Functionalization of Imidazo[1,2-a]pyridines by Means of Metal-Catalyzed Cross-Coupling Reactions

Targeting the human parasite Leishmania donovani: Discovery of a new promising anti-infectious pharmacophore in 3-nitroimidazo[1,2-a]pyridine series

(2013) Caroline Castera-Ducros et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Facile synthesis of new imidazo[1,2-a]pyridines carrying 1,2,3-triazoles via click chemistry and their antiepileptic studies

(2013) Shrikanth Ulloora et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and structure activity relationship of imidazo[1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead series

(2013) Sreekanth Ramachandran et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

One-pot sequential C–N coupling and cross dehydrogenative couplings: synthesis of novel azole fused imidazo[1,2-a]pyridines

(2013) Kasiviswanadharaju Pericherla et al.   CHEMICAL COMMUNICATIONS

3-Biphenylimidazo[1,2-a]pyridines or [1,2-b]pyridazines and analogues, novel Flaviviridae inhibitors

(2013) Cécile Enguehard-Gueiffier et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Structure–Activity Relationship Studies of Novel Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase

(2013) Karin Meirer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Trineopentylphosphine: A Conformationally Flexible Ligand for the Coupling of Sterically Demanding Substrates in the Buchwald–Hartwig Amination and Suzuki–Miyaura Reaction

(2013) Steven M. Raders et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct catalytic C–H arylation of imidazo[1,2-a]pyridine with aryl bromides using magnetically recyclable Pd–Fe3O4 nanoparticles

(2013) Jaewoo Lee et al.   TETRAHEDRON

Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a]pyridine: expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines

(2013) Marc-Antoine Bazin et al.   TETRAHEDRON LETTERS

Pd-catalysed heteroarylations of 3-bromochromen-4-one via C–H bond activation of heteroarenes

(2013) Fatma Belkessam et al.   TETRAHEDRON LETTERS

Direct heteroarylation of 5-bromothiophen-2-ylpyridine and of 8-bromoquinoline via palladium-catalysed C–H bond activation: simpler access to heteroarylated nitrogen-based derivatives

(2013) Jenny Laroche et al.   Catalysis Science & Technology

Extending the utility of [Pd(NHC)(cinnamyl)Cl] precatalysts: Direct arylation of heterocycles

(2012) Anthony R Martin et al.   Beilstein Journal of Organic Chemistry

Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds

(2012) Garrett C. Moraski et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antibacterial activities of Groebke–Blackburn–Bienaymé-derived imidazo[1,2-a]pyridin-3-amines

(2012) Nikunj M. Shukla et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors

(2012) Emily A. Peterson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors

(2012) Yoshito Terao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase

(2012) Martina Hieke et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phosphodiesterase inhibitors. Part 4: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-4,4-dimethylpyrazolones

(2012) Koji Ochiai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New imidazo[1,2-a]pyridines carrying active pharmacophores: Synthesis and anticonvulsant studies

(2012) Shrikanth Ulloora et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Double CH Functionalization in Sequential Order: Direct Synthesis of Polycyclic Compounds by a Palladium-Catalyzed CH Alkenylation-Arylation Cascade

(2012) Hiroaki Ohno et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents

(2012) Sophie Marhadour et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Domino Benzylic-Amination-Sonogashira-Heterocyclisation Reaction: Direct Access to Dipyrido[1,2-a:3′,4′-d]imidazole Salts

(2012) Nicolas Henry et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Phosphine-Free Palladium-Catalyzed Direct Arylation of Imidazo[1,2-a]pyridines with Aryl Bromides at Low Catalyst Loading

(2012) Hai Yan Fu et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and Functionalization of Imidazo[1,2-a]Pyridines and Imidazo[1,2-a]Pyrimidines on Solid Phase Using Suzuki-Miyaura Cross-Coupling Reactions

(2012) Said El Kazzouli et al.   LETTERS IN ORGANIC CHEMISTRY

Regiocontrolled Microwave Assisted Bifunctionalization of 7,8-Dihalogenated Imidazo[1,2-a]pyridines: A One Pot Double-Coupling Approach

