Catalytic Asymmetric Synthesis of Substituted Morpholines and Piperazines

125I-Radiolabeled Morpholine-Containing Arginine–Glycine–Aspartate (RGD) Ligand of αvβ3 Integrin As a Molecular Imaging Probe for Angiogenesis

(2012) Francesca Bianchini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regio- and Enantioselective Hydroamination of Dienes by Gold(I)/Menthol Cooperative Catalysis

(2011) Osamu Kanno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure–activity relationships in group 3 metal catalysts for asymmetric intramolecular alkene hydroamination. An investigation of ligands based on the axially chiral 1,1′-binaphthyl-2,2′-diamine motif

(2011) Helena M. Lovick et al.   DALTON TRANSACTIONS

Sulfinamides as Highly Effective Amine Protecting Groups and Their Use in the Conversion of Amino Alcohols into Morpholines

(2011) Sven P. Fritz et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Rhodium Phosphine−π-Arene Intermediates in the Hydroamination of Alkenes

(2011) Zhijian Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Elucidation of Intramolecular Aminoalkene Hydroamination Catalyzed by a Tethered Bis(ureate) Complex: Evidence for Proton-Assisted C–N Bond Formation at Zirconium

(2011) David C. Leitch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alkyl Complexes of Lanthanum and Samarium Supported by a Chiral Binaphthylamido Ligand. Syntheses, Structures, and Catalytic Activity in Hydroamination of Amino-1,3-dienes

(2011) Isabelle Aillaud et al.   ORGANOMETALLICS

2,5-Bis{N-(2,6-diisopropylphenyl)iminomethyl}pyrrolyl Complexes of the Heavy Alkaline Earth Metals: Synthesis, Structures, and Hydroamination Catalysis

(2011) Jelena Jenter et al.   ORGANOMETALLICS

Group 5 Metal Binaphtholate Complexes for Catalytic Asymmetric Hydroaminoalkylation and Hydroamination/Cyclization

(2011) Alexander L. Reznichenko et al.   ORGANOMETALLICS

Asymmetric Intermolecular Hydroamination of Unactivated Alkenes with Simple Amines

(2010) Alexander L. Reznichenko et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and synthesis of piperazine-indole p38α MAP kinase inhibitors with improved pharmacokinetic profiles

(2010) Xuefei Tan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enantioselective Chemoenzymatic Synthesis ofcis-andtrans-2,5-Disubstituted Morpholines

(2010) Bas Ritzen et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Enantiopure 3-Substituted Morpholines

(2010) Jan Bornholdt et al.   JOURNAL OF ORGANIC CHEMISTRY

Mild and Efficient Desymmetrization of Diynes via Hydroamination: Application to the Synthesis of (±)-Monomorine I

(2010) Vijaya Bhaskara Reddy Iska et al.   JOURNAL OF ORGANIC CHEMISTRY

CCC–N-heterocyclic carbene pincer complexes: Synthesis, characterization and hydroamination activity of a hafnium complex

(2010) Joon Cho et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Linked bis(β-diketiminato) yttrium and lanthanum complexes as catalysts in asymmetric hydroamination/cyclization of aminoalkenes (AHA)

(2010) Daniela V. Vitanova et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Atom-Economical Synthesis ofN-Heterocycles via Cascade Inter-/Intramolecular C−N Bond-Forming Reactions Catalyzed by Ti Amides

(2010) Hao Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Annulation of Thioimidates and Vinyl Carbodiimides to Prepare 2-Aminopyrimidines, Competent Nucleophiles for Intramolecular Alkyne Hydroamination. Synthesis of (−)-Crambidine

(2010) Nicholas R. Perl et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intramolecular Hydroamination/Cyclization of Aminoalkenes Catalyzed by Ln[N(SiMe3)2]3Grafted onto Periodic Mesoporous Silicas

(2010) Erwan Le Roux et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Concerted C−N and C−H Bond Formation in a Magnesium-Catalyzed Hydroamination

