Article
Biochemistry & Molecular Biology
Xiang Jing, Shuai Niu, Yi Liang, Huiping Chen, Ning Wang, Youmei Peng, Fang Ma, Wanying Yue, Qingduan Wang, Junbiao Chang, Yi Zhang, Yan Zhang
Summary: In this study, FNC was found to inhibit the proliferation and metastasis of NSCLC cells, induce apoptosis through the mitochondrial pathway, and regulate protein expression associated with cell adhesion and invasion. These findings suggest that FNC has potential as a therapeutic for NSCLC.
Article
Medicine, Research & Experimental
Xiao Li, Changqun Liu, Xin Zhang, Chen Sun, Jie Ling, Yilan Liu, Yi Zuo, Yuening Cao, Chaozheng Zhang, Tao Jiang, Maolin Wang, Jin Liu, Jun Lu
Summary: Bruceine A has demonstrated promising potential as a chemotherapeutic agent for treating triple-negative breast cancer (TNBC) and suppressing lung metastasis. Its mechanisms include inhibiting cell cycle-related proteins, inducing mitochondrial dysfunction, and repressing invasion and metastasis-related genes.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Yanhua Zhang, Hui Xu, Yue Li, Yang Sun, Xiaochun Peng
Summary: Pancreatic cancer, known as the king of cancers, is a common malignancy of the digestive system with a high degree of malignancy and poor prognosis. Although Western medicine mainly uses surgical resection, radiotherapy, and chemotherapy, the curative effect is not satisfactory. Traditional Chinese Medicine (TCM) has many advantages in the treatment of pancreatic cancer and is becoming an important aspect of comprehensive clinical treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Zhujun Yi, Shanqiao Wei, Lin Jin, Sivakumar Jeyarajan, Jing Yang, Yumei Gu, Hong Sun Kim, Shula Schechter, Shuang Lu, Michelle T. Paulsen, Karan Bedi, Ishwarya Venkata Narayanan, Mats Ljungman, Howard C. Crawford, Marina Pasca di Magliano, Kai Ge, Yali Dou, Jiaqi Shi
Summary: Loss of KDM6A is associated with metastasis in PDAC patients and up-regulation of the epithelial-mesenchymal transition pathway in PDAC cells. Mechanistically, KDM6A deficiency accelerates PDAC progression and metastasis through a noncanonical p38-dependent activin A pathway. Activin A may serve as a therapeutic target for KDM6A-deficient PDACs.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, Research & Experimental
Yuanyang Wang, Cheng Qin, Bangbo Zhao, Zeru Li, Tianyu Li, Xiaoying Yang, Yutong Zhao, Weibin Wang
Summary: This study found that EGR1 is highly expressed in pancreatic cancer and is associated with prognosis and cancer metastasis. EGR1 promotes migration and invasion ability of pancreatic cancer cells and is correlated with the epithelial-mesenchymal transition process. The study also revealed that EGR1 activates the SNAI2 gene through interaction with p300/CBP. In vivo experiments confirmed that EGR1 promotes liver metastasis of pancreatic cancer. Therefore, blocking the expression of EGR1 could be a new anticancer strategy for pancreatic cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Tulin Dadali, Anne R. Diers, Shiva Kazerounian, Senthil K. Muthuswamy, Pallavi Awate, Ryan Ng, Saie Mogre, Carrie Spencer, Katerina Krumova, Hannah E. Rockwell, Justice McDaniel, Emily Y. Chen, Fei Gao, Karl T. Diedrich, Vijetha Vemulapalli, Leonardo O. Rodrigues, Viatcheslav R. Akmaev, Khampaseuth Thapa, Manuel Hidalgo, Arindam Bose, Vivek K. Vishnudas, A. James Moser, Elder Granger, Michael A. Kiebish, Stephane Gesta, Niven R. Narain, Rangaprasad Sarangarajan
Summary: Reactive oxygen species (ROS) play a role in triggering cell signaling events to promote and maintain tumorigenicity. Chemotherapy and radiation can induce ROS to elicit cell death, making it possible to target ROS pathways for effective anti-cancer therapeutics. Coenzyme Q(10) is shown to increase ROS generation when delivered to increase mitochondrial Q-pool, resulting in anti-cancer effects in a pancreatic cancer model.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Jian Xu, Wei Zhang
Summary: This study revealed that EZR accelerates the progression of pancreatic cancer through the FAK/AKT signaling pathway, promoting proliferation and migration of PC cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Yan Sun, Huan Zhang, Junpeng Meng, Feng Guo, Dianyun Ren, Heshui Wu, Xin Jin
Summary: This study demonstrates that aberrant PCSK9 upregulation promotes cell proliferation and sorafenib resistance in HCC by inducing AKT activation. Additionally, competitive inhibition of PCSK9 palmitoylation enhances the antitumor effects of sorafenib in HCC.