(2012) Emilie Marie et al.   MOLECULES

Direct Arylation of Imidazo[1,2-a]pyridine at C-3 with Aryl Iodides, Bromides, and Triflates via Copper(I)-Catalyzed C–H Bond Functionalization

(2012) Hua Cao et al.   ORGANIC LETTERS

Copper-Catalyzed Aerobic Oxidative Synthesis of Primary Amides from (Aryl)methanamines

(2012) Hua Fu et al.   SYNLETT

Straightforward Bienaymé and copper catalyzed N-arylation sequence to access diverse 5H-pyrido[2′,1′:2,3]imidazo[4,5-b]indoles and analogues

(2012) Ahmed El Akkaoui et al.   TETRAHEDRON

Design and preparation of new palladium precatalysts for C–C and C–N cross-coupling reactions

(2012) Nicholas C. Bruno et al.   Chemical Science

Highly regioselective C–H bond functionalization: palladium-catalyzed arylation of substituted imidazo[1,2-a]pyridine with aryl chlorides

(2012) Hua Cao et al.   RSC Advances

Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors

(2011) Moira L. Bode et al.   BIOORGANIC & MEDICINAL CHEMISTRY

2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus

(2011) Abdelselam Ali et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of 2-phenylimidazo[1,2-a]pyridines as a novel class of melatonin receptor ligands

(2011) Saïd El Kazzouli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

6-Substituted imidazo[1,2-a]pyridines: Synthesis and biological activity against colon cancer cell lines HT-29 and Caco-2

(2011) Nurit Dahan-Farkas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

N-Fused Imidazoles As Novel Anticancer Agents That Inhibit Catalytic Activity of Topoisomerase IIα and Induce Apoptosis in G1/S Phase

(2011) Ashish T. Baviskar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Direct Arylation of Polycyclic Aromatic Hydrocarbons through Palladium Catalysis

(2011) Kenji Mochida et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct C5-Arylation Reaction between Imidazoles and Aryl Chlorides Catalyzed by Palladium Complexes with Phosphines and N-Heterocyclic Carbenes

(2011) P. Vijaya Kumar et al.   ORGANOMETALLICS

Grignard reagent-promoted 6-endo-dig cyclization: instantaneous synthesis of original dipyrido[1,2-a:3′,4′-d]imidazole

(2011) Romain Oudot et al.   TETRAHEDRON

Pd-catalyzed regiocontrolled Sonogashira and Suzuki cross-coupling reaction of 3,6-dihalogenoimidazo[1,2-a]pyridines: one-pot double-coupling approach

(2011) Ahmed El Akkaoui et al.   TETRAHEDRON

An efficient access to 2,3-diarylimidazo[1,2-a]pyridines via imidazo[1,2-a]pyridin-2-yl triflate through a Suzuki cross-coupling reaction-direct arylation sequence

(2011) Sophie Marhadour et al.   TETRAHEDRON LETTERS

Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity

(2011) Garrett C. Moraski et al.   ACS Medicinal Chemistry Letters

Synthesis of a Novel Series of Imidazo[1,2-α]pyridines as Acyl-CoA: Cholesterol Acyltransferase (ACAT) Inhibitors

(2010)   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

(2010) Thomas W. Lyons et al.   CHEMICAL REVIEWS

Synthesis and antiviral activity of an imidazo[1,2-a]pyrrolo[2,3-c]pyridine series against the bovine viral diarrhea virus

(2010) Jean-Michel Chezal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Post Groebke–Blackburn multicomponent protocol: Synthesis of new polyfunctional imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine derivatives as potential antimicrobial agents

(2010) Taleb H. Al-Tel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Chiral High Performance Liquid Chromatographic Resolution and Enantiospecific Activity of a Potent New Geranylgeranyl Transferase Inhibitor, 2-Hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic Acid

(2010) Charles E. McKenna et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biological importance of imidazole nucleus in the new millennium

(2010) Balasubramanian Narasimhan et al.   MEDICINAL CHEMISTRY RESEARCH

Copper(i)-mediated preparation of new pyrano[3′,4′:4,5]imidazo[1,2-a]pyridin-1-one compounds under mild palladium-free conditions

(2010) Zineb Bahlaouan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Intramolecular arylation reactions: first efficient synthesis of novel fused pyridoimidazoquinolinones or pyridoimidazoazepinones libraries

