Article
Multidisciplinary Sciences
Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederick J. Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jimenez-Alcazar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang, Albert R. La Spada, Ivan Marazzi
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects motor neurons and muscle control, with different gene mutations defining subtypes. A specific immune signature has been identified in ALS4 patients, potentially serving as a biomarker for disease progression.
Article
Multidisciplinary Sciences
Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederic Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jimenez-Alcazar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang, Albert R. La Spada, Ivan Marazzi
Summary: This study describes the presence of clonally expanded T-EMRA CD8 T cells in ALS4 knock-in mice and ALS4 patients, which may be related to disease progression and anti-glioma immunity. The results provide evidence for unraveling the disease mechanisms and serve as a potential biomarker of ALS4.
Editorial Material
Immunology
Tiani L. Louis, John T. Chang
Summary: In this study, Hirai et al. demonstrate the competition for the cytokine TGF beta as a key factor in regulating the persistence and occupancy of CD8(+) tissue-resident memory T cells in the skin epidermal niche.
Review
Immunology
Vanaja Konduri, Damilola Oyewole-Said, Jonathan Vazquez-Perez, Scott A. Weldon, Matthew M. Halpert, Jonathan M. Levitt, William K. Decker
Summary: NK1.1 and its human homolog CD161 are expressed on various immune cells and play different roles in NK cells, T cells, and NKT cells. CD161-expressing CD8(+) T cells, initially studied in viral infections, have potential implications in tumor immunology, although their exact role is not well understood.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Eliza Mari Kwesi-Maliepaard, Heinz Jacobs, Fred van Leeuwen
Summary: T-AIM cells are a subset of memory T cells that develop memory features independently of antigen exposure. They exhibit characteristics similar to conventional memory cells, including antigen-specific responses and responsiveness to innate stimuli. T-AIM cells are suggested to provide additional levels of protection against infections and cancer.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Marie Le Moine, Abdulkader Azouz, Guillem Sanchez Sanchez, Solange Dejolier, Muriel Nguyen, Severine Thomas, Valdrin Shala, Hacene Dreidi, Sebastien Denanglaire, Frederick Libert, David Vermijlen, Fabienne Andris, Stanislas Goriely
Summary: The co-inhibitory programmed death (PD)-1 signaling pathway has a crucial role in tumor-specific T cell responses as well as peripheral tolerance. This study reveals the involvement of PD-1 signaling in liver memory T cell homeostasis through the preferential expansion of CD8+ T cells with oligoclonal TCR repertoire and terminally differentiated exhaustion profile. The transcription factor EOMES is found necessary for the clonal expansion and acquisition of this differentiation program.
Review
Biochemistry & Molecular Biology
Jiaxue Zhang, Tong Lyu, Yaming Cao, Hui Feng
Summary: TCF-1, a transcription factor encoded by the TCF7 gene, plays a crucial role in T cell development and differentiation, influencing the functionality of T cells, especially CD8(+) T cells. It serves as a potential target for immunotherapy in cancer and infections, and can be used as a biomarker for assessing the efficacy of immunotherapy.
