Article
Gastroenterology & Hepatology
Yingfan Mao, Jincheng Wang, Yong Zhu, Jun Chen, Liang Mao, Weiwei Kong, Yudong Qiu, Xiaoyan Wu, Yue Guan, Jian He
Summary: The study developed preoperative models based on Gd-EOB-DTPA-enhanced MRI radiomics to predict histological grade of HCC, and compared the performance between artificial neural network (ANN) and logistic regression model. Results showed that ANN was superior to logistic regression model in predicting histological grade of HCC, with the prediction models able to distinguish between high-grade and low-grade HCCs effectively.
HEPATOBILIARY SURGERY AND NUTRITION
(2022)
Article
Medicine, General & Internal
Valentina Brancato, Nunzia Garbino, Marco Salvatore, Carlo Cavaliere
Summary: The study aims to develop an MRI-based radiomics approach for the early detection and histological grade prediction of HCC. By extracting radiomic features from T2 images and DCE-MRI, predictive models were constructed and promising results were achieved. Radiomics MRI based on T2 and DCE-MRI may serve as a suitable tool for personalized treatment of HCC patients and the development of new prognostic biomarkers.
Review
Radiology, Nuclear Medicine & Medical Imaging
Meicheng Chen, Xiaoqi Zhou, Huasong Cai, Di Li, Chenyu Song, Huayu You, Ruixia Ma, Zhi Dong, Zhenpeng Peng, Shi-Ting Feng
Summary: This review aims to evaluate the feasibility of MRI methods in assessing tumor hypoxia in hepatocellular carcinoma (HCC). Various methods, such as oxygen electrodes, protein markers, optical imaging, and positron emission tomography, are limited in clinical applicability due to invasiveness, tissue depth, and radiation exposure. MRI methods, including blood oxygenation level-dependent, dynamic contrast-enhanced MRI, diffusion-weighted imaging, MRI spectroscopy, chemical exchange saturation transfer MRI, and multinuclear MRI, are promising noninvasive alternatives that can evaluate the hypoxic microenvironment by observing biochemical processes in vivo. However, further validation and improvement of current quantitative MRI methods are necessary for clinical translation.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Medicine, Research & Experimental
Wei-Hang Zhu, Jie Chen, Run-Kai Huang, Yuan Zhang, Ze-Xuan Huang, Xiu-Qing Pang, Bo Hu, Yang Yang, Xing Li
Summary: CD45(+)EPCs play a role in promoting portal vein tumor thrombus (PVTT) formation in HCC by differentiating into erythroid-transdifferentiated myeloid cells (EDMCs) induced by HCC macrophages, which migrate from the circulation to the tumor microenvironment.
Article
Medicine, General & Internal
Guodong Pang, Chunchun Shao, Yao Lv, Fang Zhao
Summary: The study found that perfusion parameters obtained from traditional tri-phasic CT scans cannot accurately predict the histological grading of HCC. However, tumor attenuation values on different phases and the differences in attenuation values among different phases may be useful in predicting the degree of HCC differentiation non-invasively.
Review
Biology
Guoteng Qiu, Kunlin Xie, Zhaoxing Jin, Chuang Jiang, Hu Liu, Haifeng Wan, Jiwei Huang
Summary: Portal vein tumor thrombus (PVTT) is a common complication of hepatocellular carcinoma (HCC) indicating a poor prognosis. Monotherapy is ineffective for HCC-PVTT patients with high recurrence rates. Multidisciplinary management offers hope for improved survival benefits through accurate diagnosis, staging, and implementation of various treatment protocols in the absence of universal guidelines.
