Article
Chemistry, Applied
Ana Luiza Fontes, Bruna Neves, Tiago Conde, Daniela Couto, Ligia Leao Pimentel, Luis Miguel Rodriguez-Alcala, M. Rosario Domingues, Ana Maria Gomes
Summary: This study investigated potential fatty acid byproducts during microbial enrichment of CLA/CLNA and found that no additional side-fatty acid metabolites were released except for stearic acid in the presence of linoleic acid.
Article
Agriculture, Multidisciplinary
Baixi Zhang, Lijuan Ni, Xiaoshu Tang, Xuemei Chen, Bo Hu
Summary: This study achieved a high yield of t10, c12-CLA through genetic modification and reduced its degradation rate. The highest t10, c12-CLA yield reported to date was obtained in a bioreactor using low-cost carbon sources.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Food Science & Technology
Neha Baliyan, Antim Kumar Maurya, Anil Kumar, Vijai Kant Agnihotri, Rakshak Kumar
Summary: This study isolated probiotic strains from raw cow milk of the Lahaul valley capable of producing cis-9, trans-11 CLA isomer, and exhibiting antioxidant and food formulation abilities. Genome sequencing revealed the presence of antibiotic-resistance and virulence genes in Enterococcus faecalis LJM:05. The strain Latilactobacillus curvatus LGM:16 was used to develop curdled milk with superior probiotic features, antioxidant activity, and CLA-producing ability.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Applied
Suhong Li, Liangwei Xu, Junjun Qing, Xiaodan Wu, Haixing Li, Hongbing Chen, Xiaohua Liu
Summary: This article provides a review of the biological activities, biosynthesis mechanisms, and analytical methods of conjugated linoleic acid (CLA) isomers. The review focuses on the anti-obesity, cardiovascular protection, diabetes management, and anti-cancer activities of CLA isomers in both in vitro and in vivo studies. The production of specific CLA isomers is highlighted due to their biological activity. The article systematically introduces biosynthesis methods such as dietary modification in ruminants and fermentation by microorganisms & enzymes. Comparisons of various analysis methods, including UV spectrometry, GC, HPLC, MS, and CE, are discussed. The aim of this paper is to provide an overview of the current status and future trends in CLA isomer research.
Article
Neurosciences
Irene Pertici, Manuel H. Taft, Johannes N. Greve, Roman Fedorov, Marco Caremani, Dietmar J. Manstein
Summary: The direct binding of rumenic acid to cardiac myosin-2 motor domain affects the release rate of orthophosphate and the Ca2+ responsiveness of cardiac muscle. Rumenic acid can increase myocardial metabolic load and inhibit force generation in trabeculae without affecting the number of force-generating motors. Molecular docking studies show how rumenic acid binding site and associated pathways can differ among isoforms of myosin-2.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Microbiology
Nho-Eul Song, Na-Jeong Kim, Young-Hun Kim, Sang-Ho Baik
Summary: The study evaluated the probiotic properties of 10 strains of high CLA-producing lactic acid bacteria isolated from fermented seafood. Some of these strains produced significant amounts of CLA and demonstrated potential as probiotics with immune-modulating and antimicrobial activities in both cell and animal models.
Article
Chemistry, Multidisciplinary
Alexia N. Kim, Aurapat Ngamnithiporn, Michael D. Bartberger, Brian M. Stoltz
Summary: The first asymmetric trans-selective hydrogenation of 1,3-disubstituted isoquinolines has been developed, resulting in enantioenriched trans-tetrahydroisoquinolines in good yield with high enantioselectivity. Mechanistic studies reveal the crucial role of non-coordinating chlorinated solvents and halide additives in enabling trans-selectivity.
Article
Biochemistry & Molecular Biology
Sidi Liu, Siwei Sun, Wenjing Chen, Ru Jia, Baodong Zheng, Zebin Guo
Summary: This paper presents a new method using a combination of OSA esterification and high hydrostatic pressure for starch modification to form a stable complex. The formation of the complex improves thermal stability and digestion resistance, providing a potential direction for reducing starch digestibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Nutrition & Dietetics
Farzad Mohammadi, Amrita Dikpati, Nicolas Bertrand, Iwona Rudkowska
Summary: Studies have shown the potential benefits of consuming conjugated linoleic acid (CLA) and ruminant trans fatty acids (R-TFAs) in reducing the risk factors of metabolic syndrome (MetS). Encapsulation of CLA and R-TFAs can improve their oral delivery and further decrease the risk factors of MetS.
Article
Chemistry, Applied
Ahmad Nasrollahzadeh, Samaneh Mollaei Tavani, Edris Arjeh, Seid Mahdi Jafari
Summary: Conjugated linoleic acid (CLA) has gained significant attention as a health-promoting compound. Microbial biosynthesis of CLA is a practical and controllable method for commercial production, and understanding the interplay of different factors is essential in optimizing its quantity and composition.