Article
Critical Care Medicine
Suzanna Paterson, Satwik Kar, Seng Kuong Ung, Zoe Gardener, Emma Bergstrom, Stephanie Ascough, Mohini Kalyan, Joanna Zyla, Jeroen Maertzdorf, Hans-Joachim Mollenkopf, January Weiner, Agnieszka Jozwik, Hannah Jarvis, Akhilesh Jha, Bradly P. Nicholson, Timothy Veldman, Chris W. Woods, Patrick Mallia, Onn Min Kon, Stefan H. E. Kaufmann, Peter J. Openshaw, Christopher Chiu
Summary: The study highlighted the suboptimal vaccine immunogenicity, antigenic mismatch, and poor uptake leading to influenza remaining a major global disease. Investigating the kinetics, phenotypes, and function of influenza virus-specific CD8(+) resident memory T cells in the lower airway, it was found that CD8(+) Trm cells in the human lung display innate-like gene and protein expression that demonstrates blurred divisions between innate and adaptive immunity.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Immunology
Amalie Skak Scholler, Loulieta Nazerai, Jan Pravsgaard Christensen, Allan Randrup Thomsen
Summary: The expression of PD-1 within the CNS correlates with decreased severity of clinical disease and is associated with local antigen encounter, despite its link to increased infiltration of CD8(+) T cells and upregulation of PD-L1 expression levels. Furthermore, despite the expression of markers associated with T-cell exhaustion, CNS Trms cells showed no signs of limited effector capacity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Georgiana Toma, Ioana Maria Lemnian, Eliza Karapetian, Ivo Grosse, Barbara Seliger
Summary: Memory CD8(+) T cells increase with aging, leading to higher susceptibility to infections and decreased vaccine efficiency. In this study, the age-dependent expression profile of CD8(+) T cells from young and old donors was analyzed. The results showed that CD8(+)CD45RA(-) memory T cells from old donors maintained the characteristics of total CD8(+) T cells, including increased cytokine secretion and JAK-STAT pathway transcripts.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Nadine Kamenjarin, Katrin Hodapp, Felix Melchior, Gregory Harms, Ann- Kathrin Hartmann, Joschka Bartneck, Sabine Muth, Verena K. Raker, Christian Becker, Anna Brand, Bjorn E. Clausen, Markus P. Radsak, Hansjorg Schild, Hans Christian Probst
Summary: Tissue-resident memory CD8+ T cells (TRM) in the skin require epidermal Langerhans cells, which cross-present keratinocyte-derived antigens, for their reactivation to provide protection against reinfection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Medicine, Research & Experimental
Tao Peng, Khamsone Phasouk, Emily Bossard, Alexis Klock, Lei Jin, Kerry J. Laing, Christine Johnston, Noel A. Williams, Julie L. Czartoski, Dana Varon, Annalyssa N. Long, Jason H. Bielas, Thomas M. Snyder, Harlan Robins, David M. Koelle, M. Juliana McElrath, Anna Wald, Lawrence Corey, Jia Zhu
Summary: Our study identified distinct populations of CD8(+) TRMs in the human ectocervix with different expression patterns, anatomical locations, and TCR repertoires, which target relevant viral antigens for improved host defense against sexually transmitted infections.
Article
Cell Biology
Gyohei Egawa, Ben Roediger, Szun S. Tay, Lois L. Cavanagh, Thomas Guy, Barbara de Fazekas, Anthony J. Brzoska, Neville Firth, Wolfgang Weninger
Summary: Staphylococcus aureus is a common cause of bacterial infections worldwide, and CTL proliferation is influenced by the activation of LN-resident dendritic cells, with large numbers of neutrophils recruited to the LNs to engulf bacteria. However, the decrease in neutrophils does not affect CTL proliferation.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Review
Immunology
Rut Mora-Buch, Shannon K. Bromley
Summary: Resident memory CD8(+) T cells provide rapid local protection and control tumor growth, but dysregulation may contribute to autoimmune diseases. Intrinsic mechanisms and extrinsic stimuli regulate T-RM differentiation and response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Alaa Madi, Nina Weisshaar, Michael Buettner, Gernot Poschet, Sicong Ma, Jingxia Wu, Alessa Mieg, Marvin Hering, Yanan Ming, Kerstin Mohr, Nora ten Bosch, Guoliang Cui
Summary: CD8 agonism activates memory T cell metabolism and enhances the efficacy of memory T cell-based cancer immunotherapy.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Cell & Tissue Engineering
Chun S. Park, Andrew Lewis, Taylor Chen, Daniel Lacorazza
STEM CELLS TRANSLATIONAL MEDICINE
(2019)
Review
Oncology
Lauren D. Scherer, Malcolm K. Brenner, Maksim Mamonkin
FRONTIERS IN ONCOLOGY
(2019)
Article
Oncology
Sai Arun Batra, Purva Rathi, Linjie Guo, Amy N. Courtney, Julien Fleurence, Julien Balzeau, Rahamthulla S. Shaik, Thao P. Nguyen, Meng-Fen Wu, Shaun Bulsara, Maksim Mamonkin, Leonid S. Metelitsa, Andras Heczey
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Biotechnology & Applied Microbiology
Henning Olbrich, Sebastian J. Theobald, Constanze Slabik, Laura Gerasch, Andreas Schneider, Michael Mach, Thomas Shum, Maksim Mamonkin, Renata Stripecke
HUMAN GENE THERAPY
(2020)
Editorial Material
Biotechnology & Applied Microbiology
Feiyan Mo, Helen E. Heslop, Maksim Mamonkini
Article
Biotechnology & Applied Microbiology
Feiyan Mo, Norihiro Watanabe, Mary K. McKenna, M. John Hicks, Madhuwanti Srinivasan, Diogo Gomes-Silva, Erden Atilla, Tyler Smith, Pinar Ataca Atilla, Royce Ma, David Quach, Helen E. Heslop, Malcolm K. Brenner, Maksim Mamonkin
Summary: Engineered T cells targeting allogeneic lymphocytes through the alloimmune defense receptor (ADR) demonstrated effective tumor eradication in mouse models of hematopoietic and solid cancers, offering a potential 'off-the-shelf' therapy for immunocompetent recipients. The ADR selectively recognizes the 4-1BB receptor transiently expressed on activated lymphocytes, allowing for prolonged persistence and therapeutic benefit of rejection-resistant allogeneic T cells. This approach may provide a promising solution to the challenges of manufacturing autologous T cells for cancer therapy.
NATURE BIOTECHNOLOGY
(2021)
Editorial Material
Hematology
Maksim Mamonkin
Article
Oncology
Pinar Ataca Atilla, Mary K. McKenna, Haruko Tashiro, Madhuwanti Srinivasan, Feiyan Mo, Norihiro Watanabe, Brian Wesley Simons, Alexandra McLean Stevens, Michele S. Redell, Helen E. Heslop, Maksim Mamonkin, Malcolm K. Brenner, Erden Atilla
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Cell & Tissue Engineering
Pinar Ataca Atilla, Mary K. McKenna, Norihiro Watanabe, Maksim Mamonkin, Malcolm K. Brenner, Erden Atilla
Summary: This study demonstrates that combinatorial targeting of CD33 or CD123 and CLL-1 using CAR T cells can effectively control the growth of heterogeneous AML tumors and improve survival rates.
Article
Cell & Tissue Engineering
Andrew Henry Lewis, Cory Seth Bridges, David Neal Moorshead, Taylor J. Chen, Wa Du, Barry Zorman, Pavel Sumazin, Monica Puppi, H. Daniel Lacorazza
Summary: In this study, we found that KLF4 plays an important role in acute myeloid leukemia (AML) and is related to the self-renewal and stemness of leukemia stem cells. Our experiments demonstrated that loss of KLF4 in leukemic granulocyte-macrophage progenitors (L-GMP) significantly reduced the frequency of leukemia stem cells and affected the cell cycle. We also found that upregulation of the DDX58 gene is associated with KLF4 loss and may be involved in this process. Therefore, KLF4 promotes leukemia progression in AML by regulating gene expression to support the division and stemness of leukemia stem cells.
Editorial Material
Hematology
M. Paulina Velasquez, Maksim Mamonkin
Summary: The article introduces a novel approach to generate autologous CD7-specific CAR T cells for treating patients with T-lineage malignancies. The research shows that this method has shown good efficacy in patients.
Article
Hematology
Cory Seth Bridges, Taylor J. Chen, Monica Puppi, Karen R. Rabin, H. Daniel Lacorazza
Summary: Novel drugs, such as OTSSP167, have been shown to have antileukemic capacity in children with high-risk T-cell acute lymphoblastic leukemia (T-ALL). OTSSP167 inhibits MAP2K7 kinase activity and the downstream substrate, JNK, leading to apoptosis and cell cycle arrest in T-ALL cell lines. It also exhibits synergistic effects when combined with other drugs and shows potential as an adjuvant treatment to enhance response and reduce relapses in pediatric T-ALL.
Editorial Material
Hematology
Dimitrios Laurin Wagner, Maksim Mamonkin
Article
Hematology
Jay A. Read, Rayne H. Rouce, Feiyan Mo, Maksim Mamonkin, Katherine Y. King
Summary: This study investigates the mechanism of delayed bone marrow recovery following CAR-T therapy. The results indicate that the elevation of inflammatory cytokines after CAR-T therapy leads to apoptosis and depletion of hematopoietic stem and progenitor cells, resulting in cytopenias. This finding has important implications for the safety and efficacy of CAR-T therapy.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Review
Oncology
Premal D. Lulla, Maksim Mamonkin, Malcolm K. Brenner