Review
Chemistry, Multidisciplinary
Peng-Fei Cui, Xin-Ran Liu, Guo-Xin Jin
Summary: The utilization of carboranes in supramolecular chemistry has attracted attention due to their unique properties. However, there are still limited studies in this area. This article presents major findings and future research directions for carboranes in supramolecular chemistry.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Georg Niggemeyer, Anastasia Knyazeva, Raphael Gasper, Dale Corkery, Pia Bodenbinder, Julian J. Holstein, Sonja Sievers, Yao-Wen Wu, Herbert Waldmann
Summary: Design and synthesis of pseudo-natural products through recombination of natural product fragments enables the discovery of novel biologically relevant chemical matter. In this study, the combination of this principle with macrocycle formation was described, leading to the efficient synthesis of 163 macrocyclic pseudo-natural products. Biological investigation revealed their potent inducers of autophagy-related processes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Multidisciplinary Sciences
Luca Muenzfeld, Sebastian Gillhuber, Adrian Hauser, Sergei Lebedkin, Pauline Haedinger, Nicolai D. Knoefel, Christina Zovko, Michael T. Gamer, Florian Weigend, Manfred M. Kappes, Peter W. Roesky
Summary: Cyclic nanometre-scale sandwich complexes with metal ion coordination by two planar aromatic organic rings were synthesized. These complexes have broad applications in catalysis, synthesis, electrochemistry, nanotechnology, materials science, and medicine. This study presents the design, synthesis, and characterization of a series of circular sandwich compounds, called "cyclocenes". These cyclocenes consist of 18 repeating units, forming almost perfectly circular rings, and their formation is facilitated by the interplay of ionic metal-to-ligand bonds, the bulkiness of the ligand system, and energy gain on ring closure.
Article
Chemistry, Multidisciplinary
Jie Liu, Gregor S. Cremosnik, Felix Otte, Axel Pahl, Sonja Sievers, Carsten Strohmann, Herbert Waldmann
Summary: This study presents the design and synthesis of a collection of 155 pyrroquinoline pseudo-NPs, combining fragments characteristic of tetrahydroquinoline and pyrrolidine classes in novel arrangements. Cheminformatic analysis and biological evaluation revealed chemically diverse pseudo-NP classes with distinct bioactivity patterns, dependent on fragment connectivity and regioisomeric arrangement.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Evgeniy V. Suslov, Konstantin Y. Ponomarev, Oxana S. Patrusheva, Sergey O. Kuranov, Alina A. Okhina, Artem D. Rogachev, Aldar A. Munkuev, Roman V. Ottenbacher, Alexander I. Dalinger, Mikhail A. Kalinin, Sergey Z. Vatsadze, Konstantin P. Volcho, Nariman F. Salakhutdinov
Summary: A series of new chiral bispidines containing monoterpenoid fragments were synthesized and studied as ligands for Ni-catalyzed addition reactions. Conditions for chromatographic analysis were developed to separate the enantiomers of the synthesized chiral products. The bispidine-monoterpenoid conjugates were found to be effective ligands for reactions, but not chiral inducers, with the observation of significant formation of hydrogenation products in the presence of catalytic systems.
Review
Chemistry, Medicinal
Gayathri Rajendran, Deepu Bhanu, Baladhandapani Aruchamy, Prasanna Ramani, Nanjan Pandurangan, Kondapa Naidu Bobba, Eun Jung Oh, Ho Yun Chung, Prakash Gangadaran, Byeong-Cheol Ahn
Summary: This review summarizes the structures, synthesis methods, biological characteristics, and applications of chalcones over the past decade, and provides detailed insights into their structure-activity relationship studies. It offers guidelines for future design and synthesis of promising drug candidates, and provides important support for the development of drugs against infectious and non-infectious diseases.
Article
Acoustics
Sasadhar Majhi
Summary: Total synthesis is a method for preparing complex natural products from simple materials, which plays a crucial role in confirming complex structures and preparing rare bioactive substances. The use of ultrasound as a non-polluting energy source in the synthesis of bioactive natural products highlights its potential in sustainable and pharmaceutical chemistry.
