Review
Biochemistry & Molecular Biology
Andreas Kohler, Antoni Barrientos, Flavia Fontanesi, Martin Ott
Summary: The mitochondrial respiratory chain is an important system for energy conversion in eukaryotic cells. The organization of respiratory chain complexes into supercomplexes provides advantages for cellular energy conversion, although its universality is still debated. Further research is needed to fully understand the functional significance of these supercomplexes.
Article
Geriatrics & Gerontology
Sandra Lizbeth Morales-Rosales, Roberto Santin-Marquez, Pedro Posadas-Rodriguez, Ruth Rincon-Heredia, Teresa Montiel, Raul Librado-Osorio, Armando Luna-Lopez, Nadia Alejandra Rivero-Segura, Claudio Torres, Agustina Cano-Martinez, Alejandro Silva-Palacios, Paulina Cortes-Hernandez, Julio Moran, Lourdes Massieu, Mina Konigsberg
Summary: The study evaluated the impact of senescent astrocytes on neuronal mitochondrial function. Results indicated that co-cultured neurons showed altered mitochondrial functionality after exposure to senescent astrocytes. In vivo findings also suggested similar effects of senescent astrocytes on mitochondrial physiology as observed in vitro.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Food Science & Technology
A. Cimbalo, M. Frangiamone, C. Juan, G. Font, M. Lozano, L. Manyes
Summary: This study evaluated the hepatic toxicity of ENs exposure at different concentrations in Wistar rats using a proteomic approach. The results showed that ENs acute exposure caused protein expression changes related to major cellular processes in rats, hinting its involvement in liver disturbance. Bioinformatic analysis revealed metabolism as the most significant and enriched pathway in terms of overrepresentation in Reactome.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Engineering, Environmental
Siyi Lin, Hongna Zhang, Chen Wang, Xiu-Li Su, Yuanyuan Song, Pengfei Wu, Zhu Yang, Ming-Hung Wong, Zongwei Cai, Chunmiao Zheng
Summary: Plastic debris in the global biosphere is a growing concern, with the toxicity of nanoplastic (NPs) in humans not yet fully understood. This study investigates the impact of 80 nm NPs on mitochondrial functions and metabolic pathways in human liver and lung cells. The results show that NPs can enter the cells and cause mitochondrial damage, leading to altered mitochondrial functions and metabolic toxicity. Liver cells are more vulnerable to NP exposure compared to lung cells. This study provides insights into the potential adverse effects of NP-induced mitochondrial dysfunction on human health.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Hang Xu, Erkai He, Willie J. G. M. Peijnenburg, Lan Song, Ling Zhao, Xiaoyun Xu, Xinde Cao, Hao Qiu
Summary: This study highlights the significant role of microbial EPS as reducing agents and electron transfer mediators for cupric reduction and cuprous formation in natural environments. EPS from different microbial species showed varied electron transfer ability, with c-type cytochromes playing a major role in copper transformation for Shewanella oneidensis MR-1 EPS, while functional groups like phenolic and amide dominated Cu(II) reduction for Bacillus subtilis and Saccharomyces cerevisiae EPS.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Endocrinology & Metabolism
Miwon Ahn, Eunjin Oh, Erika M. McCown, Xin Wang, Rajakrishnan Veluthakal, Debbie C. Thurmond
Summary: The study demonstrates a protective role for PAK1 in beta-cells, maintaining healthy functional beta-cell mass by regulating mitochondrial function and reducing stress-induced apoptosis.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Chemistry, Physical
Outi Haapanen, Vivek Sharma
Summary: Respiratory complex I plays a crucial role in the electron transport chains of mitochondria and bacteria by efficiently coupling the redox reaction and proton pumping through a unique tunnel, leading to the synthesis of ATP. The separation of redox reaction and proton pumping in space and time raises the question of how these two reactions are so efficiently coupled. Recent structural data and molecular simulations provide insights into how quinone reduction and dynamics may be linked to proton pumping in complex I.
CURRENT OPINION IN ELECTROCHEMISTRY
(2021)
Article
Chemistry, Physical
Bo Hu, Hongbin Li, Hao Fan, Jiangxuan Song
Summary: We report a high-volumetric-capacity and long-lifetime aqueous organic redox flow battery (AORFB) anolyte based on a six-electron transfer pi-conjugated heteroaromatic hexaazatrinaphthalene tricarboxylic acid (HATNTA). HATNTA undergoes a reversible three-step six-electron redox process at pH=14. The HATNTA-based AORFB exhibits high open-circuit voltage, impressive specific capacity, high output power density, and superior cycling stability.
