Article
Cell Biology
Agnieszka Kaminska, Aleksandra Wedzinska, Marta Kot, Anna Sarnowska
Summary: The study aimed to cultivate MSC subpopulation with increased pluripotent and neural gene expression through a 3D spheroid culture system. Results showed that prolonged 3D culture led to increased senescence, decreased stemness and proliferation in MSC, but allowed for the selection of cells with elevated expression of neural markers indicating unique features.
Article
Cell Biology
Kirsty M. Ferguson, Carla Blin, Neza Alfazema, Ester Gangoso, Steven M. Pollard, Maria Angeles Marques-Torrejon
Summary: Patients with glioblastoma (GBM) have a poor prognosis. This study finds that Lrig1 protein plays an important role in the quiescent and proliferative states of GBM stem cells. Lack of Lrig1 increases proliferation and loss of quiescence, while overexpression of Lrig1 enhances quiescence and reduces proliferation. Lrig1 controls the proportions of quiescent and proliferative subpopulations in GBMs by regulating responsiveness to epidermal growth factor receptor and BMPR signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ritama Paul, Jay F. Dorsey, Yi Fan
Summary: Cancer stem cells (CSCs) play a crucial role in cancer progression, metastasis, relapse, and therapy resistance. They maintain their self-renewal capability and resist the tumor microenvironment and treatments through mechanisms such as cellular plasticity, senescence, and quiescence. Understanding these mechanisms is important for future therapeutic implications.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cell Biology
Yuan Cao, Hai-ning Wu, Xiu-li Cao, Kang-yi Yue, Wen-juan Han, Zi-peng Cao, Yu-fei Zhang, Xiang-yu Gao, Ceng Luo, Xiao-fan Jiang, Hua Han, Min-hua Zheng
Summary: Ttyh1 is essential for the stemness of neural stem cells (NSCs), with its deficiency leading to activated neurogenesis and enhanced spatial learning and memory in adult mice, and accelerated exhaustion of NSC pool and impaired neurogenesis in aged mice. The regulation of calcium signaling and involvement of transcription factor NFATc3 are critical mechanisms by which Ttyh1 affects quiescence versus activation of NSCs. Our research provides new targets for intervention to activate quiescent NSCs for injury repair during pathology and aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell & Tissue Engineering
Claudia Colussi, Claudio Grassi
Summary: Nucleoporins play a crucial role in chromatin interaction and gene expression modulation, particularly in maintaining the balance of stemness and differentiation in stem cells. They are increasingly implicated in central nervous system functions, impacting neurogenesis, neurophysiology, and neurological disorders. However, the role of Nup-mediated epigenetic regulation in neural stem cells remains largely unexplored, with mechanisms of action still being unveiled.
Article
Biochemistry & Molecular Biology
Nicola Alessio, Domenico Aprile, Salvatore Cappabianca, Gianfranco Peluso, Giovanni Di Bernardo, Umberto Galderisi
Summary: Cells can transition between different states such as quiescence, differentiation, and senescence, with the expression of Ki67, RPS6, and beta-galactosidase used to identify these changes. The study found that cells may go through different stages during the process of entering and leaving quiescence, and that there are early and late stages in the progression towards senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Samantha A. O'Connor, Heather M. Feldman, Sonali Arora, Pia Hoellerbauer, Chad M. Toledo, Philip Corrin, Lucas Carter, Megan Kufeld, Hamid Bolouri, Ryan Basom, Jeffrey Delrow, Jose L. McFaline-Figueroa, Cole Trapnell, Steven M. Pollard, Anoop Patel, Patrick J. Paddison, Christopher L. Plaisier
Summary: Single-cell RNA sequencing was used to examine the cell cycle states of expanding human neural stem cells (hNSCs), revealing a quiescent-like state in neuroepithelial-derived cells and gliomas. Neural G0 markers were enriched with quiescent NSC genes, and were significantly associated with less aggressive tumors and extended patient survival in gliomas. Knockout of genes associated with the Hippo/Yap and p53 pathways diminished Neural G0, resulting in faster G1 transit and down-regulation of quiescence-associated markers.
