Article
Environmental Sciences
Dazhuang Dong, Zhi Guo, Feiyan Wu, Xue Yang, Jie Li
Summary: The extensive use of plastic along with poor management has posed a significant environmental threat, affecting entire ecosystems. This study investigates the potential effects of plastic debris on soil nutrition substance changes and microbial metabolic behavior. The results reveal that plastic films made of polyethylene and polylactic acid lead to noticeable variations in soil enzyme activities and nutrition substance levels. Additionally, certain bacteria abundance and metabolic pathways associated with nutrition substance are significantly altered in plastic-treated soil samples.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Multidisciplinary Sciences
Nhung Le, Melissa Cregger, Asgerally Fazleabas, Andrea Braundmeier-Fleming
Summary: Endometriosis leads to changes in immune and microbial dynamics, driving disease progression. Understanding these changes can lead to innovative diagnostic tools and novel therapies for endometriosis treatment.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Rudong Zhao, Mei He, Canlan Jiang, Feng Liu
Summary: This study investigated the response of soil microbial community structure and stoichiometry to long-term land-use change in forests. The results showed that soil microbial stoichiometry had strict homeostasis regardless of soil depth, and the microbial community structure was mainly driven by environmental factors at different depths.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Plant Sciences
Bin Li, Lixiang Zhao, Dongxu Liu, Yi Zhang, Wenjiao Wang, Yanxiu Miao, Lingjuan Han
Summary: This study investigated the application of Bacillus subtilis in peat-based soilless cultivation systems with different nutrient solutions to improve the growth and quality of cucumber. The results showed that higher-nutrient solutions enhanced the flavor quality of cucumber fruit by increasing the content of specific flavor substances. B. subtilis K424 effectively improved growth performance, photosynthetic capacity, and the content of beneficial compounds in cucumber. It also regulated the microbial community structure and substrate enzyme activity, which mitigated the deleterious effects of high levels of nutrition solution.
Article
Food Science & Technology
Liang Guo, Wei-Liang Xu, Chun-Dong Li, Fu-Chao Wang, Yuan-Sheng Guo, Mei Ya
Summary: Mongolian cheese is a vital food source for nomadic Mongolians, with a unique production method, high nutritional value, and long shelf-life. It has a high protein content and low fat content. The microbiota of the cheese varies depending on the factory. The shelf-life of the cheese can be extended through high-temperature kneading. Natural spore-forming microbes can cause mold growth.
FOOD SCIENCE & NUTRITION
(2023)
Article
Microbiology
Han Liu, Jing Zhao, Wenju Zhang, Cunxi Nie
Summary: This study investigated the effects of dietary supplementation with 0.2% sodium butyrate on growth performance, intestinal tissue morphology, mucosal barrier function, and gut microbiota in weaned piglets. The results showed that supplementation with 0.2% sodium butyrate can improve the growth performance of weaned piglets and enhance intestinal mucosal barrier function by altering the gut microbiota.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Agronomy
Xin-Yue Tian, Dong-Dong He, Shuang Bai, Wen-Zhi Zeng, Zheng Wang, Mo Wang, Liang-Quan Wu, Zhi-Chang Chen
Summary: Magnesium is a crucial macronutrient for plant growth, with deficiency impacting crop yield and quality as well as human and animal diets. Research has shown that magnesium plays a role in enhancing photosynthetic efficiency, nitrogen use efficiency, and stress resistance in plants, highlighting the importance of maintaining appropriate magnesium concentrations for optimal growth.
Article
Nanoscience & Nanotechnology
Wentao Fan, Shuo Zhang, Yuting Wu, Tao Lu, Jiwen Liu, Xiuyun Cao, Shuhui Liu, Liping Yan, Xizhi Shi, Guangliang Liu, Chaobo Huang, Suquan Song
Summary: GEN-NP2 effectively delivers GEN to inflammatory sites, protects it from rapid metabolism and elimination in the gastrointestinal tract, and alleviates colitis. This nanoparticle increases the expression of estrogen receptor beta (ERβ), reduces the expression of proinflammatory mediators, modulates the gut microbiota, and ultimately relieves colitis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Immunology
Jieli Chen, Jun Yao
Summary: T-helper 22 (Th22) cells are a novel subset of CD4(+) T cells that secrete IL-22 while abstaining from secreting IL-17 and IFN-?. These cells are considered as the primary source of IL-22 and are believed to contribute to maintaining intestinal mucosal homeostasis in IBD. However, the exact functions of Th22 cells and IL-22 in this context are still debated. This study aims to provide an overview of the molecular structure characteristics and functional effects of Th22 cells and IL-22, as well as explore targeted treatment approaches and potential therapeutic strategies focusing on the Th22 and IL-22 pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Yuchen Liu, Lianhong Li, Huaxiang Yan, Zhonghua Ning, Zhong Wang
Summary: The study demonstrated that supplementing L. salivarius SNK-6 can improve feed intake and disease resistance in laying hens, but may lead to changes in production performance. This immunomodulatory function is possibly achieved by regulating the cecal microbial composition.
