Efficient Anti-Markovnikov-Selective Catalysts for Intermolecular Alkyne Hydroamination: Recent Advances and Synthetic Applications

Bis(amidate)bis(amido) Titanium Complex: A Regioselective Intermolecular Alkyne Hydroamination Catalyst

(2014) Jacky C.-H. Yim et al.   JOURNAL OF ORGANIC CHEMISTRY

The Top Prescription Drugs of 2012 Globally: Biologics Dominate, But Small Molecule CNS Drugs Hold on to Top Spots

(2013) Craig W. Lindsley   ACS Chemical Neuroscience

Copper-Catalyzed Intermolecular Regioselective Hydroamination of Styrenes with Polymethylhydrosiloxane and Hydroxylamines

(2013) Yuya Miki et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total synthesis of (−)-epimyrtine by a gold-catalyzed hydroamination approach

(2013) Thi Thanh Huyen Trinh et al.   Beilstein Journal of Organic Chemistry

Silver-catalysed intramolecular hydroamination of alkynes with trichloroacetimidates

(2013) Valerie H. L. Wong et al.   CHEMICAL COMMUNICATIONS

Asymmetric Hydroamination: A Survey of the Most Recent Developments

(2013) Jérôme Hannedouche et al.   CHEMISTRY-A EUROPEAN JOURNAL

Anti-Markovnikov Hydroamination of Alkenes Catalyzed by an Organic Photoredox System

(2013) Tien M. Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Thiourea-Catalyzed Intramolecular Cope-Type Hydroamination

(2013) Adam R. Brown et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Enantioselective Zirconium-Catalyzed Cyclization of Aminoalkenes

(2013) Kuntal Manna et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alkyne Hydroamination and Trimerization with Titanium Bis(phenolate)pyridine Complexes: Evidence for Low-Valent Titanium Intermediates and Synthesis of an Ethylene Adduct of Titanium(II)

(2013) Ian A. Tonks et al.   ORGANOMETALLICS

Catalytic Methods for Imine Synthesis

(2013) Rajendra D. Patil et al.   Asian Journal of Organic Chemistry

Catalytic Asymmetric Synthesis of Substituted Morpholines and Piperazines

(2012) Huimin Zhai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gold(I)-Catalyzed Stereoconvergent, Intermolecular Enantioselective Hydroamination of Allenes

(2012) Kristina L. Butler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Consecutive Intermolecular Reductive Hydroamination: Cooperative Transition-Metal and Chiral Brønsted Acid Catalysis

(2012) Steffen Fleischer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of the 1-Phenethyltetrahydroisoquinoline Alkaloids (+)-Dysoxyline, (+)-Colchiethanamine, and (+)-Colchiethine

(2012) Raju Jannapu Reddy et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed Cascade Process To Construct 1,2,5-Trisubstituted Pyrroles

(2012) Yong-Qiang Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Rhenium-Catalyzed Regio- and Stereoselective Addition of Imines to Terminal Alkynes Leading to N-Alkylideneallylamines

(2012) Yoshiya Fukumoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Tertiary Alkyl Amines from Terminal Alkenes: Copper-Catalyzed Amination of Alkyl Boranes

(2012) Richard P. Rucker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-Catalyzed Intermolecular Hydroamination of Unactivated Aliphatic Alkenes with Amides and Sulfonamides

(2012) Christo S. Sevov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A divergent approach to the synthesis of the yohimbinoid alkaloids venenatine and alstovenine

(2012) Terry P. Lebold et al.   Nature Chemistry

Preparation of dicationic palladium catalysts for asymmetric catalytic reactions

(2012) Andrey E Sheshenev et al.   Nature Protocols

Rhodium(III)-Catalyzed Hydroamination of Aromatic Terminal Alkynes with Anilines

(2012) Elumalai Kumaran et al.   ORGANOMETALLICS

Zirconium-Catalyzed Multistep Reaction of Hydrazines with Alkynes: A Non-Fischer-Type Pathway to Indoles

(2011) Thorsten Gehrmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gold-Catalyzed Hydroamination of Alkynes and Allenes with Parent Hydrazine

(2011) Rei Kinjo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydroamination of Alkynes with Ammonia: Unforeseen Role of the Gold(I) Catalyst

(2011) Gábor Kovács et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regio- and Enantioselective Hydroamination of Dienes by Gold(I)/Menthol Cooperative Catalysis

(2011) Osamu Kanno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Highly Enantioselective Zirconium Catalyst for Intramolecular Alkene Hydroamination: Significant Isotope Effects on Rate and Stereoselectivity

