Mediators between oral dysbiosis and cardiovascular diseases

Immunologic burden links periodontitis to acute coronary syndrome

(2018) John M. Liljestrand et al.   ATHEROSCLEROSIS

Relationship between past myocardial infarction, periodontal disease and Porphyromonas gingivalis serum antibodies: A case-control study

(2018) Radosław P. Łysek et al.   Cardiology Journal

Aggregatibacter actinomycetemcomitans serotypes associate with periodontal and coronary artery disease status

(2018) Milla Pietiäinen et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Immunization with gingipain A hemagglutinin domain of Porphyromonas gingivalis induces IgM antibodies binding to malondialdehyde-acetaldehyde modified low-density lipoprotein

(2018) Mikael Kyrklund et al.   PLoS One

Periodontal Disease, Regular Dental Care Use, and Incident Ischemic Stroke

(2018) Souvik Sen et al.   STROKE

Cross-reactive saliva IgA antibodies to oxidized LDL and periodontal pathogens in humans

(2017) Ramin Akhi et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

The subgingival microbiome, systemic inflammation and insulin resistance: The Oral Infections, Glucose Intolerance and Insulin Resistance Study

(2017) Ryan T. Demmer et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Lipopolysaccharide, a possible molecular mediator between periodontitis and coronary artery disease

(2017) John M. Liljestrand et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Genetic Susceptibility Contributing to Periodontal and Cardiovascular Disease

(2017) G. Aarabi et al.   JOURNAL OF DENTAL RESEARCH

Deposition and hydrolysis of serine dipeptide lipids of Bacteroidetes bacteria in human arteries: relationship to atherosclerosis

(2017) Reza Nemati et al.   JOURNAL OF LIPID RESEARCH

Porphyromonas gingivalis antibody levels and diagnosis of coronary artery disease in HIV-positive individuals

(2017) V. L. Berquist et al.   JOURNAL OF PERIODONTAL RESEARCH

Systemic Aggregatibacter actinomycetemcomitans Leukotoxin-Neutralizing Antibodies in Periodontitis

(2017) Anders Johansson et al.   JOURNAL OF PERIODONTOLOGY

Metabolic endotoxemia and diabetes mellitus: A systematic review

(2017) Júnia Maria Geraldo Gomes et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The Porphyromonas gingivalis/Host Interactome Shows Enrichment in GWASdb Genes Related to Alzheimer's Disease, Diabetes and Cardiovascular Diseases

(2017) Chris J. Carter et al.   Frontiers in Aging Neuroscience

Outer Membrane Vesicles (OMVs) of Gram-negative Bacteria: A Perspective Update

(2017) Arif Tasleem Jan   Frontiers in Microbiology

Periodontal diseases

(2017) Denis F. Kinane et al.   Nature Reviews Disease Primers

Association between infectious burden, socioeconomic status, and ischemic stroke

(2016) Frederick Palm et al.   ATHEROSCLEROSIS

Mechanisms of outer membrane vesicle entry into host cells

(2016) Eloise J. O'Donoghue et al.   CELLULAR MICROBIOLOGY

Adaptive Response of T and B Cells in Atherosclerosis

(2016) Daniel F.J. Ketelhuth et al.   CIRCULATION RESEARCH

Human microbiome as therapeutic intervention target to reduce cardiovascular disease risk

(2016) Annefleur M. Koopen et al.   CURRENT OPINION IN LIPIDOLOGY

Association between periodontitis and ischemic stroke: a systematic review and meta-analysis

(2016) Yago Leira et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Epigenetic characteristics in inflammatory candidate genes in aggressive periodontitis

(2016) Susanne Schulz et al.   HUMAN IMMUNOLOGY

Characterization of a natural mouse monoclonal antibody recognizing epitopes shared by oxidized low-density lipoprotein and chaperonin 60 of Aggregatibacter actinomycetemcomitans

(2016) Chunguang Wang et al.   IMMUNOLOGIC RESEARCH

Endotoxemia-menace, marker, or mistake?

(2016) Robert S. Munford   JOURNAL OF LEUKOCYTE BIOLOGY

Porphyromonas gingivalis -derived outer membrane vesicles promote calcification of vascular smooth muscle cells through ERK1/2-RUNX2

(2016) Wen Wei Yang et al.   FEBS Open Bio

Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens

(2016) Jessica D. Cecil et al.   PLoS One

Endotoxins are associated with visceral fat mass in type 1 diabetes

(2016) Mariann I. Lassenius et al.   Scientific Reports

Oral microbiota in patients with atherosclerosis

(2015) Frida Fåk et al.   ATHEROSCLEROSIS

Structural and functional changes in HDL with low grade and chronic inflammation

(2015) Francis O'Neill et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Association of periodontitis with persistent, pro-atherogenic antibody responses

(2015) Kåre Buhlin et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Evolutionary Divergence of Aggregatibacter actinomycetemcomitans

(2015) W. Kittichotirat et al.   JOURNAL OF DENTAL RESEARCH

Obesity and the gastrointestinal microbiota: a review of associations and mechanisms

