Adaptor regulation of LFA-1 signaling in T lymphocyte migration: Potential druggable targets for immunotherapies?

Cofilin: a redox sensitive mediator of actin dynamics during T-cell activation and migration

(2014) Yvonne Samstag et al.   IMMUNOLOGICAL REVIEWS

Phosphorylation of Rab5a Protein by Protein Kinase Cϵ Is Crucial for T-cell Migration

(2014) Seow Theng Ong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The STAT3-Binding Long Noncoding RNA lnc-DC Controls Human Dendritic Cell Differentiation

(2014) P. Wang et al.   SCIENCE

Imaging early signaling events in T lymphocytes with fluorescent biosensors

(2013) Clotilde Randriamampita et al.   Biotechnology Journal

The integrin coactivator Kindlin-3 is not required for lymphocyte diapedesis

(2013) S. J. Cohen et al.   BLOOD

The Mechanism of Kindlin-Mediated Activation of Integrin αIIbβ3

(2013) Feng Ye et al.   CURRENT BIOLOGY

Defects of leukocyte migration in primary immunodeficiencies

(2013) Raffaele Badolato   EUROPEAN JOURNAL OF IMMUNOLOGY

Kindlin Binds Migfilin Tandem LIM Domains and Regulates Migfilin Focal Adhesion Localization and Recruitment Dynamics

(2013) Nina N. Brahme et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Kindlin 3 Pleckstrin Homology Domain Has an Essential Role in Lymphocyte Function-associated Antigen 1 (LFA-1) Integrin-mediated B Cell Adhesion and Migration

(2013) Rosie Hart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX

(2013) B. Arndt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PAG - a multipurpose transmembrane adaptor protein

(2013) M Hrdinka et al.   ONCOGENE

p21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils

(2013) Asako Itakura et al.   PLoS One

AKAP signaling complexes: pointing towards the next generation of therapeutic targets?

(2013) Jessica L. Esseltine et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Role of STAT3 in Cancer Metastasis and Translational Advances

(2013) Mohammad Zahid Kamran et al.   Biomed Research International

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

(2012) C. T. Lefort et al.   BLOOD

Nanobody-induced perturbation of LFA-1/L-plastin phosphorylation impairs MTOC docking, immune synapse formation and T cell activation

(2012) Sarah De Clercq et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Distinct Roles of Talin and Kindlin in Regulating Integrin α5β1 Function and Trafficking

(2012) Coert Margadant et al.   CURRENT BIOLOGY

Leukocyte Function-associated Antigen-1/Intercellular Adhesion Molecule-1 Interaction Induces a Novel Genetic Signature Resulting in T-cells Refractory to Transforming Growth Factor-β Signaling

(2012) Navin K. Verma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kindlin-3 Mediates Integrin αLβ2 Outside-in Signaling, and It Interacts with Scaffold Protein Receptor for Activated-C Kinase 1 (RACK1)

(2012) Chen Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leukocyte Function Antigen-1, Kindlin-3, and Calcium Flux Orchestrate Neutrophil Recruitment during Inflammation

(2012) N. Dixit et al.   JOURNAL OF IMMUNOLOGY

L-Plastin Regulates Polarization and Migration in Chemokine-Stimulated Human T Lymphocytes

(2012) M. Freeley et al.   JOURNAL OF IMMUNOLOGY

COP9 Signalosome Component JAB1/CSN5 Is Necessary for T Cell Signaling through LFA-1 and HIV-1 Replication

(2012) Shigemi M. Kinoshita et al.   PLoS One

Kindlin-3 is required for the stabilization of TCR-stimulated LFA-1:ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells

(2011) S. W. Feigelson et al.   BLOOD

The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes

(2011) R. Evans et al.   BLOOD

Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion

(2011) Danijela Petrovic et al.   HEPATOLOGY

Structural Basis of Phosphoinositide Binding to Kindlin-2 Protein Pleckstrin Homology Domain in Regulating Integrin Activation