(2011) Kuntal Manna et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Chiral Phenoxyamine Magnesium Catalyst for the Enantioselective Hydroamination/Cyclization of Aminoalkenes and Intermolecular Hydroamination of Vinyl Arenes

(2011) Xiaoming Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent developments in gold-catalyzed cycloaddition reactions

(2011) Fernando López et al.   Beilstein Journal of Organic Chemistry

A novel Zn-catalyzed hydroamination of propargylamides: a general synthesis of di- and tri-substituted imidazoles

(2011) Anahit Pews-Davtyan et al.   CHEMICAL COMMUNICATIONS

Synthesis and hydroamination catalysis with 3-aryl substituted pyrrolyl and dipyrrolylmethane titanium(iv) complexes

(2011) Douglas L. Swartz II et al.   DALTON TRANSACTIONS

Intermolecular hydroamination of oxygen-substituted allenes. New routes for the synthesis of N,O-chelated zirconium and titanium amido complexes

(2011) Rashidat O. Ayinla et al.   DALTON TRANSACTIONS

Zirconium-Catalyzed Intermolecular Hydroamination of Alkynes with Primary Amines

(2011) Karolin Born et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A Stereocontrolled Synthesis of (+)-Saxitoxin

(2011) Vasudev R. Bhonde et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intermolecular Migratory Insertion of Unactivated Olefins into Palladium–Nitrogen Bonds. Steric and Electronic Effects on the Rate of Migratory Insertion

(2011) Patrick S. Hanley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heavier Alkaline Earth Catalysts for the Intermolecular Hydroamination of Vinylarenes, Dienes, and Alkynes

(2011) Christine Brinkmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of α-CN and α-CF3N-Heterocycles through Tandem Nucleophilic Additions

(2011) Junbin Han et al.   ORGANIC LETTERS

Total Synthesis of the Photoprotecting Dipyrrolobenzoquinone (+)-Terreusinone

(2011) Christy Wang et al.   ORGANIC LETTERS

Nickel-Catalyzed Transfer Semihydrogenation and Hydroamination of Aromatic Alkynes Using Amines As Hydrogen Donors

(2011) Adán Reyes-Sánchez et al.   ORGANOMETALLICS

2,5-Bis{N-(2,6-diisopropylphenyl)iminomethyl}pyrrolyl Complexes of the Heavy Alkaline Earth Metals: Synthesis, Structures, and Hydroamination Catalysis

(2011) Jelena Jenter et al.   ORGANOMETALLICS

Group 5 Metal Binaphtholate Complexes for Catalytic Asymmetric Hydroaminoalkylation and Hydroamination/Cyclization

(2011) Alexander L. Reznichenko et al.   ORGANOMETALLICS

Chiral Amine Synthesis - Recent Developments and Trends for Enamide Reduction, Reductive Amination, and Imine Reduction

(2010) Thomas C. Nugent et al.   ADVANCED SYNTHESIS & CATALYSIS

Regioselective Rhodium(II)-Catalyzed Hydroaminations of Propargylguanidines

(2010) Morgan J. Gainer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Intermolecular Hydroamination of Unactivated Alkenes with Simple Amines

(2010) Alexander L. Reznichenko et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium- and Iridium-Catalyzed Hydroamination of Alkenes

(2010) Kevin D. Hesp et al.   ChemCatChem

β-Diketiminate Zinc Complexes for the Hydroamination of Alkynes

(2010) Mustafa Biyikal et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Highly Convenient Regioselective Intermolecular Hydroamination of Alkynes Yielding Ketimines Catalyzed by Gold(I) Complexes of 1,2,4-triazole Based N-heterocyclic Carbenes

(2010) Chandrakanta Dash et al.   INORGANIC CHEMISTRY

Au(I)-Catalyzed Cascade Reaction Involving Formal Double Hydroamination of Alkynes Bearing Tethered Carboxylic Groups: An Easy Access to Fused Dihydrobenzimidazoles and Tetrahydroquinazolines

(2010) Nitin T. Patil et al.   JOURNAL OF ORGANIC CHEMISTRY

Mild and Efficient Desymmetrization of Diynes via Hydroamination: Application to the Synthesis of (±)-Monomorine I

(2010) Vijaya Bhaskara Reddy Iska et al.   JOURNAL OF ORGANIC CHEMISTRY

Alkyne hydroamination triggered cyclizations: A powerful tool for the construction of biologically important structural motifs

