Article
Neuroimaging
O. Goodkin, F. Prados, S. B. Vos, H. Pemberton, S. Collorone, M. H. J. Hagens, M. J. Cardoso, T. A. Yousry, J. S. Thornton, C. H. Sudre, F. Barkhof
Summary: This study focused on comparing the performance of FLAIR-only automated segmentation with conventional methods in assessing WM lesions and brain volumes in MS patients. The results showed that the FLAIR-only method was consistent with conventional methods and demonstrated expected biological effects, suggesting its potential for clinical application in radiological MS reporting.
NEUROIMAGE-CLINICAL
(2021)
Article
Clinical Neurology
Susana Otero-Romero, Luciana Midaglia, Pere Carbonell-Mirabent, Maria Zuluaga, Ingrid Galan, Jordi Rio, Georgina Arrambide, Marta Rodriguez-Barranco, Angela Vidal-Jordana, Joaquin Castillo, Breogan Rodriguez-Acevedo, Ana Zabalza, Carlos Nos, Manuel Comabella-Lopez, Patricia Mulero, Cristina Auger, Jaume Sastre-Garriga, Santiago Perez-Hoyos, Alex Rovira, Xavier Montalban, Mar Tintore
Summary: In this study, the effect of menopause on disability accumulation in women with clinically isolated syndrome (CIS) was evaluated. Results indicated that menopause did not increase the risk of disability in this population when considering Expanded Disability Status Scale (EDSS) trajectories along with age and disease duration. The annual increase in EDSS was higher in menopausal women compared to nonmenopausal women, but this difference disappeared when controlling for age and disease duration.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Immunology
Jose Fernandez-Velasco, Enric Monreal, Jens Kuhle, Virginia Meca-Lallana, Jose Meca-Lallana, Guillermo Izquierdo, Celia Oreja-Guevara, Francisco Gascon-Gimenez, Susana Sainz de la Maza, Paulette E. Walo-Delgado, Paloma Lapuente-Suanzes, Aleksandra Maceski, Eulalia Rodriguez-Martin, Ernesto Roldan, Noelia Villarrubia, Albert Saiz, Yolanda Blanco, Carolina Diaz-Perez, Gabriel Valero-Lopez, Judit Diaz-Diaz, Yolanda Aladro, Luis Brieva, Cristina Iniguez, Ines Gonzalez-Suarez, Luis A. Rodriguez de Antonio, Jose M. Garcia-Dominguez, Julia Sabin, Sara Llufriu, Jaime Masjuan, Lucienne Costa-Frossard, Luisa M. Villar
Summary: This study aimed to investigate the role of inflammation in the response to ocrelizumab in patients with PPMS. The findings showed that over 60% of patients achieved no evidence of disease activity (NEDA) after one year of treatment, regardless of their baseline characteristics. The baseline inflammation influenced the predominant immunological pathways, with inflammatory B cells playing a pivotal role in Gd+ patients and inflammatory T and innate immune cells in Gd- patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Annarita Del Gatto, Michele Saviano, Laura Zaccaro
Summary: Multiple sclerosis is a progressive and highly debilitating disease, with current treatment strategies showing limitations in preventing disease progression. Peptide-based systems offer new therapeutic opportunities for the treatment of MS.
