The First Total Synthesis of Solomonsterol B, a Marine Pregnane X Receptor Agonist

Natural Ligands for Nuclear Receptors: Biology and Potential Therapeutic Applications

(2012) Maria Valeria D'Auria et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity

(2012) Simona De Marino et al.   STEROIDS

Conicasterol E, a Small Heterodimer Partner Sparing Farnesoid X Receptor Modulator Endowed with a Pregnane X Receptor Agonistic Activity, from the Marine Sponge Theonella swinhoei

(2011) Valentina Sepe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Theonellasterols and Conicasterols fromTheonella swinhoei. Novel Marine Natural Ligands for Human Nuclear Receptors

(2011) Simona De Marino et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Synthesis and Pharmacological Characterization of Solomonsterol A, a Potent Marine Pregnane-X-Receptor Agonist Endowed with Anti-Inflammatory Activity

(2011) Valentina Sepe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Sulfated Sterols from Marine Invertebrates as a New Class of Marine Natural Antagonists of Farnesoid-X-Receptor

(2011) Valentina Sepe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quantitative NMR-Derived Interproton Distances Combined with Quantum Mechanical Calculations of 13C Chemical Shifts in the Stereochemical Determination of Conicasterol F, a Nuclear Receptor Ligand from Theonella swinhoei

(2011) Maria Giovanna Chini et al.   JOURNAL OF ORGANIC CHEMISTRY

Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei

(2011) Simona De Marino et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Solomonsterols A and B fromTheonella swinhoei. The First Example of C-24 and C-23 Sulfated Sterols from a Marine Source Endowed with a PXR Agonistic Activity

(2010) Carmen Festa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic Role of Rifaximin in Inflammatory Bowel Disease: Clinical Implication of Human Pregnane X Receptor Activation

(2010) J. Cheng et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A concise synthesis of the steroidal core of clathsterol

(2010) Rigang Cong et al.   TETRAHEDRON LETTERS

Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2−/− mice

(2009) Emina Halilbasic et al.   HEPATOLOGY

Development and Screening of Water-Soluble Analogues of Progesterone and Allopregnanolone in Models of Brain Injury

(2009) Christopher J. MacNevin et al.   JOURNAL OF MEDICINAL CHEMISTRY