Article
Oncology
Cuiyun Wu, Xingyue Du, Yang Zhang, Li Zhu, Junfa Chen, Yuan Chen, Yuguo Wei, Yang Liu
Summary: The study aimed to compare the efficacy of radiomics models in predicting the histological grade of HCC before surgery using five machine learning algorithms, and to develop the most stable model to classify high-risk HCC patients. Contrast-enhanced CT images of 175 HCC patients were analyzed, and radiomics features were extracted. The RF-based radiomics model was found to be the most stable and performed excellently in identifying high histological grade of HCC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Weiwei Zhai, Hannah Lai, Neslihan Arife Kaya, Jianbin Chen, Hechuan Yang, Bingxin Lu, Jia Qi Lim, Siming Ma, Sin Chi Chew, Khi Pin Chua, Jacob Josiah Santiago Alvarez, Pauline Jieqi Chen, Mei Mei Chang, Lingyan Wu, Brian K. P. Goh, Alexander Yaw-Fui Chung, Chung Yip Chan, Peng Chung Cheow, Ser Yee Lee, Juinn Huar Kam, Alfred Wei-Chieh Kow, Iyer Shridhar Ganpathi, Rawisak Chanwat, Jidapa Thammasiri, Boon Koon Yoong, Diana Bee-Lan Ong, Vanessa H. de Villa, Rouchelle D. Dela Cruz, Tracy Jiezhen Loh, Wei Keat Wan, Zeng Zeng, Anders Jacobsen Skanderup, Yin Huei Pang, Krishnakumar Madhavan, Tony Kiat-Hon Lim, Glenn Bonney, Wei Qiang Leow, Valerie Chew, Yock Young Dan, Wai Leong Tam, Han Chong Toh, Roger Sik-Yin Foo, Pierce Kah-Hoe Chow
Summary: This study investigated intra-tumor heterogeneity in hepatocellular carcinoma (HCC) using a large prospective surgical cohort. The results showed that phenotypic heterogeneity had a different trajectory across stages and diversified rapidly in some patients. Interestingly, phenotypic heterogeneity was found to be more informative in predicting patient survival than genomic heterogeneity, highlighting the importance of studying phenotypic evolution in cancer types.
NATIONAL SCIENCE REVIEW
(2022)
Review
Oncology
Fangzhou Luo, Mengxia Li, Jun Ding, Shusen Zheng
Summary: HCC with PVTT remains a challenging healthcare issue worldwide with no global consensus or standard guidelines for its management. In western countries, Sorafenib and Lenvatinib are recommended as first-line treatment options, but more aggressive approaches such as transarterial chemoembolization and radiotherapy have shown promise in improving prognosis and extending survival time for patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Shohei Komatsu, Masahiro Kido, Kaori Kuramitsu, Daisuke Tsugawa, Hidetoshi Gon, Kenji Fukushima, Takeshi Urade, Hiroaki Yanagimoto, Hirochika Toyama, Takumi Fukumoto
Summary: This study evaluated the impact of hepatectomy on HCC with macroscopic PVTT in 100 patients. The presence of Vp3/4 PVTT had a significant impact on survival, with hepatectomy being considered an effective treatment option.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yingqiang Zhang, Hongfei Miao, Wenlin Xie, Suxiang Jiang, Ze Song, Guihua Huang, Wenzhe Fan, Yu Wang, Jiaping Li, Yong Chen
Summary: This study identified clinical factors associated with overall survival in patients with hepatocellular carcinoma and portal vein tumor thrombus undergoing sorafenib plus transarterial chemoembolization. A prognostic score system was developed based on these factors, which accurately stratified patients into favorable, intermediate, and dismal groups with different survival outcomes. External validation confirmed the effectiveness of the prognostic scores in predicting patient outcomes.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhenkang Qiu, Chunpeng Yu, Xiaofei Qiu, Qun Li, Jian Li, Zhao Chen, Shuai Chang, Shuo Zhang, Gang Fan, Song Wang
Summary: This study evaluated the safety and efficacy of I-125 brachytherapy for treating PVTT in HCC patients. The results showed that this treatment is effective in controlling tumors with no severe adverse events. Patients younger than 60 years old with type I+II PVTT and a tumor diameter less than 5 cm have a better overall survival.
ACADEMIC RADIOLOGY
(2023)
Review
Oncology
Min Zhang, Qiuhui Ding, Chenbin Bian, Jing Su, Ying Xin, Xin Jiang
Summary: Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis and high mortality. Portal vein tumor thrombus (PVTT) is a frequent complication and poor prognostic factor for HCC. The formation of PVTT is related to the complex structure and hemodynamic changes of the portal vein, as well as cellular and molecular changes. Understanding the mechanisms of PVTT formation is crucial for better prevention and treatment strategies.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Moon Haeng, Yuri Chao, Do Young Kim, Jae Seung Lee, Gyoung Min Kim, Hyo-Cheol Kim, Dong Hyun Sinn, Dongho Hyun, Han Ah Lee, Yeon Seok Seo, In Joon Lee, Joong-Won Park, Yoon Jun Kim
Summary: This study compared the outcomes of transarterial radioembolization (TARE) and tyrosine kinase inhibitor (TKI) therapy in treatment-naive patients with advanced hepatocellular carcinoma (HCC) and portal vein tumor thrombosis (PVTT). The results showed that TARE provided superior overall survival (OS) compared to TKI in patients with locally advanced HCC and segmental or lobar PVTT. The study also found a trend of prolonged progression-free survival (PFS) in the TARE group.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Zhu-Jian Deng, Le Li, Yu-Xian Teng, Yu-Qi Zhang, Yu-Xin Zhang, Hao-Tian Liu, Jian-Li Huang, Zhen-Xiu Liu, Liang Ma, Jian-Hong Zhong
Summary: The proportions of HCC patients with PVTT vary greatly in different countries or regions, and the treatment regimens recommended also differ. In recent years, advancements in surgical concepts, radiotherapy techniques, and systematic therapies have provided more treatment options and improved prognoses for HCC patients with PVTT.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hila Tal Tamir, Dana Stav, Yitzhac Hadad, Rivka Kessner
Summary: This study aimed to characterize thyroid nodules seen on Spectral Detector computed tomography (SDCT) and compare them with their Thyroid Imaging Reporting and Data System (TI-RADS) category on Ultrasound (US). The results showed that the spectral results of SDCT can assist in differentiating thyroid nodules of different risk levels.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Volha Nizhnikava, Ursula Reiter, Gabor Kovacs, Clemens Reiter, Corina Kraeuter, Horst Olschewski, Michael Fuchsjaeger, Gert Reiter
Summary: The purpose of this study was to investigate the associations between cardiac magnetic resonance feature-tracking-derived myocardial strain parameters and volumetric function and hemodynamic parameters in patients with pulmonary hypertension. The results showed that impairment of myocardial strains was more strongly associated with alterations in ventricular function parameters than elevated pulmonary arterial pressure, limiting the diagnostic information of myocardial strain parameters in pulmonary hypertension.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-ling Qian, Rui-lin Quan, Xiao-xi Chen, Yang-yi Lin, Xiao-li Jing, Qing Gu, Chang-ming Xiong, Jian-guo He, Ai-hua Zhi
Summary: The purpose of this study was to investigate the imaging characteristics and prognostic factors for the long-term survival of Behcet's disease (BD) with arterial involvement. The results showed that arterial lesions associated with BD usually involve multiple arteries and manifest differently in different types of arteries. Cardiac involvement and pulmonary artery aneurysm/dilation were independent prognostic factors for the survival of BD patients with arterial involvement.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Yong Xie, Jian Wang, Yinghua Zou
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daria Kifjak, Maximilian Hochmair, Daniel Sobotka, Alexander R. Haug, Raphael Ambros, Florian Prayer, Benedikt H. Heidinger, Sebastian Roehrich, Ruxandra-Iulia Milos, Wolfgang Wadsak, Thorsten Fuereder, Dagmar Krenbek, Andreas Fazekas, Michael Meilinger, Marius E. Mayerhoefer, Georg Langs, Christian Herold, Helmut Prosch, Lucian Beer
Summary: The ability of pretreatment PET parameters and peripheral blood biomarkers to predict PFS and OS in NSCLC patients treated with ICIT was assessed. The study found that MTV and the number of SOI were independent risk factors for progression and overall survival, and the combination of these factors improved risk stratification.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Theresa Sophie Patzer, Jan-Peter Grunz, Henner Huflage, Jan-Lucca Hennes, Pauline Pannenbecker, Philipp Gruschwitz, Saif Afat, Judith Herrmann, Thorsten Alexander Bley, Andreas Steven Kunz
Summary: This study investigated the potential of tin prefiltration and virtual monoenergetic imaging (VMI) in suppressing metal artifacts in high-resolution CT images of the lower extremities. The results showed that VMI reconstructions had better artifact reduction compared to T3D. VMI110keV had the least image noise. In terms of image quality, interpretability of bone-metal interface, and overall image quality, VMI110keV performed the best.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yue Li, Huan Zhang, Lei Yue, Caixia Fu, Robert Grimm, Wenhua Li, Weijian Guo, Tong Tong
Summary: This study evaluated and compared the diagnostic value of diffusion-related texture analysis parameters from different magnetic resonance diffusion models in predicting the clinical response to chemotherapy in patients with colorectal liver metastases. Among the models, DKI-derived parameters showed the best performance for early prediction, followed by IVIM-derived parameters and DWI baseline features.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lu Wang, ShiXiong Zhang, Jun Xin
Summary: This study aimed to determine if sex differences in abdominal visceral fat composition and metabolism can help predict the prognosis of DLBCL patients. The results showed that females with certain fat composition and metabolism characteristics had worse progression-free survival, while no significant differences were found in males with DLBCL.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-ping Wu, Lan Wu, Jing Ou, Jin-ming Cao, Mao-yong Fu, Tian-wu Chen, Erika Ouchi, Jiani Hu
Summary: This study aimed to develop CT radiomics models to preoperatively identify lymph node (LN) status in resectable esophageal squamous cell carcinoma (ESCC) patients. The results showed that the combined model, integrating ESCC and LN radiomics features with clinical features, had the highest predictive ability among the three models. The combined model's predictive ability was validated in both the test and external validation cohorts.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