(2010) Nitin T. Patil et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Annulation of Thioimidates and Vinyl Carbodiimides to Prepare 2-Aminopyrimidines, Competent Nucleophiles for Intramolecular Alkyne Hydroamination. Synthesis of (−)-Crambidine

(2010) Nicholas R. Perl et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Concerted C−N and C−H Bond Formation in a Magnesium-Catalyzed Hydroamination

(2010) James F. Dunne et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereo- and Regioselective Gold-Catalyzed Hydroamination of Internal Alkynes with Dialkylamines

(2010) Kevin D. Hesp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Study of Gold(I)-Catalyzed Intermolecular Hydroamination of Allenes

(2010) Z. Jane Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intramolecular Hydroamination of Unbiased and Functionalized Primary Aminoalkenes Catalyzed by a Rhodium Aminophosphine Complex

(2010) Lisa D. Julian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Zirconium Complexes Supported by Imidazolones: Synthesis, Characterization, and Application of Precatalysts for the Hydroamination of Aminoalkenes

(2010) Yu-Cheng Hu et al.   ORGANOMETALLICS

Titanium catalyzed one-pot multicomponent coupling reactions for direct access to substituted pyrimidines

(2010) Supriyo Majumder et al.   TETRAHEDRON

Reusable Gold(I) Catalysts with Unique Regioselectivity for Intermolecular Hydroamination of Alkynes

(2009) Antonio Leyva et al.   ADVANCED SYNTHESIS & CATALYSIS

Pyrazole Synthesis Using a Titanium-Catalyzed Multicomponent Coupling Reaction and Synthesis of Withasomnine

(2009) Supriyo Majumder et al.   ADVANCED SYNTHESIS & CATALYSIS

Highly Efficient and Regioselective Platinum(II)-Catalyzed Tandem Synthesis of Multiply Substituted Indolines and Tetrahydroquinolines

(2009) Xin-Yuan Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium-Catalyzed Asymmetric Intramolecular Hydroamination of Unactivated Alkenes

(2009) Xiaoqiang Shen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Scaffold-based design and synthesis of potent N-type calcium channel blockers

(2009) Gerald W. Zamponi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Alkyne activation with Brønsted acids, iodine, or gold complexes, and its fate leading to synthetic application

(2009) Yoshinori Yamamoto et al.   CHEMICAL COMMUNICATIONS

A Cationic Gold(I) Complex as a General Catalyst for the Intermolecular Hydroamination of Alkynes: Application to the One-Pot Synthesis of Allenes from Two Alkynes and a Sacrificial Amine

(2009) Xiaoming Zeng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rhodium(I) and iridium(I) complexes containing bidentate phosphine-imidazolyl donor ligands as catalysts for the hydroamination and hydrothiolation of alkynes

(2009) Leslie D. Field et al.   DALTON TRANSACTIONS

Platinum-Catalyzed Formal Markownikoff’s Hydroamination/Hydroarylation Cascade of Terminal Alkynes Assisted by Tethered Hydroxyl Groups

(2009) Nitin T. Patil et al.   JOURNAL OF ORGANIC CHEMISTRY

Broadening the Scope of Group 4 Hydroamination Catalysis Using a Tethered Ureate Ligand

(2009) David C. Leitch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of a Simplified Version of Stable Bulky and Rigid Cyclic (Alkyl)(amino)carbenes, and Catalytic Activity of the Ensuing Gold(I) Complex in the Three-Component Preparation of 1,2-Dihydroquinoline Derivatives

(2009) Xiaoming Zeng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Triazole−Au(I) Complexes: A New Class of Catalysts with Improved Thermal Stability and Reactivity for Intermolecular Alkyne Hydroamination

(2009) Haifeng Duan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intermolecular Hydroamination of Ethylene and 1-Alkenes with Cyclic Ureas Catalyzed by Achiral and Chiral Gold(I) Complexes

(2009) Zhibin Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Consecutive Intramolecular Hydroamination/Asymmetric Transfer Hydrogenation under Relay Catalysis of an Achiral Gold Complex/Chiral Brønsted Acid Binary System

(2009) Zhi-Yong Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Efficient Cu(I)-Catalyzed Synthesis ofN-Heterocycles through a Cyclization-Triggered Addition of Alkynes

(2009) Junbin Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

[Ir(COD)Cl]2as a Catalyst Precursor for the Intramolecular Hydroamination of Unactivated Alkenes with Primary Amines and Secondary Alkyl- or Arylamines: A Combined Catalytic, Mechanistic, and Computational Investigation