Article
Cell Biology
Zhiqi Zhang, Haitao Yu, Wenyan Yao, Na Zhu, Ran Miao, Zhiquan Liu, Xuwei Song, Chunhua Xue, Cheng Cai, Ming Cheng, Ke Lin, Dachuan Qi
Summary: This study reveals that RRP9 plays a critical role in inducing gemcitabine chemoresistance in pancreatic cancer through the activation of the IGF2BP1/AKT signaling pathway.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Chemistry, Medicinal
Yi Gou, MeiRong Chen, Shanhe Li, JunGang Deng, Jinlong Li, GuiHua Fang, Feng Yang, GuoJin Huang
Summary: The three fluorescent dithiocarbazate-copper complexes showed significant cytotoxicity against pancreatic cancer cell lines, with complex 3 primarily targeting mitochondria and inducing cell death through mechanisms including ferroptosis. This complex is the first copper complex to demonstrate cellular events consistent with ferroptosis in cancer cells and effectively inhibited the growth of ASPC-1 cells in a mouse xenograft model.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Wenpeng Cao, Zhirui Zeng, Zhiwei He, Shan Lei
Summary: This study revealed that hypoxia upregulates the expression of miR-4465 and miR-616-3p in PSC-derived exosomes, which promote pancreatic cancer progression and metastasis by suppressing the PTEN/AKT pathway through exosome uptake.
Article
Pharmacology & Pharmacy
Da Eun Lee, Hyeon Woong Kang, So Yi Kim, Myeong Jin Kim, Jae Woong Jeong, Woosol Chris Hong, Sungsoon Fang, Hyung Sun Kim, Yun Sun Lee, Hyo Jung Kim, Joon Seong Park
Summary: This study demonstrates that the combination of ivermectin and gemcitabine effectively suppresses pancreatic cancer by inhibiting cell proliferation and inducing cell apoptosis through cell cycle arrest and mitochondrial dysfunction. In vivo experiments also support the tumor-inhibiting effect of this combination treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Eun Hye Lee, Hyun Tae Kim, So Young Chun, Jae-Wook Chung, Seock Hwan Choi, Jun Nyung Lee, Bum Soo Kim, Eun Sang Yoo, Tae Gyun Kwon, Tae-Hwan Kim, Yun-Sok Ha
Summary: Given the high morbidity and poor prognosis of bladder cancer, understanding and studying the signaling pathways and related mechanisms in bladder cancer is of great significance for the exploration of new treatment strategies.
ONCOTARGETS AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Olga Sularz, Aneta Koronowicz, Sylwester Smolen, Cayla Boycott, Barbara Stefanska
Summary: Our research shows that extracts from iodine-biofortified lettuce induce apoptosis in gastric and colon cancer cells, triggering different signaling pathways depending on the cell type. Activation of caspases and release of cytochrome c are involved in the cell death process, and poly (ADP-ribose) polymerase and Bcl-2 family proteins also play a role. Mitochondrial dysfunction is observed in cells exposed to lettuce extracts. Overall, organic iodine compounds are important for activating mitochondrial apoptotic pathways in a p53-independent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Shuang Lu, Hong Sun Kim, Yubo Cao, Karan Bedi, Lili Zhao, Ishwarya Venkata Narayanan, Brian Magnuson, Yumei Gu, Jing Yang, Zhujun Yi, Sepideh Babaniamansour, Sargis Shameon, Chang Xu, Michelle T. Paulsen, Ping Qiu, Sivakumar Jeyarajan, Mats Ljungman, Dafydd Thomas, Yali Dou, Howard Crawford, Marina Pasca di Magliano, Kai Ge, Bo Yang, Jiaqi Shi
Summary: In this study, a novel signaling axis mediated by KMT2D linking TGF-beta to the activin A pathway was discovered. Loss of KMT2D induces the expression and secretion of activin A, which activates a noncanonical p38 MAPK-mediated pathway to enhance tumor invasion and metastasis in pancreatic cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Materials Science, Multidisciplinary
Dan Li, Yuxiang Wang, Meng Guo, Mingjun Song, Yang Ren
BULLETIN OF MATERIALS SCIENCE
(2020)
Article
Chemistry, Analytical
Wei Wang, Dan Li, Yue Zhang, Wei Zhang, Pinyi Ma, Xinghua Wang, Daqian Song, Ying Sun
Article
Genetics & Heredity
Weitie Wang, Yong Wang, Hulin Piao, Bo Li, Zhicheng Zhu, Dan Li, Tiance Wang, Kexiang Liu
Summary: This study integrated miRNA and mRNA profiling analyses to demonstrate the critical roles of miR-193a-3p and ACTG2 in the pathogenesis of aortic dissection. miR-193a-3p may serve as a novel regulator of phenotypic switching in VSMCs, and the miR-193a-3p/ACTG2 axis could be a promising diagnostic biomarker and therapeutic candidate for aortic dissection.
FRONTIERS IN GENETICS
(2021)
Article
Cardiac & Cardiovascular Systems
Weitie Wang, Qing Liu, Yong Wang, Hulin Piao, Zhicheng Zhu, Dan Li, Tiance Wang, Kexiang Liu
Summary: The study reveals that linc01278 regulates VSMC phenotypic switching by controlling miR-500b-5p and ACTG2, playing a significant role in the pathogenesis of AD. This axis may have potential implications in developing diagnostic markers and therapeutic targets for AD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cell Biology
Yichen Wang, Lin Jia, Cong Wang, Zhonghua Du, Shilin Zhang, Lei Zhou, Xue Wen, Hui Li, Huiling Chen, Yuanyuan Nie, Dan Li, Shanshan Liu, Daniela Salgado Figueroa, Ferhat Ay, Wei Xu, Songling Zhang, Wei Li, Jiuwei Cui, Andrew R. Hoffman, Hui Guo, Ji-Fan Hu
Summary: Wang et al. identify Peln1 as a key chromatin long non-coding RNA that controls pluripotency exit and intrachromosomal looping in stem cells. Peln1 interacts with the Oct4 promoter, recruits DNMT3A, and alters the epigenotype to disrupt the intrachromosomal loop, leading to pluripotency exit. Peln1 also targets multiple pathway genes associated with stem cell self-renewal.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Qing Dong, Xiuna Jia, Yuling Wang, Hao Wang, Qiong Liu, Dan Li, Jin Wang, Erkang Wang
Summary: Pancreatic cancer is difficult to diagnose in the early stage due to the lack of symptoms. Current diagnosis techniques have limitations in terms of personnel expertise and cost. Therefore, alternative detection methods are highly demanded. In this study, a new strategy combining nanoparticles and amplification reaction was proposed to improve the sensitivity of pancreatic cancer cell detection. The strategy showed good specificity and potential for clinical diagnosis.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Xiuna Jia, Mengmeng Lv, Yunwei Fei, Qing Dong, Hao Wang, Qiong Liu, Dan Li, Jin Wang, Erkang Wang
Summary: Diagnosis-guided synergistic treatment based on innovative nanomaterials is important for the development of anti-cancer therapies. This study developed a smart carrier named LPAR, which can selectively deliver and release genes using near-infrared light and convert the light into heat for photothermal synergistic therapy. LPAR also possesses the capability of triple-modal imaging.
Article
Chemistry, Physical
Hao Wang, Jinxing Chen, Qing Dong, Xiuna Jia, Dan Li, Jin Wang, Erkang Wang
Summary: Recently, there has been increased attention on the study of mimic enzymes. However, research on the oxidoreductase activity of electron mediators in the biological respiratory chain is still limited. In this study, we found that cadmium sulfide (CdS) nanorods can catalyze the formation of superoxide anions and exhibit NADH oxidase-like activity and Cyt c reductase-like activity. This provides a new perspective for the in-depth study of new nanozymes.
Article
Chemistry, Multidisciplinary
Xiuna Jia, Deming Liu, Cong Yu, Niu Niu, Dan Li, Jin Wang, Erkang Wang
Summary: This study presents a new strategy for the rational design and development of a safe and efficient single near-infrared laser-triggered synergistic treatment platform for hypoxic cancer, based on the characteristics of the tumor microenvironment.
