4.8 Article

Lipase-catalysed direct Mannich reaction in water: utilization of biocatalytic promiscuity for C-C bond formation in a one-pot synthesis

Journal

GREEN CHEMISTRY
Volume 11, Issue 6, Pages 777-779

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b817524a

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Funding

  1. National Natural Science Foundation of China [20725206, 20732004, 20702034]

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A novel lipase-catalysed direct Mannich reaction has been developed under aqueous conditions in a one-pot strategy. Interestingly, these promiscuous reactions can be greatly promoted by water and generally require aromatic aldehydes.

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