(2009) Kevin D. Hesp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Multicomponent Coupling Sequence for Direct Access to Substituted Quinolines

(2009) Supriyo Majumder et al.   ORGANIC LETTERS

Highly Enantioselective Synthesis of Chiral Secondary Amines by Gold(I)/Chiral Brønsted Acid Catalyzed Tandem Intermolecular Hydroamination and Transfer Hydrogenation Reactions

(2009) Xin-Yuan Liu et al.   ORGANIC LETTERS

Titanium Hydrazinediido Half-Sandwich Complexes: Highly Active Catalysts for the Hydrohydrazination of Terminal Alkynes at Ambient Temperature

(2009) Katharina Weitershaus et al.   ORGANOMETALLICS

One-Step Route to 2,3-Diaminopyrroles Using a Titanium-Catalyzed Four-Component Coupling

(2009) Eyal Barnea et al.   ORGANOMETALLICS

Thieme Chemistry Journal Awardees - Where Are They Now? Palladium-Catalyzed N-Arylation-Hydroamination Sequence for the Synthesis of Indoles with Sterically Demanding N-Substituents

(2009) Lutz Ackermann et al.   SYNLETT

Palladium-catalyzed sequential indole synthesis using sterically hindered amines

(2009) Lutz Ackermann et al.   TETRAHEDRON

Palladium-free zinc-mediated hydroamination of alkynes: efficient synthesis of indoles from 2-akynylaniline derivatives

(2009) Kentaro Okuma et al.   TETRAHEDRON LETTERS

Hydroamination: Direct Addition of Amines to Alkenes and Alkynes

(2008) Thomas E. Müller et al.   CHEMICAL REVIEWS

General Zinc-Catalyzed Intermolecular Hydroamination of Terminal Alkynes

(2008) Karolin Alex et al.   ChemSusChem

Imido and Amido Titanium Complexes that Contain a [OSSO]-Type Bis(phenolato) Ligand: Synthesis, Structures, and Hydroamination Catalysis

(2008) Bing Lian et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Neutral Ti Complexes as Catalysts for the Hydroamination of Alkynes and Alkenes: Do the Labile Ligands Change the Catalytic Activity?

(2008) Kerstin Gräbe et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Catalytic Asymmetric Intramolecular Hydroamination of Alkynes in the Presence of a Catalyst System Consisting of Pd(0)-Methyl Norphos (or Tolyl Renorphos)-Benzoic Acid

(2008) Meda Narsireddy et al.   JOURNAL OF ORGANIC CHEMISTRY

Intermolecular, Catalytic Asymmetric Hydroamination of Bicyclic Alkenes and Dienes in High Yield and Enantioselectivity

(2008) Jianrong (Steve) Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Studies of a Palladium-Catalyzed Intramolecular Hydroamination of Unactivated Alkenes:  Protonolysis of a Stable Palladium Alkyl Complex Is the Turnover-Limiting Step

(2008) Brian M. Cochran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intramolecular Hydroamination of Aminoalkynes with Silver−Phenanthroline Catalysts

(2008) Jeffrey M. Carney et al.   ORGANIC LETTERS

(Triphenyl phosphite)gold(I)-Catalyzed Intermolecular Hydroamination of Alkenes and 1,3-Dienes†

(2008) Xavier Giner et al.   ORGANIC LETTERS

Titanium-Catalyzed Hydrohydrazination with Monosubstituted Hydrazines: Catalyst Design, Synthesis, and Reactivity

(2008) Sanjukta Banerjee et al.   ORGANOMETALLICS

Construction of Heterocycles by the Strategic Use of Alkyne π-Activation in Catalyzed Cascade Reactions

(2008) Stefan Kirsch   SYNTHESIS-STUTTGART

A highly regioselective Cu-exchanged tungstophosphoric acid catalyst for hydroarylation and hydroamination of alkynes

(2008) Nayeem Pasha et al.   TETRAHEDRON LETTERS

Reactions of Alkynes Using Heterogeneous and Homogeneous Cationic Gold Catalysts

(2008) Graham J. Hutchings   TOPICS IN CATALYSIS

Anti-Markovnikov hydroamination and hydrothiolation of electron-deficient vinylarenes catalyzed by well-defined monomeric copper(i) amido and thiolate complexes

(2007) Colleen Munro-Leighton et al.   CHEMICAL COMMUNICATIONS

Palladium catalysts immobilized in thin films of ionic liquid for the direct addition of aniline to styrene

(2007) Carsten Sievers et al.   JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL