Review
Oncology
Marcello Di Martino, Alessandro Vitale, Daniele Ferraro, Marilisa Maniscalco, Donatella Pisaniello, Giuseppe Arenga, Federica Falaschi, Alfonso Terrone, Alessandro Iacomino, Alfonso Galeota Lanza, Ciro Esposito, Umberto Cillo, Giovanni Vennarecci
Summary: This systematic review evaluates the effectiveness of downstaging therapies for hepatocellular carcinoma (HCC) patients beyond the listing criteria. The results suggest that patients who are successfully downstaged and transplanted have a longer overall survival compared to those who are not transplanted. However, there are no significant differences in the survival rates between these two groups based on an intention-to-treat analysis.
Article
Oncology
Jin Gu, Erlei Zhang, Binyong Liang, Zunyi Zhang, Xiaoping Chen, Min Xiong, Zhiyong Huang
Summary: In HCC patients with Child-Pugh grade A liver function, cirrhosis staging can be determined by measuring liver collagen contents using Collagen Proportional Area (CPA), which significantly affects the risk of Posthepatectomy Liver Failure (PHLF). The study also found a significant correlation between CPA and a non-invasive method called Cirrhotic Severity Scoring (CSS) proposed by the team, showing that higher CPA values and extent of hepatectomy are independent risk factors for PHLF, and there is a positive correlation between CPA and CSS.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Koya Yasukawa, Akira Shimizu, Koji Kubota, Tsuyoshi Notake, Kiyotaka Hosoda, Hikaru Hayashi, Yuji Soejima
Summary: This study aimed to investigate the impact of liver fibrosis on the prognosis of patients with hepatocellular carcinoma (HCC). The results showed that patients with more severe liver fibrosis had worse cancer-specific prognosis. Moreover, patients with liver fibrosis had a higher incidence of multiple recurrences.
Article
Nutrition & Dietetics
Xuan-vinh Kevin Nguyen, Jason Zhang, Ken Lee Chin, Stephen Bloom, Amanda J. Nicoll
Summary: This study compared the characteristics and survival rates of NAFLD-HCC patients to non-NAFLD-HCC patients, finding that NAFLD-HCC patients were more likely to be diagnosed based on symptoms and at an older age, with lower survival rates.
Review
Biochemistry & Molecular Biology
Asanda Koza, Ricky H. Bhogal, Nicos Fotiadis, Vasileios K. Mavroeidis
Summary: The management of hepatocellular carcinoma (HCC) involves the collaboration of multiple disciplines, including hepatologists, surgeons, radiologists, oncologists, and radiotherapists. By properly staging patients and selecting suitable treatments, the prognosis for HCC is improving. Surgical options, such as liver resection and orthotopic liver transplantation (OLT), provide curative-intent treatment but have limitations. Non-surgical ablative techniques, especially for small HCCs, have been shown to have comparable overall and disease-free survival to surgical resection. The use of ablative techniques is globally recommended and there are promising results with recent technical advancements and the use of robotic assistance.
Review
Medicine, General & Internal
Terrence C. H. Hui, Justin Kwan, Uei Pua
Summary: Percutaneous ablation is a common treatment for liver tumors, with a focus on achieving necrosis of tumor cells while minimizing damage to surrounding tissue. Considerations include choosing appropriate imaging and protective techniques to optimize outcomes and achieve satisfactory ablation margins.
Article
Oncology
Michelle Junyi He, Wenjun Pu, Xi Wang, Xiaoni Zhong, Dong Zhao, Zhipeng Zeng, Wanxia Cai, Jiayi Liu, Jianrong Huang, Donge Tang, Yong Dai
Summary: This study utilized mass spectrometry mediated spatial metabolomics technique to investigate the metabolic changes in hepatocellular carcinoma (HCC). The results revealed that amino acid metabolism and glycerophospholipid metabolism exhibited the most significant alterations during HCC progression, and these altered metabolites and pathways were interconnected through the urea cycle.
CANCER CELL INTERNATIONAL
(2022)
Article
Genetics & Heredity
Zhaobin He, Cheng Peng, Tianen Li, Jie Li
Summary: This study used single cell differentiation trajectory analysis to investigate the relevance of liver cirrhosis and hepatocellular carcinoma (HCC). It was found that the cell differentiation trajectory of liver cirrhosis can predict the prognosis of HCC, providing new perspectives on the mechanisms of progression from liver cirrhosis to HCC.
