Article
Neurosciences
Lisa Y. Maeng, Dekel Rosenfeld, Gregory J. Simandl, Florian Koehler, Alexander W. Senko, Junsang Moon, Georgios Varnavides, Maria F. Murillo, Adriano E. Reimer, Aaron Wald, Polina Anikeeva, Alik S. Widge
Summary: This study used magnetic nanoparticle (MNP) technology to remotely trigger the release of adrenal hormones and probe the effects of stress on the hypothalamic-pituitary-adrenal (HPA) axis and sympathoadrenal-medullary (SAM) system. The results showed that aversive conditioning reduced corticosterone levels and blunted heart rate increases. MNP-based organ stimulation offers a novel approach for investigating the function of SAM, HPA, and other neuro-endocrine axes.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Ken Takao, Katsumi Iizuka, Yanyan Liu, Teruaki Sakurai, Sodai Kubota, Saki Kubota-Okamoto, Toshinori Imaizumi, Yoshihiro Takahashi, Yermek Rakhat, Satoko Komori, Tokuyuki Hirose, Kenta Nonomura, Takehiro Kato, Masami Mizuno, Tetsuya Suwa, Yukio Horikawa, Masakatsu Sone, Daisuke Yabe
Summary: ChREBP's role in the adrenal glands requires further investigation, with Chrebp(-/-) mice showing various changes but no impact on corticosterone synthesis and release.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
N. Yaglova, S. S. Obernikhin, D. A. Tsomartova, V. V. Yaglov, S. Nazimova, E. P. Timokhina, E. S. Tsomartova
Summary: This study investigated the mechanisms underlying decreased production of epinephrine in rats exposed to DDT during development. The findings suggest that DDT disrupts adrenal medulla growth, reduces the number of mitochondria in adrenal cells (particularly under the outer cytoplasmic membrane), causes destructive changes in mitochondria, and progressively decreases the synthesis of tyrosine hydroxylase, ultimately leading to decreased secretion of epinephrine. The decrease in mitochondria and suppression of tyrosine hydroxylase synthesis in adrenal cells are predominant during puberty, while the slowdown of adrenal medulla growth and progressive decrease in tyrosine hydroxylase synthesis are the most evident mechanisms after puberty.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Eric Seidel, Julia Schewe, Junhui Zhang, Hoang An Dinh, Sofia K. Forslund, Lajos Marko, Nicole Hellmig, Joerg Peters, Dominik N. Muller, Richard P. Lifton, Timothy Nottoli, Gabriel Stoelting, Ute Scholl
Summary: Gain-of-function mutations in the CACNA1H gene lead to familial hyperaldosteronism and early-onset hypertension, while knockout of the gene can be compensated for by activating alternative calcium entry pathways for aldosterone production.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Endocrinology & Metabolism
Nour Abou Nader, Alexandre Boyer
Summary: The development and maintenance of the adrenal cortex is a complex process, involving multiple stages from fetal to adult adrenal formation, relying on the activities of stem cells and progenitor cells, which are sex-specific. Advances using transgenic mouse models have helped delineate the molecular mechanisms regulating these processes.
Article
Anatomy & Morphology
Sara M. M. El-Desoky, Fatma El-Zahraa A. Mustafa
Summary: The adrenal gland in Japanese quail is located near the kidney, with a creamy to yellow color. It is subdivided into three zones and contains interrenal tissue, chromaffin islets, and blood sinusoids. The gland has a higher proportion of chromaffin cells due to the bird's migratory nature.
MICROSCOPY RESEARCH AND TECHNIQUE
(2021)
Article
Biochemistry & Molecular Biology
Hirofumi Fujita, Munenori Habuta, Takako Hattori, Satoshi Kubota, Hiromi Kumon, Hideyo Ohuchi
Summary: The expression of UCP1 in the adrenal gland is a novel phenomenon in mice, and its expression is not upregulated by cold exposure.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Melissa A. Davis, Leticia E. Camacho, Alexander L. Pendleton, Andrew T. Antolic, Rosa Luna-Ramirez, Amy C. Kelly, Nathan R. Steffens, Miranda J. Anderson, Sean W. Limesand
Summary: In this study, fetuses with intrauterine growth restriction (IUGR) were found to have higher concentrations of catecholamines, but their glucose metabolism adaptation was independent of catecholamines and appeared to be driven by hypoxemia and hypoglycemia.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Renjie Hu, Wenhui Zhang, Ran Li, Li Qin, Rucheng Chen, Lu Zhang, Weijia Gu, Qinghua Sun, Cuiqing Liu
Summary: New evidence suggests that exposure to ambient PM2.5 is associated with metabolic syndrome, with potential impact on the hypothalamic-pituitary-adrenal axis and disruption of circadian rhythms. The study found that PM2.5 exposure significantly affected the expression of clock genes in the hypothalamus and adrenal gland, leading to disturbances in metabolic homeostasis. This research provides insights into the mechanisms through which ambient PM2.5 exposure may contribute to metabolic disorders.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Peng, Guanglei Tang, Mengya Sun, Shuang Yu, Yanglei Cheng, Yu Wang, Weiwei Deng, Yanbing Li, Jian Guan
Summary: This study assessed the feasibility of using spectral CT-derived extracellular volume (ECV) to differentiate aldosterone-producing nodules (APN) from nonfunctioning adrenal nodules (NFN). The results showed that the ECV fraction can effectively differentiate APN from NFN.
