Article
Gastroenterology & Hepatology
Breanna J. Sheahan, Casey M. Theriot, Jocsa E. Cortes, Christopher M. Dekaney
Summary: Acute intestinal mucositis is a common side effect of chemotherapy, and recent evidence suggests that the presence of enteric bacteria influences the extent of damage to jejunal epithelial cells. In this study, it was found that in mice without microbiota, chemotherapy led to a decrease in intestinal stem cells, while mice treated to remove microbiota retained these cells. It was discovered that microbiota sends a pro-survival signal to the stem cells, which helps maintain their presence in the face of chemotherapy-induced injury. This finding highlights the potential of manipulating enteric microbiota as a therapeutic target for reducing the severity of chemotherapy-associated mucositis.
Article
Food Science & Technology
Nikhil Maheshwari, Aijaz Ahmed Khan, Riaz Mahmood
Summary: This study aimed to investigate the therapeutic potential of curcumin and gallic acid against PCP-induced damage in rat intestine. The results showed that curcumin and gallic acid can effectively ameliorate oxidative damage caused by PCP and reduce tissue injury.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Fahed Al-Azzawi, Israa Mahmoud, Francois Haguinet, Andrew Bate, Maurizio Sessa
Summary: This study aimed to develop a new artificial intelligence (AI)-based framework to automate resource- and time-consuming steps of signal detection and signal validation. Machine learning, specifically conditional inference trees, was used to identify control groups and alternative causes, reducing the number of cases for manual validation.
Article
Medicine, General & Internal
Marta Michali-Stolarska, Andrzej Tukiendorf, Anna Zacharzewska-Gondek, Jagoda Jackow-Nowicka, Joanna Chrzanowska, Grzegorz Trybek, Joanna Bladowska
Summary: The study aimed to assess the diagnostic value of non-contrast pituitary MRI in children with GPDs and found that in most cases, using contrast agent in pituitary MRI is unnecessary. The AP pituitary dimension was the most significant factor in determining the need for contrast, with a high sensitivity and specificity. The omission of contrast agent can save time, increase MRI availability for waiting children, and accelerate further clinical management.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Peripheral Vascular Disease
Rebecca N. Treffalls, Kelly Poe, Hossam Abdou, David P. Stonko, Joseph Edwards, Randall R. DeMartino, Thomas Ptak, Jonathan J. Morrison
Summary: Intraoperative CT imaging with IA contrast provides higher attenuation and requires lower contrast volume compared to IV administration. In this study, IA and IV contrast protocols were compared for abdominal imaging in anesthetized swine. IA contrast achieved adequate aortic opacification with a higher peak attenuation and a superior contrast-to-noise ratio compared to IV contrast. The use of IA contrast also resulted in less bolus broadening and required a smaller contrast volume for directed organ-specific imaging.
Review
Pharmacology & Pharmacy
Dario Donoso-Meneses, Aliosha I. Figueroa-Valdes, Maroun Khoury, Francisca Alcayaga-Miranda
Summary: Small extracellular vesicles (sEVs) have emerged as a natural therapeutic alternative in biomedicine. They can resist the degradative conditions of the gastrointestinal tract and be absorbed regionally in the intestine, making them ideal for oral administration. Additionally, food-derived vesicles (FDVs) hold potential as nutraceutical agents due to their high nutritional content.
Article
Hematology
Adi Elias, Doron Aronson
Summary: In patients with suspected pulmonary embolism, the use of intravenous contrast material during CTPA did not increase the risk of AKI. The diagnostic superiority of CTPA supports its reassuring use in patients with suspected PE perceived to be at risk for AKI.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Multidisciplinary Sciences
Pascale Vonaesch, Joao R. Araujo, Jean-Chrysostome Gody, Jean-Robert Mbecko, Hugues Sanke, Lova Andrianonimiadana, Tanteliniaina Naharimanananirina, Synthia Nazita Ningatoloum, Sonia Sandrine Vondo, Privat Bolmbaye Gondje, Andre Rodriguez-Pozo, Maheninasy Rakotondrainipiana, Kaleb Jephte Estime Kandou, Alison Nestoret, Nathalie Kapel, Serge Ghislain Djorie, B. Brett Finlay, Laura Wegener Parfrey, Jean-Marc Collard, Rindra Vatosoa Randremanana, Philippe J. Sansonetti
Summary: This study reveals the high prevalence of small intestinal bacterial overgrowth (SIBO) in stunted children, which leads to increased intestinal permeability, inflammation, and reduced lipid absorption. Additionally, specific fecal signatures associated with EED markers were identified. These findings are crucial for the development of microbiota-targeted interventions for treating EED.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Jae Won Choi, Yeon Jin Cho, Ji Young Ha, Seul Bi Lee, Seunghyun Lee, Young Hun Choi, Jung-Eun Cheon, Woo Sun Kim
Summary: Synthetic CECT generated from NCCT improves the depiction of mediastinal lymph nodes.
