Review
Cell Biology
Xuanzhi Zhu, Hanyao Huang, Lei Zhao
Summary: Atherosclerosis is a chronic artery disease, and periodontitis is a risk factor for it. There is a molecular pathological mechanism connecting the two conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vadim Z. Z. Lankin, Alla K. K. Tikhaze, Arthur M. M. Melkumyants
Summary: This mini review discusses the role of malondialdehyde (MDA) in the molecular mechanisms of primary atherosclerotic vascular wall lesions. It highlights the important role of chemically modified LDL particles containing MDA in atherogenesis, rather than oxidized LDL. The review also presents experimental evidence of MDA damaging the endothelial glycocalyx, impairing the endothelium's ability to regulate arterial tone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
George Hindy, Daniel J. Tyrrell, Alexi Vasbinder, Changli Wei, Feriel Presswalla, Hui Wang, Pennelope K. Blakely, Ayse Bilge Ozel, Sarah E. Graham, Grace H. Holton, Joseph Dowsett, Akl C. Fahed, Kingsley-Michael Amadi, Grace K. Erne, Annika Tekumulla, Anis Ismail, Christopher Launius, Nona Sotoodehnia, James S. Pankow, Lise Wegner Thorner, Christian Erikstrup, Ole Birger Pedersen, Karina Banasik, Soren Brunak, Henrik Ullum, Jesper Eugen-Olsen, Sisse Rye Ostrowski, Mary E. Haas, Jonas B. Nielsen, Luca A. Lotta, Gunnar Engstrom, Olle Melander, Marju Orho-Melander, Lili Zhao, Venkatesh L. Murthy, David J. Pinsky, Cristen J. Willer, Susan R. Heckbert, Jochen Reiser, Daniel R. Goldstein, Karl C. Desch, Salim S. Hayek
Summary: The study using epidemiologic, genetic, and experimental approaches found that suPAR is a pathogenic factor for atherosclerosis, with its levels strongly associated with cardiovascular outcomes and predictive of coronary artery calcification. The missense variant rs4760 in the PLAUR gene leads to higher suPAR levels, and Mendelian randomization analysis confirms a causal relationship between genetically predicted suPAR levels and atherosclerotic phenotypes. In experimental models, increased suPAR levels modulate monocyte function to promote atherosclerosis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Food Science & Technology
Phung Diep Huy Vu, Akkaratch Rodklongtan, Pakamon Chitprasert
Summary: The study found that the encapsulant weight ratio of whey protein isolate-lignin complex significantly affects the survival rate of spray-dried probiotics, with the 9:1 ratio offering the best protection. Lignin improves the survival of probiotics by enhancing the structure and antioxidant properties of WPI.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Alireza Behnamifar, Shaban Rahimi, Mohammad Amir Karimi Torshizi, Mohsen Sharafi, J. L. Grimes
Summary: This study investigated the effects of alpha-lipoic acid supplementation on the semen quality and fertility parameters of aging breeder roosters, finding that appropriate levels of ALA can improve sperm quality, while higher doses do not result in further improvement.
Review
Biochemistry & Molecular Biology
Onchuma Mueangson, Aongart Mahittikorn, Nsoh Godwin Anabire, Wanida Mala, Manas Kotepui
Summary: This study examined the relationship between malondialdehyde (MDA) concentrations and Plasmodium infections. The results showed that MDA concentrations were significantly elevated in patients with malaria compared to uninfected controls, indicating an increase in oxidative stress and lipid peroxidation. MDA levels can be a valuable biomarker for evaluating these processes in individuals with malaria.
Article
Plant Sciences
Zhen Zhang, Shasha Yang, Xia Lin, You Huang, Xinyi Wei, Jinwei Zhou, Rui Li, Bin Deng, Chaomei Fu
Summary: The study investigated the essence of Spleen-Yang deficiency (SYD) through metabolomics and revealed the anti-SYD action mechanisms of Fuzi Lizhong pill (FLZP). Results showed that FLZP regulated biomarkers related to SYD, alleviating diarrhea and gastrointestinal motility disorder, and exhibiting anti-peroxidation, anti-inflammatory, and immune regulation effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Linas Cerniauskas, Asta Mazeikiene, Egle Mazgelyte, Egle Petrylaite, Ausra Linkeviciute-Dumce, Neringa Burokiene, Dovile Karciauskaite
Summary: Cardiovascular diseases are the leading cause of mortality worldwide. This study aimed to evaluate oxidative lipid degradation biomarkers and antioxidant defense system components in healthy women and their relationships with age, anthropometric measures, and lipid metabolism biomarkers. The findings suggest that these indices could be useful biomarkers in the research of aging, obesity, and atherosclerosis pathogenesis.
