Article
Engineering, Biomedical
Hanane Aliouat, Ying Peng, Zoya Waseem, Shengfeng Wang, Wenhu Zhou
Summary: This article reviews drug delivery systems that purely consist of DNA and discusses their applications in targeted tumor therapy. Drugs can be incorporated into DNA via distinct mechanisms, and various DNA architectures have been developed for different types of anti-tumor therapeutics. The focus is on their intracellular delivery and drug release, with discussions on DNA-based platforms with different cellular uptake pathways and stimuliresponsive drug release profiles. Research opportunities in the field are speculated to pave the way for future research direction.
Review
Chemistry, Multidisciplinary
Wenlu Yan, Tianqun Lang, Runqi Zhu, Xiao Zhu, Yu Li, Ting Wu, Qi Yin, Yaping Li
Summary: This review summarizes the latest research progress on improving cancer therapy using anti-hypoxia nanosized drug delivery systems (NDDSs), including mechanisms such as increasing oxygen supply, reducing oxygen consumption, and inhibiting hypoxia-related signaling pathways.
Review
Chemistry, Multidisciplinary
Sofia Torres Quintas, Ana Canha-Borges, Maria Jose Oliveira, Bruno Sarmento, Flavia Castro
Summary: Breast cancer is the leading cause of cancer-related deaths in women, with a significant number of cases and fatalities reported globally in 2020. Triple-negative breast cancer (TNBC), which lacks certain receptors, accounts for approximately 20% of all breast cancers and has a more aggressive clinical course, particularly in younger women. Current standard therapy for advanced TNBC is chemotherapy, but its effectiveness is limited and relapse rates are high. However, recent advances in cancer nanomedicine have provided innovative therapeutic options to overcome the drawbacks of conventional therapies. This review summarizes the recent developments in nanomedicine for TNBC treatment, including novel nanoparticle, exosome, and hybrid-based formulations, and discusses their limitations and challenges for future clinical applications.
Article
Biochemistry & Molecular Biology
Denise Pinessi, Andrea Resovi, Fabio Sangalli, Lavinia Morosi, Lorena Zentilin, Patrizia Borsotti, Elena Carlessi, Alice Passoni, Enrico Davoli, Dorina Belotti, Raffaella Giavazzi, Mauro Giacca, Giovanni Valbusa, Alexander Berndt, Massimo Zucchetti, Giulia Taraboletti
Summary: The T3R domain of thrombospondin-1 not only inhibits tumor angiogenesis but also remodels the tumor vasculature, affecting its morphological and functional properties. T3R expression can slow down tumor growth and enhance responsiveness to chemotherapy.
Review
Pharmacology & Pharmacy
Ahsan Ayub, Shawn Wettig
Summary: Drug delivery to the brain is a challenging task due to the blood-brain barrier. Nanomedicine, which combines nanotechnology, chemistry, and medicine, has shown promising results in improving drug delivery to the brain. Inorganic and organic nanoparticulate systems are being studied for this purpose.
Article
Chemistry, Multidisciplinary
Liping Dong, Jinsong Ding, Lemei Zhu, Yujun Liu, Xiang Gao, Wenhu Zhou
Summary: Macromolecular drugs have significant potential for treating previously untreatable diseases, but they face challenges in terms of stability and penetration. In this study, biocompatible transition metals were screened for biomineralization with carbonate to load macromolecules. Copper carbonate nanoparticles were prepared to co-load glucose oxidase (GOx) and a HIF-alpha DNAzyme (DZ), achieving high loading capacity. The nanoparticles could accumulate in tumors, penetrate cell membranes, and release their payloads to exert anti-tumor effects. The combination of GOx and DZ resulted in synergistic tumor growth inhibition.
CHINESE CHEMICAL LETTERS
(2023)
Review
Chemistry, Multidisciplinary
Chunling Wang, Junchao Xu, Yinlong Zhang, Guangjun Nie
Summary: Abnormal angiogenesis is a significant characteristic of malignant tumors, and nanomedicine provides a precise approach to regulate tumor blood vessels. Nanomedicines have the advantage of reducing systemic toxicity and enhancing therapeutic efficacy, as well as enabling more precise drug delivery and release through specific structural designs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Engineering, Biomedical
Xiaoxuan Xu, Yao Wu, Xindi Qian, Yuqi Wang, Jiaoying Wang, Jie Li, Yaping Li, Zhiwen Zhang
Summary: By regulating the physiochemical properties of nanomedicines and remodeling the components and structure of the ECM, intratumor ECM barriers can be effectively overcome, leading to improved drug delivery and anticancer efficacy.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Oncology
Mingshu Xiao, Yueli Shi, Sujing Jiang, Mengqing Cao, Weiyu Chen, Yun Xu, Zhiyong Xu, Kai Wang
Summary: Anti-angiogenesis therapy and immunotherapy are important strategies for tumor treatment. Nanomedicine has unique advantages in anti-angiogenesis therapy, such as targeted delivery and photothermal effects. This review provides a comprehensive overview on the use of nanomaterials in anti-angiogenesis therapy, focusing on the immunosuppressive effects of abnormal tumor vessels, targeting strategies of anti-angiogenesis nanomedicines, and the synergistic effects and molecular mechanisms when combined with immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Frederic Padilla, Jacqueline Brenner, Francesco Prada, Alexander L. Klibanov
Summary: Ultrasound-triggered microbubbles destruction can lead to vascular shutdown and has shown potential in preclinical studies for tumor growth delay, lesion formation, radio-sensitization, and modulation of the immune micro-environment. Antivascular ultrasound has the potential to be a focal, targeted, non-invasive, mechanical, and non-thermal treatment either alone or in combination with other therapies. The main mechanism behind these effects is believed to be cavitation, with both non-inertial and inertial cavitation playing significant roles.
Review
Chemistry, Multidisciplinary
Xinyuan Shen, Chaojie Zhu, Qing Wu, Jiaqi Shi, Wei Wu, Xiao Zhao, Jie Sun, Hongjun Li, Zhen Gu
Summary: This review explores the rational design of nanomodulators to target tumor-resident immunosuppressive cells and provides an overview of the basic functions and therapeutic strategies for each cell type. Challenges and future research perspectives are also discussed.
Review
Pharmacology & Pharmacy
Xu Xin Sun, Zeynab Nosrati, Janell Ko, Che-Min Lee, Kevin L. Bennewith, Marcel B. Bally
Summary: Immunotherapy has revolutionized cancer treatment, but there is a need for further improvements to enhance its positive benefits. Our team believes that combining drug delivery methods with the right small-molecule drugs can help double the overall survival rate for patients receiving immunotherapeutics.
Article
Chemistry, Multidisciplinary
Yaxuan Zhao, Kai Feng, Guojun Lei, Jingjing Shen, Yang Liu, Yiling Ruan, Xiaolian Sun
Summary: This study constructs a nanosystem for the sequential release of TRAIL and GOx to achieve synergistic cancer treatment. The nanosystem can quickly release TRAIL to induce tumor cell apoptosis and enhance the cellular uptake of the cores. It can also release GOx to trigger a cascade reaction to generate free radicals for tumor inhibition. Experimental results demonstrate the separate delivery of TRAIL and GOx and their remarkable synergistic anti-cancer effect.
Review
Pharmacology & Pharmacy
Jia Nong, Patrick M. Glassman, Vladimir R. Muzykantov
Summary: Acute inflammation is a common component of many prevalent conditions, and targeting endothelial cells for therapeutic intervention shows promise in correcting the damaging effects of inflammation. However, current drugs and drug delivery systems lack precision and effectiveness.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Oncology
Alessandro Parodi, Dmitry Kostyushev, Sergey Brezgin, Anastasiya Kostyusheva, Tatiana Borodina, Roman Akasov, Anastasia Frolova, Vladimir Chulanov, Andrey A. Zamyatnin Jr
Summary: In order to increase the accumulation of drugs in tumors, various nanocarriers have been designed. The development of biomimetic nanomedicine allows the generation of nanoparticles with the same characteristics as cells that naturally infiltrate tumors. Moreover, strategies such as cell membrane transfer and biomimetic targeting can enhance the targeting efficiency of drugs in tumors.
SEMINARS IN CANCER BIOLOGY
(2022)