Review
Rehabilitation
Ana Torres-Costoso, Vicente Martinez-Vizcaino, Sara Reina-Gutierrez, Celia Alvarez-Bueno, Maria Jose Guzman-Pavon, Diana P. Pozuelo-Carrascosa, Ruben Fernandez-Rodriguez, Mairena Sanchez-Lopez, Ivan Cavero-Redondo
Summary: This study conducted a network meta-analysis to determine the positive influence of physical exercise on multiple sclerosis fatigue, with combined exercise and resistance training showing the most significant effects on fatigue improvement, particularly in physical and total fatigue. Exercise should be considered an effective strategy in managing fatigue among individuals with MS.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Clinical Neurology
Marco Pisa, Tommaso Croese, Gloria Dalla Costa, Simone Guerrieri, Su-Chun Huang, Annamaria Finardi, Lorena Fabbella, Francesca Sangalli, Bruno Colombo, Lucia Moiola, Vittorio Martinelli, Giancarlo Comi, Roberto Furlan, Letizia Leocani
Summary: Optical coherence tomography (OCT) is increasingly important in evaluating patients with multiple sclerosis, showing neuro-retinal changes indicative of inflammatory and disease burden. Subclinical optic nerve involvement and thinning of ganglion cell layer in eyes without acute optic neuritis are associated with greater disease burden, reflecting early disease phases.
Review
Public, Environmental & Occupational Health
Bruno Kusznir Vitturi, Alfredo Montecucco, Alborz Rahmani, Guglielmo Dini, Paolo Durando
Summary: This study conducted the first systematic review with meta-analysis to investigate the occupational risk factors of Multiple Sclerosis. It found that agricultural workers, offshore workers, hairdressers, individuals exposed to toxic fumes from oil wells, low-frequency magnetic fields, and pesticides had an increased likelihood of being diagnosed with MS, which could potentially influence public policies and calls for future research in this area.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Anna Isabella Pisani, Antonio Scalfari, Francesco Crescenzo, Chiara Romualdi, Massimiliano Calabrese
Summary: By using machine learning methods in RRMS patients, predictive factors associated with the risk of converting to SPMS were identified, leading to the development of the SP-RiSc score, which can help improve management strategies.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Steven C. Pike, Francesca Gilli, Andrew R. Pachner
Summary: Multiple sclerosis (MS) is a clinically heterogeneous disease and it is currently difficult to identify patients who may benefit from earlier interventions. Previous data showed that the CXCL13 index (I-CXCL13) can predict future disease activity in MS patients two years after diagnosis. This study confirms that the predictive ability of I-CXCL13 extends to CIS and RIS patients for at least five years, suggesting its potential use in guiding immunomodulatory therapy in MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Charidimos Tsagkas, Katrin Parmar, Simon Pezold, Christian Barro, Mallar M. Chakravarty, Laura Gaetano, Yvonne Naegelin, Michael Amann, Athina Papadopoulou, Jens Wuerfel, Ludwig Kappos, Jens Kuhle, Till Sprenger, Cristina Granziera, Stefano Magon
Summary: Distinct patterns of volume loss over time were found in different central nervous system structures in multiple sclerosis (MS) patients, independent of disease duration and lesion-load but associated with sNfL levels, relapse rates, and clinical worsening. This suggests a need for a more biologic classification of MS subtypes incorporating volumetric and body-fluid markers.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Aaron M. Carlson, Carlos Vervloet Sollero, Kavita Nair, Stefan Sillau, Quran Wu, Tirisham Gyang, Zhigang Li, Melissa J. Armstrong
