Journal
EUROPEAN JOURNAL OF RADIOLOGY
Volume 82, Issue 11, Pages E669-E675Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2013.07.027
Keywords
PET/MRI; PET/CT; Liver metastases
Funding
- German Research Foundation (DFG, Grossgeraeteinitiative)
- PET/MRI scanner
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Objectives: To assess the value of PET/MRI with [F-18]-FDG using a whole body protocol for the depiction and characterization of liver lesions in comparison to PET/CT. Methods: 70 patients (31 women, 39 men) with solid tumors underwent [F-18]-FDG PET/CT and followed by an additional PET/MRI using an integrated scanner. Two readers rated the datasets (PET/CT; PET/MRI) regarding conspicuity of hepatic lesions (4-point ordinal scale) and diagnostic confidence (5-point ordinal scale). Median scores for lesion conspicuity and diagnostic confidence were compared using Wilcoxon's rank sum test. Prior examinations, histopathology and clinical follow-up (116 +/- 54 days) served as standard of reference. Results: 36 of 70 (51%) patients showed liver lesions. Using PET/CT and PET/MRI all patients with liver metastases could correctly be identified. A total of 97 lesions were found (malignant n = 26; benign n = 71). For lesion conspicuity significantly higher scores were obtained for PET/MRI in comparison to PET/CT (p < 0.001). Significantly better performance for diagnostic confidence was observed in PET/MRI, both for malignant as for benign lesions (p < 0.001). Conclusions: PET/MRI, even in the setting of a whole body approach, provides higher lesion conspicuity and diagnostic confidence compared to PET/CT and may therefore evolve as an attractive alternative in oncologic imaging. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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