Emodin inhibits lipid accumulation and inflammation in adipose tissue of high‐fat diet‐fed mice by inducing M2 polarization of adipose tissue macrophages

Adipose tissue macrophages as a therapeutic target in obesity‐associated diseases

(2021) Andrés A. Herrada et al.   Obesity Reviews

Adipose tissue macrophages: Unique polarization and bioenergetics in obesity

(2020) Heather L. Caslin et al.   IMMUNOLOGICAL REVIEWS

Radix Polygoni Multiflori and Its Main Component Emodin Attenuate Non-Alcoholic Fatty Liver Disease in Zebrafish by Regulation of AMPK Signaling Pathway

(2020) Linyuan Yu et al.   Drug Design Development and Therapy

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

Emodin Alleviates the Airway Inflammation of Cough Variant Asthma in Mice by Regulating the Notch Pathway

(2019) Shu Hua et al.   MEDICAL SCIENCE MONITOR

TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding

(2019) Can Liu et al.   Journal of Translational Medicine

Anticancer activity of emodin is associated with downregulation of CD155

(2019) Liang Fang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Emodin alleviates alternatively activated macrophage and asthmatic airway inflammation in a murine asthma model

(2018) Yun-duan Song et al.   ACTA PHARMACOLOGICA SINICA

Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine AtherosclerosisNovelty and Significance

(2018) Clément Cochain et al.   CIRCULATION RESEARCH

Emodin attenuates cell injury and inflammation in pancreatic acinar AR42J cells

(2017) Jia-Yu Zhao et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

TREM2-Ligand Interactions in Health and Disease

(2017) Daniel L. Kober et al.   JOURNAL OF MOLECULAR BIOLOGY

TREM-1 associated macrophage polarization plays a significant role in inducing insulin resistance in obese population

(2017) Saravanan Subramanian et al.   Journal of Translational Medicine

Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia

(2017) Xiaobao Zhang et al.   MEDIATORS OF INFLAMMATION

Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?

(2016) M. Bluher   CLINICAL SCIENCE

Emodin improves lipid and glucose metabolism in high fat diet-induced obese mice through regulating SREBP pathway

(2016) Jinmei Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Emodin Bidirectionally Modulates Macrophage Polarization and Epigenetically Regulates Macrophage Memory

(2016) Stephen Iwanowycz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emodin Inhibits Breast Cancer Growth by Blocking the Tumor-Promoting Feedforward Loop between Cancer Cells and Macrophages

(2016) S. Iwanowycz et al.   MOLECULAR CANCER THERAPEUTICS

Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages

(2015) Yi Zhou et al.   Cell Metabolism

Emodin Protects Against Concanavalin A-Induced Hepatitis in Mice Through Inhibiting Activation of the p38 MAPK-NF-κB Signaling Pathway

(2015) Jihua Xue et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Anti-Inflammatory Effect of Emodin via Attenuation of NLRP3 Inflammasome Activation

(2015) Ji-Won Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Emodin suppresses pulmonary metastasis of breast cancer accompanied with decreased macrophage recruitment and M2 polarization in the lungs

(2014) Xuemei Jia et al.   BREAST CANCER RESEARCH AND TREATMENT

Inflammation and macrophage modulation in adipose tissues

(2014) Victoria J. Vieira-Potter   CELLULAR MICROBIOLOGY

Emodin attenuates systemic and liver inflammation in hyperlipidemic mice administrated with lipopolysaccharides

(2014) Xuemei Jia et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis

(2014) Marco Genua et al.   Journal of Translational Medicine

Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer

(2013) Deepti Shrimali et al.   CANCER LETTERS

Local proliferation of macrophages in adipose tissue during obesity-induced inflammation

(2013) Julia Haase et al.   DIABETOLOGIA

Emodin inhibits ATP-induced IL-1β secretion, ROS production and phagocytosis attenuation in rat peritoneal macrophages via antagonizing P2X7receptor

(2013) Shuyan Zhu et al.   PHARMACEUTICAL BIOLOGY

Emodin, an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in ob/ob mice

(2012) Yue-jing Wang et al.   ACTA PHARMACOLOGICA SINICA

Promotion of adiponectin multimerization by emodin: A novel AMPK activator with PPARγ-agonist activity

(2012) Zhifen Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Emodin Protects against High-Fat Diet-Induced Obesity via Regulation of AMP-Activated Protein Kinase Pathways in White Adipose Tissue

(2012) Thing-Fong Tzeng et al.   PLANTA MEDICA

Emodin Prolongs Recipient Survival Time After Orthotopic Liver Transplantation in Rats by Polarizing the Th1/Th2 Paradigm to Th2

(2011) Hongfei Tong et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation

(2011) Yue Lu et al.   BIOCHEMICAL PHARMACOLOGY

Emodin reverses gemcitabine resistance in pancreatic cancer cells via the mitochondrial apoptosis pathway in vitro

(2011) DIAN-LEI LIU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Emodin, a natural product, selectively inhibits 11β-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice

(2010) Ying Feng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anti-diabetic effects of emodin involved in the activation of PPARγ on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice

(2009) Jianfeng Xue et al.   FITOTERAPIA