Summary: This article reports the 7-year prevalence and demographics of multiple sclerosis (MS) and disease modifying therapy (DMT) utilization in a large and diverse population. The study found that MS prevalence is higher in women of all races and ethnicities, and DMT prescription is more common in Hispanic PwMS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Irene Schiavetti, Luca Carmisciano, Marta Ponzano, Cinzia Cordioli, Eleonora Cocco, Girolama Alessandra Marfia, Matilde Inglese, Massimo Filippi, Marta Radaelli, Roberto Bergamaschi, Paolo Immovilli, Marco Capobianco, Nicola De Rossi, Giampaolo Brichetto, Cinzia Scandellari, Paola Cavalla, Ilaria Pesci, Paolo Confalonieri, Paola Perini, Maria Trojano, Roberta Lanzillo, Gioacchino Tedeschi, Giancarlo Comi, Mario Alberto Battaglia, Francesco Patti, Marco Salvetti, Maria Pia Sormani
Summary: The study found that the most common symptoms of COVID-19 in multiple sclerosis patients are ageusia and anosmia, which are often associated with smoking, substance abuse, conjunctivitis, and other comorbidities. Certain disease-modifying therapies may also impact the occurrence of COVID-19 symptoms.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
O. Gonzales-Gamarra, C. Alva-Diaz, K. Pacheco-Barrios, W. Aguirre-Quispe, M. Malaga, J. Inca, E. Rojas, C. Caparo-Zamalloa, M. Montalvan, E. Salcedo, A. M. Solis-Quispe, J. Barreto, M. Rojas-Benites, A. Chereque, M. L. Rodriguez
Summary: This study found that Peru has a moderate MS prevalence compared to other Latin American countries, with Lima having the highest number of cases. The majority of patients were female aged 35 to 45, and the most common type of MS was relapsing-remitting.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Clinical Neurology
Kelsi A. Smith, Fredrik Piehl, Tomas Olsson, Lars Alfredsson, Jan Hillert, Ingrid Kockum, Pernilla Strid, Scott Montgomery
Summary: This study aimed to describe spasticity treatment patterns among people with multiple sclerosis (MS). The results showed that younger patients were more likely to receive baclofen treatment and had high discontinuation rates. This highlights the need for more tolerable and effective spasticity treatments and monitoring of spasticity among people with MS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Marion Selton, Guillaume Mathey, Marc Soudant, Philippe Manceau, Rene Anxionnat, Marc Debouverie, Jacques Jonas
Summary: This study aims to evaluate whether epileptic seizures may be a prognostic marker of MS disability. The results suggest that epileptic seizures may be associated with the severity and progression of MS. If epileptic seizures occur early in MS, they may serve as a prognostic marker, while if they develop during the course of the disease, they may worsen the progression of MS.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Kevin Ahrweiller, Chloe Rousseau, Emmanuelle Le Page, Emma Bajeux, Emmanuelle Leray, Laure Michel, Gilles Edan, Anne Kerbrat
MULTIPLE SCLEROSIS JOURNAL
(2020)
Article
Clinical Neurology
Sandra Vukusic, Fabien Rollot, Romain Casey, Julie Pique, Romain Marignier, Guillaume Mathey, Gilles Edan, David Brassat, Aurelie Ruet, Jerome De Seze, Elisabeth Maillart, Helene Zephir, Pierre Labauge, Nathalie Derache, Christine Lebrun-Frenay, Thibault Moreau, Sandrine Wiertlewski, Eric Berger, Xavier Moisset, Audrey Rico-Lamy, Bruno Stankoff, Caroline Bensa, Eric Thouvenot, Olivier Heinzlef, Abdullatif Al-Khedr, Bertrand Bourre, Mathieu Vaillant, Philippe Cabre, Alexis Montcuquet, Abir Wahab, Jean-Philippe Camdessanche, Ayman Tourbah, Anne-Marie Guennoc, Karolina Hankiewicz, Ivania Patry, Chantal Nifle, Nicolas Maubeuge, Celine Labeyrie, Patrick Vermersch, David-Axel Laplaud, Francis Guillemin, Michel Clanet, Bruno Brochet, Jean Pelletier, Francois Cotton, Bertrand Fontaine, Muriel Malbezin, Javier Olaiz, Claire Rigaud-Bully, Nadine Debard, Francoise Durand-Dubief, Amalle Abdelalli, Marc Debouverie, Amandine Ziegler, Emmanuelle Leray, Laure Michel, Romain Muraz, Damien Le Port, Jonathan Ciron, Damien Biotti, Jean-Christophe Ouallet, Katy-Kim Kounkou, Nicolas Collongues, Carole Berthe, Patrick Hautecoeur, Olivier Outteryck, Fabienne Deruelle, Caroline Papeix, Catherine Lubetzki, Mikael Cohen, Celine Callier, Gilles Defer, Pierre Branger, Xavier Ayrignac, Clarisse Carra-Dalliere, Frederic Pinna, Agnes Fromont, Alexia Protin, Natacha Jousset, Nathalie Devys-Meyer, Mathieu Bereau, Chrystelle Cappe, Pierre Clavelou, Frederic Taithe, Emilie Dumont, Bertrand Audoin, Bernadette Di Lelio, Giovanni Castelnovo, Claire Giannesini, Ombeline Fagniez, Clemence Laage, Romain Lefaucheur, David Maltete, Christine Vimont, Sabrina Sehaki, Olivier Gout, Antoine Guegen, Irene Tabellah Kasonde, Aymeric De Vilmarrest, Laurent Magy, Marie Nicol, Olivier Casez, Maty Diop Kane, Vincent Visneux, Stephane Beltran, Geraldine Meunier, Alain Creange, Jerome Hodel, Mohamed Abdellaoui, Corinne Pottier, Iuliana Slesari, Mathilde Sampaio, Jean-Philippe Neau, Emilie Rabois, Edwige Lescieux, Jerome Servan, Fernando Pico, Virginie Chatagner, Carole Henry, Thomas De Broucker, Cedric Castex, Sadou-Safa Diallo
Article
Clinical Neurology
Laura Couloume, Laetitia Barbin, Emmanuelle Leray, Sandrine Wiertlewski, Emmanuelle Le Page, Anne Kerbrat, Solenn Ory, Damien Le Port, Gilles Edan, David-Axel Laplaud, Laure Michel
MULTIPLE SCLEROSIS JOURNAL
(2020)
Article
Pharmacology & Pharmacy
Viviane Kovess-Masfety, Frederic Balusson, Emmanuelle Leray, Mathilde Husky, Lucie-Marie Scailteux
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2020)
Review
Clinical Neurology
Julie Havas, Emmanuelle Leray, Fabien Rollot, Romain Casey, Laure Michel, Flora Lejeune, Sandrine Wiertlewski, David Laplaud, Yohann Foucher
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2020)
Article
Clinical Neurology
Izanne Roos, Emmanuelle Leray, Federico Frascoli, Romain Casey, J. William L. Brown, Dana Horakova, Eva K. Havrdova, Maria Trojano, Francesco Patti, Guillermo Izquierdo, Sara Eichau, Marco Onofrj, Alessandra Lugaresi, Alexandre Prat, Marc Girard, Pierre Grammond, Patrizia Sola, Diana Ferraro, Serkan Ozakbas, Roberto Bergamaschi, Maria Jose Sa, Elisabetta Cartechini, Cavit Boz, Franco Granella, Raymond Hupperts, Murat Terzi, Jeannette Lechner-Scott, Daniele Spitaleri, Vincent Van Pesch, Aysun Soysal, Javier Olascoaga, Julie Prevost, Eduardo Aguera-Morales, Mark Slee, Tunde Csepany, Recai Turkoglu, Youssef Sidhom, Riadh Gouider, Bart Van Wijmeersch, Pamela McCombe, Richard Macdonell, Alasdair Coles, Charles B. Malpas, Helmut Butzkueven, Sandra Vukusic, Tomas Kalincik
Article
Public, Environmental & Occupational Health
Mathilde Lefort, Yohann Foucher, Remi Lenain, Sandra Vukusic, Gilles Edan, Emmanuelle Leray
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2020)
Article
Mathematical & Computational Biology
Alice J. Sommer, Emmanuelle Leray, Young Lee, Marie-Abele C. Bind
Summary: Environmental epidemiology mainly estimates associations between environmental exposures and health outcomes, and a causal inference pipeline has been developed to help researchers estimate the effects of plausible hypothetical interventions.
STATISTICS IN MEDICINE
(2021)
Article
Clinical Neurology
Jonathan Roux, Elaine Kingwell, Feng Zhu, Helen Tremlett, Emmanuelle Leray
Summary: The study applied multi-channel sequence analysis (MCSA) to identify care consumption patterns of persons with multiple sclerosis in British Columbia, Canada, revealing disparities between different care consumption clusters and associations based on demographics and clinical features both in incident and prevalent cases.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Clare Walton, Rachel King, Lindsay Rechtman, Wendy Kaye, Emmanuelle Leray, Ruth Ann Marrie, Neil Robertson, Nicholas La Rocca, Bernard Uitdehaag, Ingrid van der Mei, Mitchell Wallin, Anne Helme, Ceri Angood Napier, Nick Rijke, Peer Baneke
MULTIPLE SCLEROSIS JOURNAL
(2020)
Meeting Abstract
Clinical Neurology
Izanne Roos, Emmanuelle Leray, Federico Frascoli, Romain Casey, Dana Horakova, Eva Havrdova, Maria Trojano, Guillermo Izquierdo Ayuso, Sara Eichau Madueno, Francesco Patti, Marco Onofrj, Alessandra Lugaresi, Alexandre Prat, Marc Girard, Pierre Duquette, Serkan Ozakbas, Pierre Grammond, Patrizia Sola, Diana Ferraro, Roberto Bergamaschi, Cavit Boz, Elisabetta Cartechini, Maria Jose Sa, Murat Terzi, Raed Alroughani, Francois Grand'Maison, Franco Granella, Gerardo Iuliano, Raymond Hupperts, Jeannette Lechner-Scott, Daniele Litterio A. Spitaleri, Vincent Van Pesch, Aysun Soysal, Julie Prevost, Eduardo Aguera Morales, Francisco Javier Olascoaga Urtaza, Recai Turkoglu, Youssef Sidhom, Riadh Gouider, Bart Van Wijmeersch, Helmut Butzkueven, Charles Malpas, Sandra Vukusic, Tomas Kalincik
Meeting Abstract
Clinical Neurology
Izanne Roos, Emmanuelle Leray, Federico Frascoli, Romain Casey, Dana Horakova, Eva Havrdova, Maria Trojano, Guillermo Izquierdo Ayuso, Sara Eichau Madueno, Francesco Patti, Alexandre Prat, Marc Girard, Pierre Duquette, Marco Onofrj, Alessandra Lugaresi, Pierre Grammond, Serkan Ozakbas, Patrizia Sola, Diana Ferraro, Roberto Bergamaschi, Elisabetta Cartechini, Maria Jose Sa, Cavit Boz, Francois Grand-Maison, Jeannette Lechner-Scott, Murat Terzi, Franco Granella, Raed Alroughani, Gerardo Iuliano, Raymond Hupperts, Daniele Litterio A. Spitaleri, Vincent Van Pesch, Aysun Soysal, Julie Prevost, Francisco Javier Olascoaga Urtaza, Eduardo Morales, Recai Turkoglu, Mark Slee, Cristina Ramo, Youssef Sidhom, Riadh Gouider, Pamela McCombe, Helmut Butzkueven, Charles Malpas, Sandra Vukusic, Tomas Kalincik
Meeting Abstract
Clinical Neurology
H. Tillaut, S. Kerbrat, A. Degremont, E. Polard, E. Leray
EUROPEAN JOURNAL OF NEUROLOGY
(2020)
Meeting Abstract
Clinical Neurology
M. Lefort, S. Shannin, J. Andersen, S. Vukusic, N. J. Koch-Henriksen, D. Lapland, H. Butzkueven, M. Magyari, T. Kalincik, E. Leray
EUROPEAN JOURNAL OF NEUROLOGY
(2020)
Article
Clinical Neurology
Astrid Barataud-Reilhac, Sandrine Kerbrat, Jonathan Roux, Alice Guilleux, Elisabeth Polard, Emmanuelle Leray
NEUROLOGY-CLINICAL PRACTICE
(2020)