Article
Biotechnology & Applied Microbiology
Barbara Giordani, Marina Naldi, Vanessa Croatti, Carola Parolin, Ulfet Erdogan, Manuela Bartolini, Beatrice Vitali
Summary: The exopolysaccharides (EPS) secreted by lactobacilli have been found to stimulate the formation of biofilms in lactobacilli themselves while inhibiting the formation of biofilms by opportunistic pathogens. These findings support the potential use of EPS as postbiotics in medicine for the treatment and prevention of vaginal infections.
MICROBIAL CELL FACTORIES
(2023)
Article
Biochemistry & Molecular Biology
Tal Ilani, Nava Reznik, Noa Yeshaya, Tal Feldman, Patrick Vilela, Zipora Lansky, Gabriel Javitt, Michal Shemesh, Ori Brenner, Yoav Elkis, Neta Varsano, Ana M. Jaramillo, Christopher M. Evans, Deborah Fass
Summary: Mucus is composed of mucin glycoproteins that polymerize through disulfide crosslinking in the Golgi apparatus. QSOX1, localized in the Golgi, acts as a catalyst for disulfide bond formation. Knockout mice lacking QSOX1 exhibit impaired mucus barrier function due to defective mucus production. Furthermore, QSOX1 controls the sialylation process, which is essential for maintaining mucosal function.
Article
Biochemistry & Molecular Biology
Mengting Zhan, Zhenyu Huang, Gaofeng Cheng, Yongyao Yu, Jianguo Su, Zhen Xu
Summary: This study found that infection with infectious hematopoietic necrosis virus (IHNV) affects the skin immune response and microbial composition in rainbow trout. IHNV invasion induces strong antiviral and antibacterial immune responses and leads to dysbiosis of the skin microbial community.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Wei Cheng, Huiqiang Fan, Yuan Yun, Xueqing Zhao, Zhaoying Su, Xuefeng Tian, Dakun Liu, Ting Ma, Guoqiang Li
Summary: Microbial Enhanced Oil Recovery (MEOR) is a viable option for recovering oil from depleted reservoirs. This study built a laboratory-scale microbial flooding simulation device to investigate the dynamic changes of indigenous microbial communities in the Qizhong Block, Xinjiang oil field. The results showed that nutrition is one of the factors affecting microbial communities in oil reservoirs, and the introduction of nutrients activated hydrocarbon oxidizing bacteria, facultative anaerobes, and anaerobic fermenting bacteria. Metagenomic analysis also revealed the potential functions of these microorganisms in hydrocarbon degradation, gas production, and surfactant production.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Agricultural Engineering
Shiyou Pan, Hossain M. Zabed, Zhenchong Li, Xianghui Qi, Yutuo Wei
Summary: This study establishes a strategy of balancing sugar-fiber-nitrogen nutrients for improved methane production by co-digesting banana pseudostem, sugarcane baggage, and chicken manure. The co-digestion process remains stable and provides a deeper understanding of nutrient balance.
BIORESOURCE TECHNOLOGY
(2022)
Article
Allergy
Stefanie Gilles, Cornelia Blume, Maria Wimmer, Athanasios Damialis, Laura Meulenbroek, Mehmet Goekkaya, Carolin Bergougnan, Selina Eisenbart, Nicklas Sundell, Magnus Lindh, Lars-Magnus Andersson, Aslog Dahl, Adam Chaker, Franziska Kolek, Sabrina Wagner, Avidan U. Neumann, Cezmi A. Akdis, Johan Garssen, Johan Westin, Belinda van't Land, Donna E. Davies, Claudia Traidl-Hoffmann
Article
Immunology
Berthe C. Oosterlo, Belinda van't Land, Wilco de Jager, Nicole B. Rutten, Margot Klopping, Johan Garssen, Arine M. Vlieger, Ruurd M. van Elburg
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Immunology
Marit Zuurveld, Nikita P. van Witzenburg, Johan Garssen, Gert Folkerts, Bernd Stahl, Belinda van't Land, Linette E. M. Willemsen
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Veronica Ayechu-Muruzabal, Saskia A. Overbeek, Atanaska I. Kostadinova, Bernd Stahl, Johan Garssen, Belinda van't Land, Linette E. M. Willemsen
Article
Immunology
Veronica Ayechu-Muruzabal, Ling Xiao, Tjalling Wehkamp, Ingrid van Ark, Elisabeth J. Hoogendoorn, Thea Leusink-Muis, Gert Folkerts, Johan Garssen, Linette E. M. Willemsen, Belinda Van't Land
Summary: The fermentation product from Bifidobacterium breve C50 and Streptococcus thermophilus 065 may enhance immune response by promoting Th1- and Th17-type cytokines in vitro. In vivo, dietary intervention with this product increased vaccine-specific delayed-type hypersensitivity responses, indicating a potential positive impact on adaptive immunity. Although no effects were observed on humoral immunity and specific T-cell responses, increased levels of systemic galectin-3 and galectin-4 ratios were correlated with enhanced DTH response, suggesting a shift in immune balance.