(2011) Jianmin Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contact-Dependent T Cell Activation and T Cell Stopping Require Talin1

(2011) S. A. Wernimont et al.   JOURNAL OF IMMUNOLOGY

A Novel Leukocyte Adhesion Deficiency III Variant: Kindlin-3 Deficiency Results in Integrin- and Nonintegrin-Related Defects in Different Steps of Leukocyte Adhesion

(2011) P. Robert et al.   JOURNAL OF IMMUNOLOGY

Progressive multifocal leukoencephalopathy associated with efalizumab use in psoriasis patients

(2011) Namita Kothary et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Elucidation of the integrin LFA-1-mediated signaling pathway of actin polarization in natural killer cells

(2010) E. M. Mace et al.   BLOOD

Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency III patient reveal distinct effects on leukocyte function in vitro

(2010) A. McDowall et al.   BLOOD

Analysis of dynamic tyrosine phosphoproteome in LFA-1 triggered migrating t-cells

(2010) Navin K. Verma et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

T Cell Specific Adapter Protein (TSAd) Interacts with Tec Kinase ITK to Promote CXCL12 Induced Migration of Human and Murine T Cells

(2010) Tone Berge et al.   PLoS One

T Cell LFA-1 Engagement Induces HuR-Dependent Cytokine mRNA Stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 Signaling Cascade

(2010) Vinod S. Ramgolam et al.   PLoS One

JAB1/CSN5: a new player in cell cycle control and cancer

(2010) Terry J Shackleford et al.   Cell Division

Mediation of T-Cell Activation by Actin Meshworks

(2010) P. Beemiller et al.   Cold Spring Harbor Perspectives in Biology

Biochemical and Structural Properties of the Integrin-Associated Cytoskeletal Protein Talin

(2009) David R. Critchley   Annual Review of Biophysics

The Ins and Outs of Leukocyte Integrin Signaling

(2009) Clare L. Abram et al.   Annual Review of Immunology

The adaptor protein EBP50 is important for localization of the protein kinase A–Ezrin complex in T-cells and the immunomodulating effect of cAMP

(2009) Anne Jorunn Stokka et al.   BIOCHEMICAL JOURNAL

Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells

(2009) T. Quast et al.   BLOOD

Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions

(2009) E. Manevich-Mendelson et al.   BLOOD

STAT3-Stathmin Interactions Control Microtubule Dynamics in Migrating T-cells

(2009) Navin K. Verma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrins in immunity

(2009) R. Evans et al.   JOURNAL OF CELL SCIENCE

Src Homology 2-Domain Containing Leukocyte-Specific Phosphoprotein of 76 kDa Is Mandatory for TCR-Mediated Inside-Out Signaling, but Dispensable for CXCR4-Mediated LFA-1 Activation, Adhesion, and Migration of T Cells

(2009) J. Horn et al.   JOURNAL OF IMMUNOLOGY

Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project

(2009) Kenneth R Carson et al.   LANCET ONCOLOGY

The Adapter Protein SLP-76 Mediates "Outside-In" Integrin Signaling and Function in T Cells

(2009) R. G. Baker et al.   MOLECULAR AND CELLULAR BIOLOGY

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

(2009) Lena Svensson et al.   NATURE MEDICINE

Targeted but not trouble-free: efalizumab and PML

(2009) Eamonn S. Molloy et al.   Nature Reviews Rheumatology

SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility

(2009) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins

(2008) E. Y. Choi et al.   BLOOD

Kindlin-2 controls bidirectional signaling of integrins

(2008) E. Montanez et al.   GENES & DEVELOPMENT

Talin at a glance

(2008) D. R. Critchley et al.   JOURNAL OF CELL SCIENCE

A new twist to adaptor proteins contributes to regulation of lymphocyte cell signaling

(2008) Noah Isakov   TRENDS IN IMMUNOLOGY