ENERGY STORAGE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Taiki Adachi, Keisei Sowa, Yuki Kitazumi, Osamu Shirai, Kenji Kano
Summary: The study showed that cyanide enhanced the bioelectrocatalytic activity of membrane-bound alcohol dehydrogenase (ADH) from Gluconobacter oxydans, while not affecting its catalytic activity in solution. Electrochemical methods and electron spin resonance spectroscopy revealed the detailed electron transfer pathway in the DET-type bioelectrocatalysis by ADH.
BIOELECTROCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Xianfei Ji, Jennifer L. Bradley, Guanghui Zheng, Weiwei Ge, Jing Xu, Juntao Hu, Fenglian He, Rabiya Shabnam, Mary Ann Peberdy, Joseph P. Ornato, Qun Chen, Edward J. Lesnefsky, Wanchun Tang
Summary: Brain mitochondria are more sensitive to injury during cardiac arrest and resuscitation compared to cardiac mitochondria, particularly in terms of the sensitivity of Complex I in brain mitochondria. Therapeutic preservation of cerebral mitochondrial activity and function during cardiac arrest may improve post-resuscitation neurologic function.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Andre Gemuende, Jonas Gail, Dirk Holtmann
Summary: Vibrio natriegens shows great potential as a biotechnological organism due to its fast growth, high productivity, and availability of genomic tools. It was found that V. natriegens possesses a similar extracellular electron transfer pathway as other electroactive organisms. This study demonstrated for the first time that V. natriegens can transfer electrons to an electrode through direct contact and an artificial redox mediator, highlighting its superior electron-transfer capabilities and metabolism.
Article
Biochemistry & Molecular Biology
Mahfuzur Rahman, Maximilian Billmann, Michael Costanzo, Michael Aregger, Amy H. Y. Tong, Katherine Chan, Henry N. Ward, Kevin R. Brown, Brenda J. Andrews, Charles Boone, Jason Moffat, Chad L. Myers
Summary: FLEX is a pipeline that establishes reference standards for benchmarking human genome-wide CRISPR screen data, identifying a predominant mitochondria-associated signal within co-essentiality networks. By characterizing functional bias associated with mitochondria genes, it provides insights into interpreting differential hits in CRISPR screening. The utility of the FLEX pipeline for performing robust comparative evaluations of CRISPR screens or methods for processing them is demonstrated.
MOLECULAR SYSTEMS BIOLOGY
(2021)
Article
Engineering, Biomedical
Farnaz H. Foomani, Jason A. Jarzembowski, Soudeh Mostaghimi, Shima Mehrvar, Suresh N. Kumar, Mahsa Ranji
Summary: The study reveals that changes in mitochondrial redox state can be accurately assessed in newborn rat organs using optical imaging. Hearts with low redox ratio in FAO mutants may be more vulnerable to damages than kidneys, leading to premature heart failure.
IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Yuseung Jo, Jin Seok Woo, A. Ram Lee, Seon-Yeong Lee, Yonghee Shin, Luke P. Lee, Mi-La Cho, Taewook Kang
Summary: This study demonstrates the use of gold nanoparticles as efficient electron transfer mediators to enhance the activity of the mitochondrial electron transport chain. The hybridization of GNPs with mitochondria, regardless of the presence of the outer membrane, increases the membrane potential, oxygen consumption, and ATP production of mitochondria.
Article
Chemistry, Inorganic & Nuclear
Sujit Kamilya, Sakshi Mehta, Rodrigue Lescouezec, Yanling Li, Jiri Pechousek, Mohini Semwal, Abhishake Mondal
Summary: A two-step thermo-induced spin-state switching was observed in a cyanide-bridged [Fe2Fe2] molecular square complex. The low-temperature ground state transformed into the high-temperature state via a stable intermediate phase. Additionally, the desolvated phase also exhibited gradual and reversible thermo-induced spin state change as well as photo-induced spin-state switching at 20 K.