(2015) C. Graham et al.   NUTRITION REVIEWS

Oral Administration of P. gingivalis Induces Dysbiosis of Gut Microbiota and Impaired Barrier Function Leading to Dissemination of Enterobacteria to the Liver

(2015) Mayuka Nakajima et al.   PLoS One

Proteomics of Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles

(2015) Thomas Kieselbach et al.   PLoS One

Endotoxemia, nutrition, and cardiometabolic disorders

(2014) K. A. Elisa Kallio et al.   ACTA DIABETOLOGICA

Systemic exposure to a common periodontal pathogen and missing teeth are associated with metabolic syndrome

(2014) K. Hyvärinen et al.   ACTA DIABETOLOGICA

Antibodies to periodontal pathogens are associated with coronary plaque remodeling but not with vulnerability or burden

(2014) Sanneke P.M. de Boer et al.   ATHEROSCLEROSIS

Oral cavity contains distinct niches with dynamic microbial communities

(2014) Xin Xu et al.   ENVIRONMENTAL MICROBIOLOGY

Immunization with malondialdehyde-modified low-density lipoprotein (LDL) reduces atherosclerosis in LDL receptor-deficient mice challenged with Porphyromonas gingivalis

(2014) S Pauliina Turunen et al.   Innate Immunity

Changes in Lipoprotein Kinetics Associated With Type 2 Diabetes Affect the Distribution of Lipopolysaccharides Among Lipoproteins

(2014) Bruno Vergès et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The role of heat shock proteins in atherosclerosis

(2014) Georg Wick et al.   Nature Reviews Cardiology

Patients with type 1 diabetes show signs of vascular dysfunction in response to multiple high-fat meals

(2014) Mariann I Lassenius et al.   Nutrition & Metabolism

The effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein E-deficient mice

(2013) Kati Hyvärinen et al.   BMC GENOMICS

Serine Lipids of Porphyromonas gingivalis Are Human and Mouse Toll-Like Receptor 2 Ligands

(2013) Robert B. Clark et al.   INFECTION AND IMMUNITY

Natural antibodies of newborns recognize oxidative stress-related malondialdehyde acetaldehyde adducts on apoptotic cells and atherosclerotic plaques

(2013) Chunguang Wang et al.   INTERNATIONAL IMMUNOLOGY

Evidence that periodontal treatment improves biomarkers and CVD outcomes

(2013) Francesco D'Aiuto et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta-analysis

(2013) Wijnand J. Teeuw et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

SubgingivalAggregatibacter actinomycetemcomitansassociates with the risk of coronary artery disease

(2013) Päivi Mäntylä et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Periodontal Pathogen Accelerates Lipid Peroxidation and Atherosclerosis

(2013) R. Jia et al.   JOURNAL OF DENTAL RESEARCH

Metabolic endotoxemia: a molecular link between obesity and cardiovascular risk

(2013) Ana Luísa Neves et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Changes in Clinical and Microbiological Periodontal Profiles Relate to Progression of Carotid Intima‐Media Thickness: The Oral Infections and Vascular Disease Epidemiology Study

(2013) Moïse Desvarieux et al.   Journal of the American Heart Association

A common periodontal pathogen has an adverse association with both acute and stable coronary artery disease

(2012) Kati Hyvärinen et al.   ATHEROSCLEROSIS

Periodontal Disease and Atherosclerotic Vascular Disease: Does the Evidence Support an Independent Association?

(2012) Peter B. Lockhart et al.   CIRCULATION

Nurture trumps nature in a longitudinal survey of salivary bacterial communities in twins from early adolescence to early adulthood

(2012) S. S. Stahringer et al.   GENOME RESEARCH

Prediagnostic Plasma Antibody Levels to Periodontopathic Bacteria and Risk of Coronary Heart Disease

(2012) Masayuki Ueno et al.   International Heart Journal

Periodontal pathogen load and increased antibody response to heat shock protein 60 in patients with cardiovascular disease

(2012) Shaneen J. Leishman et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Oxidation-Specific Biomarkers, Prospective 15-Year Cardiovascular and Stroke Outcomes, and Net Reclassification of Cardiovascular Events

(2012) Sotirios Tsimikas et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Very low density lipoproteins derived from periodontitis patients facilitate macrophage activation via lipopolysaccharide function

(2012) K.A. Elisa Kallio et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The oral microbiome in health and disease

(2012) William G. Wade   PHARMACOLOGICAL RESEARCH

Recognition of Porphyromonas gingivalis Gingipain Epitopes by Natural IgM Binding to Malondialdehyde Modified Low-Density Lipoprotein

(2012) S. Pauliina Turunen et al.   PLoS One

Diet, commensals and the intestine as sources of pathogen-associated molecular patterns in atherosclerosis, type 2 diabetes and non-alcoholic fatty liver disease

(2011) Clett Erridge   ATHEROSCLEROSIS

Association between periodontal pathogens and risk of nonfatal myocardial infarction

(2011) Oelisoa Andriankaja et al.   COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY

Bacterial Endotoxin Activity in Human Serum Is Associated With Dyslipidemia, Insulin Resistance, Obesity, and Chronic Inflammation