Article
Chemistry, Physical
Hao Wang, Jinxing Chen, Qing Dong, Xu Sun, Qiong Liu, Dan Li, Erkang Wang, Jin Wang
Summary: In this study, N, P, or S doped carbon nanotubes (CNTs) were used as enzyme mimics of nicotinamide adenine dinucleotide (NADH) oxidase and cytochrome c (Cyt c) reductase. Through N doping, the NADH oxidase-like activity of CNTs was significantly enhanced, with a 4.28-fold increase in the maximum initial velocity for N-doped CNTs (N-CNTs) compared to the unmodified ones. Biologically active NAD* was produced during NADH oxidation, and oxygen was selectively reduced to water or hydrogen peroxide, consistent with natural NADH oxidase. Additionally, it was discovered for the first time that carbon nanotubes can facilitate the electron transfer from NADH to Cyt c, mimicking the properties of Cyt c reductase.
Article
Oncology
Huikun Niu, Dexiang Wang, Tingting Wen, Han Liu, Jing Jie, Lei Song, Dan Li
Summary: Background: Anwuligan (ANW), isolated from nutmeg, has been found to have potential therapeutic effects in diseases. However, its effect on lung cancer is still unclear. Methods: In this study, the cytotoxicity of ANW on non-small cell lung cancer (NSCLC) cells was investigated using various assays. Results: ANW treatment showed clear cytotoxicity against NSCLC cells, inhibiting cell proliferation and migration both in vitro and in vivo. The overexpression of let-7c-3p also inhibited the growth of NSCLC cells. Conclusions: ANW inhibits the growth and metastasis of NSCLC cells by upregulating the expression of let-7c-3p and targeting PIK3CA.
Article
Engineering, Biomedical
Shuaining Ma, Weiguo Xu, Yunwei Fei, Dan Li, Xiuna Jia, Jin Wang, Erkang Wang
Summary: A TME-responsive nanoplatform is designed for synergistic photothermal therapy and photodynamic therapy against cancer. The nanoplatform allows for effective tumor accumulation and payload release through aptamer modification and acid degradable shell. It also exhibits excellent photodynamic therapy properties and achieves synergistic therapy through a single wavelength of near-infrared laser.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Physical
Hao Wang, Jinxing Chen, Qing Dong, Xu Sun, Qiong Liu, Dan Li, Erkang Wang, Jin Wang
Summary: Most nanozyme research focuses on oxidase and peroxidase capabilities, but this study explores N, P, or S doped carbon nanotubes (CNTs) as enzyme mimics of NADH oxidase and Cyt c reductase. Doping N significantly enhances the NADH oxidase-like activity of CNTs, increasing the maximum initial velocity by 4.28 times. NAD(+) is produced as a biologically active product during NADH oxidation, while oxygen is selectively reduced to water or hydrogen peroxide, similar to natural NADH oxidase. Additionally, carbon nanotubes can promote electron transfer from NADH to Cyt c, mimicking the properties of Cyt c reductase.
Article
Chemistry, Analytical
Wei Zhang, Ling Wang, Dan Li, Douglas H. Campbell, Bradley J. Walsh, Nicolle H. Packer, Qing Dong, Erkang Wang, Yuling Wang
Summary: Circulating sEVs derived from PDAC cells have potential applications in cancer diagnosis. The phenotype of sEVs is closely associated with the presence and progression of PDAC, and can be validated through various imaging techniques. The proposed SERS assay enables simultaneous detection of multiple surface membrane proteins on sEVs, providing a potential method for PDAC diagnosis and early cancer stage prediction.
ANALYTICAL METHODS
(2022)
Article
Biotechnology & Applied Microbiology
Zhonghua Du, Xue Wen, Yichen Wang, Lin Jia, Shilin Zhang, Yudi Liu, Lei Zhou, Hui Li, Wang Yang, Cong Wang, Jingcheng Chen, Yajing Hao, Huiling Chen, Dan Li, Naifei Chen, Ilkay Celik, Yanbo Zhu, Zi Yan, Changhao Fu, Shanshan Liu, Benzheng Jiao, Zhuo Wang, Hui Zhang, Gunhan Gulsoy, Jianjun Luo, Baoming Qin, Sujun Gao, Philipp Kapranov, Miguel A. Esteban, Songling Zhang, Wei Li, Ferhat Ay, Runsheng Chen, Andrew R. Hoffman, Jiuwei Cui, Ji-Fan Hu
Summary: Platr10 is a novel chromatin RNA molecule activated during somatic cell reprogramming, essential for maintaining pluripotency by modulating chromatin architecture and regulating DNA methylation.