DALTON TRANSACTIONS
(2023)
Article
Neurosciences
Marcos Roberto de Oliveira, Flavia de Bittencourt Brasil, Cristina Ribas Furstenau
MOLECULAR NEUROBIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Marcos Roberto de Oliveira, Claudia Marlise Balbinotti Andrade, Cristina Ribas Furstenau
NEUROCHEMICAL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Marcos Roberto de Oliveira, Flavia Bittencourt Brasil, Cristina Ribas Furstenau
JOURNAL OF MOLECULAR NEUROSCIENCE
(2019)
Article
Neurosciences
Marcos Roberto de Oliveira, Adriane Ribeiro Duarte, Aline Lukasievicz Chenet, Fhelipe Jolner Souza de Almeida, Claudia Marlise Balbinotti Andrade
NEUROTOXICITY RESEARCH
(2019)
Article
Neurosciences
Cristina Ribas Furstenau, Izabel Cristina Custodio de Souza, Marcos Roberto de Oliveira
NEUROTOXICITY RESEARCH
(2019)
Article
Neurosciences
Marcos Roberto de Oliveira, Izabel Cristina Custodio de Souza, Cristina Ribas Furstenau
NEUROTOXICITY RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Fernanda Rafaela Jardim, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Marcos Roberto de Oliveira
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2020)
Article
Neurosciences
Marcos Roberto de Oliveira, Izabel Cristina Custodio de Souza, Flavia Bittencourt Brasil
Summary: The study found that emodin can prevent mitochondrial dysfunction induced by methylglyoxal in neuroblastoma cells, and the mechanism of action is related to the AMPK/Nrf2/HO-1 signaling pathway.
NEUROTOXICITY RESEARCH
(2021)
Article
Endocrinology & Metabolism
Izabel Cristina Custodio de Souza, Renata Cristina Bertolini Gobbo, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Marcos Roberto de Oliveira
Summary: The study demonstrated that pretreatment with carnosic acid (CA) can promote mitochondrial protection in human neuroblastoma SH-SY5Y cells exposed to MG by reducing lipid peroxidation and protein carbonylation and nitration, preventing dysfunction of Complexes I and V, decline in ATP levels, and loss of MMP, as well as decreasing the production of superoxide. These protective effects were mediated by upregulating glutathione synthesis through the PI3K/Akt/Nrf2/gamma-GCL/GSH axis.
METABOLIC BRAIN DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Marcos Roberto de Oliveira, Izabel Cristina Custodio de Souza, Flavia Bittencourt Brasil
Summary: The research findings demonstrate that pretreatment with Emodin can protect mitochondria, inhibit the effects of hydrogen peroxide, and have anti-inflammatory properties in human neuroblastoma cells. This protection is dependent on the AMPK/Nrf2 pathway.
NEUROCHEMICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Flavia Bittencourt Brasil, Renata Cristina Bertolini Gobbo, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Fernanda dos Santos Petry, Marcos Roberto de Oliveira
Summary: The study demonstrates that SFN protects mitochondria of MG-challenged cells by stimulating the Nrf2/gamma-GCL/GSH axis, leading to increased synthesis of GSH and prevention of OXPHOS dysfunction and mitochondrial redox impairment.
NEUROCHEMICAL RESEARCH
(2021)
Article
Neurosciences
Flavia Bittencourt Brasil, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Evandro Luiz Dall'Oglio, Marcos Roberto de Oliveira
Summary: Pretreatment with Tanshinone I can reduce oxidative damage and mitochondrial dysfunction caused by chlorpyrifos, and induce anti-inflammatory effects. It relies on the Nrf2/HO-1 axis to prevent the deleterious effects of chlorpyrifos in this experimental model.
NEUROTOXICITY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Flavia Bittencourt Brasil, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Evandro Luiz Dall'Oglio, Marcos Roberto de Oliveira
Summary: The study showed that astaxanthin can prevent mitochondrial dysfunction in GLU-challenged cells through a mechanism related to the Nrf2/HO-1 axis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Flavia Bittencourt Brasil, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Evandro Luiz Dall'Oglio, Marcos Roberto de Oliveira
Summary: Sulforaphane (SFN) has potential protective effects in cells, and it promotes gene expression by regulating the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), leading to cytoprotective actions through products like heme oxygenase-1 (HO-1) in multiple cell types.
METABOLIC BRAIN DISEASE
(2023)
Review
Obstetrics & Gynecology
Thayane Ferreira da Costa Fernandes, Poliana dos Santos Conde, Flavia de Bittencourt Brasil, Marcos Roberto de Oliveira
Summary: Supplementation with folic acid during gestation is widely recommended but high intake may have detrimental effects on descendants. This systematic review aimed to investigate the effects of maternal supplementation with folic acid on offspring's kidney. The results showed that gestational folic acid intake did not affect renal volume, glomerular filtration rate, or essential gene expression in the puppies' kidney.
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2023)