Article
Cell Biology
Michael Fassler, Clara Benaim, Jacob George
Summary: This study investigated the effects of the TREM2 monoclonal antibody Ab-T1 on Tau protein in neurodegenerative diseases. The results showed that Ab-T1 enhanced the uptake of Tau protein by microglia, reduced Tau propagation and phosphorylation, and improved cognitive decline and neuroinflammation. These findings indicate that TREM2 activation has beneficial effects in reducing Tau-driven neurodegeneration.
Review
Medicine, General & Internal
Maria Laura Passaro, Francesco Matarazzo, Gianmarco Abbadessa, Antonio Pezone, Antonio Porcellini, Fausto Tranfa, Michele Rinaldi, Ciro Costagliola
Summary: Glaucoma is a chronic neurodegenerative disorder that can cause vision loss and blindness. Recent research has found that glaucoma patients also have abnormal tau protein aggregation, suggesting similarities with other neurodegenerative disorders. Studies have shown that tau modifications play a crucial role in neuronal injury caused by ocular hypertension in glaucoma patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Pragati, Surajit Sarkar
Summary: Neurodegenerative tauopathies like Alzheimer's and Parkinson's diseases are characterized by the hyperphosphorylation of tau protein leading to the formation of neurofibrillary tangles. Research suggests that a multitarget-based combinatorial approach may provide an efficient rescue against tauopathies.
Article
Multidisciplinary Sciences
Randall J. Eck, Rebecca L. Kow, Aristide H. Black, Nicole F. Liachko, Brian C. Kraemer
Summary: The pathological accumulation of the microtubule binding protein tau is the main cause of age-related neurodegenerative diseases known as tauopathies. A study using a Caenorhabditis elegans model found that the toxicity of tau depends on the nuclear E3 ubiquitin ligase adaptor protein SPOP. Loss of function mutations in the spop-1 gene improved behavioral deficits in tau transgenic animals, while overexpression of SPOP-1 worsened these deficits. Furthermore, loss of spop-1 rescued various tau-related phenotypes, including tau protein accumulation, neurodegeneration, and shortened lifespan.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Clinical Neurology
Luca Marsili, Kevin R. Duque, Nathan Gregor, Elhusseini Abdelghany, Jesus Abanto, Andrew P. Duker, Matthew C. Hagen, Alberto J. Espay, Matteo Bologna
Summary: This study found no significant differences in the features of bradykinesia between patients with synucleinopathies and tauopathies.
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Ann C. McKee, Thor D. Stein, Bertrand R. Huber, John F. Crary, Kevin Bieniek, Dennis Dickson, Victor E. Alvarez, Jonathan D. Cherry, Kurt Farrell, Morgane Butler, Madeline Uretsky, Bobak Abdolmohammadi, Michael L. Alosco, Yorghos Tripodis, Jesse Mez, Daniel H. Daneshvar
Summary: There has been a significant increase in scientific research on chronic traumatic encephalopathy (CTE) in the past 17 years. CTE has been diagnosed in hundreds of contact sport athletes and others through postmortem examination, and there is a strong causal relationship between repetitive head impacts (RHI) and CTE. The neuropathological features of CTE are unique, and the NINDS-NIBIB criteria have greatly advanced the diagnosis of CTE.