EUROPEAN RADIOLOGY
(2023)
Review
Environmental Sciences
Ekaterina P. Timokhina, Valentin V. Yaglov, Svetlana V. Nazimova
Summary: The pesticide DDT is a common endocrine disruptor that can cause both toxic and disruptive effects on the adrenal glands, with different levels of sensitivity and damage in the various adrenal cortex zones. Low-dose disruptive exposure to DDT leads to more severe affection of adrenal function.
Article
Biochemistry & Molecular Biology
Huifei Sophia Zheng, Yuan Kang, Qiongxia Lyu, Kristina Junghans, Courtney Cleary, Olivia Reid, Greer Cauthen, Karly Laprocina, Chen-Che Jeff Huang
Summary: Steroid hormones are synthesized through enzymatic reactions using cholesterol as the substrate. DHCR24 is a key enzyme controlling cholesterol synthesis. DHCR24 is highly expressed in the adrenal gland and its expression can be regulated by thyroid hormone treatment. The cellular expression pattern of DHCR24 in mouse adrenal glands is similar to that of the X-zone marker gene 20 alpha HSD in most developmental stages. DHCR24 is not essential for overall adrenal gland development or acute stress-induced corticosterone secretion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Eman Mohamed Faruk, Wardah Abdullah Alasmari, Hanan Fouad, Ola Elsayed Nafea, Rehab Abd Allah Hasan
Summary: This study demonstrated the therapeutic potential of extracellular vesicles derived from bone marrow mesenchymal stem cells (BMSC-EVs) against fluoride-induced adrenal toxicity. BMSC-EVs effectively repaired damaged adrenal tissue and recovered its function following NaF consumption, reversing the toxic effects of fluoride and reprogramming injured adrenal cells by activating regenerative processes.
Article
Endocrinology & Metabolism
Malena Dos Santos Guilherme, Theodora Tsoutsouli, Monika Chanu Chongtham, Jennifer Winter, Susanne Gerber, Marianne B. Mueller, Kristina Endres
Summary: Prolonged social stress is a major cause for depression and pathophysiological changes. The chronic social defeat paradigm in mice is commonly used to study this stress. However, it is limited to males and involves physical stress. Expanding models to females is desirable as the prevalence of depression is higher in women. The social instability model was tested in female mice and resulted in elevated corticosterone levels and long-term effects such as increased body weight and fat deposits. Resilience in the model was associated with upregulated neurotrophic factor artemin.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jooyoung Kim, Min Rye Eom, Eun Ji Jeong, Ji Suk Choi, Seong Keun Kwon
Summary: In this study, regeneration of radiation-damaged salivary glands (SGs) was enhanced by combining adult SG stem cells (SGSCs) and adipose-derived stem cells (ASCs) in spheroids. Multiple stimulations improved the viability, differentiation, and vascular endothelial growth factor (VEGF) secretion of SGSC/ASC spheroids, leading to increased in vivo regeneration and functional recovery of SG tissue in mice.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Neurosciences
Sudip Pandit, Chiranjivi Neupane, Junsung Woo, Ramesh Sharma, Min-Ho Nam, Gyu-Seung Lee, Min-Hee Yi, Nara Shin, Dong Woon Kim, Hyunsill Cho, Byeong Hwa Jeon, Hyun-Woo Kim, C. Justin Lee, Jin Bong Park
Article
Cell Biology
Jae Ryong Lim, Hyun Jik Lee, Young Hyun Jung, Jun Sung Kim, Chang Woo Chae, Seo Yihl Kim, Ho Jae Han
CELL COMMUNICATION AND SIGNALING
(2020)
Article
Neurosciences
Suk-Yun Kang, Se Kyun Bang, O. Sang Kwon, Su-Yeon Seo, Kwang-Ho Choi, Seong Jin Cho, Hwa Seung Yoo, Jin Sun Lee, Hyun-Woo Kim, Yeonhee Ryu
BRAIN RESEARCH BULLETIN
(2020)
Article
Neurosciences
Chiranjivi Neupane, Ramesh Sharma, Yoon Hyung Pai, So Yeong Lee, Byeong Hwa Jeon, Hyun-Woo Kim, Javier E. Stern, Jin Bong Park
Summary: Chronic salt loading recruits NR2D subunit-containing NMDARs to generate an Mg2+-resistant tonic I-NMDA in nondepolarized VP neurons, affecting the E/I balance, with NR2D activation being a key factor in this mechanism.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Gee Euhn Choi, Hyun Jik Lee, Chang Woo Chae, Ji Hyeon Cho, Young Hyun Jung, Jun Sung Kim, Seo Yihl Kim, Jae Ryong Lim, Ho Jae Han
Summary: The study found that glucocorticoids inhibit NIX-dependent basal mitophagy, leading to reduced synaptic density and neurodegeneration, which can be reversed in a mouse model by pretreatment with a NIX enhancer.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Seo-Yeon Yoon, Dae-Hyun Roh, Ji-Hee Yeo, Jiwan Woo, Se Hee Han, Key-Sun Kim
Summary: The efficacy of alpha-2 adrenergic receptor (α2AR) agonists in relieving chronic neuropathic pain varies greatly among individuals, and is influenced by the timing of treatment post-establishment of neuropathic pain and the activity of regulator of G-protein signaling protein 4 (RGS4). Increased plasma membrane expression of RGS4 may be associated with reduced efficacy of α2AR agonists in a model of persistent neuropathic pain.
