Imidazole- and Benzimidazole-Based Inhibitors of the Kinase IspE: Targeting the Substrate-Binding Site and the Triphosphate-Binding Loop of the ATP Site

Exploring the Ribose Sub-Pocket of the Substrate-Binding Site in Escherichia coli IspE: Structure-Based Design, Synthesis, and Biological Evaluation of Cytosines and Cytosine Analogues

(2012) Andri P. Schütz et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The isoprenoid-precursor dependence of Plasmodium spp.

(2012) Jan-Ytzen van der Meer et al.   NATURAL PRODUCT REPORTS

The MEP pathway and the development of inhibitors as potential anti-infective agents

(2012) Ian Hale et al.   MedChemComm

Biochemistry of the non-mevalonate isoprenoid pathway

(2011) Tobias Gräwert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Crystal structure of 4-diphosphocytidyl-2-C-methyl-d-erythritol kinase (IspE) from Mycobacterium tuberculosis

(2011) Shan Shan et al.   FASEB JOURNAL

Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake

(2008) Amanda C Brown et al.   BMC MICROBIOLOGY

Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery

(2008) Tanja Sgraja et al.   FEBS Journal

Inhibitors of the kinase IspE: structure–activity relationships and co-crystal structure analysis

(2008) Anna K. H. Hirsch et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Physiological function of IspE, a plastid MEP pathway gene for isoprenoid biosynthesis, in organelle biogenesis and cell morphogenesis in Nicotiana benthamiana

(2008) Chang Sook Ahn et al.   PLANT MOLECULAR BIOLOGY

Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase IspE of the Non-Mevalonate Pathway for Isoprenoid Biosynthesis

(2007) Christine M. Crane et al.   ChemMedChem