Article
Biochemistry & Molecular Biology
Aline Almeida da Silva, Elisangela Martins da Silva Perez, Ingrid Samantha Tavares de Figueiredo, Nylane Maria Nunes de Alencar, Ana Paula Negreiros Nunes Alves, Fabiano Andre Narciso Fernandes, Renata Prado Vasconcelos, Ariclecio Cunha de Oliveira, Socorro Vanesca Frota Gaban
Summary: This study investigated the effects of virgin coconut oil (VCO) on body weight, white fat depots, and biochemical and morphological parameters in male Swiss mice fed standard (SD) or high-fat (HFD) diets. The results showed that low-dose VCO supplementation did not improve obesity, had no effects on hepatic or renal function, and had beneficial effects on the lipid profile only in animals fed HFD.
Review
Nutrition & Dietetics
Natalia Santillana, Camila Astudillo-Guerrero, Amanda D'Espessailles, Gonzalo Cruz
Summary: White adipose tissue dysfunction is crucial in the pathogenesis of cardiometabolic alterations related to obesity. Dysfunction is characterized by limited expansion capacity, increased adipocyte hypertrophy, altered adipokine secretion, macrophage accumulation and inflammation. Simple tools are needed to identify individuals with dysfunctional adipose tissue who are at risk of developing metabolic alterations. This review highlights the current pathophysiological mechanisms and emerging measurements for assessing white adipose tissue functionality.
Article
Medicine, Research & Experimental
Chaowei Li, Qi Chen, Yanrong Liu, Zhuwen Sun, Zhentong Shen, Shuhan Li, Dingrui Cha, Chao Sun
Summary: In this study, it was found that MetEnk effectively prevented obesity and improved glucose tolerance and insulin sensitivity. It also improved mitochondrial function, promoted lipolysis and thermogenesis through the activation of the cAMP/PKA pathway.
Review
Cardiac & Cardiovascular Systems
Gianluca Iacobellis
Summary: Patients with obesity are at a higher risk of developing cardiovascular diseases. However, regional and organ specific adiposity appear to play a stronger role than obesity itself. Epicardial adipose tissue, located around the heart, is directly involved in major obesity-related cardiovascular complications. Current imaging techniques can assess epicardial fat to predict cardiovascular risk. Pharmacological modulation of epicardial fat can reduce cardiovascular risk. Assessing epicardial fat could change the traditional paradigm linking obesity to heart disease.
PROGRESS IN CARDIOVASCULAR DISEASES
(2023)
Review
Cell Biology
Qian Li, Kirsty L. Spalding
Summary: Adipocytes undergo extensive cytoskeletal remodeling to accommodate their dramatic morphological changes. Cell growth-related signaling pathways are activated to meet the increasing cellular needs. Continued expansion of adipocytes can lead to metabolic dysfunction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michele Moruzzi, Nora Kloeting, Matthias Blueher, Ilenia Martinelli, Seyed Khosrow Tayebati, Maria Gabriella Gabrielli, Proshanta Roy, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Giulio Lupidi, Francesco Amenta, Daniele Tomassoni
Summary: Although tart cherries are rich in anthocyanins, the study found that a tart cherry-enriched diet did not alter the accumulation of visceral fat, but could decrease inflammatory markers in adipose tissue.
Article
Medicine, Research & Experimental
Seyyed Mohammad Reza Hashemnia, Reza Meshkani, Fahimeh Zamani-Garmsiri, Maryam Shabani, Maryam Tajabadi-Ebrahimi, Iraj Ragerdi Kashani, Seyed Davar Siadat, Samaneh Mohassel Azadi, Solaleh Emamgholipour
Summary: New evidence suggests that B. coagulans can be a promising alternative for treating metabolic disorders. However, its effects on obesity-induced adipose tissue inflammation are still unknown.
Article
Endocrinology & Metabolism
Hanying Liu, Di Yang, Shaobo Li, Yunfeng Xiao, Yinfang Tu, Danfeng Peng, Yuqian Bao, Junfeng Han, Haoyong Yu
Summary: A simple model to predict VFA using age, waist circumference, and neck circumference was developed and validated in overweight and obese Chinese individuals, demonstrating good predictive power for both men and women. The equations provide an ideal tool for early detection of visceral obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Pavel Hruska, Jan Kucera, Matej Pekar, Pavol Holeczy, Miloslav Mazur, Marek Buzga, Daniela Kuruczova, Peter Lenart, Jana Fialova Kucerova, David Potesil, Zbynek Zdrahal, Julie Bienertova-Vasku
Summary: The study compared the proteomic profiles of mature adipocytes from different adipose tissue depots, with findings showing that subcutaneous adipocytes are more active in vesicular transport, secretion, and lipid metabolism, while visceral adipocytes have higher protein expression related to mitochondrial energy metabolism and translational or biosynthetic activity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Vanessa M. Lima, Jianming Liu, Bruna B. Brandao, Caroline A. Lino, Camila S. Balbino Silva, Marcio A. C. Ribeiro, Tiago E. Oliveira, Caroline C. Real, Daniele de Paula Faria, Carly Cederquist, Zhan-Peng Huang, Xiaoyun Hu, Maria Luiza Barreto-Chaves, Julio C. B. Ferreira, William T. Festuccia, Marcelo A. Mori, C. Ronald Kahn, Da-Zhi Wang, Gabriela P. Diniz
Summary: miR-22 plays a role in white, beige, and brown adipocyte differentiation. Deletion of miR-22 reduces white adipocyte differentiation, increases BAT activity, and enhances resistance in HFD-fed mice.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Food Science & Technology
Lin Ding, Jinyue Yang, Haoran Guo, Peixu Cong, Jie Xu, Changhu Xue, Xiangzhao Mao, Tiantian Zhang, Yuming Wang
Summary: Dietary supplementation of docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) in the form of phosphoethanolamine plasmalogens (PlsEtn) has been shown to remodel lipidome and regulate fatty acid metabolic process in white adipose tissue (WAT), suggesting it as a potential strategy for obesity treatment in the future.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Genetics & Heredity
Gabriel Wagner, Anna Fenzl, Josefine Lindroos-Christensen, Elisa Einwallner, Julia Husa, Nadine Witzeneder, Sabine Rauscher, Marion Groger, Sophia Derdak, Thomas Mohr, Hedwig Sutterluty, Florian Klinglmuller, Silviya Wolkerstorfer, Martina Fondi, Gregor Hoermann, Lei Cao, Oswald Wagner, Florian W. Kiefer, Harald Esterbauer, Martin Bilban
Summary: LMO3 can improve the function of visceral adipose tissue during obesity, promoting glucose uptake and mitochondrial activity in adipocytes.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Biochemistry & Molecular Biology
Laura Braud, Maria Pini, Donald F. Stec, Sylvie Manin, Genevieve Derumeaux, David E. Stec, Roberta Foresti, Roberto Motterlini
Summary: The up-regulation of Sirt1 levels specifically in the visceral adipose tissue of Nrf2(-/-) mice is a key adaptive mechanism that mitigates glucose intolerance induced by nutritional stress.
