Paracetamol: a focus for the general pediatrician

Myth: Ibuprofen is superior to acetaminophen for the treatment of benign headaches in children and adults

(2016) Sergio Manzano et al.   Canadian Journal of Emergency Medicine

Question 2: Does a failure to respond to antipyretics predict serious illness in children with a fever?

(2013) D. King   ARCHIVES OF DISEASE IN CHILDHOOD

Dosing and Antipyretic Efficacy of Oral Acetaminophen in Children

(2013) Anthony R. Temple et al.   CLINICAL THERAPEUTICS

FDA: Acetaminophen May Trigger Serious Skin Problems

(2013) Bridget M. Kuehn   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of Intravenous Paracetamol on Postoperative Morphine Requirements in Neonates and Infants Undergoing Major Noncardiac Surgery

(2013) Ilse Ceelie et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Nonsteroidal Anti-Inflammatory Drugs Are an Important Cause of Acute Kidney Injury in Children

(2013) Jason M. Misurac et al.   JOURNAL OF PEDIATRICS

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

(2013) Mitchell R. McGill et al.   PHARMACEUTICAL RESEARCH

Drug use and upper gastrointestinal complications in children: a case-control study

(2012) M. Bianciotto et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations

(2012) Laura P. James et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Regulatory Review of Acetaminophen Clinical Pharmacology in Young Pediatric Patients

(2012) Ping Ji et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Advances in treatment of bacterial meningitis

(2012) Diederik van de Beek et al.   LANCET

Acetaminophen and asthma

(2012) A. John Henderson et al.   Paediatric Respiratory Reviews

The paracetamol concentration-effect relation in neonates

(2012) Karel Allegaert et al.   PEDIATRIC ANESTHESIA

Intravenous Acetaminophen in the United States: Iatrogenic Dosing Errors

(2012) R. C. Dart et al.   PEDIATRICS

Relief of Pain and Anxiety in Pediatric Patients in Emergency Medical Systems

(2012) J. A. Fein et al.   PEDIATRICS

Plasma and Cerebrospinal Fluid Pharmacokinetic Parameters After Single-Dose Administration of Intravenous, Oral, or Rectal Acetaminophen

(2012) Neil K. Singla et al.   Pain Practice

Systematic review of studies comparing combined treatment with paracetamol and ibuprofen, with either drug alone

(2011) E. Purssell   ARCHIVES OF DISEASE IN CHILDHOOD

Efficacy of Standard Doses of Ibuprofen Alone, Alternating, and Combined With Acetaminophen for the Treatment of Febrile Children

(2011) Ian M. Paul et al.   CLINICAL THERAPEUTICS

Acute liver failure after recommended doses of acetaminophen in patients with myopathies

(2011) Ilse Ceelie et al.   CRITICAL CARE MEDICINE

Slow initial β-lactam infusion and oral paracetamol to treat childhood bacterial meningitis: a randomised, controlled trial

(2011) Tuula Pelkonen et al.   LANCET INFECTIOUS DISEASES

Explaining the acetaminophen-ibuprofen analgesic interaction using a response surface model

(2011) Jacqueline Hannam et al.   PEDIATRIC ANESTHESIA

Fever and Antipyretic Use in Children

(2011) J. E. Sullivan et al.   PEDIATRICS

Comparison of the analgesic efficacy of concurrent ibuprofen and paracetamol with ibuprofen or paracetamol alone in the management of moderate to severe acute postoperative dental pain in adolescents and adults: A randomized, double-blind, placebo-controlled, parallel-group, single-dose, two-center, modified factorial study

(2010) Donald R. Mehlisch et al.   CLINICAL THERAPEUTICS

Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents

(2010) Romina Nassini et al.   FASEB JOURNAL

Pain Management of Musculoskeletal Injuries in Children

(2010) Samina Ali et al.   PEDIATRIC EMERGENCY CARE

Therapeutic Acetaminophen Is Not Associated With Liver Injury in Children: A Systematic Review

(2010) E. J. Lavonas et al.   PEDIATRICS

Paracetamol induced skin blood flow and blood pressure changes in febrile intensive care patients: An observational study

(2010) Martin Boyle et al.   Australian Critical Care

I.V. acetaminophen pharmacokinetics in neonates after multiple doses

(2008) G.M. Palmer et al.   BRITISH JOURNAL OF ANAESTHESIA

Alternating Antipyretics: Antipyretic Efficacy of Acetaminophen Versus Acetaminophen Alternated With Ibuprofen in Children

(2008) Lynne C. Kramer et al.   CLINICAL PEDIATRICS

Endogenous Cannabinoids: Structure and Metabolism

(2008) T. Bisogno   JOURNAL OF NEUROENDOCRINOLOGY

Paracetamol (Acetaminophen): mechanisms of action

(2008) BRIAN J. ANDERSON   PEDIATRIC ANESTHESIA

Febrile Seizures: Clinical Practice Guideline for the Long-term Management of the Child With Simple Febrile Seizures

(2008)   PEDIATRICS

Paracetamol (acetaminophen) pharmacodynamics: interpreting the plasma concentration

(2007) I A Gibb et al.   ARCHIVES OF DISEASE IN CHILDHOOD