期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 65, 期 -, 页码 232-239出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2013.04.021
关键词
Ferrrocene; 1,4-Dihydropyrimidines; Ferrocenyl chalcones; Amidines; Anti breast cancer activity
A novel series of ferrocene tagged multi-functionalized 1,4-dihydropyrimidines is synthesized by base catalyzed cyclocondensation between ferrocenyl chalcones and amidines. The structures of synthesized compounds were established on the basis of H-1 NMR, C-13 NMR, FTIR spectroscopy as well as by mass spectrometry. The compounds were evaluated for in vitro anticancer activity. The most active compounds from the series displayed GI(50) value equal to doxorubicin against the strain of human breast cancer cell line MDA-MB-435. (C) 2013 Elsevier Masson SAS. All rights reserved.
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