ACTA NEUROPATHOLOGICA
(2023)
Review
Neurosciences
Preetpal Kaur, Alisha Khera, Hema K. Alajangi, Akanksha Sharma, Pradeep K. Jaiswal, Gurpal Singh, Ravi P. Barnwal
Summary: Several protein kinases and phosphatases regulate tau protein phosphorylation, and an imbalance in their activity leads to tau hyper-phosphorylation. Aberrant tau phosphorylation causes it to dissociate from microtubules and form neurofibrillary tangles, contributing to neurodegenerative disorders. Restorative approaches targeting hyperphosphorylated tau protein are being explored, and drug delivery systems based on nanocarriers provide a potential solution for the limited transport of drugs to the central nervous system. This review discusses tau protein, regulation of its phosphorylation, drugs in use or under clinical trials, and treatment strategies for tauopathies based on the role of tau hyperphosphorylation in disease pathogenesis.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Rana E. Kamal, Esther Menze, Amgad Albohy, Hebatalla I. Ahmed, Samar S. Azab
Summary: This study evaluated the potential of carvedilol as an anti-Parkinson's drug and anti-tau protein target through computational simulation and in vivo experiments. The results suggest that carvedilol has neuro-protective effects and may be a candidate for the management of Parkinson's disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sarah Holper, Rosie Watson, Nawaf Yassi
Summary: The advances in tau detection have revolutionized the diagnosis of neurodegenerative diseases, offering improved diagnostic accuracy and potential as a predictor of clinical progression and drug therapy response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Aiko Robert, Michael Scholl, Thomas Vogels
Summary: Recent research has shown that injecting purified tau aggregates from human tauopathy patients can replicate the structural features and cell type specificity of the original tau pathology. These models may have unique translational value in studying the functional consequences of tau pathology, tau-based diagnostics, and tau-targeting therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Marta Sidoryk-Wegrzynowicz, Beata Dabrowska-Bouta, Grzegorz Sulkowski, Lidia Struzynska
Summary: Tau-dependent neurodegeneration in a transgenic mouse model is accompanied by astrocytosis, indicating the critical role of astrocytes in the disease development. Alterations in glutamine transport and recycling affect the neuronal-astrocytic integrity, suggesting potential mechanisms operating in Tau pathology.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Cell Biology
Valeria Parrales-Macias, Patrick P. Michel, Aurore Tourville, Rita Raisman-Vozari, Stephane Haik, Stephane Hunot, Nicolas Bizat, Annie Lannuzel
Summary: Chlordecone, an organochlorine pesticide, leads to neurodegeneration similar to Parkinson's disease by killing dopamine neurons and causing oxidative stress and mitochondrial disturbances. It also promotes the phosphorylation of tau protein, indicating its association with atypical Parkinsonism characterized by tau pathology.
Article
Neurosciences
Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Gutierrez de Rave, Dick Terwel, Astrid Bottelbergs, Ilse Dewachter
Summary: This study reveals the significant role of NLRP3 inflammasome in Alzheimer's disease and related tauopathies, with implications for both tau-associated neurodegeneration and tau propagation.
Article
Biochemistry & Molecular Biology
Dominika Olesova, Petra Majerova, Roman Hajek, Juraj Piest'ansky, Radana Brumarova, Alena Michalicova, Bernadeta Jurkanin, David Friedecky, Andrej Kovac
Summary: This study characterized the glycosphingolipid profile in rat brain tissue using hydrophilic interaction liquid chromatography coupled to high-resolution tandem mass spectrometry. It revealed the important roles of gangliosides and sulfatides in neurodevelopment, aging, and neurodegeneration. The semi-targeted screening identified changes in levels of sulfatides and GM1a gangliosides during the aging process, and elevated levels of GM3 gangliosides in the tauopathy rat model, indicating a higher rate of apoptotic processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Garrett Dalton Smedley, Keenan E. Walker, Shauna H. Yuan
Summary: Neurodegenerative diseases are a growing concern for the aging population, and errors within the PERK pathway have been linked to a variety of pathologies. However, conflicting narratives exist due to the wide array of methodological approaches in genetic and clinical studies. As PERK is connected to pathology, it has become a valuable target for research in understanding and potentially treating neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Kim A. Staats, Diana Pombal, Susann Schonefeldt, Lawrence Van Helleputte, Herve Maurin, Tom Dresselaers, Kristof Govaerts, Uwe Himmelreich, Fred Van Leuven, Ludo Van den Bosch, James Dooley, Stephanie Humblet-Baron, Adrian Liston
Article
Anatomy & Morphology
