Article
Multidisciplinary Sciences
Caner Caglar, Jeffrey Friedman
Summary: Activation of PPP1R17 neurons in Leptin-deficient mice does not increase food intake as hypothesized, but instead decreases it, suggesting these neurons play a role in limiting overconsumption. The neurons in the DMH expressing PPP1R17 are indirectly affected by Leptin and serve to constrain binge eating behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Isin Cakir, Pauline Lining Pan, Colleen K. Hadley, Abdulrahman El-Gamal, Amina Fadel, Dina Elsayegh, Omnia Mohamed, Nasser M. Rizk, Masoud Ghamari-Langroudi
Summary: The rising prevalence of obesity has led to increased morbidity and mortality rates, as well as higher healthcare costs and decreased quality of life. This study demonstrates that the natural compound sulforaphane can reverse diet-induced obesity by activating the transcription factor NRF2, which plays a critical role in inflammation resolution. The antiobesity effect of sulforaphane relies on functional leptin receptor signaling and hyperleptinemia. Furthermore, the skeletal muscle appears to be the primary site of action for sulforaphane, as it alleviates leptin resistance through peripheral NRF2 signaling. Overall, the findings suggest that sulforaphane could be clinically evaluated for weight loss and obesity-related metabolic disorders.
Article
Nutrition & Dietetics
Nicole Fearnbach, Amanda E. Staiano, Neil M. Johannsen, Daniel S. Hsia, Robbie A. Beyl, Owen T. Carmichael, Corby K. Martin
Summary: Exercise may impact energy intake in adolescents by influencing appetite states rather than traits. Additionally, baseline energy intake after exercise is associated with weight change over time, indicating that appetitive cues play a significant role in post-exercise energy intake.
Article
Biochemistry & Molecular Biology
Maria Vittoria Micioni Di Bonaventura, Maria Magdalena Coman, Daniele Tomassoni, Emanuela Micioni Di Bonaventura, Luca Botticelli, Maria Gabriella Gabrielli, Gian Maria Rossolini, Vincenzo Di Pilato, Cinzia Cecchini, Amedeo Amedei, Stefania Silvi, Maria Cristina Verdenelli, Carlo Cifani
Summary: The study found that L. plantarum IMC 510 has beneficial effects on reducing food intake, weight gain, improving body mass index, liver and white adipose tissue weight in a rat model of diet-induced obesity, potentially through leptin control. Additionally, this probiotic has beneficial effects on gut microbiota by limiting microbial imbalance and preserving the proportion of different bacterial taxa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Alyssa Weber, Kyle D. Medak, Logan K. Townsend, David C. Wright
Summary: Ketogenic diets can effectively reduce food intake, increase energy expenditure, promote weight loss, and improve glucose homeostasis. However, the effects of ketogenic diets are not influenced by housing temperature. The weight changes when transitioning from an obesogenic to a ketogenic diet or vice versa are largely dependent on food intake, rather than the housing temperature.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Microbiology
Carmen P. Ortega-Santos, Layla Al-Nakkash, Corrie M. Whisner
Summary: This study aimed to investigate the effects of genistein, exercise, and their combined effect on gut microbiota changes and obesity. The results showed that exercise and genistein could reduce weight gain and gut microbiota richness, but switching from a high-fat, high-sugar diet to chow had the greatest potential to revert these characteristics.
Article
Nutrition & Dietetics
Otilia Perichart-Perera, Jennifer Mier-Cabrera, Claudia Montserrat Flores-Robles, Nayeli Martinez-Cruz, Lidia Arce-Sanchez, Itzel Nallely Alvarado-Maldonado, Araceli Montoya-Estrada, Jose Romo-Yanez, Ameyalli Mariana Rodriguez-Cano, Guadalupe Estrada-Gutierrez, Salvador Sosa, Mario Guzman-Huerta, Rodrigo Ayala-Yanez, Enrique Reyes-Munoz
Summary: The addition of metformin to intensive medical nutrition therapy does not provide any benefit in preventing gestational diabetes mellitus among high-risk Mexican women.
Article
Endocrinology & Metabolism
Shan Luo, Brendan C. Angelo, Ting Chow, John R. Monterosso, Paul M. Thompson, Anny H. Xiang, Kathleen A. Page
Summary: Children exposed to gestational diabetes mellitus (GDM) or maternal obesity in utero have increased propensity to develop obesity, affecting daily energy intake, brain responses to food cues within reward regions, and adiposity.
Article
Chemistry, Analytical
Ryong Sung, Yun Seok Heo
Summary: Leptin, a peptide hormone produced in adipose tissues, is considered a biomarker for obesity-related diseases. An electrochemical biosensor was introduced in this study to detect leptin in mouse blood, showing high stability, sensitivity, and selectivity. The biosensor could potentially serve as a sensitive analytical tool for detecting biomarkers in clinical settings and point-of-care testing.
Article
Endocrinology & Metabolism
Mengyang Tang, Yi Zhang, Rong Zhang, Yuemei Zhang, Jiangfei Zheng, Daixi Wang, Xinyu Wang, Jing Yan, Cheng Hu
Summary: This study aimed to explore the role of GPSM1 in POMC neurons and the underlying mechanisms in metabolic homeostasis. Through various molecular, biochemical, immunofluorescent, immunohistochemical analyses, and cell culture studies, the study revealed the pathophysiological role of GPSM1 in POMC neurons and its regulation of POMC neuron activity.
MOLECULAR METABOLISM
(2024)
Article
Pharmacology & Pharmacy
Yaoli Liu, Xiazhou Fu, Zhiyong Chen, Tingting Luo, Chunxia Zhu, Yaoting Ji, Zhuan Bian
Summary: Sulforaphane (SFN) shows potential as a nutritional factor in combating obesity by promoting the browning of white fat, which decreases fat mass, improves glucose metabolism, and enhances insulin sensitivity. This suggests that SFN could serve as a potential medicine in anti-obesity and related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nina A. Wilson, Anthony Villani, Sze-Yen Tan, Evangeline Mantzioris
Summary: This observational study examined the changes in body weight, eating behaviors, physical activity, and basal metabolic rate among first-year university students. The results showed that female students are at risk of unfavorable changes in body composition, while male students are more prone to sedentary behaviors. Intervention measures targeting high intakes of saturated fat, sugars, and sodium are warranted in this vulnerable group.
Article
Endocrinology & Metabolism
Jessie Nallely Zurita-Cruz, Miguel Angel Villasis-Keever, Leticia Manuel-Apolinar, Leticia Damasio-Santana, Eulalia Garrido-Magana, Aleida de Jesus Rivera-Hernandez
Summary: In girls with central precocious puberty (CPP) undergoing GnRH analogs treatment, leptin levels and higher leptin/adiponectin ratio (LAR) are associated with greater weight gain. This association is particularly evident in girls with BMI < 94th percentile.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Margriet Bijlholt, Lieveke Ameye, Hanne Van Uytsel, Roland Devlieger, Annick Bogaerts
Summary: This study evaluated the impact of the postpartum phase of the INTER-ACT randomized controlled trial on food intake, eating behavior, physical activity, and sedentary time. The intervention led to improvements in nutrition-related outcomes, but these improvements were not sustained at follow-up.
Article
Medicine, Research & Experimental
Vaishali Jayashankar, Elizabeth Selwan, Sarah E. Hancock, Amandine Verlande, Maggie O. Goodson, Kazumi H. Eckenstein, Giedre Milinkeviciute, Brianna M. Hoover, Bin Chen, Angela G. Fleischman, Karina S. Cramer, Stephen Hanessian, Selma Masri, Nigel Turner, Aimee L. Edinger
Summary: Compounds targeting mitochondrial dynamics are ineffective at blocking ceramide-induced fission, while targeting endolysosomal trafficking events can rapidly and effectively prevent disruptions in mitochondrial form and function caused by ceramide.
EMBO MOLECULAR MEDICINE
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
L. Segar, P. Pichavaram, N. Shawky, J. Jun
Article
Biochemistry & Molecular Biology
Noha M. Shawky, Prahalathan Pichavaram, George S. G. Shehatou, Ghada M. Suddek, Nariman M. Gameil, John Y. Jun, Lakshman Segar
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2016)
Article
Pharmacology & Pharmacy
Arwa Fairaq, Noha M. Shawky, Islam Osman, Prahalathan Pichavaram, Lakshman Segar
PHARMACOLOGICAL RESEARCH
(2017)
Article
Pharmacology & Pharmacy
Noha M. Shawky, Lakshman Segar
PHARMACOLOGICAL RESEARCH
(2017)
Article
Pharmacology & Pharmacy
Noha M. Shawky, George S. G. Shehatou, Mona Abdel Rahim, Ghada M. Suddek, Nariman M. Gameil
EUROPEAN JOURNAL OF PHARMACOLOGY
(2014)
Article
Immunology
El-Sayed M. Ammar, Nariman M. Gameil, Noha M. Shawky, Manar A. Nader
INTERNATIONAL IMMUNOPHARMACOLOGY
(2011)
Article
Pharmacology & Pharmacy
Mukund P. Srinivasan, Noha M. Shawky, Bhupendra S. Kaphalia, Muthusamy Thangaraju, Lakshman Segar
BIOCHEMICAL PHARMACOLOGY
(2019)
Article
Environmental Sciences
Noha M. Shawky, George S. G. Shehatou, Ghada M. Suddek, Nariman M. Gameil
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Yhiya Amen, Asmaa E. Sherif, Noha M. Shawky, Rehab S. Abdelrahman, Michael Wink, Mansour Sobeh
Article
Pharmacology & Pharmacy
Prahalathan Pichavaram, Noha M. Shawky, Thomas J. Hartney, John Y. Jun, Lakshman Segar
Summary: Imatinib, a PDGF receptor tyrosine kinase inhibitor, was found to significantly attenuate neointimal hyperplasia and improve metabolic parameters in a mouse model of high fat diet-induced insulin resistance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Peripheral Vascular Disease
Noha M. Shawky, Chetan N. Patil, Carolina Dalmasso, Rodrigo O. Maranon, Damian G. Romero, Heather Drummond, Jane F. Reckelhoff
Meeting Abstract
Peripheral Vascular Disease
Noha M. Shawky, Jane F. Reckelhoff
Meeting Abstract
Peripheral Vascular Disease
Noha M. Shawky, Ruth M. Vinson, Jane F. Reckelhoff