Article
Biochemistry & Molecular Biology
Ali Jalilian, Taghi Golmohammadi, Reza Meshkani, Mehdi Koushki, Neda Eivazi, Reyhaneh Babaei Khorzoughi, Seyed Reza Hosseini Fard, Maliheh Paknejad
Summary: High concentrations of CLA-mix can significantly reduce intracellular total lipid and triglyceride deposition, playing a protective role against hepatic steatosis through regulating fatty acid oxidation and bile excretion via the PPAR alpha pathway.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Food Science & Technology
Yongchao Mei, Haiqin Chen, Bo Yang, Jianxin Zhao, Hao Zhang, Wei Chen
Summary: This article reviews the current knowledge about Bifidobacterium CLA producers, the complex factors regulating CLA production in Bifidobacterium, the role of CLA production in Bifidobacterium, and the potential mechanism underlying Bifidobacterium CLA production. It offers novel insights into the production of food-grade CLA as well as the rational design of health-promoting fermented foods or synbiotics.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Saori Hata, Kazunori Kikuchi, Kuniyuki Kano, Haruka Saito, Yuriko Sobu, Shoichi Kinoshita, Takashi Saito, Takaomi C. Saido, Yoshitake Sano, Hidenori Taru, Junken Aoki, Hiroto Komano, Taisuke Tomita, Shunji Natori, Toshiharu Suzuki
Summary: The study shows that c9,t11 CLA can suppress the generation of neurotoxic A beta protein in mouse neurons by affecting the localization of BACE1 and APP in different intracellular compartments.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Brian T. H. Tsui, Robert H. Morris
Summary: This study analyzed the change in interaction force constant between element-hydrogen stretching modes of trans-dihydrides of d block and p block elements for the first time. The results showed that as the transition metal M approaches group 12, the energy of symmetric and antisymmetric vibrations become closer, but drops below antisymmetric vibration when transitioning to group 13 elements E. The study also used DFT calculations to reveal the trend and demonstrate that the magnitude of these interactions increases down groups 11, 12, and 14 but remains fairly constant for group 13. Additionally, the study showed that this reversal is seen in the transition state for hydride transfer to CO2 from certain model compounds.
INORGANIC CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Yafang He, Kun Xu, Yunfeng Li, Huan Chang, Xia Liao, Hang Yu, Tian Tian, Chao Li, Yuan Shen, Qian Wu, Xin Liu, Lin Shi
Summary: The study found that CLA can improve body composition, with changes in the metabolome predicting responsiveness to intervention. Post-intervention metabolite alterations were associated with changes in body composition, showing the potential of baseline metabolite profiling in predicting CLA-induced benefits.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Food Science & Technology
Sunduz Sezer Kiralan, Ferruh Erdogdu, Aziz Tekin
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
(2017)
Article
Food Science & Technology
Beyza Gelmez, Onur Ketenoglu, Huseyin Yavuz, Aziz Tekin
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
(2017)
Article
Food Science & Technology
Issa Javidipour, Hakan Erinc, Ayhan Basturk, Aziz Tekin
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2017)
Article
Engineering, Environmental
Sevilay Kiris, Yakup Sedat Velioglu, Aziz Tekin
OZONE-SCIENCE & ENGINEERING
(2017)
Article
Food Science & Technology
Ayse H. Altuntas, Onur Ketenoglu, Sena Cetinbas, Ferruh Erdogdu, Aziz Tekin
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
(2018)
Article
Food Science & Technology
Necla Ozdemir, Meryem Nur Kantekin-Erdogan, Tuba Tat, Aziz Tekin
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2018)
Article
Food Science & Technology
Hakan Erinc, Behic Mert, Aziz Tekin
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2018)
Article
Chemistry, Applied
Onur Ketenoglu, Ferruh Erdogdu, Aziz Tekin
JOURNAL OF OLEO SCIENCE
(2018)
Correction
Food Science & Technology
Onur Ketenoglu, Kubra Sahin Ozkan, Asli Yorulmaz, Aziz Tekin
LWT-FOOD SCIENCE AND TECHNOLOGY
(2018)
Article
Food Science & Technology
Onur Ketenoglu, Kubra Sahin Ozkan, Asli Yorulmaz, Aziz Tekin
LWT-FOOD SCIENCE AND TECHNOLOGY
(2018)
Article
Food Science & Technology
Onur Ketenoglu, Aziz Tekin
LWT-FOOD SCIENCE AND TECHNOLOGY
(2018)
Article
Food Science & Technology
Meryem Nur Kantekin-Erdogan, Onur Ketenoglu, Aziz Tekin
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2019)
Article
Food Science & Technology
S. Sezer Kiralan, Isra Toptanci, Aziz Tekin
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
(2019)
Article
Food Science & Technology
Kubra Sahin Ozkan, Onur Ketenoglu, Asli Yorulmaz, Aziz Tekin
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2019)
Article
Chemistry, Applied
S. Sezer Kiralan, Aziz Tekin
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2020)