ULTRASONICS SONOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Guo-Qing Chen, Hong-Yan Guo, Zhe-Shan Quan, Qing-Kun Shen, Xiaoting Li, Tian Luan
Summary: This review summarizes the structure, biological activity, and mechanism of natural product derivatives containing pyrazine fragments reported from 2000 to September 2023. The results show that pyrazine-modified natural product derivatives have a wide range of biological activities and lower toxicity.
Article
Biochemistry & Molecular Biology
Emilia P. T. Leitao, Osvaldo S. Ascenso, Tania Santos de Almeida, Ignacio Gonzalez, Inmaculada Hernandez, Jose Quintana, Francisco Estevez, Patricia Rijo
Summary: A series of hydroxylated chalcone derivatives with different substitution patterns were prepared, and it was found that the naphthylchalcone containing a methoxy group in position 6 ' of the A ring exhibited the highest cytotoxicity against human leukaemia cells.
BIOORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Xiamin Cheng, Hui Yan, Songhao Pang, Mingjun Ya, Feng Qiu, Pinzhu Qin, Chao Zeng, Yongna Lu
Summary: This review discusses the targeted delivery of medicinal natural products, focusing on the preparation of functional liposomes and the application of liposomal medicinal natural products. It provides useful guidance to enhance targeted therapy of medicinal natural products.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Organic
Nazar Dovhaniuk, Oleksandr P. Blahun, Bohdan Sosunovych, Mykhailo O. Redka, Bohdan V. Vashchenko, Oleksandr O. Grygorenko
Summary: A new and efficient method for synthesizing licochalcone C in good yield has been developed, involving directed ortho-metalation for regioselective C-prenylation, metalation-formylation, selective O-deprotection, methylation, and aldol reaction. The synthesis of structurally related retrochalcones licoagrochalcones B, C, and D was also proposed.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Inorganic & Nuclear
George E. Kostakis
Summary: This article introduces a contemporary approach in molecular design and synthesis, called Chemical Chartographisis, which enhances the potential of flexible molecular systems by taking a holistic view of the reaction processes. The article discusses three projects in detail, involving catalytic and biologically related examples.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
William K. Chu, Charles K. Rono, Banothile C. E. Makhubela
Summary: In this study, a series of nine novel cationic triazole-based complexes were synthesized and evaluated for their anticancer activity against different cancer cells. One ruthenium(II) complex, C7, showed good activity and selectivity against all cancer cell lines. These complexes demonstrated selectivity towards specific cancer cells and interacted with certain biomolecules, potentially serving as templates for targeted drug development.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Tek Long Chan, Zhenpin Lu, Zuowei Xie
Summary: New types of ligands, carborane-fused cyclopentenyl and dicarbollyl-fused cyclopentene, were conveniently prepared in high yields. These new metallacarborane compounds were fully characterized by NMR spectroscopy, high-resolution mass spectroscopy, and single-crystal X-ray analyses, showcasing their potential for further study in the field of organometallic chemistry.