Article
Nutrition & Dietetics
Negisa Seyed Toutounchi, Saskia Braber, Astrid Hogenkamp, Soheil Varasteh, Yang Cai, Tjalling Wehkamp, Sebastian Tims, Thea Leusink-Muis, Ingrid van Ark, Selma Wiertsema, Bernd Stahl, Aletta D. Kraneveld, Johan Garssen, Gert Folkerts, Belinda van't Land
Summary: Dietary intervention with specific mixtures of trans-galactosyl-oligosaccharides (TOS) can attenuate the adverse effects of deoxynivalenol (DON) on immune responses and gut homeostasis. The use of TOS improved immune responses, restored immune cell balance, and increased SCFA concentrations in the gut.
Article
Infectious Diseases
Arthur H. van Stigt, Katrien Oude Rengerink, Kitty W. M. Bloemenkamp, Wouter de Waal, Sabine M. P. J. Prevaes, Thuy-My Le, Femke van Wijk, Maaike Nederend, Anneke H. Hellinga, Christianne S. Lammers, Gerco den Hartog, Martijn J. C. van Herwijnen, Johan Garssen, Leon M. J. Knippels, Lilly M. Verhagen, Caroline G. M. de Theije, Alejandro Lopez-Rincon, Jeanette H. W. Leusen, Belinda Van't Land, Louis Bont
Summary: The PRIMA cohort aims to identify novel functions of components in human milk that are protective against respiratory tract infections and allergic diseases early in life through an observational, prospective, and multi-center birth study. It will provide new insights into immunomodulatory components in human milk by collecting and analyzing human milk samples in relation to clinical data.
BMC INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Francesca A. Ververs, Suzanne E. Engelen, Roos Nuboer, Bas Vastert, Cornelis K. van der Ent, Belinda van't Land, Johan Garssen, Claudia Monaco, Marianne Boes, Henk S. Schipper
Summary: This study investigated iNKT cell function in adolescents with chronic diseases and immunometabolic abnormalities, finding that obese adolescents had a Th1-skewed iNKT cell cytokine response possibly influenced by circulating immunometabolic factors such as lipoproteins.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Negisa Seyed Toutounchi, Saskia Braber, Belinda Van't Land, Suzan Thijssen, Johan Garssen, Aletta D. Kraneveld, Gert Folkerts, Astrid Hogenkamp
Summary: The study found that perinatal exposure to DON can negatively impact immune development in offspring, leading to enhanced allergic immune response to food allergens in female offspring and decreased immune response to influenza vaccine in male offspring. This suggests that maternal exposure to DON during pregnancy and lactation may have lasting effects on the immune system of offspring.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Veronica Ayechu-Muruzabal, Melanie van de Kaa, Reshmi Mukherjee, Johan Garssen, Bernd Stahl, Roland J. Pieters, Belinda van't Land, Aletta D. Kraneveld, Linette E. M. Willemsen
Summary: Prebiotic galacto-oligosaccharides (GOS) can support mucosal immune development by enhancing regulatory-type Th1 immune polarization and the secretion of epithelial-derived galectin. Among them, DP3-sized beta-3'galactosyllactose (beta-3'GL) showed the most effective immunomodulatory capacity.
Article
Biochemistry & Molecular Biology
Veronica Ayechu-Muruzabal, Bente Poelmann, Alinda J. Berends, Nienke Kettelarij, Johan Garssen, Belinda van't Land, Linette E. M. Willemsen
Summary: This study explores the protective capacity of bioactive components in human milk against viral infections in early life, specifically in the prevention of enteric viral infections. The effects of 2'FL, abundantly present in human milk, on intestinal epithelial cells (IEC) and innate immune cells were studied, shedding light on mucosal host-defense mechanisms upon viral triggers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Marit Zuurveld, Pien C. J. Kiliaan, Sophie E. L. van Grinsven, Gert Folkerts, Johan Garssen, Belinda van't Land, Linette E. M. Willemsen
Summary: The study reveals that food allergens activate intestinal epithelial cells, leading to mucosal immune responses. Human milk oligosaccharides can modulate the allergic phenotype by shaping immune cell development and responses.
JOURNAL OF INNATE IMMUNITY
(2023)
Article
Reproductive Biology
Negisa Seyed Toutounchi, Saskia Braber, Belinda van't Land, Suzan Thijssen, Johan Garssen, Gert Folkerts, Astrid Hogenkamp
Summary: Exposure to the food contaminant Deoxynivalenol (DON) during pregnancy can negatively affect the placental barrier, immune function, and fetal survival. This study highlights the importance of maternal diet quality during pregnancy in order to minimize the harmful effects of commonly present food contaminants.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Immunology
Marit Zuurveld, Pien C. J. Kiliaan, Sophie E. L. van Grinsven, Gert Folkerts, Johan Garssen, Belinda van't Land, Linette E. M. Willemsen
Summary: This study investigates the development of mucosal immunity after allergen exposure and demonstrates the role of human milk oligosaccharides in shaping the immune response to alleviate allergic symptoms.
JOURNAL OF INNATE IMMUNITY
(2022)
Meeting Abstract
Allergy
Seyed N. Toutounchi, S. Braber, B. Van't Land, S. Thijssen, J. Garssen, A. D. Kraneveld, G. Folkerts, A. Hogenkamp