(2011) Mariann I. Lassenius et al.   DIABETES CARE

Endotoxemia Is Associated With an Increased Risk of Incident Diabetes

(2011) P. J. Pussinen et al.   DIABETES CARE

Periodontal pathogen carriage, rather than periodontitis, determines the serum antibody levels

(2011) Pirkko J. Pussinen et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Stimulants of Toll-like receptors 2 and 4 are elevated in saliva of periodontitis patients compared with healthy subjects

(2011) D. F. Lappin et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

The effect of proatherogenic microbes on macrophage cholesterol homeostasis in apoE-deficient mice

(2011) Anita M. Tuomainen et al.   MICROBIAL PATHOGENESIS

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

Genetic susceptibility to periodontitis

(2011) Marja L. Laine et al.   PERIODONTOLOGY 2000

High-density lipoprotein proteome dynamics in human endotoxemia

(2011) Johannes HM Levels et al.   Proteome Science

Periodontopathogen- and Host-Derived Immune Response in Acute Coronary Syndrome

(2011) H. Alfakry et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Bacterial biogeography of the human digestive tract

(2011) Jennifer C. Stearns et al.   Scientific Reports

Lipoproteins and lipoprotein metabolism in periodontal disease

(2010) Rachel Griffiths et al.   Clinical Lipidology

High Antibody Levels to P. gingivalis in Cardiovascular Disease

(2010) S. Bohnstedt et al.   JOURNAL OF DENTAL RESEARCH

Elevated endotoxin levels in non-alcoholic fatty liver disease

(2010) Alison L Harte et al.   Journal of Inflammation-London

Endogenous ligands of TLR2 and TLR4: agonists or assistants?

(2010) Clett Erridge   JOURNAL OF LEUKOCYTE BIOLOGY

Characterization of a new serotype g isolate of Aggregatibacter actinomycetemcomitans

(2010) K. Takada et al.   Molecular Oral Microbiology

Human oral, gut, and plaque microbiota in patients with atherosclerosis

(2010) O. Koren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum Lipopolysaccharide Activity Is Associated With the Progression of Kidney Disease in Finnish Patients With Type 1 Diabetes

(2009) M. Nymark et al.   DIABETES CARE

Chlamydial and Periodontal Pathogens Induce Hepatic Inflammation and Fatty Acid Imbalance in Apolipoprotein E-Deficient Mice

(2009) K. Hyvarinen et al.   INFECTION AND IMMUNITY

Porphyromonas gingivalis (Pg) a possible link between impaired oral health and acute myocardial infarction

(2009) Anders Holmlund et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Risk factors for atherosclerosis in cases with severe periodontitis

(2009) Kåre Buhlin et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Heterogeneity of systemic inflammatory responses to periodontal therapy

(2009) Jan H. Behle et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Results From the Periodontitis and Vascular Events (PAVE) Study: A Pilot Multicentered, Randomized, Controlled Trial to Study Effects of Periodontal Therapy in a Secondary Prevention Model of Cardiovascular Disease

(2009) Steven Offenbacher et al.   JOURNAL OF PERIODONTOLOGY

Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis

(2009) Arne S. Schaefer et al.   PLoS Genetics

Tracking of plasma antibodies againstAggregatibacter actinomycetemcomitansandPorphyromonas gingivalisduring 15 years

(2009) Laura Lakio et al.   Journal of Oral Microbiology

Bacteremia Associated With Toothbrushing and Dental Extraction

(2008) Peter B. Lockhart et al.   CIRCULATION

Lipopolysaccharide associates with pro-atherogenic lipoproteins in periodontitis patients

(2008) K.A. Elisa Kallio et al.   Innate Immunity

Antibody levels to single bacteria or in combination evaluated against myocardial infarction

(2008) Lise Lund Håheim et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Periodontal Disease and Coronary Heart Disease Incidence: A Systematic Review and Meta-analysis

(2008) Linda L. Humphrey et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

The periodontal pathogen Porphyromonas gingivalis cleaves apoB-100 and increases the expression of apoM in LDL in whole blood leading to cell proliferation

(2008) T. Bengtsson et al.   JOURNAL OF INTERNAL MEDICINE

The Problem With Composite End Points in Cardiovascular Studies

(2008) Kevin E. Kip et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Systemic host immuno-inflammatory response to dental extractions and periodontitis

(2008) Farah K. Bahrani-Mougeot et al.   ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS

Update on bacteraemia related to dental procedures

(2008) Ingar Olsen   TRANSFUSION AND APHERESIS SCIENCE

P. gingivalis interactions with epithelial cells

(2007) Denis et al.   Frontiers in Bioscience-Landmark

The Periodontitis and Vascular Events (PAVE) Pilot Study: Adverse Events

(2007) James D. Beck et al.   JOURNAL OF PERIODONTOLOGY

Aggregatibacter actinomycetemcomitans induces MMP-9 expression and proatherogenic lipoprotein profile in apoE-deficient mice

(2007) Anita M. Tuomainen et al.   MICROBIAL PATHOGENESIS