CD8+CD161+ T-Cells: Cytotoxic Memory Cells With High Therapeutic Potential

MHC class I and II peptide homology regulates the cellular immune response

(2020) Matthew M. Halpert et al.   FASEB JOURNAL

Changes of frequency and expression level of CD161 in CD8 + T cells and natural killer T cells in peripheral blood of patients with systemic lupus erythematosus

(2020) Yumi Park et al.   MICROBIOLOGY AND IMMUNOLOGY

CD161 Is Expressed in a Subset of T-Cell Prolymphocytic Leukemia Cases and Is Useful for Disease Follow-up

(2019) Scott R Gilles et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Mouse CD8+NKT-like cells exert dual cytotoxicity against mouse tumor cells and myeloid-derived suppressor cells

(2019) Zhengyuan Li et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions

(2019) Tianqi Leng et al.   Cell Reports

Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

(2019) Timothy S.C. Hinks et al.   Cell Reports

TCR- or Cytokine-Activated CD8+ Mucosal-Associated Invariant T Cells Are Rapid Polyfunctional Effectors That Can Coordinate Immune Responses

(2019) Rajesh Lamichhane et al.   Cell Reports

Loss of Circulating CD8+ CD161high T Cells in Primary Progressive Multiple Sclerosis

(2019) Massimo Acquaviva et al.   Frontiers in Immunology

Innate-like CD8+ T-cells and NK cells: converging functions and phenotypes

(2018) Ayako Kurioka et al.   IMMUNOLOGY

An intermediate level of CD161 expression defines a novel activated, inflammatory, and pathogenic subset of CD8 + T cells involved in multiple sclerosis

(2018) Bryan Nicol et al.   JOURNAL OF AUTOIMMUNITY

Expression of LLT1 and its receptor CD161 in lung cancer is associated with better clinical outcome

(2018) Véronique M. Braud et al.   OncoImmunology

IL-21 Selectively Protects CD62L+NKT Cells and Enhances Their Effector Functions for Adoptive Immunotherapy

(2018) Ho Ngai et al.   JOURNAL OF IMMUNOLOGY

Loss of natural killer T cells promotes pancreatic cancer in LSL-KrasG12D/+ mice

(2017) Naveena B. Janakiram et al.   IMMUNOLOGY

Transcriptional Regulation of Tissue-Resident Lymphocytes

(2017) Laura K. Mackay et al.   TRENDS IN IMMUNOLOGY

A subset of virus-specific CD161+T cells selectively express the multidrug transporter MDR1 and are resistant to chemotherapy in AML

(2016) Abdullah Alsuliman et al.   BLOOD

Chemo-immunotherapy mediates durable cure of orthotopic KrasG12D/p53−/− pancreatic ductal adenocarcinoma

(2016) Vanaja Konduri et al.   OncoImmunology

Dissecting CD8+NKT Cell Responses toListeriaInfection Reveals a Component of Innate Resistance

(2015) Sergey S. Seregin et al.   JOURNAL OF IMMUNOLOGY

CD161intCD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut

(2015) J R Fergusson et al.   Mucosal Immunology

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Beyond ecto-nucleotidase: CD39 defines human Th17 cells with CD161

(2015) Aiping Bai et al.   Purinergic Signalling

Lectin-like transcript 1 is a marker of germinal center-derived B-cell non-Hodgkin's lymphomas dampening natural killer cell functions

(2015) Claire Germain et al.   OncoImmunology

IL-15 Expands Unconventional CD8  NK1.1+ T Cells but Not V 14J 18+ NKT Cells

(2014) M. Terabe et al.   JOURNAL OF IMMUNOLOGY

Hepatitis C Virus-Specific Th17 Cells Are Suppressed by Virus-Induced TGF- 

(2014) A. G. Rowan et al.   JOURNAL OF IMMUNOLOGY

Functional Consequences of Interactions between Human NKR-P1A and Its Ligand LLT1 Expressed on Activated Dendritic Cells and B Cells

(2014) D. B. Rosen et al.   JOURNAL OF IMMUNOLOGY

CD39 and CD161 Modulate Th17 Responses in Crohn's Disease

(2014) Aiping Bai et al.   JOURNAL OF IMMUNOLOGY

MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets

(2014) A Kurioka et al.   Mucosal Immunology

NK1.1+ CD8+ T cells escape TGF-β control and contribute to early microbial pathogen response

(2014) Anne L. Ruiz et al.   Nature Communications

CD161 Defines a Transcriptional and Functional Phenotype across Distinct Human T Cell Lineages

(2014) Joannah R. Fergusson et al.   Cell Reports

MAIT cells, surveyors of a new class of antigen: development and functions

(2013) Lionel Le Bourhis et al.   CURRENT OPINION IN IMMUNOLOGY

Activated CD8 T cells acquire NK1.1 expression and preferentially locate in the liver in mice after allogeneic hematopoietic cell transplantation

(2013) Yi Wang et al.   IMMUNOLOGY LETTERS

CD161highCD8+T cells bear pathogenetic potential in multiple sclerosis

(2011) Viviana Annibali et al.   BRAIN

The number of CD161 positive Th17 cells are decreased in head and neck cancer patients

(2011) Rebecca Kesselring et al.   CELLULAR IMMUNOLOGY

Induction of Lectin-like Transcript 1 (LLT1) Protein Cell Surface Expression by Pathogens and Interferon-γ Contributes to Modulate Immune Responses

(2011) Claire Germain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Invariant NKT Cell Reconstitution in Pediatric Leukemia Patients Given HLA-Haploidentical Stem Cell Transplantation Defines Distinct CD4 + and CD4 − Subset Dynamics and Correlates with Remission State

(2011) Claudia de Lalla et al.   JOURNAL OF IMMUNOLOGY

CD161-Expressing Human T Cells

(2011) Joannah R. Fergusson et al.   Frontiers in Immunology

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Progress in dendritic cell immunotherapy: Elucidating the enigma of Th-1 polarization

(2010) William K. Decker et al.   Human vaccines & immunotherapeutics

Comparative Analysis of Activation Phenotype, Proliferation, and IFN-γ Production by Spleen NK1.1+ and NK1.1− T Cells During Plasmodium chabaudi AS Malaria

(2010) Sandra Marcia Muxel et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Antimicrobial activity of mucosal-associated invariant T cells

(2010) Lionel Le Bourhis et al.   NATURE IMMUNOLOGY

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties

(2010) E. Billerbeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Th17-like developmental process leads to CD8+Tc17 cells with reduced cytotoxic activity

(2009) Magdalena Huber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Distinct Subset of Self-Renewing Human Memory CD8+ T Cells Survives Cytotoxic Chemotherapy

(2009) Cameron J. Turtle et al.   IMMUNITY

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

(2009) Melanie A. Kleinschek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tc17, a Unique Subset of CD8 T Cells That Can Protect against Lethal Influenza Challenge

(2009) H. Hamada et al.   JOURNAL OF IMMUNOLOGY

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

Stepwise Development of MAIT Cells in Mouse and Human

(2009) Emmanuel Martin et al.   PLOS BIOLOGY

PILAR is a novel modulator of human T-cell expansion

(2008) E. Huarte et al.   BLOOD

CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation

(2008) John W. Northfield et al.   HEPATOLOGY

Human interleukin 17–producing cells originate from a CD161+CD4+T cell precursor

(2008) Lorenzo Cosmi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY