Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 65, Issue -, Pages 232-239Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2013.04.021
Keywords
Ferrrocene; 1,4-Dihydropyrimidines; Ferrocenyl chalcones; Amidines; Anti breast cancer activity
Categories
Ask authors/readers for more resources
A novel series of ferrocene tagged multi-functionalized 1,4-dihydropyrimidines is synthesized by base catalyzed cyclocondensation between ferrocenyl chalcones and amidines. The structures of synthesized compounds were established on the basis of H-1 NMR, C-13 NMR, FTIR spectroscopy as well as by mass spectrometry. The compounds were evaluated for in vitro anticancer activity. The most active compounds from the series displayed GI(50) value equal to doxorubicin against the strain of human breast cancer cell line MDA-MB-435. (C) 2013 Elsevier Masson SAS. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available