DALTON TRANSACTIONS
(2021)
Review
Chemistry, Medicinal
Varun Aggarwal, Ekta Bala, Pawan Kumar, Pankaj Raizada, Pardeep Singh, Praveen Kumar Verma
Summary: This review discusses the potential of using natural product-based drugs to fight against SARS-CoV-2. Seven human coronaviruses have been identified, and natural products play an important role in drug discovery.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Kirill Nikitin, Yannick Ortin, Helge Muller-Bunz, Declan G. Gilheany, Michael J. McGlinchey
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Yong Wang, Patrick M. Dansette, Pascal Pigeon, Siden Top, Michael J. McGlinchey, Daniel Mansuy, Gerard Jaouen
Article
Chemistry, Inorganic & Nuclear
Kirill Nikitin, Helge Mueller-Bunz, Patrick J. Guiry, Michael J. McGlinchey
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Yong Wang, Pascal Pigeon, Siden Top, Juan Sanz Garcia, Claire Troufflard, Ilaria Ciofini, Michael J. McGlinchey, Gerard Jaouen
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Review
Chemistry, Inorganic & Nuclear
Mauro Ravera, Elisabetta Gabano, Michael J. McGlinchey, Domenico Osella
INORGANICA CHIMICA ACTA
(2019)
Article
Chemistry, Medicinal
Federica Tonolo, Michele Salmain, Valeria Scalcon, Siden Top, Pascal Pigeon, Alessandra Folda, Benoit Caron, Michael J. McGlinchey, Robert-Alain Toillon, Alberto Bindoli, Gerard Jaouen, Anne Vessieres, Maria Pia Rigobello
Article
Biochemistry & Molecular Biology
Laura Cunningham, Yong Wang, Chris Nottingham, Jammah Pagsulingan, Gerard Jaouen, Michael J. McGlinchey, Patrick J. Guiry
Review
Biochemistry & Molecular Biology
Michael J. McGlinchey, Kirill Nikitin
Review
Biochemistry & Molecular Biology
Michael J. McGlinchey
Review
Chemistry, Inorganic & Nuclear
Anne Vessieres, Yong Wang, Michael J. McGlinchey, Gerard Jaouen
Summary: Organometallic quinone methides (OM-QMs) exhibit unique chemical and biological properties when incorporated into specific substrates like ferrocifens, leading to disruption of cancer cell metabolism and cytotoxicity. Among these, ferrocifens show the highest toxicity within the iron, ruthenium, osmium triad, and the complexes can be utilized as imaging probes.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Physical
Kirill Nikitin, Yannick Ortin, Michael J. McGlinchey
Summary: Directional internal rotation in molecular systems is typically controlled by chirality, and a designed molecular rotor with ferrocene and triptycene linked by a methylene bridge provides two rotational degrees of freedom. Experimental observations and computational data suggest strong coupling between the two rotation modes, with the spatial orientation of the bistable ferrocene moiety influencing its rotation barrier. These findings demonstrate the potential for locally preferred thermal directional intramolecular rotation in dynamically interconverting enantiomers.
JOURNAL OF PHYSICAL CHEMISTRY A
(2021)
Article
Chemistry, Medicinal
Yong Wang, Pascal Pigeon, Wei Li, Jiangkun Yan, Patrick M. Dansette, Mohamed Othman, Michael J. McGlinchey, Gerard Jaouen
Summary: Ferrociphenols, compounds characterized by a biologically active redox motif, have anticancer properties. This study synthesized a variety of ferrociphenols with nitrogen-containing substituents and investigated their structure-activity relationships. Oxidative metabolism experiments and ROS-related bioactivity measurements were conducted to explore the cytotoxicity of imidoferrociphenols. Additionally, dimerization phenomenon observed in the crystal structure of a ferrociphenol may affect its antitumor activity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Yu-Jie Zhong, Jian-Hong Liao, Tzu-Hao Chiu, Ying-Yann Wu, Samia Kahlal, Michael J. McGlinchey, Jean-Yves Saillard, C. W. Liu
Summary: Encouraged by successful syntheses of alloy nanoclusters through intercluster reactions, a series of bimetallic hydride clusters were prepared and characterized using ESI-MS, multi-NMR, and X-ray diffraction. Metal exchanges in solution drove a dynamic chemical equilibrium, as indicated by P-31 NMR spectroscopy and 2D exchange spectroscopy. DFT calculations confirmed the preferential metal positions within the clusters, as observed in crystal structures.
DALTON TRANSACTIONS
(2021)
Review
Chemistry, Inorganic & Nuclear
Michael J. McGlinchey
Article
Chemistry, Inorganic & Nuclear
E. Gabano, M. Ravera, E. Perin, I. Zanellato, B. Rangone, M. J. McGlinchey, D. Osella
DALTON TRANSACTIONS
(2019)