Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 26, Issue 14, Pages 1898-1906Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458519894713
Keywords
Biotin; multiple sclerosis; primary progressive multiple sclerosis; secondary progressive multiple sclerosis; progression; effectiveness
Categories
Funding
- MedDay Pharma
- ANTARES association
Ask authors/readers for more resources
Background: A recent controlled trial suggested that high-dose biotin supplementation reverses disability progression in patients with progressive multiple sclerosis. Objective: To analyze the impact of high-dose biotin in routine clinical practice on disability progression at 12 months. Methods: Progressive multiple sclerosis patients who started high-dose biotin at Nantes or Rennes Hospital between 3 June 2015 and 15 September 2017 were included in this prospective study. Disability outcome measures, patient-reported outcome measures, relapses, magnetic resonance imaging (MRI) data, and adverse events were collected at baseline, 6, and 12 months. Results: A total of 178 patients were included. At baseline, patients were 52.0 +/- 9.4 years old, mean Expanded Disability Status Scale (EDSS) score was 6.1 +/- 1.3, mean disease duration was 16.9 +/- 9.5 years. At 12 months, 3.8% of the patients had an improved EDSS score. Regarding the other disability scales, scores either remained stable or increased significantly. In total, 47.4% of the patients described stability, 27.6% felt an improvement, and 25% described a worsening. Four patients (2.2%) had a relapse. Of the 74 patients (41.6%) who underwent an MRI, 20 (27.0%) had new T2 lesions, 8 (10.8%) had gadolinium-enhancing lesions. Twenty-five (14%) reported adverse event. Conclusion: In this study, high-dose biotin did not seem to be associated with a clear improvement in disability.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available