(2010) James F. Dunne et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereo- and Regioselective Gold-Catalyzed Hydroamination of Internal Alkynes with Dialkylamines

(2010) Kevin D. Hesp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism of Catalytic Cyclohydroamination by Zirconium Salicyloxazoline Complexes

(2010) Laura E. N. Allan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Stereocontrolled Synthesis of (±)-Xenovenine via a Scandium(III)-Catalyzed Internal Aminodiene Bicyclization Terminated by a 2-(5-Ethyl-2-thienyl)ethenyl Group

(2010) Tao Jiang et al.   ORGANIC LETTERS

Zirconium Alkyl Complexes Supported by Ureate Ligands: Synthesis, Characterization, and Precursors to Metal−Element Multiple Bonds†

(2010) David C. Leitch et al.   ORGANOMETALLICS

On the scope of Pd-catalyzed carboamination reactions—synthesis of 2,4-disubstituted pyrrolidines and 2-substituted piperidines and morpholines

(2010) Tue Heesgaard Jepsen et al.   TETRAHEDRON

Rhodium-Catalyzed Asymmetric Intramolecular Hydroamination of Unactivated Alkenes

(2009) Xiaoqiang Shen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gold-Catalyzedendo-Cyclizations of 1,4-Diynes to Seven-Membered Ring Heterocycles

(2009) Kristina Wilckens et al.   CHEMISTRY-A EUROPEAN JOURNAL

New Strategy for the Synthesis of Substituted Morpholines

(2009) Matthew L. Leathen et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Syntheses of Morpholines and Their Homologues via SN2-Type Ring Opening of Aziridines and Azetidines with Haloalcohols

(2009) Manas K. Ghorai et al.   JOURNAL OF ORGANIC CHEMISTRY

The Tandem Cope-Type Hydroamination/[2,3]-Rearrangement Sequence: A Strategy to Favor the Formation of Intermolecular Hydroamination Products and Enable Difficult Cyclizations

(2009) Joffré Bourgeois et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heavier Group 2 Metals and Intermolecular Hydroamination: A Computational and Synthetic Assessment

(2009) Anthony G. M. Barrett et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Broadening the Scope of Group 4 Hydroamination Catalysis Using a Tethered Ureate Ligand

(2009) David C. Leitch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Efficient Cu(I)-Catalyzed Synthesis ofN-Heterocycles through a Cyclization-Triggered Addition of Alkynes

(2009) Junbin Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

[Ir(COD)Cl]2as a Catalyst Precursor for the Intramolecular Hydroamination of Unactivated Alkenes with Primary Amines and Secondary Alkyl- or Arylamines: A Combined Catalytic, Mechanistic, and Computational Investigation

(2009) Kevin D. Hesp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Annulation Reaction for the Synthesis of Morpholines, Thiomorpholines, and Piperazines from β-Heteroatom Amino Compounds and Vinyl Sulfonium Salts

(2008) Muhammad Yar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

4-(1,3-Thiazol-2-yl)morpholine derivatives as inhibitors of phosphoinositide 3-kinase

(2008) Rikki Alexander et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hydroamination: Direct Addition of Amines to Alkenes and Alkynes

(2008) Thomas E. Müller et al.   CHEMICAL REVIEWS

Concise Synthesis of the CDE Ring System of Tetrahydroisoquinoline Alkaloids Using Carbophilic Lewis Acid-Catalyzed Hydroamidation and Oxidative Friedel−Crafts Cyclization

(2008) Shingo Obika et al.   JOURNAL OF ORGANIC CHEMISTRY

Carbon–heteroatom bond formation catalysed by organometallic complexes

(2008) John F. Hartwig   NATURE

Synthesis of 2,6-Disubstituted Piperazines by a Diastereoselective Palladium-Catalyzed Hydroamination Reaction

(2007) Brian M. Cochran et al.   ORGANIC LETTERS