Article
Medicine, General & Internal
Sungeun Hwang, Chang-Hyun Park, Regina Eun-Young Kim, Hyeon Jin Kim, Yun Seo Choi, Sol-Ah Kim, Jeong Hyun Yoo, Ki Wha Chung, Byung-Ok Choi, Hyang Woon Lee
Summary: Structural changes were observed in cerebellar white matter in CMT patients with NEFL mutations, while abnormal diffusion tensor imaging findings were found in specific cerebellar regions associated with NEFL and GJB1 mutations. The presence of cerebellar ataxia was linked to cerebellar white matter abnormalities in the NEFL subgroup, highlighting the importance of neuroimaging in detecting these abnormalities in CMT patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Yong-Ho Choi, Jong-Min Lee, Joo Young Lee, Ji Young Lee, Young-Jun Lee, Ja Hye Ahn, Hyun Ju Lee
Summary: The study found that the white matter maturation of VLBW infants is associated with neurodevelopmental outcomes at 18 months of corrected age, with particular significance in the MCP region. The FA values in the MCP region are significantly related to cognitive and motor scores, potentially predicting cognitive and motor impairments in infants.
Article
Biology
Bo Kyung Shin, Hae-Yeon Park, Hanee Rim, Ji Yoon Jung, Sungwoo Paek, Yeun Jie Yoo, Mi-Jeong Yoon, Bo Young Hong, Seong Hoon Lim
Summary: Many chronic stroke patients experience worsening hand function, and recovery of hand function is often limited after six months. Predicting final hand function after stroke is crucial for counseling and planning rehabilitation strategies. This study investigated the remaining white matter integrity in the corticospinal tract (CST) and cortico-ponto-cerebellar tract (CPCT) during the acute stage of stroke and its correlation with chronic hand function. The results suggest that the integrity of the CPCT in the early stage after stroke onset can be used to predict long-term hand function. Consideration of cerebellar afferent fiber measurements may be useful in predicting hand function and designing targeted rehabilitation strategies for stroke patients.
Article
Clinical Neurology
Gang Liu, Yaomin Guo, Chao Dang, Kangqiang Peng, Shuangquan Tan, Chuanmiao Xie, Shihui Xing, Jinsheng Zeng
Summary: Bilateral inferior cerebellar peduncle degeneration occurs in the early phase of supratentorial stroke, and diffusion metric values of the contralesional ICP are useful indicators of affected lower limb function after stroke.
Review
Clinical Neurology
Juming Ma, Xue Yang, Fan Xu, Hongjun Li
Summary: This research evaluates the consistency and differences in the correlation between HAND and DTI measures in various studies. The results show that patients with HAND have significant changes in white matter fibers compared to healthy individuals in terms of fractional anisotropy and mean diffusivity. However, there are heterogeneities between the studies, which can be attributed to demographics, antiretroviral therapy, nadir CD4+ T cell levels, and the use of different neurocognitive function scales. DTI is an effective method for diagnosing HAND, but there are still limitations, particularly in the absence of neurocognitive function scales.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Youngkook Kim, Se-Hong Kim, Bo Young Hong, Jeehae Oh, So-youn Chang
Summary: Degeneration of the inferior cerebellar peduncle (ICP) occurs after intracerebral hemorrhage (ICH), and its degree is associated with ambulatory function. The ICP fractional anisotropy (FA) laterality index has a moderate correlation with ambulatory function, and this correlation is stronger in patients with severe disability. The ICP FA laterality index and age are independently associated with the Mobility score.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Medicine, General & Internal
Ernest Tyburski, Piotr Podwalski, Katarzyna Waszczuk, Katarzyna Rek-Owodzin, Monika Mak, Piotr Plichta, Maksymilian Bielecki, Krzysztof Rudkowski, Michal Szelepajlo, Jolanta Kucharska-Mazur, Wojciech Andrusewicz, Blazej Misiak, Magdalena Kerestey, Adrianna Bober, Krzysztof Wietrzynski, Anna Michalczyk, Magdalena Wiedlocha, Piotr Marcinowicz, Jerzy Samochowiec, Leszek Sagan
Summary: This study examined the relationship between the integrity of the corpus callosum and cognitive functioning in schizophrenia patients. Results showed impaired integrity in the middle and posterior corpus callosum, with patients displaying cognitive impairments.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
D. Longo, F. Bottino, G. Lucignani, L. Scarciolla, L. Pasquini, M. C. Rossi Espagnet, C. Polito, L. Figa-Talamanca, G. Calbi, I. Savarese, P. Giliberti, A. Napolitano
Summary: This study compared the changes in DTI parameters in newborns after one week and six months of total-body cooling with healthy controls. The results showed significant differences in some parameters between the HIE group and the control group in newborns, but these differences disappeared after 6 months. This suggests that changes in the parameters cannot serve as early biomarkers to evaluate therapeutic hypothermia in newborns with moderate HIE and normal conventional MRI.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Neurosciences
Junya Matsumoto, Masaki Fukunaga, Kenichiro Miura, Kiyotaka Nemoto, Daisuke Koshiyama, Naohiro Okada, Kentaro Morita, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Naomi Hasegawa, Yoshiyuki Watanabe, Kiyoto Kasai, Ryota Hashimoto
Summary: This study examined the associations between social activities, represented by work hours, and brain connectivity using diffusion tensor imaging. The findings suggested that work hours were correlated with the white matter microstructure of the anterior limb of the internal capsule (ALIC) and the superior fronto-occipital fasciculus (SFO), particularly in paid employment. The results indicate that externally motivated social activities are related to the white matter microstructure of the ALIC and SFO.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Kerem Ozturk, David Nascene
Summary: The study revealed that the administration of gadobutrol in pediatric patients led to significantly lower FA values and higher MD values in the dentate nucleus (DN) compared to the control group. Additionally, there was a significant correlation between FA/MD values and the number of gadobutrol administrations, indicating potential differences in cerebellar tissue integrity between children exposed to macrocyclic GBCAs and the control group.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lamiaa Galal Elsorogy, Amany Mohamed Abdelrazek, Hanee Ali Awad, Rihame Mohamed Abdelwahab
Summary: This study evaluated the role of DTI in detecting structural alterations in TBI patients with persistent symptoms. The results showed a significant decrease in FA and an increase in MD in the CC and CS. The combined use of FA and MD showed better diagnostic accuracy in differentiating between control and trauma patients.
EGYPTIAN JOURNAL OF RADIOLOGY AND NUCLEAR MEDICINE
(2022)
Article
Otorhinolaryngology
Direnc Ozlem Aksoy, Yesim Karagoz, Kemal Furkan Kaldirimoglu, Melis Baykara Ulusan, Abdullah Soydan Mahmutoglu
Summary: The study aimed to investigate changes in the auditory neural network in pediatric congenital hearing loss cases. Diffusion tensor imaging metrics were used to compare cochlear implant candidates and normal-hearing controls. The results showed differences in apparent diffusion coefficient and radial diffusivity values between patients and controls in various regions. Fractional anisotropy values were lower in patients in certain areas, and the cochlear nerve area was smaller in patients.
JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
(2023)
Article
Clinical Neurology
Mattia Rosso, Brian C. Healy, Shrishti Saxena, Anu Paul, Kjetil Bjornevik, Jens Kuhle, Pascal Benkert, David Leppert, Charles Guttmann, Rohit Bakshi, Howard L. Weiner, Tanuja Chitnis
Summary: This study investigated the relationship between serum neurofilament light levels and age in multiple sclerosis patients, revealing a more significant increase in sNfL levels after Gad+ lesions in younger patients. This insight provides new understanding of the effects of neuroinflammation on aging in MS.
JOURNAL OF NEUROIMAGING
(2021)
Article
Clinical Neurology
Salem Hannoun, Gabriel Kocevar, Pekes Codjia, Delphine Maucort-Boulch, Francois Cotton, Sandra Vukusic, Francoise Durand-Dubief, Dominique Sappey-Marinier
Summary: Longitudinal analysis of T1-weighted images in multiple sclerosis patients over 4 years showed no significant signal intensity increases in the dentate nuclei and subcortical gray matter structures with cumulative administration of the macrocyclic gadolinium-based contrast agent, gadoterate meglumine.
CLINICAL NEURORADIOLOGY
(2022)
Review
Clinical Neurology
Lara Chaaban, Nancy Safwan, Hussein Moussa, Sally El-Sammak, Samia J. Khoury, Salem Hannoun
Summary: The central vein sign (CVS) has been identified as a biomarker for multiple sclerosis (MS) diagnosis and has proven to be accurate in differentiating MS from other diseases. Various rules based on susceptibility-based magnetic resonance venography have been introduced to assist in identifying MS lesions with high sensitivity and accuracy.
ACTA NEUROLOGICA SCANDINAVICA
(2022)
Article
Clinical Neurology
Salem Hannoun, Gabriel Kocevar, Pekes Codjia, Berardino Barile, Francois Cotton, Francoise Durand-Dubief, Dominique Sappey-Marinier
Summary: The study aimed to determine if T1/T2 ratio measurements can accurately detect cerebral white matter microstructural damage in RRMS patients compared to healthy controls. Results showed significant differences between RRMS and HC in both DTI and T1/T2 ratio measurements, highlighting the potential clinical use of T1/T2 ratio in evaluating WM abnormalities in the brain.
JOURNAL OF NEUROIMAGING
(2022)
Editorial Material
Neurosciences
Salem Hannoun, Roula Hourani
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Carine Ciceron, Dominique Sappey-Marinier, Paola Riffo, Soline Bellaiche, Gabriel Kocevar, Salem Hannoun, Claudio Stamile, Jerome Redoute, Francois Cotton, Patrice Revol, Nathalie Andre-Obadia, Jacques Luaute, Gilles Rode
Summary: This article reports a remarkable late recovery of the right upper-limb motor function after a left middle cerebral artery stroke, occurring progressively from two to 12 years post-stroke onset. The recovery was characterized by clinical assessments, quantified movement analysis, diffusion tensor imaging, functional magnetic resonance imaging, and transcranial magnetic stimulation. The findings suggest that the motor control of the paretic hand is mainly mediated by the contralateral sensorimotor cortex and the corresponding corticospinal tract, as well as plasticity in motor-related areas in both hemispheres.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neuroimaging
Rida Salman, Wassim Nasreddine, Salem Hannoun, Widad Abou Chaar, Karl Asmar, Ahmad Beydoun, Roula Hourani
Summary: This study found no association between specific brain MRI abnormalities and BRE, but the altered cortical and subcortical development in BRE patients suggests a microstructural-functional correlation.
NEURORADIOLOGY JOURNAL
(2022)
Article
Clinical Neurology
Elise Peter, Le Duy Do, Salem Hannoun, Sergio Muniz-Castrillo, Alberto Vogrig, Valentin Wucher, Anne-Laurie Pinto, Naura Chounlamountri, Walaa Zakaria, Veronique Rogemond, Geraldine Picard, Julien-Jacques Hedou, Aditya Ambati, Agusti Alentorn, Alexandra Traverse-Glehen, Mario Manto, Dimitri Psimaras, Emmanuel Mignot, Francois Cotton, Virginie Desestret, Jerome Honnorat, Bastien Joubert
Summary: This study describes the clinical-immunologic features and long-term outcomes of patients with anti-DNER antibodies. Most patients had cerebellar ataxia and became moderately to severely disabled. Half of the patients improved, and younger age, milder clinical presentations, and less decrease of cerebellar gray matter volumes were associated with a better outcome.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Review
Clinical Neurology
Marwa Summaka, Salem Hannoun, Hayat Harati, Rama Daoud, Hiba Zein, Elias Estephan, Ibrahim Naim, Zeina Nasser
Summary: This systematic review aims to describe and identify the neuroanatomical regions associated with non-progressive dysarthria following stroke. The study found that pontine infarctions were the most common, followed by infarctions in the corona radiata and the cerebellum. The findings have important implications for clinical practice and provide a framework for early detection and management of dysarthria post-stroke.
Article
Clinical Neurology
Nabil K. El Ayoubi, Hadi M. Sabbagh, Nicole Bou Rjeily, Salem Hannoun, Samia J. Khoury
Summary: This study found that patients who converted to secondary progressive multiple sclerosis (SPMS) had faster retinal thinning compared to patients with relapsing-remitting multiple sclerosis (RRMS) who did not convert to SPMS, as detected by optical coherence tomography (OCT).
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Psychology
Alexandrine Faye, Francois Osiurak, Mathieu Lesourd, Salem Hannoun, Francois Cotton, Jeremy Besnard, Sophie Jacquin-Courtois
Summary: This study tested the main prediction of ATOM by examining right brain-damaged patients, left brain-damaged patients, and healthy subjects on different magnitude estimation tasks. Contrary to the prediction, the results showed partial independence between the different forms of magnitude estimation processing.
NEUROPSYCHOLOGICAL TRENDS
(2022)
Review
Clinical Neurology
Tatiana Abou Mrad, Kim Naja, Samia J. Khoury, Salem Hannoun
Summary: The widespread use of MRI has resulted in an increase in incidental findings in the central nervous system. Radiologically isolated syndrome (RIS) is characterized by imaging-detected lesions suggestive of demyelinating disease without clinical episodes consistent with multiple sclerosis (MS). This article reviews two potential biomarkers, the central vein sign (CVS) and the paramagnetic rim sign (PRS), and their role in the diagnosis and prognosis of MS and RIS. Both CVS and PRS have shown to be accurate diagnostic markers with high sensitivity and specificity in distinguishing MS from other disorders.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Salem Hannoun
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hila Tal Tamir, Dana Stav, Yitzhac Hadad, Rivka Kessner
Summary: This study aimed to characterize thyroid nodules seen on Spectral Detector computed tomography (SDCT) and compare them with their Thyroid Imaging Reporting and Data System (TI-RADS) category on Ultrasound (US). The results showed that the spectral results of SDCT can assist in differentiating thyroid nodules of different risk levels.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Volha Nizhnikava, Ursula Reiter, Gabor Kovacs, Clemens Reiter, Corina Kraeuter, Horst Olschewski, Michael Fuchsjaeger, Gert Reiter
Summary: The purpose of this study was to investigate the associations between cardiac magnetic resonance feature-tracking-derived myocardial strain parameters and volumetric function and hemodynamic parameters in patients with pulmonary hypertension. The results showed that impairment of myocardial strains was more strongly associated with alterations in ventricular function parameters than elevated pulmonary arterial pressure, limiting the diagnostic information of myocardial strain parameters in pulmonary hypertension.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-ling Qian, Rui-lin Quan, Xiao-xi Chen, Yang-yi Lin, Xiao-li Jing, Qing Gu, Chang-ming Xiong, Jian-guo He, Ai-hua Zhi
Summary: The purpose of this study was to investigate the imaging characteristics and prognostic factors for the long-term survival of Behcet's disease (BD) with arterial involvement. The results showed that arterial lesions associated with BD usually involve multiple arteries and manifest differently in different types of arteries. Cardiac involvement and pulmonary artery aneurysm/dilation were independent prognostic factors for the survival of BD patients with arterial involvement.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Yong Xie, Jian Wang, Yinghua Zou
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daria Kifjak, Maximilian Hochmair, Daniel Sobotka, Alexander R. Haug, Raphael Ambros, Florian Prayer, Benedikt H. Heidinger, Sebastian Roehrich, Ruxandra-Iulia Milos, Wolfgang Wadsak, Thorsten Fuereder, Dagmar Krenbek, Andreas Fazekas, Michael Meilinger, Marius E. Mayerhoefer, Georg Langs, Christian Herold, Helmut Prosch, Lucian Beer
Summary: The ability of pretreatment PET parameters and peripheral blood biomarkers to predict PFS and OS in NSCLC patients treated with ICIT was assessed. The study found that MTV and the number of SOI were independent risk factors for progression and overall survival, and the combination of these factors improved risk stratification.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Theresa Sophie Patzer, Jan-Peter Grunz, Henner Huflage, Jan-Lucca Hennes, Pauline Pannenbecker, Philipp Gruschwitz, Saif Afat, Judith Herrmann, Thorsten Alexander Bley, Andreas Steven Kunz
Summary: This study investigated the potential of tin prefiltration and virtual monoenergetic imaging (VMI) in suppressing metal artifacts in high-resolution CT images of the lower extremities. The results showed that VMI reconstructions had better artifact reduction compared to T3D. VMI110keV had the least image noise. In terms of image quality, interpretability of bone-metal interface, and overall image quality, VMI110keV performed the best.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yue Li, Huan Zhang, Lei Yue, Caixia Fu, Robert Grimm, Wenhua Li, Weijian Guo, Tong Tong
Summary: This study evaluated and compared the diagnostic value of diffusion-related texture analysis parameters from different magnetic resonance diffusion models in predicting the clinical response to chemotherapy in patients with colorectal liver metastases. Among the models, DKI-derived parameters showed the best performance for early prediction, followed by IVIM-derived parameters and DWI baseline features.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lu Wang, ShiXiong Zhang, Jun Xin
Summary: This study aimed to determine if sex differences in abdominal visceral fat composition and metabolism can help predict the prognosis of DLBCL patients. The results showed that females with certain fat composition and metabolism characteristics had worse progression-free survival, while no significant differences were found in males with DLBCL.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-ping Wu, Lan Wu, Jing Ou, Jin-ming Cao, Mao-yong Fu, Tian-wu Chen, Erika Ouchi, Jiani Hu
Summary: This study aimed to develop CT radiomics models to preoperatively identify lymph node (LN) status in resectable esophageal squamous cell carcinoma (ESCC) patients. The results showed that the combined model, integrating ESCC and LN radiomics features with clinical features, had the highest predictive ability among the three models. The combined model's predictive ability was validated in both the test and external validation cohorts.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)