FRONTIERS IN GENETICS
(2022)
Article
Gastroenterology & Hepatology
Ji H. Nahm, Hye S. Lee, Haeryoung Kim, Sun Y. Yim, Ji-hyun Shin, Jeong E. Yoo, Sang H. Ahn, Jin S. Choi, Ju-Seog Lee, Young N. Park
Summary: This study developed a nomogram for predicting late recurrence of hepatocellular carcinoma (HCC) based on clinicopathological and molecular factors. The combination of pSTAT3, pERK1/2 and SYK immunoexpression with high lobular inflammatory activity and cirrhosis was found to predict late HCC recurrence.
LIVER INTERNATIONAL
(2021)
Article
Oncology
Giacomo Zanus, Giovanni Tagliente, Serena Rossi, Alessandro Bonis, Mattia Zambon, Michele Scopelliti, Marco Brizzolari, Ugo Grossi, Maurizio Romano, Michele Finotti
Summary: This study analyzes the safety and efficacy of pulsed microwave liver ablation as an additional treatment option for HCC patients. The results show that this technique effectively controls tumor progression and recurrence and results in high overall survival rates. It is applicable not only to early-stage patients but also to those with advanced disease.
Article
Cell Biology
Naoto Fujiwara, Naoto Kubota, Emilie Crouchet, Bhuvaneswari Koneru, Cesia A. Marquez, Arun K. Jajoriya, Gayatri Panda, Tongqi Qian, Shijia Zhu, Nicolas Goossens, Xiaochen Wang, Shuang Liang, Zhenyu Zhong, Sara Lewis, Bachir Taouli, Myron E. Schwartz, Maria Isabel Fiel, Amit G. Singal, Jorge A. Marrero, Austin J. Fobar, Neehar D. Parikh, Indu Raman, Quan-Zhen Li, Masataka Taguri, Atsushi Ono, Hiroshi Aikata, Takashi Nakahara, Hayato Nakagawa, Yuki Matsushita, Ryosuke Tateishi, Kazuhiko Koike, Masahiro Kobayashi, Takaaki Higashi, Shigeki Nakagawa, Yo-ichi Yamashita, Toru Beppu, Hideo Baba, Hiromitsu Kumada, Kazuaki Chayama, Thomas F. Baumert, Yujin Hoshida
Summary: This study analyzed multiple cohorts of NAFLD patients globally to define and validate signatures predictive of long-term HCC risk in NAFLD patients. These signatures can accurately predict the risk of developing HCC in patients and provide assistance for clinical treatment.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Peiman Habibollahi, Rahul A. Sheth, Erik N. K. Cressman
Summary: Liver cancer is a growing global concern with limited treatment options. The most common treatment methods are ablation techniques such as radiofrequency ablation and microwave ablation. However, difficulties in completely identifying residual cancer cells remain in these procedures, highlighting the need for further advancements in treatment strategies.
Article
Biology
Abdolamir Allameh, Nico Huettmann, Edouard Charlebois, Angeliki Katsarou, Wen Gu, Konstantinos Gkouvatsos, Elisa Pasini, Mamatha Bhat, Zoran Minic, Maxim Berezovski, Maria Guido, Carine Fillebeen, Kostas Pantopoulos
Summary: HJV has a hepatoprotective function and its deficiency in mice leads to mitochondrial dysfunction and hepatocarcinogenesis.
