Andy D. Tran, Taekyu Ha, Jing-Xin Feng, Michael DiPrima, Hyeongil Kwak, Dunrui Wang, Yanlin Yu, Michael Kruhlak, Giovanna Tosato
Summary: SHP2 is essential for promoting endothelial cell survival and growth in tumor vasculature remodeling. Inhibiting SHP2 activity leads to reduced tumor growth and degeneration of tumor vasculature. Combination of SHP2 inhibitors with Ang2/TIE2 inhibitors shows promise in effectively targeting the tumor endothelium.
EMBO MOLECULAR MEDICINE
(2021)
Review
Oncology
Leena Arora, Durba Pal
Summary: The molecular understanding of carcinogenesis and tumor progression relies on the intra and inter-tumoral heterogeneity. Recent advances in single-cell sequencing technology have provided insights into the complexity of the tumor microenvironment, guiding potential therapeutic strategies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Denise Pinessi, Andrea Resovi, Fabio Sangalli, Lavinia Morosi, Lorena Zentilin, Patrizia Borsotti, Elena Carlessi, Alice Passoni, Enrico Davoli, Dorina Belotti, Raffaella Giavazzi, Mauro Giacca, Giovanni Valbusa, Alexander Berndt, Massimo Zucchetti, Giulia Taraboletti
Summary: The T3R domain of thrombospondin-1 not only inhibits tumor angiogenesis but also remodels the tumor vasculature, affecting its morphological and functional properties. T3R expression can slow down tumor growth and enhance responsiveness to chemotherapy.
Review
Immunology
Xiao-Wei Wei, Yu-Chen Zhang, Fan Wu, Fu-Ju Tian, Yi Lin
Summary: Uterine spiral artery remodeling plays a crucial role in successful pregnancy, which is regulated by uterine NK cells and extravillous trophoblasts.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yan-Ting Shiu, Yuxia He, Jason C. S. Tey, Marina Knysheva, Blake Anderson, Katalin Kauser
Summary: The NVS Therapy, a new technology that interlinks collagen and elastin, may improve AVF remodeling by increasing vascular lumen area, reducing inflammatory markers, and influencing collagen fiber structure. This treatment shows potential in enhancing AVF maturation and is well tolerated by rats.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Physics, Condensed Matter
Chao Zhang, Heiko Rieger
EUROPEAN PHYSICAL JOURNAL B
(2020)
Article
Physics, Multidisciplinary
Chao Zhang, Heiko Rieger
FRONTIERS IN PHYSICS
(2020)
Editorial Material
Physics, Condensed Matter
Ferenc Igloi, Heiko Rieger
EUROPEAN PHYSICAL JOURNAL B
(2020)
Article
Physics, Condensed Matter
Johannes Sicks, Heiko Rieger
EUROPEAN PHYSICAL JOURNAL B
(2020)
Article
Biophysics
Zeinab Sadjadi, Renping Zhao, Markus Hoth, Bin Qu, Heiko Rieger
BIOPHYSICAL JOURNAL
(2020)
Article
Physics, Multidisciplinary
Hugues Meyer, Heiko Rieger
Summary: This study investigates the efficiency of non-Markovian search processes with long-lasting memory, showing that the optimal search strategies can be simplified to simple cycles defined by a small parameter set and that mirror-asymmetric walks are more efficient.
PHYSICAL REVIEW LETTERS
(2021)
Article
Biophysics
Ivan Hornak, Heiko Rieger
Summary: This study analyzes the dynamics of the repositioning of microtubule organizing center (MTOC) during the formation of the immunological synapse (IS) between cytotoxic T lymphocytes and target cells. The study finds that the initial position of the MTOC determines the dominant mechanism and the time of repositioning does not increase linearly with the distance between MTOC and IS. In the case of two IS, different scenarios are observed, including alternating, wiggling, and being pulled to one of the IS. The presence of capture-shrinkage mechanism in at least one IS is necessary for the transitions in every cell configuration.
BIOPHYSICAL JOURNAL
(2022)
Article
Physics, Fluids & Plasmas
Mintu Karmakar, Swarnajit Chatterjee, Matthieu Mangeat, Heiko Rieger, Raja Paul
Summary: We studied the active Potts model with site occupancy restriction or on-site repulsion and found that it exhibits a surprisingly rich variety of self-organized spatial patterns. The introduction of volume exclusion features leads to the occurrence of bands and lanes of moving particles, and with strong volume exclusion, low temperature, high activity, and large particle density, jams due to motility-induced phase separation can be facilitated. Through phase diagrams, we identified phase boundaries and studied the transition between jammed and free-flowing phases, providing qualitative and quantitative predictions on how jamming might be delayed or dissolved. We also formulated and analyzed a hydrodynamic theory for the restricted APM, which predicts various features of the microscopic model.
Article
Physics, Fluids & Plasmas
Chul-Ung Woo, Heiko Rieger, Jae Dong Noh
Summary: We investigate the phase transitions of the q-state Brownian Potts model in 2D. Through Monte Carlo simulations, we find a continuous phase transition from a paramagnetic to a ferromagnetic phase even for q > 4. In contrast to the equilibrium model, diffusion-induced dynamical positional disorder suppresses phase coexistence, leading to a continuous transition.
Article
Physics, Fluids & Plasmas
Matthieu Mangeat, Heiko Rieger
Summary: This paper investigates the impact of spatial heterogeneity in intracellular transport in living cells on the mean first passage time (MFPT) for Brownian particles, comparing active transport and passive Brownian motion to determine if optimization can be achieved in a two-compartment domain. The study derives asymptotic expressions for MFPT in thin cortex and small escape region limits in two and three dimensions, confirmed by numerical calculations using the finite-element method and stochastic simulations. The analysis reveals the dependence of MFPT on diffusion constants ratio, potential barrier height, and outer shell width, with potential for a minimum value in the latter under specific conditions.
Article
Immunology
Yan Zhou, Renping Zhao, Eva C. Schwarz, Rahmad Akbar, Mayis Kaba, Varsha Pattu, Volkhard Helms, Heiko Rieger, Paula Nunes-Hasler, Bin Qu
JOURNAL OF IMMUNOLOGY
(2020)
Article
Physics, Fluids & Plasmas
Matthieu Mangeat, Swarnajit Chatterjee, Raja Paul, Heiko Rieger
Article
Physics, Multidisciplinary
Swarnajit Chatterjee, Matthieu Mangeat, Raja Paul, Heiko Rieger
Article
Materials Science, Multidisciplinary
Peter Lajko, Jean-Christian Angles d'Auriac, Heiko Rieger, Ferenc Igloi
Review
Physics, Applied
M. Reza Shaebani, Adam Wysocki, Roland G. Winkler, Gerhard Gompper, Heiko Rieger
NATURE REVIEWS PHYSICS
(2020)