SCIENTIFIC REPORTS
(2021)
Review
Gastroenterology & Hepatology
Shunji Fujimori, Ryohei Hamakubo, Aitoshi Hoshimoto, Takayoshi Nishimoto, Jun Omori, Naohiko Akimoto, Shu Tanaka, Atsushi Tatsuguchi, Katsuhiko Iwakiri
Summary: The frequency of primary small intestinal adenocarcinoma is low, and it mainly occurs in the proximal small intestine. Dietary factors and the influence of intestinal content may contribute to its carcinogenesis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yoshihiko Fukukura, Yuichi Kumagae, Yosuke Fujisaki, Ryoji Yamagishi, Shinya Nakamura, Junki Kamizono, Masanori Nakajo, Kiyohisa Kamimura, Hiroaki Nagano, Koji Takumi, Takashi Yoshiura
Summary: The addition of a delayed phase to pancreatic and portal venous phase CT increases sensitivity for small PDAC without loss of specificity, partly related to delayed phase hyperattenuation of some small PDACs showing pancreatic phase isoattenuation.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Endocrinology & Metabolism
Daniel B. Martinez-Arguelles, Jennifer W. Nedow, Hovhannes J. Gukasyan, Vassilios Papadopoulos
Summary: Cholesterol is the rate-limiting step of steroidogenesis, and its entry into mitochondria is controlled by Voltage-dependent anion channel (VDAC1). This study presents the development of a new class of small molecules that increase testosterone levels specifically by targeting VDAC1. The study involves the identification of a biologically active core peptide and the design of synthetic derivatives that can be administered orally. Several active compounds were identified, and dose-response experiments narrowed down to 4 synthetic peptides that significantly increased androgen levels.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ping Yan, Ning-Ya Zhang, Xiao-Qin Luo, Mei Wang, Ying-Hao Deng, Ting Wu, Xi Wu, Qian Liu, Hong-Shen Wang, Lin Wang, Yi-Xin Kang, Shao-Bin Duan
Summary: This study evaluated the effects of intravenous iodinated contrast medium (ICM) on AKI patients and found that its administration during AKI duration did not increase the risks of renal function deterioration, new RRT induction, and mortality within 7 and 30 days after CT scan.
EUROPEAN RADIOLOGY
(2022)
Review
Surgery
Kyle D. D. Klingbeil, James X. X. Wu, Antonia Osuna-Garcia, Edward H. H. Livingston
Summary: Water-soluble contrast (WSC) may decrease hospital length of stay in nonoperative adhesive small bowel obstruction (SBO) patients, but the current literature is heterogeneous with varied quality. High-quality randomized controlled trials are needed to determine the full benefit of WSC in SBO management.