COMMUNICATIONS BIOLOGY
(2022)
Article
Surgery
Maria Baimas-George, Michael Watson, Patrick Salibi, Keith J. Murphy, Dionisios Vrochides, John B. Martinie, Erin H. Baker, David A. Iannitti
Summary: This study aimed to determine an algorithm for pre-operative platelet transfusion in patients with cirrhosis and hepatocellular carcinoma undergoing laparoscopic microwave ablation. Through logistic regression models and analysis of laboratory values, it was found that patients with thrombocytopenia and anemia or thrombocytopenia without anemia were at higher risk of bleeding complications and could benefit from pre-operative platelet transfusion. Further validation and potential application in novel therapies for platelet-based clinical treatment in liver disease are warranted.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Nutrition & Dietetics
Silvia Ferri, Bernardo Stefanini, Lorenzo Mulazzani, Margherita Alvisi, Francesco Tovoli, Simona Leoni, Luca Muratori, Tommaso Lotti, Alessandro Granito, Luigi Bolondi, Fabio Piscaglia
Summary: The role of moderate alcohol consumption in the evolution of NAFLD is still debated. This study evaluated the impact of current and lifelong alcohol consumption in NAFLD patients using a new estimation tool called LACU. The results showed that very low alcohol consumption was associated with lower rates of cirrhosis and hepatocellular carcinoma compared to abstainers and moderate consumers.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hila Tal Tamir, Dana Stav, Yitzhac Hadad, Rivka Kessner
Summary: This study aimed to characterize thyroid nodules seen on Spectral Detector computed tomography (SDCT) and compare them with their Thyroid Imaging Reporting and Data System (TI-RADS) category on Ultrasound (US). The results showed that the spectral results of SDCT can assist in differentiating thyroid nodules of different risk levels.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Volha Nizhnikava, Ursula Reiter, Gabor Kovacs, Clemens Reiter, Corina Kraeuter, Horst Olschewski, Michael Fuchsjaeger, Gert Reiter
Summary: The purpose of this study was to investigate the associations between cardiac magnetic resonance feature-tracking-derived myocardial strain parameters and volumetric function and hemodynamic parameters in patients with pulmonary hypertension. The results showed that impairment of myocardial strains was more strongly associated with alterations in ventricular function parameters than elevated pulmonary arterial pressure, limiting the diagnostic information of myocardial strain parameters in pulmonary hypertension.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-ling Qian, Rui-lin Quan, Xiao-xi Chen, Yang-yi Lin, Xiao-li Jing, Qing Gu, Chang-ming Xiong, Jian-guo He, Ai-hua Zhi
Summary: The purpose of this study was to investigate the imaging characteristics and prognostic factors for the long-term survival of Behcet's disease (BD) with arterial involvement. The results showed that arterial lesions associated with BD usually involve multiple arteries and manifest differently in different types of arteries. Cardiac involvement and pulmonary artery aneurysm/dilation were independent prognostic factors for the survival of BD patients with arterial involvement.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Yong Xie, Jian Wang, Yinghua Zou
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daria Kifjak, Maximilian Hochmair, Daniel Sobotka, Alexander R. Haug, Raphael Ambros, Florian Prayer, Benedikt H. Heidinger, Sebastian Roehrich, Ruxandra-Iulia Milos, Wolfgang Wadsak, Thorsten Fuereder, Dagmar Krenbek, Andreas Fazekas, Michael Meilinger, Marius E. Mayerhoefer, Georg Langs, Christian Herold, Helmut Prosch, Lucian Beer
Summary: The ability of pretreatment PET parameters and peripheral blood biomarkers to predict PFS and OS in NSCLC patients treated with ICIT was assessed. The study found that MTV and the number of SOI were independent risk factors for progression and overall survival, and the combination of these factors improved risk stratification.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Theresa Sophie Patzer, Jan-Peter Grunz, Henner Huflage, Jan-Lucca Hennes, Pauline Pannenbecker, Philipp Gruschwitz, Saif Afat, Judith Herrmann, Thorsten Alexander Bley, Andreas Steven Kunz
Summary: This study investigated the potential of tin prefiltration and virtual monoenergetic imaging (VMI) in suppressing metal artifacts in high-resolution CT images of the lower extremities. The results showed that VMI reconstructions had better artifact reduction compared to T3D. VMI110keV had the least image noise. In terms of image quality, interpretability of bone-metal interface, and overall image quality, VMI110keV performed the best.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yue Li, Huan Zhang, Lei Yue, Caixia Fu, Robert Grimm, Wenhua Li, Weijian Guo, Tong Tong
Summary: This study evaluated and compared the diagnostic value of diffusion-related texture analysis parameters from different magnetic resonance diffusion models in predicting the clinical response to chemotherapy in patients with colorectal liver metastases. Among the models, DKI-derived parameters showed the best performance for early prediction, followed by IVIM-derived parameters and DWI baseline features.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lu Wang, ShiXiong Zhang, Jun Xin
Summary: This study aimed to determine if sex differences in abdominal visceral fat composition and metabolism can help predict the prognosis of DLBCL patients. The results showed that females with certain fat composition and metabolism characteristics had worse progression-free survival, while no significant differences were found in males with DLBCL.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-ping Wu, Lan Wu, Jing Ou, Jin-ming Cao, Mao-yong Fu, Tian-wu Chen, Erika Ouchi, Jiani Hu
Summary: This study aimed to develop CT radiomics models to preoperatively identify lymph node (LN) status in resectable esophageal squamous cell carcinoma (ESCC) patients. The results showed that the combined model, integrating ESCC and LN radiomics features with clinical features, had the highest predictive ability among the three models. The combined model's predictive ability was validated in both the test and external validation cohorts.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
