Article
Neurosciences
Wenyue Liu, Changpeng Wang, Tingting He, Minghong Su, Yuan Lu, Guanyu Zhang, Thomas F. Munte, Lirong Jin, Zheng Ye
Summary: In Parkinson's disease, damage to the substantia nigra may lead to deficits in sequential working memory, mediated by dysfunction in the basal ganglia. Patients showed poorer performance in a digitordering task and smaller SNs compared to healthy controls. The study suggests that SN integrity is crucial for sequencing performance in PD patients.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Mohammed E. Choudhury, Yuka Kigami, Junya Tanaka
Summary: With the increasing age of the population, the incidence of Parkinson's disease has grown significantly. Microglia play important roles in both the degeneration of dopaminergic neurons and the compensatory mechanisms in different regions of the basal ganglia, making it challenging to target them for PD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Kelsey Barcomb, Christopher P. Ford
Summary: This review summarizes the previous work on the changes in neurotransmitter co-release and circuit dysfunction associated with the degeneration of midbrain dopamine neurons in Parkinson's disease.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Junichi Yoshida, Maritza Onate, Leila Khatami, Jorge Vera, Farzan Nadim, Kamran Khodakhah
Summary: The cerebellum and basal ganglia are connected through direct pathways, influencing motor coordination and dopamine release, and impacting motor deficits and addictive behavior.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Deepak K. Ravi, Christian R. Baumann, Elena Bernasconi, Michelle Gwerder, Niklas K. Ignasiak, Mechtild Uhl, Lennart Stieglitz, William R. Taylor, Navrag B. Singh
Summary: This study systematically investigated changes in gait asymmetry and dyscoordination in PD patients 6 months postoperatively, revealing that STN-DBS increased step time asymmetry and phase coordination index, with higher effects in PIGD subgroup compared to tremor dominant subtype. The study suggests subtype-associated differences in treatment response.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Neurosciences
Tiago Monteiro, Filipe S. Rodrigues, Margarida Pexirra, Bruno F. Cruz, Ana I. Goncalves, Pavel E. Rueda-Orozco, Joseph J. Paton
Summary: Temperature changes in the striatum affect neural activity and time judgments in rats, but not movement. The striatum may play a role in discrete decisions rather than continuous motor control.
NATURE NEUROSCIENCE
(2023)
Review
Neurosciences
Monavareh Soti, Hoda Ranjbar, Kristi A. Kohlmeier, Mohammad Shabani
Summary: Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons. Recent studies have shown that modulation of GABA and cannabinoid receptors can improve motor functions in Parkinson's disease patients. Therefore, investigating the changes of cannabinoid receptors in different stages of the disease and utilizing them in treatment could be significant for Parkinson's disease management.
BRAIN RESEARCH BULLETIN
(2022)
Article
Multidisciplinary Sciences
Emil Warnberg, Arvind Kumar
Summary: This article discusses the role of midbrain dopaminergic neurons in the basal ganglia and how to explain how dopamine supports learning of continuous outputs instead of discrete action values. The authors propose a model and demonstrate its validity through a learning rule.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Neurosciences
Dalton James Surmeier, Shenyu Zhai, Qiaoling Cui, DeNard V. Simmons
Summary: For the past 30 years, the prevailing belief has been that striatal dopamine depletion is the critical factor underlying the motor symptoms of Parkinson's disease. However, recent research has shown that the current network model fails to consider important aspects of the basal ganglia and that dopamine acts beyond the striatum. Studies using a progressive mouse model have demonstrated that striatal dopamine depletion alone is not enough to induce parkinsonism, and restoring dopamine signaling outside the striatum can alleviate motor deficits. Therefore, it is time to develop a new model for understanding the network determinants of motor disability in Parkinson's disease.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Javier Garcia-Pardo, Fernando Novio, Fabiana Nador, Ivana Cavaliere, Salvio Suarez-Garcia, Silvia Lope-Piedrafita, Ana Paula Candiota, Jordi Romero-Gimenez, Beatriz Rodriguez-Galvan, Jordi Bove, Miquel Vila, Julia Lorenzo, Daniel Ruiz-Molina
Summary: This study demonstrates the synthesis of neuromelanin bioinspired polymeric nanoparticles for encapsulating DA with high loading efficiency. In vitro, the DA-NCPs showed lower toxicity and enhanced uptake by dopaminergic cells compared to free DA. In vivo, nasal administration of DA-NCPs increased striatal DA levels and reduced apomorphine-induced rotations, highlighting the potential of nanostructured DA for DA-replacement therapy.
Article
Neurosciences
Rong Li, Ting Zou, Xuyang Wang, Hongyu Wang, Xiaofei Hu, Fangfang Xie, Li Meng, Huafu Chen
Summary: Parkinson's disease is a progressive neurodegenerative disease characterized by both motor and non-motor symptoms. Research suggests that as the disease progresses, gray matter atrophy in Parkinson's patients spreads from the basal ganglia to other brain regions, potentially playing a key role in motor and non-motor circuits.
HUMAN BRAIN MAPPING
(2022)
Article
Multidisciplinary Sciences
Matthew J. D. Pilgrim, Zhen-Yi Andy Ou, Madeleine Sharp
Summary: Patients with Parkinson's disease may not utilize the reward value of stimuli when automatically allocating attention, and dopamine replacement therapy does not seem to modulate the effect of reward on automatic attention allocation.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Chunxiu Yu, Tony Tianlun Jiang, Charles T. Shoemaker, David Fan, Mark A. Rossi, Henry H. Yin
Summary: Unilateral dopamine depletion leads to asymmetric striatal output, resulting in turning behavior towards the side with lower output. The direction of turning is determined by the relative striatal outputs from the two cerebral hemispheres.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Aviv D. Mizrahi-Kliger, Lucia K. Feldmann, Andrea A. Kuehn, Hagai Bergman
Summary: Insomnia is a common and debilitating aspect of Parkinson's disease, perceived as a multifactorial entity with origins in disease symptoms, comorbidities, therapeutic strategies, and neural degeneration. Recent evidence has provided insights into the neural underpinnings of insomnia in PD, offering potential neuromodulation-based therapeutic avenues for treatment.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Liqiang Chen, Samuel Daniels, Yerim Kim, Hong-Yuan Chu
Summary: The intrinsic excitability of pyramidal tract neurons (PTNs) in the primary motor cortical layer was greatly decreased in parkinsonism, specifically affecting M1 PTNs but not intratelencephalic neurons (ITNs). The decreased excitability may be associated with impaired function of sodium channels and potassium channels, leading to abnormal firing patterns in parkinsonian state.
JOURNAL OF NEUROSCIENCE
(2021)
Editorial Material
Clinical Neurology
Matt J. N. Brown, Antonella Macerollo, James M. Kilner, Robert Chen
MOVEMENT DISORDERS
(2016)
Article
Neurosciences
Antonella Macerollo, Matt J. N. Brown
JOURNAL OF NEUROPHYSIOLOGY
(2017)
Article
Clinical Neurology
Antonella Macerollo, Matt J. N. Brown
MOVEMENT DISORDERS
(2018)
Letter
Clinical Neurology
Shannon C. Lefaivre, Matt J. N. Brown, Quincy J. Almeida
MOVEMENT DISORDERS
(2018)
Review
Neurosciences
Antonella Macerollo, Matt J. N. Brown, James M. Kilner, Robert Chen
TRENDS IN NEUROSCIENCES
(2018)
Article
Clinical Neurology
Matt J. N. Brown, Anne Weissbach, Martje G. Pauly, Michael Vesia, Carolyn Gunraj, Julianne Baarbe, Alexander Muenchau, Tobias Baeumer, Robert Chen
Editorial Material
Neurosciences
Martijn Beudel, Antonella Macerollo, Matt J. N. Brown, Robert Chen
FRONTIERS IN HUMAN NEUROSCIENCE
(2020)
Article
Neurosciences
Elana R. Goldenkoff, Heather R. McGregor, Joshua Mergos, Puyan Gholizadeh, John Bridenstine, Matt J. N. Brown, Michael Vesia
Summary: The study found that unimanual training with reversed visual feedback enhances transfer of skills to the untrained hand, modulates plasticity in motor areas of the brain, and affects somatosensory areas. After training with reversed vision, cortical suppression of S1 activity supports skilled motor performance, presumably through sensory gating.
Article
Neurosciences
Julianne Baarbe, Michael Vesia, Matt J. N. Brown, Karlo J. Lizarraga, Carolyn Gunraj, Gaayathiri Jegatheeswaran, Neil M. Drummond, Cricia Rinchon, Anne Weissbach, James Saravanamuttu, Robert Chen
Summary: This study reveals that stimulation of the right angular gyrus facilitates motor output from the left motor cortex for right hand movements while inhibiting indirect waves in the left motor cortex. Combined stimulation of the right and left angular gyrus increases GABAB receptor-mediated inhibition in the left motor cortex. These findings highlight unique interactions between the right angular gyrus and the left motor cortex.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Julianne Baarbe, Karlo J. Lizarraga, Matt J. N. Brown, Utpal Saha, Alfonso Fasano, William D. Hutchison, Robert Chen
Summary: The study found that lower limb motor blocks during bilateral stepping in a virtual environment can predict the presence and severity of freezing of gait in patients with Parkinson's disease. This method can help detect FOG symptoms in patients who are unable or unsafe to walk.
PARKINSONISM & RELATED DISORDERS
(2021)
Letter
Clinical Neurology
Anne Weissbach, Annika Steinmeier, Martje G. Pauly, Duha M. Al-Shorafat, Gerard Saranza, Anthony E. Lang, Norbert Brueggemann, Vera Tadic, Christine Klein, Katja Lohmann, Matt J. N. Brown, Christian Beste, Alexander Munchau, Tobias Baeumer
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Anne Weissbach, Annika Steinmeier, Martje Pauly, Duha M. Al-Shorafat, Gerard Saranza, Anthony Lang, Norbert Brueggemann, Vera Tadic, Christine Klein, Alexander Muenchau, Tobias Baeumer, Matt J. N. Brown
Summary: This study examined sensorimotor inhibition in GCH1 mutation carriers and found that their short-latency afferent inhibition (SAI) and dual-site transcranial magnetic stimulation (ds-TMS) levels were not significantly different from the control group. However, SAI decreased over time in mutation carriers off dopamine replacement therapy (DRT). These results suggest changes in plasticity in the sensorimotor networks.
PARKINSONISM & RELATED DISORDERS
(2022)
Editorial Material
Neurosciences
Martijn Beudel, Antonella Macerollo, Matt J. N. Brown, Robert Chen
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Meeting Abstract
Sport Sciences
Anthony Colvard, Daryl L. Parker, Matt J. N. Brown
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2020)
Article
Neurosciences
Matt J. N. Brown, Elana R. Goldenkoff, Robert Chen, Carolyn Gunraj, Michael Vesia