Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 24, Issue 8, Pages 1648-1652Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2016.02.036
Keywords
Carbonic anhydrase; Carbonic anhydrase inhibitors; Candida; Isatins; Sulfonamides
Funding
- Istanbul University Scientific Research Projects Department [UDP-32911]
Ask authors/readers for more resources
Enzyme inhibition data of structurally novel isatin-containing sulfonamides were determined for two carbonic anhydrases (CAs, EC 4.2.1.1) from pathogenic Candida species (CaNce103 from C. albicans and CgNce103 from C. glabrata). The compounds show K-I values in the low nanomolar range for the fungal CAs, while they have significantly higher K-I values for the human CAs. Homology models were constructed for the CaNce103 and CgNce103 and subsequently the ligands were docked into these models to rationalize their enzyme inhibitory properties. (C) 2016 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