MOLECULAR SYSTEMS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
David A. Yefroyev, Sha Jin
Summary: Neurodegenerative diseases are severe pathologies that affect cognitive ability, motor control, and everyday function. Pluripotent stem cell technology offers hope in addressing this problem, with induced pluripotent stem cells providing an alternative and endless source without the ethical and practical concerns of embryonic stem cells. This review focuses on iPSC technology, the pathophysiology of Alzheimer's and Parkinson's diseases, and current state-of-the-art approaches using iPSCs for treatment.
Review
Biochemistry & Molecular Biology
Taeko Kobayashi, Ryoichiro Kageyama
Summary: Quiescence is a cellular strategy that maintains somatic stem cells in a low metabolic state in a specific niche to prevent premature exhaustion in the brain. During development, neural stem cells actively proliferate and differentiate, while most adult neural stem cells are quiescent to ensure a sustainable source of stem cells throughout life. The transition between quiescence and proliferation is tightly regulated by various signaling pathways, with recent studies highlighting the role of proteostasis and lysosomes in the quiescence of adult NSCs.
Article
Cell Biology
Florian M. Hatzmann, Asim Ejaz, G. Jan Wiegers, Markus Mandl, Camille Brucker, Stefan Lechner, Tina Rauchenwald, Marit Zwierzina, Saphira Baumgarten, Sonja Wagner, Monika Mattesich, Petra Waldegger, Gerhard Pierer, Werner Zwerschke
Summary: This study reveals that DLK1(-)/CD34(+) ASCs in human subcutaneous white adipose tissue exist in a quiescent state, express high levels of somatic stemness factors and the early adipogenic transcription factor C/EBP beta, but senescence and pluripotency markers are barely detectable. CD24 is shown to be necessary for proper ASC proliferation and adipogenesis, and DLK1(-)/CD34(+)/CD24(+) cells exhibit higher stemness and lower adipogenic capacity compared to DLK1(-)/CD34(+)/CD24(-) subpopulations.
Article
Cell Biology
Cristina Almenglo, Pilar Caamano, Maximo Fraga, Jesus Devesa, Jose A. Costoya, Victor M. Arce
Summary: GBM, the most common and aggressive primary brain tumor in adults, presents vast genetic variation and phenotypic diversity, making therapeutic strategy development challenging. Transformation of primary mouse embryo astrocytes into immortalized cultures with neural stem cell characteristics provides a model for studying gliomagenesis and testing drug effectiveness throughout GBM's natural history.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Veterinary Sciences
Woo Keyoung Kim, Yeon Sung Son, Ji-Hey Lim, Wan Hee Kim, Byung-Jae Kang
Summary: This study demonstrates the successful isolation and propagation of NSPCs derived from the canine cervical spinal cord, which have the potential to differentiate into neuronal and glial cells.
BMC VETERINARY RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Liang Wang, Wenjuan Zhou, Hongru Yang, Feng Liu, Ying Kong, Wenhan Wang, Hang Zhao, Wenjun Ma, Yuanhua Sang, Fan Yi, Hong Liu, Chao Liu, Aijun Hao, Jichuan Qiu
Summary: Alzheimer's disease (AD) is characterized by the loss of cholinergic neurons in the mesopontine area, and there is currently no effective method to repair these damaged neurons. Neural stem cell (NSC)-based therapy is a promising approach for AD treatment, but directing NSCs to differentiate into cholinergic neurons is challenging. This study synthesized calcium folate (CaFO) nanoparticles to promote the differentiation of NSCs into functional cholinergic neurons. The experiments demonstrated that under the stimulation of CaFO nanoparticles, NSCs differentiated into cholinergic neurons within 5 days. Animal experiments also showed that CaFO nanoparticles improved the cognitive memory ability of AD mice by promoting neuronal differentiation of NSCs. This study provides a new strategy for the treatment of AD by inducing the quick differentiation of NSCs into functional cholinergic neurons.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Neurosciences
Peibin Zou, Chongyun Wu, Timon Cheng-Yi Liu, Rui Duan, Luodan Yang
Summary: This review highlights the indispensable role of oligodendrocyte progenitor cells (OPCs) in central nervous system (CNS) function and their involvement in the pathogenesis of Alzheimer's disease (AD). The intricate interplay between OPCs and the AD brain microenvironment underscores the complexity of neurodegenerative diseases.