Article
Pharmacology & Pharmacy
Ji-Hee Yeo, Sol-Ji Kim, Dae-Hyun Roh
Summary: This study showed that rapamycin, an mTOR inhibitor, can reduce orofacial nociception and Fos expression in the trigeminal nucleus caudalis (TNC). The antinociceptive action of rapamycin on orofacial pain may be associated with the inhibition of p-p38 MAPK in the microglia.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jae-Gyun Choi, Sheu-Ran Choi, Dong-Wook Kang, Jaehyuk Kim, Jin Bong Park, Hyun-Woo Kim
Summary: The study investigates the effects of ACE inhibitors on the expression of SP and the induction of mechanical allodynia in mice. The findings suggest that inhibition of ACE increases SP levels, contributing to mechanical allodynia.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Biology
Ji-Hee Yeo, Dae-Hyun Roh
Summary: This study found that the combination of a low dose of dexmedetomidine with lidocaine can effectively reduce orofacial nociception without adverse side events, making it a potentially safe approach for managing acute inflammatory pain in the orofacial region, particularly mucogingival pain.
Article
Pharmacology & Pharmacy
Chang Woo Chae, Gee Euhn Choi, Young Hyun Jung, Jae Ryong Lim, Ji Hyeon Cho, Jee Hyeon Yoon, Ho Jae Han
Summary: The study investigates the relationship between hyperglycemia-induced retromer dysfunction and Alzheimer's disease (AD). The researchers found that high glucose down-regulated the vacuolar protein sorting-associated protein 26a (VPS26a) through a methylation pathway, leading to impaired intracellular trafficking and increased AD-like pathology. Restoring VPS26a levels improved cellular transport and decreased levels of amyloid beta (A beta) and phosphorylated tau (p-tau), suggesting that VPS26a plays a role in inhibiting DM-associated AD pathogenesis.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gee Euhn Choi, Chang Woo Chae, Mo Ran Park, Jee Hyeon Yoon, Young Hyun Jung, Hyun Jik Lee, Ho Jae Han
Summary: Exposure to prenatal stress has irreversible effects on neurogenesis and can lead to cognitive and neuropsychiatric abnormalities in adulthood. This study identified glucocorticoid as a key factor impairing neurogenesis and inducing abnormal behaviors. The researchers also discovered that astrocytes derived from neural stem cells exhibited neurotoxic properties after glucocorticoid treatment. Additionally, the study revealed that cortisol-treated astrocytic conditioned media inhibited glutamatergic synaptic formation and transmission in differentiating neurons. Restoring the expression of neuroligin 1 and neuronal FGFR1 through FGF2 treatment improved glutamatergic synaptogenesis and overall neurogenesis. The findings highlight the importance of understanding the impact of prenatal stress on brain development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biology
Sol-Ji Kim, Ji-Hee Yeo, Seo-Yeon Yoon, Dae-Hyun Roh
Summary: In a mouse model of repetitive nitroglycerin-induced migraine, facial cold allodynia and hindpaw mechanical allodynia are mediated by activation of TRPA1 and ASIC, respectively. Both types of allodynia showed a decrease in c-Fos expression after treatment with specific blockers.
Article
Cell Biology
Min Jeong Kim, Gee Euhn Choi, Chang Woo Chae, Jae Ryong Lim, Young Hyun Jung, Jee Hyeon Yoon, Ji Yong Park, Ho Jae Han
Summary: Carrots can decrease the likelihood of rabbits developing nearsightedness.
CELL DEATH & DISEASE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ji-Hoi Moon, Dae-Hyun Roh, Kyu Hwan Kwack, Jae-Hyung Lee
Summary: By using single-cell RNA sequencing (scRNA-seq), researchers have overcome the limitations of traditional methods in exploring individual cells and heterogeneity within mixed microbial communities, providing new insights into cell-to-cell diversity and interactions between the oral microbiome and the host.
JAPANESE DENTAL SCIENCE REVIEW
(2023)
Article
Veterinary Sciences
Dong-Wook Kang, Jae-Gyun Choi, Jaehyuk Kim, Jin Bong Park, Jang-Hern Lee, Hyun-Woo Kim
Summary: This study showed that treatment with bee venom can effectively alleviate burn-induced pain responses and improve walking performances. Additionally, bee venom has an inhibitory effect on the increased expression of substance P in the peripheral and central nervous systems following burn injury.
JOURNAL OF VETERINARY SCIENCE
(2021)