Squalene - biochemistry, molecular biology, process biotechnology, and applications

Squalene Selectively Protects Mouse Bone Marrow Progenitors Against Cisplatin and Carboplatin-Induced Cytotoxicity In Vivo Without Protecting Tumor Growth

(2015) Bikul Das et al.   NEOPLASIA

Observations on squalene accumulation in Saccharomyces cerevisiae due to the manipulation of HMG2 and ERG6

(2011) Fani Mantzouridou et al.   FEMS YEAST RESEARCH

Vaccine adjuvants: The dream becomes real

(2011) Aldo Tagliabue et al.   Human vaccines & immunotherapeutics

Novel Fractionation Method for Squalene and Phytosterols Contained in the Deodorization Distillate of Rice Bran Oil

(2011) Naoko Sugihara et al.   Journal of Oleo Science

Interaction of a new anticancer prodrug, gemcitabine–squalene, with a model membrane

(2010) Barbara Pili et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Squalenoyl nucleoside monophosphate nanoassemblies: New prodrug strategy for the delivery of nucleotide analogues

(2010) Joachim Caron et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Observations on squalene accumulation in Saccharomyces cerevisiae due to the manipulation of HMG2 and ERG6

(2010) Fani Mantzouridou et al.   FEMS YEAST RESEARCH

Supercritical CO2 extraction of oil, carotenoids, squalene and sterols from lotus (Nelumbo nucifera Gaertn) bee pollen

(2010) Xiang Xu et al.   FOOD AND BIOPRODUCTS PROCESSING

Squalene protects against oxidative DNA damage in MCF10A human mammary epithelial cells but not in MCF7 and MDA-MB-231 human breast cancer cells

(2010) Fernando Warleta et al.   FOOD AND CHEMICAL TOXICOLOGY

Cytoprotective effects of DL-alpha-lipoic acid or squalene on cyclophosphamide-induced oxidative injury: An experimental study on rat myocardium, testicles and urinary bladder

(2010) Tarek M.K. Motawi et al.   FOOD AND CHEMICAL TOXICOLOGY

Improvement of Reproduction Performance in AA+ Meat-Type Male Chicken by Feeding with Squalene

(2010) Shijun Li et al.   Journal of Animal and Veterinary Advances

Optimization of nitrogen source for enhanced production of squalene from thraustochytrid Aurantiochytrium sp.

(2010) Guanqun Chen et al.   New Biotechnology

The Arabidopsis thaliana FPP synthase isozymes have overlapping and specific functions in isoprenoid biosynthesis, and complete loss of FPP synthase activity causes early developmental arrest

(2010) Marta Closa et al.   PLANT JOURNAL

A new family of enzymes catalyzing the first committed step of the methylerythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis in bacteria

(2010) F. J. Sangari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced production of squalene in the thraustochytrid Aurantiochytrium mangrovei by medium optimization and treatment with terbinafine

(2010) King Wai Fan et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Squalene: A natural triterpene for use in disease management and therapy

(2009) L. Harivardhan Reddy et al.   ADVANCED DRUG DELIVERY REVIEWS

Improved Squalene Production via Modulation of the Methylerythritol 4-Phosphate Pathway and Heterologous Expression of Genes from Streptomyces peucetius ATCC 27952 in Escherichia coli

(2009) G. P. Ghimire et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Squalene-based oil-in-water emulsion adjuvants perturb metabolism of neutral lipids and enhance lipid droplet formation

(2009) Lucie Kalvodova   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High-dose squalene ingestion increases type I procollagen and decreases ultraviolet-induced DNA damage in human skinin vivobut is associated with transient adverse effects

(2009) S. Cho et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Cellular processes relying on sterol function in plants

(2009) Yohann Boutté et al.   CURRENT OPINION IN PLANT BIOLOGY

Vaccination, squalene and anti-squalene antibodies: Facts or fiction?