Review
Biochemistry & Molecular Biology
Zhiyu Ma, Jinsong Wang, Lei Hu, Songlin Wang
Summary: Periodontitis is an irreversible inflammatory response that occurs in periodontal tissues. Innate lymphoid cells (ILCs) have been found to play a crucial role in regulating immune responses in periodontitis. This review focuses on the intricate crosstalk between ILCs and the microenvironment in periodontal tissue homeostasis for the purpose of regulating or improving immune responses in periodontitis prevention and therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Adam Wronski, Agnieszka Gegotek, Elzbieta Skrzydlewska
Summary: Psoriasis is an immune-mediated skin disease characterized by excessive proliferation and keratinization of epidermal cells, resulting in psoriatic lesions. It is caused by pathological interaction with immune cells, particularly lymphocytes, which are responsible for systemic inflammation. Oxidative stress and lipid peroxidation products exacerbate the inflammation. This review focuses on the changes in lipid peroxidation products and their influence on protein structures during psoriasis development, emphasizing the importance of understanding their role in the design of preventive cosmetics or anti-psoriasis therapies.
Review
Medicine, General & Internal
Fanwen Jiang, Lin Zhou, Chun Zhang, Hui Jiang, Zhuping Xu
Summary: This systematic review compared circulating malondialdehyde (MDA) levels in people with and without diabetic retinopathy (DR). The results showed that circulating MDA levels were higher in people with DR compared to those without.
CHINESE MEDICAL JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Maria Carmina Pau, Elisabetta Zinellu, Sara S. Fois, Barbara Piras, Gianfranco Pintus, Ciriaco Carru, Arduino A. Mangoni, Alessandro G. Fois, Angelo Zinellu, Pietro Pirina
Summary: The study found that the MDA concentrations were significantly higher in patients with obstructive sleep apnea (OSA) compared to controls, indicating that MDA may be involved in the pathogenesis of OSA and providing insights for future research on its potential clinical use.
Article
Dentistry, Oral Surgery & Medicine
Dogukan Yilmaz, Emel Gonullu, Mervi Gursoy, Eija Kononen, Ulvi Kahraman Gursoy
Summary: The study found elevated levels of MCP-1, MIF, and fractalkine in saliva in patients with rheumatoid arthritis. Higher concentrations of MCP-1 and fractalkine were observed in saliva of the control group compared to the periodontitis group. In serum, MCP-1 concentrations were higher in the rheumatoid arthritis with periodontitis group than in the periodontitis-only group.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Food Science & Technology
Wenjie Wang, Zhiwen Zhang, Xiaoying Liu, Xiaoji Cao, Lianzhu Wang, Yuting Ding, Xuxia Zhou
Summary: Malondialdehyde (MDA) is an important indicator of lipid oxidation in food. However, the reaction between MDA and nitrite in salted lean pork leads to an underestimation of lipid oxidation in traditional assays. This study successfully improved the accuracy of MDA quantification by using GC-MS analysis with deuterium substituted MDA as an internal standard and applying perfluorophenylhydrazine as a derivative reagent.
Article
Ecology
Coraline Bichet, Maria Moiron, Kevin D. Matson, Oscar Vedder, Sandra Bouwhuis
Summary: Studies on common tern populations have shown no clear signs of senescence in haemagglutination titre and haptoglobin concentration, possibly due to immune parameter canalisation or the colonial breeding behavior of the study species. Further longitudinal studies are needed to investigate the links between species characteristics and immunosenescence in wild animals.
JOURNAL OF ANIMAL ECOLOGY
(2022)
Article
Biology
Mariliis Jaago, Nadezda Pupina, Annika Rahni, Arno Pihlak, Helle Sadam, Nihal Engin Vrana, Juha Sinisalo, Pirkko Pussinen, Kaia Palm
Summary: This study finds that antibodies against antigens present in oral biofilm may serve as potential biomarkers for acute coronary syndrome (ACS). The authors investigate the antibody response to periodontal pathogens and find that patients with ACS have little or no immune response to a specific antigen epitope. These findings highlight the importance of understanding the immune mechanisms linking oral health to severe heart conditions such as ACS.