Article
Pharmacology & Pharmacy
Xuezhi Zhuo, Vito Fodera, Per Larsson, Zarah Schaal, Christel A. S. Bergstrom, Korbinian Lobmann, Aleksei Kabedev
Summary: Our previous work demonstrated that beta-lactoglobulin-stabilized amorphous solid dispersion (ASD) loaded with 70 % indomethacin remains stable for over 12 months. We further investigated the stabilization mechanisms by testing five other drug molecules and using experimental techniques and molecular dynamics simulations. The results showed that steric confinement, hydrogen bonding, and the glass transition temperature of the drug molecule play important roles in stabilizing ASDs with high drug loadings.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Sebastian Schmidt, Ulrike Holzgrabe
Summary: The binding of drugs to plasma proteins, such as human serum albumin (HSA), is crucial for determining pharmacokinetic parameters. This study investigated the enantioselective binding of S- and R-ketamine to HSA. It was found that ketamine has weak affinity to HSA, with no significant differences in binding behavior between the individual enantiomers and the racemate. The aromatic ring and N-methyl group were identified as the most strongly involved structural moieties in the binding of ketamine to HSA.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Yuchen Zhao, Han Wang, Lin Jin, Ziwei Zhang, Lianghu Liu, Mengqi Zhou, Xianzheng Zhang, Lingling Zhang
Summary: Interleukins (ILs) are important for communication between immune cells and non-immune cells, but dysregulation of ILs expression is a characteristic of autoinflammatory diseases. Drugs targeting ILs have significant clinical benefits, but may also cause adverse reactions. Fusion protein technology, with its ability to enhance therapeutic efficacy, has been explored for developing anti-inflammatory drugs. This review discusses the efficacy of fusion protein drugs developed with ILs or their receptors in treating autoinflammatory diseases, highlighting the potential of this technology in future anti-inflammatory drug development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Serena Bertoni, Elena Simone, Stefano Sangiorgi, Beatrice Albertini, Nadia Passerini
Summary: This study investigated the correlation between the structure and release properties of solid lipid microparticles (MPs) with different liquid additives. The additives accelerated the conversion of the unstable alpha-form of tristearin to the stable beta-polymorph and caused structural modifications in the MPs. The presence of additives prolonged the drug release in water and resulted in higher release profiles in biorelevant media. The findings suggest that the release behavior can be influenced by the polymorphism and supramolecular-level structural modification of lipid formulations containing crystal modifiers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Juulia Jarvinen, Ahmed B. Montaser, Santosh Kumar Adla, Jukka Leppanen, Marko Lehtonen, Kati-Sisko Vellonen, Tuomo Laitinen, Aaro Jalkanen, William F. Elmquist, Juri Timonen, Kristiina M. Huttunen, Jarkko Rautio
Summary: This study attempted to alter the brain distribution pattern of Palbociclib by creating and assessing two novel prodrugs. Although the prodrug design did not significantly improve Palbociclib brain delivery, the study provides valuable insights for future prodrug development and drug delivery strategies targeting specific transporters.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Review
Pharmacology & Pharmacy
Miao Wang, Xinyu Ma, Shiyu Zong, Yaqiong Su, Rui Su, Hong Zhang, Yang Liu, Chunliu Wang, Ye Li
Summary: This article discusses the potential and limitations of nasal administration in central nervous system drug delivery. Nasal gel viscosity can alleviate the impact of nasal mucociliary clearance on drug delivery, and materials such as gellan gum, chitosan, carbomer, cellulose, and poloxamer can be used to prepare nasal gels.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Bjarke Strom Larsen, Eric Kissi, Liebert Parreiras Nogueira, Natalja Genina, Ingunn Tho
Summary: This study investigates the influence of drug load and polymer molecular weight on the structure of 3D printed tablets. The results show that drug load and polymer molecular weight have a significant impact on the porosity and size of the tablets, while the effect of drug load on the total porosity of the tablets is minimal.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Zhentao Qiao, Fuhang Wang, Dongjian Han, Yuansong Zhuang, Qingjiao Jiang, Yi Zhang, Miaomiao Liu, Quanxu An, Zhiwei Wang, Deliang Shen
Summary: In this study, it was demonstrated that periadventitial delivery of rapamycin-fibrin glue (RPM-FG) can inhibit intimal hyperplasia (IH) in a rat carotid artery injury model without compromising re-endothelialization. This provides a promising direction for the future development of a safe, effective, and minimally invasive perivascular drug delivery method to treat vascular disease.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Neele Puhlmann, Rodrigo Vidaurre, Klaus Kuemmerer
Summary: Active pharmaceutical ingredients and their metabolites and transformation products are pollutants that can harm human and environmental health. Designing greener APIs is an effective strategy to address this issue. The drug discovery and development process can incorporate environmental parameters to achieve this design, and this process is highly flexible.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