(2009) Giuseppe Lippi et al.   European Journal of Internal Medicine

Conjugation of squalene to acyclovir improves the affinity for biomembrane models

(2009) Maria Grazia Sarpietro et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Screening and Characterization of Squalene-Producing Thraustochytrids from Hong Kong Mangroves

(2009) Qian Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Squalene versus Ergosterol Formation Using Saccharomyces cerevisiae: Combined Effect of Oxygen Supply, Inoculum Size, and Fermentation Time on Yield and Selectivity of the Bioprocess

(2009) Fani Mantzouridou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Hopanoids Play a Role in Membrane Integrity and pH Homeostasis in Rhodopseudomonas palustris TIE-1

(2009) P. V. Welander et al.   JOURNAL OF BACTERIOLOGY

Geranylgeranyl Pyrophosphate Is a Potent Regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA Reductase Degradation in Yeast

(2009) Renee M. Garza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Lipid Particle Biogenesis on the Subcellular Distribution of Squalene in the Yeast Saccharomyces cerevisiae

(2009) Miroslava Spanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complete blockage of the mevalonate pathway results in male gametophyte lethality

(2009) M. Suzuki et al.   JOURNAL OF EXPERIMENTAL BOTANY

Pan-frying of French fries in three different edible oils enriched with olive leaf extract: Oxidative stability and fate of microconstituents

(2009) Antonia Chiou et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Squalene Emulsions for Parenteral Vaccine and Drug Delivery

(2009) Christopher Fox   MOLECULES

Biological and Pharmacological Activities of Squalene and Related Compounds: Potential Uses in Cosmetic Dermatology

(2009) Zih-Rou Huang et al.   MOLECULES

A unified mechanism of action for volatile isoprenoids in plant abiotic stress

(2009) Claudia E Vickers et al.   Nature Chemical Biology

Identification of the Arabidopsisdry2/sqe1-5mutant reveals a central role for sterols in drought tolerance and regulation of reactive oxygen species

(2009) David Posé et al.   PLANT JOURNAL

Impact of methyl jasmonate on squalene biosynthesis in microalga Schizochytrium mangrovei

(2009) Cai-Jun Yue et al.   PROCESS BIOCHEMISTRY

Novel PEGylated Nanoassemblies Made of Self-Assembled Squalenoyl Nucleoside Analogues

(2008) Fawzia Bekkara-Aounallah et al.   ADVANCED FUNCTIONAL MATERIALS

The isolation and characterization of Pseudozyma sp. JCC 207, a novel producer of squalene

(2008) Mi-Hee Chang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Breaking the cells of rape bee pollen and consecutive extraction of functional oil with supercritical carbon dioxide

(2008) Xiang Xu et al.   Innovative Food Science & Emerging Technologies

Rubritalea sabuli sp. nov., a carotenoid- and squalene-producing member of the family Verrucomicrobiaceae, isolated from marine sediment

(2008) J. Yoon et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Processing Stability of Squalene in Amaranth and Antioxidant Potential of Amaranth Extract

(2008) Rohan V. Tikekar et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cloning, Solubilization, and Characterization of Squalene Synthase from Thermosynechococcus elongatus BP-1

(2008) S. Lee et al.   JOURNAL OF BACTERIOLOGY

Evaluation of Asymmetric Liposomal Nanoparticles for Encapsulation of Polynucleotides

(2008) Jeremiah Whittenton et al.   LANGMUIR

Arabidopsis 3-hydroxy-3-methylglutaryl-CoA reductase is regulated at the post-translational level in response to alterations of the sphingolipid and the sterol biosynthetic pathways

(2008) Benjamín Nieto et al.   PHYTOCHEMISTRY

Arabidopsis thaliana contains a single gene encoding squalene synthase

(2008) Antoni Busquets et al.   PLANT MOLECULAR BIOLOGY

Discovery of New Hexagonal Supramolecular Nanostructures Formed by Squalenoylation of an Anticancer Nucleoside Analogue

(2008) Patrick Couvreur et al.   Small

The plastidial MEP pathway: unified nomenclature and resources

(2008) M PHILLIPS et al.   TRENDS IN PLANT SCIENCE

Safety of MF59™ adjuvant

(2008) Viola Schultze et al.   VACCINE

Supercritical carbon dioxide fractionation of the model mixture squalene/oleic acid in a membrane contactor

(2007) Rui Ruivo et al.   SEPARATION AND PURIFICATION TECHNOLOGY