Article
Biochemistry & Molecular Biology
Jan Homolak, Ana Babic Perhoc, Ana Knezovic, Jelena Osmanovic Barilar, Davor Virag, Mihovil Joja, Melita Salkovic-Petrisic
Summary: This study investigated the acute time-response of intestinal redox homeostasis following oral administration of d-galactose. The results showed that acute oral administration of d-galactose increased the activity of antioxidative enzymes and decreased lipid peroxidation in the intestine, suggesting the activation of defense mechanisms against oxidative damage. The small intestine demonstrated a tolerance to high concentrations of galactose, and oral galactose treatment was associated with a reduction in intestinal oxidative stress.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hila Tal Tamir, Dana Stav, Yitzhac Hadad, Rivka Kessner
Summary: This study aimed to characterize thyroid nodules seen on Spectral Detector computed tomography (SDCT) and compare them with their Thyroid Imaging Reporting and Data System (TI-RADS) category on Ultrasound (US). The results showed that the spectral results of SDCT can assist in differentiating thyroid nodules of different risk levels.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Volha Nizhnikava, Ursula Reiter, Gabor Kovacs, Clemens Reiter, Corina Kraeuter, Horst Olschewski, Michael Fuchsjaeger, Gert Reiter
Summary: The purpose of this study was to investigate the associations between cardiac magnetic resonance feature-tracking-derived myocardial strain parameters and volumetric function and hemodynamic parameters in patients with pulmonary hypertension. The results showed that impairment of myocardial strains was more strongly associated with alterations in ventricular function parameters than elevated pulmonary arterial pressure, limiting the diagnostic information of myocardial strain parameters in pulmonary hypertension.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-ling Qian, Rui-lin Quan, Xiao-xi Chen, Yang-yi Lin, Xiao-li Jing, Qing Gu, Chang-ming Xiong, Jian-guo He, Ai-hua Zhi
Summary: The purpose of this study was to investigate the imaging characteristics and prognostic factors for the long-term survival of Behcet's disease (BD) with arterial involvement. The results showed that arterial lesions associated with BD usually involve multiple arteries and manifest differently in different types of arteries. Cardiac involvement and pulmonary artery aneurysm/dilation were independent prognostic factors for the survival of BD patients with arterial involvement.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Yong Xie, Jian Wang, Yinghua Zou
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daria Kifjak, Maximilian Hochmair, Daniel Sobotka, Alexander R. Haug, Raphael Ambros, Florian Prayer, Benedikt H. Heidinger, Sebastian Roehrich, Ruxandra-Iulia Milos, Wolfgang Wadsak, Thorsten Fuereder, Dagmar Krenbek, Andreas Fazekas, Michael Meilinger, Marius E. Mayerhoefer, Georg Langs, Christian Herold, Helmut Prosch, Lucian Beer
Summary: The ability of pretreatment PET parameters and peripheral blood biomarkers to predict PFS and OS in NSCLC patients treated with ICIT was assessed. The study found that MTV and the number of SOI were independent risk factors for progression and overall survival, and the combination of these factors improved risk stratification.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Theresa Sophie Patzer, Jan-Peter Grunz, Henner Huflage, Jan-Lucca Hennes, Pauline Pannenbecker, Philipp Gruschwitz, Saif Afat, Judith Herrmann, Thorsten Alexander Bley, Andreas Steven Kunz
Summary: This study investigated the potential of tin prefiltration and virtual monoenergetic imaging (VMI) in suppressing metal artifacts in high-resolution CT images of the lower extremities. The results showed that VMI reconstructions had better artifact reduction compared to T3D. VMI110keV had the least image noise. In terms of image quality, interpretability of bone-metal interface, and overall image quality, VMI110keV performed the best.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yue Li, Huan Zhang, Lei Yue, Caixia Fu, Robert Grimm, Wenhua Li, Weijian Guo, Tong Tong
Summary: This study evaluated and compared the diagnostic value of diffusion-related texture analysis parameters from different magnetic resonance diffusion models in predicting the clinical response to chemotherapy in patients with colorectal liver metastases. Among the models, DKI-derived parameters showed the best performance for early prediction, followed by IVIM-derived parameters and DWI baseline features.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lu Wang, ShiXiong Zhang, Jun Xin
Summary: This study aimed to determine if sex differences in abdominal visceral fat composition and metabolism can help predict the prognosis of DLBCL patients. The results showed that females with certain fat composition and metabolism characteristics had worse progression-free survival, while no significant differences were found in males with DLBCL.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-ping Wu, Lan Wu, Jing Ou, Jin-ming Cao, Mao-yong Fu, Tian-wu Chen, Erika Ouchi, Jiani Hu
Summary: This study aimed to develop CT radiomics models to preoperatively identify lymph node (LN) status in resectable esophageal squamous cell carcinoma (ESCC) patients. The results showed that the combined model, integrating ESCC and LN radiomics features with clinical features, had the highest predictive ability among the three models. The combined model's predictive ability was validated in both the test and external validation cohorts.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)