TRANSLATIONAL NEURODEGENERATION
(2023)
Review
Neurosciences
Xiaokun Chen, Shenzhong Jiang, Renzhi Wang, Xinjie Bao, Yongning Li
Summary: Alzheimer's disease is one of the most dangerous and debilitating diseases in the world, and there are currently no effective treatment strategies. Neural stem cell therapy may provide new treatment options for Alzheimer's disease, but there are still challenges to overcome. This article aims to introduce recent advances in the treatment of Alzheimer's disease and discuss the challenges and prospects associated with cell transplant therapy.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Environmental Sciences
Wendy Wills, Giada Danesi, Ariadne Beatrice Kapetanaki, Laura Hamilton
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Article
Biology
Sandra E. Joppe, Loic M. Cochard, Louis-Charles Levros, Laura K. Hamilton, Pierre Ameslon, Anne Aumont, Fanie Barnabe-Heider, Karl J. L. Fernandes
LIFE SCIENCE ALLIANCE
(2020)
Book Review
Education & Educational Research
Laura Hamilton
BRITISH JOURNAL OF EDUCATIONAL STUDIES
(2021)
Article
Multidisciplinary Sciences
Laura K. Hamilton, Gael Moquin-Beaudry, Chenicka L. Mangahas, Federico Pratesi, Myriam Aubin, Anne Aumont, Sandra E. Joppe, Alexandre Legiot, Annick Vachon, Melanie Plourde, Catherine Mounier, Martine Tetreault, Karl J. L. Fernandes
Summary: This study investigates the role of Stearoyl-CoA desaturase (SCD) in Alzheimer's disease (AD) and shows that inhibiting SCD activity can induce transcriptional changes in the brain and immune cells, restore dendritic structure and improve learning and memory. These findings suggest that targeting SCD may have therapeutic potential for AD treatment.
NATURE COMMUNICATIONS
(2022)
Article
Public, Environmental & Occupational Health
Claire Thompson, Laura Hamilton, Angela Dickinson, Rosalind Fallaize, Elspeth Mathie, Samantha Rogers, Wendy Wills
Summary: Measures to control the spread of COVID-19 have led to changes in food shopping practices in the East of England, with disruptions to supermarket routines, a shift to online shopping, and increased reliance on local stores. The impact of the pandemic has been disproportionate on lower-income households and neighborhoods, necessitating further investigation into the long-term implications for dietary health inequalities.
Article
Medicine, Research & Experimental
Charvi Syal, Jayasankar Kosaraju, Laura Hamilton, Anne Aumont, Alphonse Chu, Sailendra Nath Sarma, Jacob Thomas, Matthew Seegobin, F. Jeffrey Dilworth, Ling He, Fredric E. Wondisford, Robert Zimmermann, Martin Parent, Karl Fernandes, Jing Wang
Review
Gerontology
Daksha P. Trivedi, Andreas Braun, Angela Dickinson, Heather Gage, Laura Hamilton, Claire Goodman, Kunle Ashaye, Steve Iliffe, Jill Manthorpe
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2019)
Review
Gerontology
Andreas Braun, Daksha P. Trivedi, Angela Dickinson, Laura Hamilton, Claire Goodman, Heather Gage, Kunle Ashaye, Steve Iliffe, Jill Manthorpe
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2019)
Article
Social Issues
Abigail Knight, Julia Brannen, Rebecca O'Connell, Laura Hamilton
JOURNAL OF POVERTY AND SOCIAL JUSTICE
(2018)
Article
Social Work
Wendy J. Wills, Giada Danesi, Ariadne B. Kapetanaki, Laura K. Hamilton
CHILDREN & SOCIETY
(2018)
Article
Behavioral Sciences
Laura Kate Hamilton, Wendy J. Wills