COMMUNICATIONS BIOLOGY
(2022)
Article
Immunology
Laura Lahdentausta, Anne Kivimaki, Lotta Oksanen, Marika Tallgren, Sampo Oksanen, Enni Sanmark, Aino Salminen, Ahmed Geneid, Mikko Sairanen, Susanna Paju, Kalle Saksela, Pirkko Pussinen, Milla Pietiainen
Summary: This study examined the usefulness of dried spot blood and saliva samples in analyzing SARS-CoV-2 antibodies. The results showed that the level of exposure was the strongest determinant of all blood antibody classes and saliva IgG. Both blood and saliva IgG levels followed similar trends to the exposures reported in the questionnaires. Self-collected dry blood and saliva spot samples combined with the GSP/DELFIA technique are valuable tools for investigating an individual's immune response to SARS-CoV-2 exposure or vaccination. Saliva IgG has high potential to monitor vaccination response wane.
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2022)
Letter
Obstetrics & Gynecology
Terhi Piltonen, Laure Morin-Papunen, Meri-Maija Ollila, Juha Tapanainen, Riikka Arffman, Marjo-Riitta Jaervelin, Stephen Franks
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
M. H. Kangasniemi, R. K. Arffman, S. Joenvaara, A. Haverinen, K. Luiro, T. Tohmola, R. Renkonen, O. Heikinheimo, J. S. Tapanainen, T. T. Piltonen
Summary: This study compares the effects of an estradiol-based combined oral contraceptive (COC) with an ethinylestradiol-based COC and a dienogest-only preparation on the serum proteome. The results demonstrate that the synthetic COC has a wider range of effects on the serum proteome compared to the natural estrogen COC and the progestin-only preparation, involving multiple biological functions.
HUMAN REPRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Mervi Gursoy, Jaana Rautava, Pirkko Pussinen, Anna Karin Kristoffersen, Morten Enersen, Vuokko Loimaranta, Ulvi Kahraman Gursoy
Summary: This study evaluated the levels of IgA and IgG antibodies against Porphyromonas gingivalis, Tannerella forsythia, Aggregatibacter actinomycetemcomitans, and Prevotella intermedia in the saliva of Crohn's disease patients. Higher levels of salivary IgG2 and IgG3 antibodies, as well as IgG antibodies against P. gingivalis, A. actinomycetemcomitans, and P. intermedia, were detected in Crohn's disease patients. The carriage of P. gingivalis in the saliva was lower in Crohn's disease patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Mohammad Mobashir, S. Pauliina Turunen, Mohammad Asrar Izhari, Ibraheem Mohammed Ashankyty, Thomas Helleday, Kaisa Lehti
Summary: The study analyzed the interaction and key components of cancer pathways using gene expression datasets, constructed a network prediction model, and identified important pathways enriched in different datasets. The results indicated that focal adhesion and PI3K pathways are the most critical pathways.
Article
Endocrinology & Metabolism
Terhi T. Piltonen, Elina Komsi, Laure C. Morin-Papunen, Elisa Korhonen, Stephen Franks, Marjo-Riitta Jarvelin, Riikka K. Arffman, Meri-Maija Ollila
Summary: Using AMH as a surrogate marker for PCOM can help identify women with typical PCOS characteristics in large data sets; the prevalence of PCOS changes depending on the cut-off value used for AMH.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ida Aulanko, Enni Sanmark, Lotta Oksanen, Sampo Oksanen, Laura Lahdentausta, Anne Kivimaeki, Susanna Paju, Milla Pietiaeinen, Pirkko Pussinen, Ahmed Geneid
Summary: This study aimed to increase knowledge about the effects of the COVID-19 pandemic on working conditions in tertiary and primary healthcare. The findings demonstrate that primary healthcare workers had poorer working conditions and wellbeing compared to tertiary healthcare workers. They experienced more stress at work, had difficulty recovering from work, reported mental wellbeing below normal levels, and had increased working hours. Therefore, the study suggests that the challenges in the health and wellbeing of healthcare workers during the COVID-19 pandemic are even greater in primary care than in tertiary care.
INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
(2023)
Article
Pharmacology & Pharmacy
Tiina Koivikko, Priscila Campioni Rodrigues, Mari Vehvilaeinen, Petra Hyvonen, Elias Sundquist, Riikka K. Arffman, Ahmed Al-Samadi, Hanna Valimaa, Tuula Salo, Maija Risteli
Summary: This study investigates the predominance of HSV-1 in oral HSV infections and its effect on oral tongue squamous cell carcinoma (OTSCC). The results show that HSV-1 is the predominant type in oral HSV infections and is also detected in OTSCC samples without clinical significance. Furthermore, low doses of HSV-1 do not affect cell survival or invasion in OTSCC.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Nele Fogelholm, Jaakko Leskela, Muhammed Manzoor, Jacob Holmer, Susanna Paju, Kaija Hiltunen, Hanna-Maria Roitto, Riitta Kt Saarela, Kaisu Pitkala, Maria Eriksdotter, Kare Buhlin, Pirkko J. Pussinen, Paivi Mantyla
Summary: Oral health and declining cognition may have a bi-directional association. The composition of the subgingival microbiota was analyzed in subjects with normal cognition to severe cognitive decline. The study found that certain taxa of oral bacteria were associated with the MMSE score, and Lachnospiraceae [XIV] increased with decreasing MMSE. Impaired cognition is accompanied by changes in the composition of the oral microbiota, highlighting the importance of oral health-care practices among older adults.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Meri-Maija Ollila, Riikka K. Arffman, Kari Kaikkonen, Laure Morin-Papunen, Juhani Junttila, Terhi T. Piltonen
Summary: This study investigated the association between common female sex-specific health conditions and high-sensitivity troponin-T (hs-TnT) levels. The study found that women with oligo/amenorrhea and early menopause had slightly higher hs-TnT levels compared to women without these conditions, while women with hyperandrogenism or PCOS had comparable hs-TnT levels to their controls. However, larger studies are needed to better understand the effects of oligo/amenorrhea on cardiovascular health.
ANNALS OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Meri-Maija Ollila, Riikka K. Arffman, Elisa Korhonen, Laure Morin-Papunen, Stephen Franks, Juhani Junttila, Terhi T. Piltonen
Summary: Polycystic ovary syndrome (PCOS) is associated with various cardiovascular disease (CVD) risk factors, including obesity, type 2 diabetes mellitus, and hypertension. However, it is still unclear whether the presence of multiple CVD risk factors leads to an increased risk of CVD events.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Mikko Karpale, Outi Kummu, Olli Karkkainen, Marko Lehtonen, Juha Napankangas, Uta M. Herfurth, Albert Braeuning, Jaana Rysa, Jukka Hakkola
Summary: This study found that both obesity and chemical exposure can induce non-alcoholic fatty liver disease (NAFLD), and the Pregnane X Receptor (PXR) plays a key role in liver glucose and lipid metabolism. Activation of PXR worsened obesity-induced liver steatosis and impaired hepatic insulin sensitivity. The research also suggests that obese individuals may be more susceptible to harmful metabolic effects of PXR-activating drugs and environmental chemicals.
MOLECULAR METABOLISM
(2023)
Article
Dentistry, Oral Surgery & Medicine
Lili Yu, Yigit Firatli, Samira Elmanfi, Mervi Gursoy, Meltem Ozdemir Kabalak, Gokhan Kasnak, Pirkko Pussinen, Floris J. Bikker, Feriha Caglayan, Erhan Firatli, Ulvi Kahraman Gursoy
Summary: The study aimed to localize MCPIP-1 and MALT-1 in gingival tissues and profile their protein expression levels in relation to inflammation, P. gingivalis colonization, and IL-8 levels. The results showed that MCPIP-1 was present in the epithelium and connective tissue, while MALT-1 was observed in all layers of the gingival epithelium and around inflammatory cells. There was no difference in MCPIP-1 and MALT-1 levels based on gingival inflammation severity, but MALT-1 levels were elevated with an increase in P. gingivalis levels and showed an association with IL-8 levels.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
A. Salminen, A. M. Maatta, P. Mantyla, J. Leskela, M. Pietiainen, K. Buhlin, A. L. Suominen, S. Paju, W. Sattler, J. Sinisalo, P. J. Pussinen
Summary: This study investigates the systemic metabolic signatures of oral diseases and finds associations between current or past infectious/inflammatory oral diseases and circulating metabolites. Periodontitis, in particular, is associated with metabolic profiles typical for inflammation, suggesting that oral diseases may represent a modifiable risk factor for systemic chronic inflammation and cardiometabolic disorders.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Binbin Chang, Zhang Wang, Hui Cheng, Tingyuan Xu, Jieyu Chen, Wan Wu, Yizhi Li, Yong Zhang
Summary: Acacetin can attenuate sepsis-induced ALI by inhibiting the inflammatory response and promoting macrophage polarization. This study is of great significance for the development of new treatments for sepsis-induced ALI.
Review
Biochemistry & Molecular Biology
Nikoleta Bizymi, Andreas M. Matthaiou, Irene Mavroudi, Aristea Batsali, Helen A. Papadaki
Summary: Myeloid-derived suppressor cells (MDSCs) are innate immune cells that have immunomodulatory properties. They interact extensively with other innate or adaptive immune cells and can either enhance or attenuate immune responses depending on the triggering conditions. However, their positive role in host defense mechanisms is rarely discussed in the literature.