Vera Stamenkovic, Stefan Stamenkovic, Tomasz Jaworski, Maciej Gawlak, Milos Jovanovic, Igor Jakovcevski, Grzegorz M. Wilczynski, Leszek Kaczmarek, Melitta Schachner, Lidija Radenovic, Pavle R. Andjus
BRAIN STRUCTURE & FUNCTION
(2017)
Article
Neurosciences
Ilona Kondratiuk, Szymon Leski, Malgorzata Urbanska, Przemysaw Biecek, Herman Devijver, Benoit Lechat, Fred Van Leuven, Leszek Kaczmarek, Tomasz Jaworski
MOLECULAR NEUROBIOLOGY
(2017)
Article
Oncology
Sylvie L. Lesuis, Herve Maurin, Peter Borghgraef, Paul J. Lucassen, Fred Van Leuven, Harm J. Krugers
Article
Neurosciences
Miriana Jlenia Quattromani, Mathilde Pruvost, Carla Guerreiro, Fredrik Backlund, Elisabet Englund, Anders Aspberg, Tomasz Jaworski, Jakob Hakon, Karsten Ruscher, Leszek Kaczmarek, Denis Vivien, Tadeusz Wieloch
MOLECULAR NEUROBIOLOGY
(2018)
Article
Multidisciplinary Sciences
Herve Maurin, Seon-Ah Chong, Igor Kraev, Heather Davies, Anna Kremer, Claire Marie Seymour, Benoit Lechat, Tomasz Jaworski, Peter Borghgraef, Herman Devijver, Geert Callewaert, Michael G. Stewart, Fred Van Leuven
Article
Multidisciplinary Sciences
Laurie-Anne Roeckel, Valerie Utard, David Reiss, Jinane Mouheiche, Herve Maurin, Anne Robe, Emilie Audouard, John N. Wood, Yannick Goumon, Frederic Simonin, Claire Gaveriaux-Ruff
SCIENTIFIC REPORTS
(2017)
Article
Medicine, General & Internal
Malgorzata Urbanska, Paulina Kazmierska-Grebowska, Tomasz Kowalczyk, Bartosz Caban, Karolina Nader, Barbara Pijet, Katarzyna Kalita, Agata Gozdz, Herman Devijver, Benoit Lechat, Tomasz Jaworski, Wieslawa Grajkowska, Krzysztof Sadowski, Sergiusz Jozwiak, Katarzyna Kotulska, Jan Konopacki, Fred Van Leuven, Erwin A. van Vliet, Eleonora Aronica, Jacek Jaworski
Article
Neurosciences
Jan R. Detrez, Herve Maurin, Kristof Van Kolen, Roland Willems, Julien Colombelli, Benoit Lechat, Bart Roucourt, Fred Van Leuven, Sarah Baatout, Peter Larsen, Rony Nuydens, Jean-Pierre Timmermans, Winnok H. De Vos
NEUROBIOLOGY OF DISEASE
(2019)
Review
Neurosciences
Tomasz Jaworski, Ewa Banach-Kasper, Katarzyna Gralec
Article
Neurosciences
David Reiss, Tando Maduna, Herve Maurin, Emilie Audouard, Claire Gaveriaux-Ruff
Summary: One major challenge in medicine is to develop potent pain therapies without the adverse effects of opiates. This study investigated the role of microglial mu opioid receptor (MOR) in opiate analgesic tolerance, opioid-induced hyperalgesia (OIH), and physical dependence. The researchers found that deleting MOR in microglia delayed morphine analgesic tolerance and abolished OIH in mice. Their results suggest that blocking microglial MOR could be a therapeutic target for opiate analgesia without the opiate adverse effects.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Neurosciences
Kristof Van Kolen, Thomas J. Malia, Clara Theunis, Rupesh Nanjunda, Alexey Teplyakov, Robin Ernst, Sheng-Jiun Wu, Jinquan Luo, Marianne Borgers, Marc Vandermeeren, Astrid Bottelbergs, Cindy Wintmolders, Eilyn Lacy, Herve Maurin, Peter Larsen, Roland Willems, Tom Van De Casteele, Gallen Triana-Baltzer, Randy Slemmon, Wendy Galpern, John Q. Trojanowski, Hong Sun, Marc H. Mercken
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Neurosciences
David Reiss, Herve Maurin, Emilie Audouard, Miriam Martinez-Navarro, Yaping Xue, Yann Herault, Rafael Maldonado, David Cabanero, Claire Gaveriaux-Ruff
Summary: The study found that astrocytic DOR plays a significant role in promoting cold allodynia and analgesic tolerance in females, while overall DOR activity is protective. DOR activity in astrocytes exacerbates neuropathic allodynia, while DOR activity in other cells attenuates this form of pain.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
S. Tok, H. Maurin, C. Delay, D. Crauwels, N. Manyakov, W. Van der Elst, D. Moechars, W. H. I. M. Drinkenburg
Summary: This study examines the interaction between amyloid plaques and tau neurofibrillary tangles in Alzheimer's Disease. Results show that the development of tau pathology is influenced by the presence of amyloid pathology at the time of injection, as well as factors such as age, genotype, and time after injection. The study also finds temporary hippocampal dysfunction associated with tau seeding, and genotype-related differences in pathology and neurophysiological changes.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
S. Tok, H. Maurin, C. Delay, D. Crauwels, N. Manyakov, W. Van der Elst, D. Moechars, W. H. I. M. Drinkenburg
Summary: This study reveals the neurophysiological effects of amyloid and tau pathology by studying APP-KI animals and tau-seeded animals. Older animals with amyloid pathology exhibit more amyloid pathology and impairments in gamma oscillations. Tau-seeded animals show immediate deficits in neurophysiology after seeding, with persisting gamma power spectra deficits in younger animals. Deficits in hippocampal phase-amplitude coupling and gamma power differentiate tau-seeded, amyloid-positive animals from buffer controls.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)