(2010) J. Koubachi et al.   TETRAHEDRON

Transition-Metal-Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage

(2009) Lutz Ackermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Paradoxical effects of the hypnotic Zolpidem in the neonatal ferret

(2009) Nina Hsu et al.   BEHAVIOURAL BRAIN RESEARCH

3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists

(2009) Robert R. Singhaus et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor

(2009) Gary Tresadern et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Palladium-Catalyzed C3 or C4 Direct Arylation of Heteroaromatic Compounds with Aryl Halides by CH Bond Activation

(2009) Julien Roger et al.   ChemCatChem

Recent advances in aryl–aryl bond formation by direct arylation

(2009) Gerard P. McGlacken et al.   CHEMICAL SOCIETY REVIEWS

Physicochemical properties and membrane interactions of anti-apoptotic derivatives 2-(4-fluorophenyl)-3-(pyridin-4-yl)imidazo[1,2-a]pyridine depending on the hydroxyalkylamino side chain length and conformation: An NMR and ESR study

(2009) Sébastien Follot et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Novel Substituted Phenanthrenes and Polycyclic Heteroarenes by Pd-Catalyzed, Direct, Intramolecular Arylation/Heteroarylation

(2009) Ashok K. Yadav et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Recent advances in the synthesis of (hetero)aryl-substituted heteroarenes via transition metal-catalysed direct (hetero)arylation of heteroarene C–H bonds with aryl halides or pseudohalides, diaryliodonium salts, and potassium aryltrifluoroborates

(2009) Fabio Bellina et al.   TETRAHEDRON

Copper/Amino Acid Catalyzed Cross-Couplings of Aryl and Vinyl Halides with Nucleophiles†

(2008) Dawei Ma et al.   ACCOUNTS OF CHEMICAL RESEARCH

Direct Functionalization of Nitrogen Heterocycles via Rh-Catalyzed C−H Bond Activation

(2008) Jared C. Lewis et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Development of Versatile Methods for Palladium-Catalyzed Coupling Reactions of Aryl Electrophiles through the Use of P(t-Bu)3and PCy3as Ligands

(2008) Gregory C. Fu   ACCOUNTS OF CHEMICAL RESEARCH

The Promise and Challenge of Iron-Catalyzed Cross Coupling

(2008) Benjamin D. Sherry et al.   ACCOUNTS OF CHEMICAL RESEARCH

Palladium-Catalyzed Cross-Coupling Reactions of Organosilanols and Their Salts: Practical Alternatives to Boron- and Tin-Based Methods

(2008) Scott E. Denmark et al.   ACCOUNTS OF CHEMICAL RESEARCH

Well-Defined N-Heterocyclic Carbenes−Palladium(II) Precatalysts for Cross-Coupling Reactions

(2008) Nicolas Marion et al.   ACCOUNTS OF CHEMICAL RESEARCH

Biaryl Phosphane Ligands in Palladium-Catalyzed Amination

(2008) David S. Surry et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Influence of 6- or 8-substitution on the antiviral activity of 3-arylalkylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (CMV) and varicella-zoster virus (VZV): Part II

(2008) Jean-Baptiste Véron et al.   BIOORGANIC & MEDICINAL CHEMISTRY

IRAK-4 inhibitors. Part III: A series of imidazo[1,2-a]pyridines

(2008) George M. Buckley et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity

(2008) Stephen P. East et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antidepressants for the Treatment of Insomnia

(2008) Michael H Wiegand   DRUGS

Novel imidazo[1,2-a]naphthyridinic systems (part 1): Synthesis, antiproliferative and DNA-intercalating activities

(2008) Mounir Andaloussi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

One-Pot Dual Substitutions of Bromobenzyl Chloride, 2-Chloromethyl-6-halogenoimidazo[1,2-a]pyridine and -[1,2-b]pyridazine by Suzuki-Miyaura Cross-Coupling Reactions

(2008) Nicolas Henry et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Structural Requirements for Eszopiclone and Zolpidem Binding to the γ-Aminobutyric Acid Type-A (GABAA) Receptor Are Different

(2008) Susan M. Hanson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines

(2007) Mohamed A. Ismail et al.   BIOORGANIC & MEDICINAL CHEMISTRY