Article
Nutrition & Dietetics
Debora Basile, Michele Bartoletti, Maurizio Polano, Lucia Bortot, Lorenzo Gerratana, Paola Di Nardo, Matteo Borghi, Valentina Fanotto, Giacomo Pelizzari, Camilla Lisanti, Mattia Garutti, Silvia Buriolla, Elena Ongaro, Eva Andreuzzi, Marcella Montico, Luca Balestreri, Gianmaria Miolo, Giuseppe Toffoli, Giuseppe Aprile, Fabio Puglisi, Angela Buonadonna
Summary: This study investigated the prognostic role of adiposity, especially visceral fat, in patients with metastatic colorectal cancer. The results showed that higher visceral fat values were associated with worse outcomes in these patients. Further research is needed to explore the impact of visceral fat on colorectal cancer patients.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Oscar Osorio-Conles, Arturo Vega-Beyhart, Ainitze Ibarzabal, Jose Maria Balibrea, Josep Vidal, Ana de Hollanda
Summary: The metabolic syndrome is a cluster of dangerous heart attack risk factors. This study compares the dysfunction of obesity-associated white adipose tissue (WAT) between women with severe obesity with or without metabolic syndrome. The results show that women with metabolic syndrome exhibit greater adipocyte hypertrophy, increased fibrosis, and higher expression of macrophage and hypoxia markers in subcutaneous adipose tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Laia Oliva, Tania Aranda, Maria Alemany, Jose-Antonio Fernandez-Lopez, Xavier Remesar
MOLECULAR NUTRITION & FOOD RESEARCH
(2020)
Article
Medicine, General & Internal
Juan P. Sanabria-Mazo, Carlos G. Forero, Paula Cristobal-Narvaez, Carlos Suso-Ribera, Azucena Garcia-Palacios, Ariadna Colomer-Carbonell, Adrian Perez-Aranda, Laura Andres-Rodriguez, Lance M. McCracken, Francesco D'Amico, Pere Estivill-Rodriguez, Bernat Carreras-Marcos, Antonio Montes-Perez, Olga Comps-Vicente, Montserrat Esteve, Mar Grasa, Araceli Rosa, Antonio Cuesta-Vargas, Michael Maes, Xavier Borras, Silvia Edo, Antoni Sanz, Albert Feliu-Soler, Juan R. Castano-Asins, Juan Luciano
Review
Biochemistry & Molecular Biology
Xavier Remesar, Maria Alemany
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Nutrition & Dietetics
Montserrat Esteve
FRONTIERS IN NUTRITION
(2020)
Article
Nutrition & Dietetics
Carme Grau-Bove, Alba Miguens-Gomez, Carlos Gonzalez-Quilen, Jose-Antonio Fernandez-Lopez, Xavier Remesar, Cristina Torres-Fuentes, Javier Avila-Roman, Esther Rodriguez-Gallego, Raul Beltran-Debon, M. Teresa Blay, Ximena Terra, Anna Ardevol, Montserrat Pinent
Article
Multidisciplinary Sciences
Jose Gulfo, Joana Perez de San Roman, Angelo Ledda, Felix Junyent, Maria J. Ramirez, Francisco J. Gil-Bea, Montserrat Esteve, Mar Grasa
Summary: The lack of CBG can trigger metabolic imbalance and affect hippocampal glucocorticoid levels and neuronal function, potentially leading to long-term neurological pathologies.
Article
Nutrition & Dietetics
Laia Oliva, Maria Alemany, Jose-Antonio Fernandez-Lopez, Xavier Remesar
Summary: The study found that excess lipid ingestion in male rats leads to liver fat accumulation, and the modulation of diet energy partition affects this process. Differences in cholesterol and triglyceride content in the blood and liver of male rats showed sex-related differences due to diet. Circulating estradiol in males was negatively correlated with cholesterol levels, indicating that estradiol plays a regulatory role in the distribution of energy substrates and cholesterol deposition.
BRITISH JOURNAL OF NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Maria Alemany
Summary: Androgens are important steroid hormones with diverse functions including energy control, skeletal maintenance, brain development, and reproductive mechanism regulation. Testosterone plays a key role in maintaining metabolism and its insufficiency is associated with aging and metabolic disorders. T replacement therapy is effective in maintaining core metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Juan P. Sanabria-Mazo, Ariadna Colomer-Carbonell, Meritxell Carmona-Cervello, Albert Feliu-Soler, Xavier Borras, Mar Grasa, Montserrat Esteve, Michael Maes, Silvia Edo, Antoni Sanz, Juan V. Luciano
Summary: This systematic review identified preliminary evidence of increased levels of certain immune-inflammatory and HPA axis biomarkers in individuals with NSLBP, but also noted inconsistent results for some biomarkers. Additionally, insufficient evidence was found for IL-6, TNF-alpha, and CRP levels in NSLBP when compared exclusively with healthy controls. The dysregulated functioning of cortisol in NSLBP patients further adds complexity to the understanding of the immune-inflammatory and HPA axis biomarkers in this population.
FRONTIERS IN IMMUNOLOGY
(2022)
Book Review
Medieval & Renaissance Studies
Maria Del Prado Rodriguez Romero
Article
Biotechnology & Applied Microbiology
M. Carmen Soler-Vazquez, Maria del Mar Romero, Marijana Todorcevic, Katia Delgado, Carles Calatayud, Aleyda Benitez-Amaro, Maria Teresa La Chica Lhoest, Paula Mera, Sebastian Zagmutt, Marianela Bastias-Perez, Kevin Ibeas, Nuria Casals, Joan Carles Escola-Gil, Vicenta Llorente-Cortes, Antonella Consiglio, Dolors Serra, Laura Herrero
Summary: Obesity and its associated metabolic comorbidities are a global health issue, and adipose tissue-derived mesenchymal stem cells (AT-MSCs) are of interest for cell therapy. In this study, adipocytes expressing a constitutively active form of the enzyme CPT1A were generated and implanted into mice fed a high-fat diet (HFD). The CPT1A-implanted mice showed improvements in body weight, hepatic steatosis, serum insulin and cholesterol levels, and glucose tolerance. Additionally, HFD-induced adipose tissue abnormalities and mitochondrial respiratory chain complex expression were reduced in the CPT1A-implanted mice. These findings support the potential clinical use of ex vivo gene therapy for obesity.
METABOLIC ENGINEERING
(2023)
Article
Endocrinology & Metabolism
Sebastian Zagmutt, Paula Mera, Ismael Gonzalez-Garcia, Kevin Ibeas, Maria del Mar Romero, Arnaud Obri, Beatriz Martin, Anna Esteve-Codina, M. Carmen Soler-Vazquez, Marianela Bastias-Perez, Laia Canes, Elisabeth Auge, Carme Pelegri, Jordi Vilaplana, Xavier Ariza, Jordi Garcia, Jose Martinez-Gonzalez, Nuria Casals, Miguel Lopez, Richard Palmiter, Elisenda Sanz, Albert Quintana, Laura Herrero, Dolors Serra
Summary: Fatty acid metabolism and CPT1A in AgRP neurons play a key role in the maintenance of whole-body fluid and energy balance. This study reveals marked sex differences in fatty acid metabolism and CPT1A expression in AgRP neurons.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Gastroenterology & Hepatology
Robert N. Helsley, Se-Hyung Park, Hemendra J. Vekaria, Patrick G. Sullivan, Lindsey R. Conroy, Ramon C. Sun, Maria del Mar Romero, Laura Herrero, Joanna Bons, Christina D. King, Jacob Rose, Jesse G. Meyer, Birgit Schilling, C. Ronald Kahn, Samir Softic
Summary: The consumption of sugar and a high-fat diet promotes the development of obesity and metabolic dysfunction. The study found that glucose or fructose supplementation increases the enzyme KHK-C, which leads to abnormal lipogenesis. The researchers also discovered that KHK-C increases lipogenesis and decreases fatty acid oxidation by acetylating CPT1a protein. This finding reveals the mechanism by which dietary fructose exacerbates metabolic complications caused by a high-fat diet.
JOURNAL OF HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Veronica Arreaza-Gil, Hector Palacios-Jordan, Maria del Mar Romero, Cristina Torres-Fuentes, Miguel A. A. Rodriguez, Xavier Remesar, Jose-Antonio Fernandez-Lopez, Anna Arola-Arnal
Summary: This study aimed to investigate the influence of timing, sex, and diet on the effects of proanthocyanidins (PAs) on the metabolome. The results showed that the effects of PAs on metabolites were sex and diet-dependent, and were also modulated by the timing of consumption.